The Physiology of Mechanoelectrical Transduction Channels in Hearing

Mutations in TMC1 are a Common Cause of DFNB7/11 Hearing Loss in the Iranian Population

(2014) Michael S. Hildebrand et al.   ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY

Adenylate cyclase 1 (ADCY1) mutations cause recessive hearing impairment in humans and defects in hair cell function and hearing in zebrafish

(2014) R. L. P. Santos-Cortez et al.   HUMAN MOLECULAR GENETICS

Piezo2 is required for Merkel-cell mechanotransduction

(2014) Seung-Hyun Woo et al.   NATURE

Phosphatidylinositol Is Crucial for the Mechanosensitivity of Mycobacterium tuberculosis MscL

(2013) Dalian Zhong et al.   BIOCHEMISTRY

The composition and role of cross links in mechanoelectrical transduction in vertebrate sensory hair cells

(2013) C. M. Hackney et al.   JOURNAL OF CELL SCIENCE

The role of transmembrane channel–like proteins in the operation of hair cell mechanotransducer channels

(2013) Kyunghee X. Kim et al.   JOURNAL OF GENERAL PHYSIOLOGY

Electrical tuning and transduction in short hair cells of the chicken auditory papilla

(2013) Xiaodong Tan et al.   JOURNAL OF NEUROPHYSIOLOGY

tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans

(2013) Marios Chatzigeorgiou et al.   NATURE

A Prestin Motor in Chicken Auditory Hair Cells: Active Force Generation in a Nonmammalian Species

(2013) Maryline Beurg et al.   NEURON

Adaptation of Mammalian Auditory Hair Cell Mechanotransduction Is Independent of Calcium Entry

(2013) Anthony W. Peng et al.   NEURON

TMC1 and TMC2 Are Components of the Mechanotransduction Channel in Hair Cells of the Mammalian Inner Ear

(2013) Bifeng Pan et al.   NEURON

Integrity and Regeneration of Mechanotransduction Machinery Regulate Aminoglycoside Entry and Sensory Cell Death

(2013) Andrew A. Vu et al.   PLoS One

Stiffened lipid platforms at molecular force foci

(2013) A. Anishkin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2

(2013) David N. Furness et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Remodeling of Tip Links Underlies Mechanosensory Regeneration in Auditory Hair Cells

(2013) Artur A. Indzhykulian et al.   PLOS BIOLOGY

Stereocilia Membrane Deformation: Implications for the Gating Spring and Mechanotransduction Channel

(2012) Richard J. Powers et al.   BIOPHYSICAL JOURNAL

TMHS Is an Integral Component of the Mechanotransduction Machinery of Cochlear Hair Cells

(2012) Wei Xiong et al.   CELL

Kinocilia Mediate Mechanosensitivity in Developing Zebrafish Hair Cells

(2012) Katie S. Kindt et al.   DEVELOPMENTAL CELL

The development, distribution and density of the plasma membrane calcium ATPase 2 calcium pump in rat cochlear hair cells

(2012) Qingguo Chen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

How are inner hair cells stimulated? Evidence for multiple mechanical drives

(2012) John J. Guinan   HEARING RESEARCH

Localization of Usher 1 proteins to the photoreceptor calyceal processes, which are absent from mice

(2012) Iman Sahly et al.   JOURNAL OF CELL BIOLOGY

Developmental changes in the cochlear hair cell mechanotransducer channel and their regulation by transmembrane channel–like proteins

(2012) Kyunghee X. Kim et al.   JOURNAL OF GENERAL PHYSIOLOGY

Permeation properties of the hair cell mechanotransducer channel provide insight into its molecular structure

(2012) B. Pan et al.   JOURNAL OF NEUROPHYSIOLOGY

Large Membrane Domains in Hair Bundles Specify Spatially Constricted Radixin Activation

(2012) H. Zhao et al.   JOURNAL OF NEUROSCIENCE

Cornichons Modify Channel Properties of Recombinant and Glial AMPA Receptors

(2012) I. D. Coombs et al.   JOURNAL OF NEUROSCIENCE

Faster than the Speed of Hearing: Nanomechanical Force Probes Enable the Electromechanical Observation of Cochlear Hair Cells

(2012) Joseph C. Doll et al.   NANO LETTERS

Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction

(2012) Marcos Sotomayor et al.   NATURE

Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation

(2012) Zhiqiang Yan et al.   NATURE

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48

(2012) Saima Riazuddin et al.   NATURE GENETICS

Optimal Electrical Properties of Outer Hair Cells Ensure Cochlear Amplification

(2012) Jong-Hoon Nam et al.   PLoS One

Contribution of active hair-bundle motility to nonlinear amplification in the mammalian cochlea

(2012) F. Nin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mouse model for human deafness DFNB22 reveals that hearing impairment is due to a loss of inner hair cell stimulation

(2012) A. N. Lukashkin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Photomechanical Responses in Drosophila Photoreceptors

(2012) R. C. Hardie et al.   SCIENCE

TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells

(2012) K. Quick et al.   Open Biology

How the Genetics of Deafness Illuminates Auditory Physiology

(2011) Guy P. Richardson et al.   Annual Review of Physiology

Regulation of Stereocilia Length by Myosin XVa and Whirlin Depends on the Actin-Regulatory Protein Eps8

(2011) Uri Manor et al.   CURRENT BIOLOGY

The regulation of glutamate receptor trafficking and function by TARPs and other transmembrane auxiliary subunits

(2011) Christoph Straub et al.   CURRENT OPINION IN NEUROBIOLOGY

Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain

(2011) S. W. Webb et al.   DEVELOPMENT

Mechanotransduction in mouse inner ear hair cells requires transmembrane channel–like genes

(2011) Yoshiyuki Kawashima et al.   JOURNAL OF CLINICAL INVESTIGATION

The DEG/ENaC Protein MEC-10 Regulates the Transduction Channel Complex in Caenorhabditis elegans Touch Receptor Neurons

(2011) J. Arnadottir et al.   JOURNAL OF NEUROSCIENCE

Vibration responses of the organ of Corti and the tectorial membrane to electrical stimulation

(2011) Manuela Nowotny et al.   JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA

Prestin-Driven Cochlear Amplification Is Not Limited by the Outer Hair Cell Membrane Time Constant

(2011) Stuart L. Johnson et al.   NEURON

Mutations in Protocadherin 15 and Cadherin 23 Affect Tip Links and Mechanotransduction in Mammalian Sensory Hair Cells

(2011) Kumar N. Alagramam et al.   PLoS One

Functional Hair Cell Mechanotransducer Channels Are Required for Aminoglycoside Ototoxicity

(2011) Abdelrahman Alharazneh et al.   PLoS One

Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction

(2011) M. Grati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eukaryotic Mechanosensitive Channels

(2010) Jóhanna Árnadóttir et al.   Annual Review of Biophysics

Mechanosensitive Channels in Microbes

(2010) Ching Kung et al.   Annual Review of Microbiology

Topology of Transmembrane Channel-like Gene 1 Protein

(2010) Valentina Labay et al.   BIOCHEMISTRY

Actin-Bundling Protein TRIOBP Forms Resilient Rootlets of Hair Cell Stereocilia Essential for Hearing

(2010) Shin-ichiro Kitajiri et al.   CELL

Dynamic state and evoked motility in coupled hair bundles of the bullfrog sacculus

(2010) C.E. Strimbu et al.   HEARING RESEARCH

Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids

(2010) Amel Bahloul et al.   HUMAN MOLECULAR GENETICS

Asymmetric distribution of cadherin 23 and protocadherin 15 in the kinocilial links of avian sensory hair cells

(2010) Richard J. Goodyear et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane

(2010) Elisabeth Verpy et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Calcium Balance and Mechanotransduction in Rat Cochlear Hair Cells

(2010) Maryline Beurg et al.   JOURNAL OF NEUROPHYSIOLOGY

Development and Regeneration of Sensory Transduction in Auditory Hair Cells Requires Functional Interaction Between Cadherin-23 and Protocadherin-15

(2010) A. Lelli et al.   JOURNAL OF NEUROSCIENCE

The R109H Variant of Fascin-2, a Developmentally Regulated Actin Crosslinker in Hair-Cell Stereocilia, Underlies Early-Onset Hearing Loss of DBA/2J Mice

(2010) J.-B. Shin et al.   JOURNAL OF NEUROSCIENCE

Canonical TRP channels and mechanotransduction: from physiology to disease states

(2010) Amanda Patel et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

HCN Channels Are Not Required for Mechanotransduction in Sensory Hair Cells of the Mouse Inner Ear

(2010) Geoffrey C. Horwitz et al.   PLoS One

Genetic Inactivation of Trpml3 Does Not Lead to Hearing and Vestibular Impairment in Mice

(2010) Simone Jörs et al.   PLoS One

Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore

(2010) M. G. Derebe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Effectiveness of Hair Bundle Motility as the Cochlear Amplifier

(2009) Bora Sul et al.   BIOPHYSICAL JOURNAL

Mammalian somatosensory mechanotransduction

(2009) Makoto Tsunozaki et al.   CURRENT OPINION IN NEUROBIOLOGY

Tonotopic Gradient in the Developmental Acquisition of Sensory Transduction in Outer Hair Cells of the Mouse Cochlea

(2009) Andrea Lelli et al.   JOURNAL OF NEUROPHYSIOLOGY

Fast Adaptation and Ca2+ Sensitivity of the Mechanotransducer Require Myosin-XVa in Inner But Not Outer Cochlear Hair Cells

(2009) R. Stepanyan et al.   JOURNAL OF NEUROSCIENCE

Twinfilin 2 Regulates Actin Filament Lengths in Cochlear Stereocilia

(2009) A. W. Peng et al.   JOURNAL OF NEUROSCIENCE

Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filaments

(2009) Felipe T. Salles et al.   NATURE CELL BIOLOGY

Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging

(2009) Maryline Beurg et al.   NATURE NEUROSCIENCE

Harmonin Mutations Cause Mechanotransduction Defects in Cochlear Hair Cells

(2009) Nicolas Grillet et al.   NEURON

Harmonin-b, an actin-binding scaffold protein, is involved in the adaptation of mechanoelectrical transduction by sensory hair cells

(2009) Nicolas Michalski et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The transmembrane inner ear (Tmie) protein is essential for normal hearing and balance in the zebrafish

(2009) Michelle R. Gleason et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Actions of Calcium on Hair Bundle Mechanics in Mammalian Cochlear Hair Cells

(2008) Maryline Beurg et al.   BIOPHYSICAL JOURNAL

Cochlear amplification, outer hair cells and prestin

(2008) Peter Dallos   CURRENT OPINION IN NEUROBIOLOGY

The tectorial membrane: one slice of a complex cochlear sandwich

(2008) Guy P Richardson et al.   Current Opinion in Otolaryngology & Head and Neck Surgery

A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth

(2008) G. Lefevre et al.   DEVELOPMENT

TRPML3 mutations cause impaired mechano-electrical transduction and depolarization by an inward-rectifier cation current in auditory hair cells of varitint-waddler mice

(2008) Alexander F. J. Van Aken et al.   JOURNAL OF PHYSIOLOGY-LONDON

Making an Effort to Listen: Mechanical Amplification in the Ear

(2008) A.J. Hudspeth   NEURON

Prestin-Based Outer Hair Cell Motility Is Necessary for Mammalian Cochlear Amplification

(2008) Peter Dallos et al.   NEURON

The dimensions and structural attachments of tip links in mammalian cochlear hair cells and the effects of exposure to different levels of extracellular calcium

(2008) D.N. Furness et al.   NEUROSCIENCE

Cochlear Outer Hair Cell Motility

(2008) Jonathan Ashmore   PHYSIOLOGICAL REVIEWS