Sepsis: Multiple Abnormalities, Heterogeneous Responses, and Evolving Understanding

Evaluation of Neutrophil CD64 Expression and Procalcitonin as Useful Markers in Early Diagnosis of Sepsis

(2017) P. Cardelli et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Sepsis-Associated Encephalopathy: Review of the Neuropsychiatric Manifestations and Cognitive Outcome

(2014) Cory D. Lamar et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Human Recombinant Lactoferrin for Sepsis

(2013) Russell McCulloh et al.   CRITICAL CARE MEDICINE

A Phase 2 Randomized, Double-Blind, Placebo–Controlled Study of the Safety and Efficacy of Talactoferrin in Patients With Severe Sepsis*

(2013) Kalpalatha Guntupalli et al.   CRITICAL CARE MEDICINE

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

(2013) R. P. Dellinger et al.   INTENSIVE CARE MEDICINE

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach

(2013) Richard S Hotchkiss et al.   LANCET INFECTIOUS DISEASES

Effect of Daily Chlorhexidine Bathing on Hospital-Acquired Infection

(2013) Michael W. Climo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydroxyethyl starch 130/0.38-0.45 versus crystalloid or albumin in patients with sepsis: systematic review with meta-analysis and trial sequential analysis

(2013) N. Haase et al.   BMJ-British Medical Journal

Solulin increases clot stability in whole blood from humans and dogs with hemophilia

(2012) J. H. Foley et al.   BLOOD

suPAR as a prognostic biomarker in sepsis

(2012) Katia Donadello et al.   BMC Medicine

Cecal Ligation and Puncture-Induced Murine Sepsis Does Not Cause Lung Injury*

(2012) Kendra N. Iskander et al.   CRITICAL CARE MEDICINE

Predictors of survival in sepsis

(2012) Christoph Lichtenstern et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Serum procalcitonin in the diagnosis and management of intra-abdominal infections

(2012) Richard R Watkins et al.   Expert Review of Anti-Infective Therapy

Systematic analysis of hydroxyethyl starch (HES) reviews: proliferation of low-quality reviews overwhelms the results of well-performed meta-analyses

(2012) Christiane S. Hartog et al.   INTENSIVE CARE MEDICINE

The sensitivity of neutrophil CD64 expression as a biomarker of bacterial infection is low in critically ill patients

(2012) Antoine Gros et al.   INTENSIVE CARE MEDICINE

Sepsis Chronically in MARS: Systemic Cytokine Responses Are Always Mixed Regardless of the Outcome, Magnitude, or Phase of Sepsis

(2012) Marcin F. Osuchowski et al.   JOURNAL OF IMMUNOLOGY

Persistent inflammation and immunosuppression

(2012) Lori F. Gentile et al.   Journal of Trauma and Acute Care Surgery

After Xigris, researchers look to new targets to combat sepsis

(2012) Sarah C P Williams   NATURE MEDICINE

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Charting the NF-κB Pathway Interactome Map

(2012) Paolo Tieri et al.   PLoS One

Relationship between Age/Gender-Induced Survival Changes and the Magnitude of Inflammatory Activation and Organ Dysfunction in Post-Traumatic Sepsis

(2012) Susanne Drechsler et al.   PLoS One

The methylproteome and the intracellular methylation network

(2012) Melissa A. Erce et al.   PROTEOMICS

Diagnostic Accuracy of HMGB-1, sTREM-1, and CD64 as Markers of Sepsis in Patients Recently Admitted to the Emergency Department

(2011) Laura Y. Gámez-Díaz et al.   ACADEMIC EMERGENCY MEDICINE

Recombinant Tissue Factor Pathway Inhibitor in Severe Community-acquired Pneumonia

(2011) Richard G. Wunderink et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Review of α1-Antitrypsin Deficiency

(2011) James K. Stoller et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Acute Respiratory Distress Syndrome: Pathogenesis and Treatment

(2011) Michael A. Matthay et al.   Annual Review of Pathology-Mechanisms of Disease

The Pathogenesis of Sepsis

(2011) Deborah J. Stearns-Kurosawa et al.   Annual Review of Pathology-Mechanisms of Disease

Procalcitonin Algorithms for Antibiotic Therapy Decisions

(2011) Philipp Schuetz   ARCHIVES OF INTERNAL MEDICINE

The use of steroids in the treatment of severe sepsis and septic shock

(2011) Baruch M. Batzofin et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Antithrombotic drug candidate ALX-0081 shows superior preclinical efficacy and safety compared with currently marketed antiplatelet drugs

(2011) H. Ulrichts et al.   BLOOD

Dynamic changes of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) reflect sepsis severity and can predict prognosis: a prospective study

(2011) Jie Zhang et al.   BMC INFECTIOUS DISEASES

Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future

(2011) Philipp Schuetz et al.   BMC Medicine

Nationwide Trends of Severe Sepsis in the 21st Century (2000–2007)

(2011) Gagan Kumar et al.   CHEST

Biomarkers in the Critically Ill Patient: C-reactive Protein

(2011) Jean-Louis Vincent et al.   CRITICAL CARE CLINICS

Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury

(2011) Carolyn S. Calfee et al.   CRITICAL CARE MEDICINE

Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007

(2011) Tara Lagu et al.   CRITICAL CARE MEDICINE

Temporal trends in patient characteristics and survival of intensive care admissions with sepsis

(2011) Jacob Dreiher et al.   CRITICAL CARE MEDICINE

Immuno-imaging using nanobodies

(2011) Ilse Vaneycken et al.   CURRENT OPINION IN BIOTECHNOLOGY

Sepsis leads to a reduced antigen-specific primary antibody response

(2011) Arno Mohr et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Early diagnosis of sepsis using serum biomarkers

(2011) Terence Chan et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Preclinical screening of anti-HER2 nanobodies for molecular imaging of breast cancer

(2011) Ilse Vaneycken et al.   FASEB JOURNAL

High pentraxin 3 level predicts septic shock and bacteremia at the onset of febrile neutropenia after intensive chemotherapy of hematologic patients

(2011) M. Vanska et al.   HAEMATOLOGICA

Mixed antagonist response and sepsis severity-dependent dysbalance of pro- and anti-inflammatory responses at the onset of postoperative sepsis

(2011) Alexander R. Novotny et al.   IMMUNOBIOLOGY

The difficulties of clinical trials evaluating therapeutic agents in patients with severe sepsis

(2011) T. C. Hall et al.   IRISH JOURNAL OF MEDICAL SCIENCE

The Search for Effective Therapy for Sepsis

(2011) Derek C. Angus   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Diagnostic and prognostic biomarkers of sepsis in critical care

(2011) S. Kibe et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Disease-Related Outcomes With Long-Term Follow-Up: An Updated Analysis of the Intergroup Exemestane Study

(2011) Judith M. Bliss et al.   JOURNAL OF CLINICAL ONCOLOGY

Analysis of progression in risk, injury, failure, loss, and end-stage renal disease classification on outcome in patients with severe sepsis and septic shock

(2011) Won Young Kim et al.   JOURNAL OF CRITICAL CARE

Discriminative Value of Inflammatory Biomarkers for Suspected Sepsis

(2011) Ephraim L. Tsalik et al.   JOURNAL OF EMERGENCY MEDICINE

A2B Adenosine Receptor Blockade Enhances Macrophage-Mediated Bacterial Phagocytosis and Improves Polymicrobial Sepsis Survival in Mice

(2011) B. G. Belikoff et al.   JOURNAL OF IMMUNOLOGY

Dangers Within: DAMP Responses to Damage and Cell Death in Kidney Disease

(2011) D. L. Rosin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Predictability of Adjuvant Trastuzumab Benefit in N9831 Patients Using the ASCO/CAP HER2-Positivity Criteria

(2011) Edith A. Perez et al.   JNCI-Journal of the National Cancer Institute

The thrombomodulin analog Solulin promotes reperfusion and reduces infarct volume in a thrombotic stroke model

(2011) E. J. SU et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Apoptosis and acute kidney injury

(2011) Andrea Havasi et al.   KIDNEY INTERNATIONAL

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

High Plasma Level of Long Pentraxin 3 (PTX3) Is Associated with Fatal Disease in Bacteremic Patients: A Prospective Cohort Study

(2011) Reetta Huttunen et al.   PLoS One

Extracellular Administration of BCL2 Protein Reduces Apoptosis and Improves Survival in a Murine Model of Sepsis

(2011) Akiko Iwata et al.   PLoS One

Lipopolysaccharide-Binding Protein for Monitoring of Postoperative Sepsis: Complemental to C-Reactive Protein or Redundant?

(2011) Klaus Tschaikowsky et al.   PLoS One

Endoplasmic Reticulum Stress Pathway-Mediated Apoptosis in Macrophages Contributes to the Survival of Mycobacterium tuberculosis

(2011) Yun-Ji Lim et al.   PLoS One

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Factor V Leiden Mutation in Severe Infection and Sepsis

(2011) Marcel Levi et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Mass Spectometry-Based Protein Patterns in the Diagnosis of Sepsis/Systemic Inflammatory Response Syndrome

(2011) Michael Kiehntopf et al.   SHOCK

Epidermal Growth Factor Improves SurvivaL and Prevents Intestinal Injury in a Murine Model of Pseudomonas aeruginosa Pneumonia

(2011) Jessica A. Dominguez et al.   SHOCK

Adenosine Negative Feedback on A2A Adenosine Receptors Mediates Hyporesponsiveness in Chronically Septic Mice

(2011) Bryan Belikoff et al.   SHOCK

The in vitro effect of the new antithrombotic drug candidate ALX-0081 on blood samples of patients undergoing percutaneous coronary intervention

(2011) Janine E. van Loon et al.   THROMBOSIS AND HAEMOSTASIS

Pathogenesis of indirect (secondary) acute lung injury

(2011) Mario Perl et al.   Expert Review of Respiratory Medicine

Mortality in Patients With Septic Shock Correlates With Anti-Inflammatory But not Proinflammatory Immunomodulatory Molecules

(2011) Raúl de Pablo et al.   JOURNAL OF INTENSIVE CARE MEDICINE

PKR-dependent CHOP induction limits hyperoxia-induced lung injury

(2010) Tricia I. Lozon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Management of sepsis in neutropenic patients: guidelines from the infectious diseases working party of the German Society of Hematology and Oncology

(2010) O. Penack et al.   ANNALS OF ONCOLOGY

Multiplex cytokine profiling in patients with sepsis

(2010) SIMONA MERA et al.   APMIS

Nanotechnologies for pathogen detection: Future alternatives?

(2010) Chantal Fournier-Wirth et al.   BIOLOGICALS

Computational modeling with forward and reverse engineering links signaling network and genomic regulatory responses: NF-κB signaling-induced gene expression responses in inflammation

(2010) Shih Peng et al.   BMC BIOINFORMATICS

High-mobility group box-1 protein, lipopolysaccharide-binding protein, interleukin-6 and C-reactive protein in children with community acquired infections and bacteraemia: a prospective study

(2010) Jana Pavare et al.   BMC INFECTIOUS DISEASES

Point: Adherence to Early Goal-Directed Therapy

(2010) Emanuel P. Rivers   CHEST

Endoplasmic Reticulum Stress As a Therapeutic Target in Cardiovascular Disease

(2010) Tetsuo Minamino et al.   CIRCULATION RESEARCH

Diagnostic accuracy of sTREM-1 to identify infection in critically ill patients with systemic inflammatory response syndrome

(2010) Jaime Latour-Pérez et al.   CLINICAL BIOCHEMISTRY

The Era of Molecular and Other Non-Culture-Based Methods in Diagnosis of Sepsis

(2010) N. Mancini et al.   CLINICAL MICROBIOLOGY REVIEWS

From mice to men: Systematic reviews of animal data could make sepsis trials safer and more productive*

(2010) Lucas R. Pitts et al.   CRITICAL CARE MEDICINE

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

(2010) Todd W. Rice et al.   CRITICAL CARE MEDICINE

Hypoglycemia is associated with intensive care unit mortality*

(2010) Jeroen Hermanides et al.   CRITICAL CARE MEDICINE

Impact of the Surviving Sepsis Campaign protocols on hospital length of stay and mortality in septic shock patients: Results of a three-year follow-up quasi-experimental study*

(2010) Álvaro Castellanos-Ortega et al.   CRITICAL CARE MEDICINE

Restoring endoplasmic reticulum function by chemical chaperones: an emerging therapeutic approach for metabolic diseases

(2010) F. Engin et al.   DIABETES OBESITY & METABOLISM

Impact of the Surviving Sepsis Campaign on the recognition and management of severe sepsis in the emergency department: are we failing?

(2010) H. L. Cronshaw et al.   EMERGENCY MEDICINE JOURNAL

Mammalian ER stress sensor IRE1β specifically down-regulates the synthesis of secretory pathway proteins

(2010) Daisuke Nakamura et al.   FEBS LETTERS

Interleukin-7 (IL-7) Treatment Accelerates Neutrophil Recruitment through    T-Cell IL-17 Production in a Murine Model of Sepsis

(2010) K. R. Kasten et al.   INFECTION AND IMMUNITY

Distinct Physiologic and Inflammatory Responses Elicited in Baboons after Challenge with Shiga Toxin Type 1 or 2 from Enterohemorrhagic Escherichia coli

(2010) D. J. Stearns-Kurosawa et al.   INFECTION AND IMMUNITY

Diagnostic utility of elevated serum soluble triggering receptor expressed on myeloid cells (sTREM)-1 in infected neonates

(2010) Kosmas Sarafidis et al.   INTENSIVE CARE MEDICINE

Effects of fluids on microvascular perfusion in patients with severe sepsis

(2010) Gustavo Ospina-Tascon et al.   INTENSIVE CARE MEDICINE

The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis

(2010) Mitchell M. Levy et al.   INTENSIVE CARE MEDICINE

Early changes of procalcitonin may advise about prognosis and appropriateness of antimicrobial therapy in sepsis

(2010) Antonia-Panagiota Georgopoulou et al.   JOURNAL OF CRITICAL CARE

Predictive value of procalcitonin, interleukin-6, and C-reactive protein for survival in postoperative patients with severe sepsis

(2010) Klaus Tschaikowsky et al.   JOURNAL OF CRITICAL CARE

Early Enhanced Local Neutrophil Recruitment in Peritonitis-Induced Sepsis Improves Bacterial Clearance and Survival

(2010) F. L. Craciun et al.   JOURNAL OF IMMUNOLOGY

IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in Sepsis

(2010) J. Unsinger et al.   JOURNAL OF IMMUNOLOGY

Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock

(2010) H Bryant Nguyen et al.   Journal of Inflammation-London

Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis

(2010) P. Brahmamdam et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Generation and characterization of inhibitory nanobodies towards thrombin activatable fibrinolysis inhibitor

(2010) K. BUELENS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Activated protein C modulates inflammation, apoptosis and tissue factor procoagulant activity by regulating endoplasmic reticulum calcium depletion in blood monocytes

(2010) L. J. TOLTL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial

(2010) Lila Bouadma et al.   LANCET

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Immunotherapy for Sepsis — A New Approach against an Ancient Foe

(2010) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Translational systems biology of inflammation: potential applications to personalized medicine

(2010) Qi Mi et al.   Personalized Medicine

Agent-Based Modeling of Endotoxin-Induced Acute Inflammatory Response in Human Blood Leukocytes

(2010) Xu Dong et al.   PLoS One

Phenylbutyric Acid Rescues Endoplasmic Reticulum Stress-Induced Suppression of APP Proteolysis and Prevents Apoptosis in Neuronal Cells

(2010) Jesse C. Wiley et al.   PLoS One

Early-Age-Related Changes in Proteostasis Augment Immunopathogenesis of Sepsis and Acute Lung Injury

(2010) Manish Bodas et al.   PLoS One

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UNTREATED TYPE 1 DIABETES INCREASES SEPSIS-INDUCED MORTALITY WITHOUT INDUCING A PRELETHAL CYTOKINE RESPONSE

(2010) Marcin F. Osuchowski et al.   SHOCK

REPETITIVE LOW-VOLUME BLOOD SAMPLING METHOD AS A FEASIBLE MONITORING TOOL IN A MOUSE MODEL OF SEPSIS

(2010) Katrin M. Weixelbaumer et al.   SHOCK

REPERFUSION DOES NOT INDUCE OXIDATIVE STRESS BUT SUSTAINED ENDOPLASMIC RETICULUM STRESS IN LIVERS OF RATS SUBJECTED TO TRAUMATIC-HEMORRHAGIC SHOCK

(2010) Johanna Catharina Duvigneau et al.   SHOCK

Prospective evaluation of three different diagnostic criteria for disseminated intravascular coagulation

(2010) T. Takemitsu et al.   THROMBOSIS AND HAEMOSTASIS

Phase I study of Solulin, a novel recombinant soluble human thrombomodulin analogue

(2010) Thijs van Iersel et al.   THROMBOSIS AND HAEMOSTASIS

Granulocyte–Macrophage Colony-stimulating Factor to Reverse Sepsis-associated Immunosuppression

(2009) Christian Meisel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

New methods for selective isolation of bacterial DNA from human clinical specimens

(2009) Hans-Peter Horz et al.   ANAEROBE

Multicenter Study of Central Venous Oxygen Saturation (ScvO2) as a Predictor of Mortality in Patients With Sepsis

(2009) Jennifer V. Pope et al.   ANNALS OF EMERGENCY MEDICINE

NR2F1 and IRE1β Suppress Microsomal Triglyceride Transfer Protein Expression and Lipoprotein Assembly in Undifferentiated Intestinal Epithelial Cells

(2009) Kezhi Dai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The origin, evolution and structure of the protein world

(2009) Gustavo Caetano-Anollés et al.   BIOCHEMICAL JOURNAL

Endotoxin causes functional endoplasmic reticulum failure, possibly mediated by mitochondria

(2009) Andrey V. Kozlov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Guidelines for the diagnosis and management of disseminated intravascular coagulation

(2009) M Levi et al.   BRITISH JOURNAL OF HAEMATOLOGY

The Importance of Fluid Management in Acute Lung Injury Secondary to Septic Shock

(2009) Claire V. Murphy et al.   CHEST

Initiation of Inappropriate Antimicrobial Therapy Results in a Fivefold Reduction of Survival in Human Septic Shock

(2009) Anand Kumar et al.   CHEST

Simultaneous quantitative analysis of FcγRI (CD64) and CR1 (CD35) on neutrophils in distinguishing between bacterial infections, viral infections, and inflammatory diseases

(2009) Päivi Jalava-Karvinen et al.   CLINICAL IMMUNOLOGY

Diagnosis and Management of Infectious Complications in Critically Ill Patients with Cancer

(2009) Raghukumar Thirumala et al.   CRITICAL CARE CLINICS

Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America

(2009) Naomi P. O’Grady et al.   CRITICAL CARE MEDICINE

Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008

(2009) R Phillip Dellinger et al.   CRITICAL CARE MEDICINE

Gender impact on the outcomes of critically ill patients with nosocomial infections*

(2009) Alain Combes et al.   CRITICAL CARE MEDICINE

Biomarkers of sepsis

(2009) John C. Marshall et al.   CRITICAL CARE MEDICINE

Stratification is the key: Inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis*

(2009) Marcin F. Osuchowski et al.   CRITICAL CARE MEDICINE

Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock*

(2009) Mark E. Mikkelsen et al.   CRITICAL CARE MEDICINE

Circulating NT-proCNP predicts sepsis in multiple-traumatized patients without traumatic brain injury*

(2009) Soheyl Bahrami et al.   CRITICAL CARE MEDICINE

Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis*

(2009) Mark Tidswell et al.   CRITICAL CARE MEDICINE

Epidemiology of Septic Acute Kidney Injury

(2009) Ambica Parmar et al.   CURRENT DRUG TARGETS

American Association of Clinical Endocrinologists and American Diabetes Association Consensus Statement on Inpatient Glycemic Control

(2009) Etie Moghissi et al.   Endocrine Practice

Enhanced T-cell apoptosis in human septic shock is associated with alteration of the costimulatory pathway

(2009) P.-M. Roger et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Functional consequences of the prothrombotic SERPINC1 rs2227589 polymorphism on antithrombin levels

(2009) A. I. Anton et al.   HAEMATOLOGICA

Severe sepsis in cirrhosis

(2009) Thierry Gustot et al.   HEPATOLOGY

Neutrophil and monocyte CD64 indexes, lipopolysaccharide-binding protein, procalcitonin and C-reactive protein in sepsis of critically ill neonates and children

(2009) Mojca Groselj-Grenc et al.   INTENSIVE CARE MEDICINE

A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study

(2009) Jean-Charles Preiser et al.   INTENSIVE CARE MEDICINE

Corticosteroids in the Treatment of Severe Sepsis and Septic Shock in Adults

(2009) Djillali Annane et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Molecular Diagnosis of Polymicrobial Sepsis

(2009) N. Mancini et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Soluble triggering receptor expressed on myeloid cells 1 and the diagnosis of sepsis

(2009) Mitra Barati et al.   JOURNAL OF CRITICAL CARE

IL-15 Prevents Apoptosis, Reverses Innate and Adaptive Immune Dysfunction, and Improves Survival in Sepsis

(2009) S. Inoue et al.   JOURNAL OF IMMUNOLOGY

Adaptive suppression of the ATF4–CHOP branch of the unfolded protein response by toll-like receptor signalling

(2009) Connie W. Woo et al.   NATURE CELL BIOLOGY

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

The sepsis seesaw: tilting toward immunosuppression

(2009) Richard S Hotchkiss et al.   NATURE MEDICINE

Use of Procalcitonin-Guided Decision-Making to Shorten Antibiotic Therapy in Suspected Neonatal Early-Onset Sepsis: Prospective Randomized Intervention Trial

(2009) Martin Stocker et al.   Neonatology

Intensive versus Conventional Glucose Control in Critically Ill Patients

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

Pseudomonas aeruginosa and the hyperlipidaemia of sepsis

(2009) Rajkumar Cheluvappa et al.   PATHOLOGY

Procalcitonin and C-reactive protein as markers of bacterial infection in critically ill children at onset of systemic inflammatory response syndrome*

(2009) Liliana Simon et al.   Pediatric Critical Care Medicine

Differential Role for CD80 and CD86 in the Regulation of the Innate Immune Response in Murine Polymicrobial Sepsis

(2009) Anna Nolan et al.   PLoS One

PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis

(2009) X. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Utility of Interleukin-12 and Interleukin-10 in Comparison with Other Cytokines and Acute-Phase Reactants in the Diagnosis of Neonatal Sepsis

(2008) Catherine Sherwin et al.   AMERICAN JOURNAL OF PERINATOLOGY

Chemical and Biological Approaches Synergize to Ameliorate Protein-Folding Diseases

(2008) Ting-Wei Mu et al.   CELL

Host Inactivation of Bacterial Lipopolysaccharide Prevents Prolonged Tolerance Following Gram-Negative Bacterial Infection

(2008) Mingfang Lu et al.   Cell Host & Microbe

Combination of biphasic transmittance waveform with blood procalcitonin levels for diagnosis of sepsis in acutely ill patients

(2008) Ahmed N. Zakariah et al.   CRITICAL CARE MEDICINE

Intensive versus conventional insulin therapy: A randomized controlled trial in medical and surgical critically ill patients*

(2008) Yaseen M. Arabi et al.   CRITICAL CARE MEDICINE

A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis

(2008) Nathan I. Shapiro et al.   CRITICAL CARE MEDICINE

Improving clinical trials in the critically ill: Unique challenge—Sepsis

(2008) Djillali Annane   CRITICAL CARE MEDICINE

Apoptosis in Sepsis: Mechanisms, Clinical Impact and Potential Therapeutic Targets

(2008) Alfred Ayala et al.   CURRENT PHARMACEUTICAL DESIGN

The Endoplasmic Reticulum Stress-Mediated Apoptosis Signal Pathway Is Involved in Sepsis-Induced Abnormal Lymphocyte Apoptosis

(2008) T. Ma et al.   EUROPEAN SURGICAL RESEARCH

Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy

(2008) Sean M. Bagshaw et al.   INTENSIVE CARE MEDICINE

Benefits and Risks of Tight Glucose Control in Critically Ill Adults

(2008) Renda Soylemez Wiener et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Potential of immunomodulatory agents for prevention and treatment of neonatal sepsis

(2008) J L Wynn et al.   Journal of Perinatology

Animal models of sepsis and its complications

(2008) Mitchell P. Fink   KIDNEY INTERNATIONAL

Unknown

(2008) Stefanie Flohe et al.   MOLECULAR MEDICINE

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

Hydrocortisone Therapy for Patients with Septic Shock

(2008) Charles L. Sprung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Plasticity of the Systemic Inflammatory Response to Acute Infection during Critical Illness: Development of the Riboleukogram

(2008) Jonathan E. McDunn et al.   PLoS One

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

EXPERIMENTAL MODELS OF SEPSIS AND THEIR CLINICAL RELEVANCE

(2008) Luiz F. Poli-de-Figueiredo et al.   SHOCK

CD40 and CD80/86 Act Synergistically to Regulate Inflammation and Mortality in Polymicrobial Sepsis

(2007) Anna Nolan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE