期刊
PHYSIOLOGICAL MEASUREMENT
卷 32, 期 3, 页码 N13-N22出版社
IOP PUBLISHING LTD
DOI: 10.1088/0967-3334/32/3/N02
关键词
slow waves; multi-electrode; isochronal mapping; activation mapping
资金
- American Neurogastroenterology & Motility Society (ANMS)
- NZ Health Research Council
- NIH [R01 DK64775]
- University of Auckland
- Auckland Medical Research Foundation
Stomach contractions are initiated and coordinated by electrical events termed slow waves, and slow wave abnormalities contribute to gastric motility disorders. Recently, flexible printed circuit board (PCB) multi-electrode arrays were introduced, facilitating high-resolution mapping of slow wave activity in humans. However PCBs with gold contacts have shown a moderately inferior signal quality to previous custom-built silver-wire platforms, potentially limiting analyses. This study determined if using silver instead of gold contacts improved flexible PCB performance. In a salt-bath test, modestly higher stimulus amplitudes were recorded from silver PCBs (mean 312, s.d. 89 mu V) than those from gold (mean 281, s.d. 85 mu V) (p < 0.001); however, the signal-to-noise ratio (SNR) was similar (p = 0.26). In eight in vivo experimental studies, involving gastric serosal recordings from five pigs, no silver versus gold differences were found in terms of slow wave amplitudes (mean 677 versus 682 mu V; p = 0.91), SNR (mean 8.8 versus 8.8 dB; p = 0.94) or baseline drift (NRMS; mean 12.0 versus 12.1; p = 0.97). Under the prescribed conditions, flexible PCBs with silver or gold contacts provide comparable results in vivo, and contact material difference does not explain the performance difference between current-generation slow wave mapping platforms. Alternative explanations for this difference and the implications for electrode design are discussed.
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