Article
Veterinary Sciences
Rosanna Marsella, Kim Ahrens, Rachel Wilkes
Summary: Skin barrier dysfunction is important in atopic dermatitis and may be related to differences in cell growth behavior rather than tight junction protein differences. Atopic keratinocytes have lower TEER than normal keratinocytes, indicating higher epithelial permeability.
VETERINARY SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Tomohiro Edamitsu, Keiko Taguchi, Ryuhei Okuyama, Masayuki Yamamoto
Summary: The skin is constantly exposed to environmental insults, which can disrupt epidermal homeostasis and lead to skin diseases. AHR and NRF2 are transcription factors that play important roles in maintaining skin homeostasis and their dysfunction may contribute to the pathogenesis of skin diseases, particularly atopic dermatitis. AHR and NRF2 may serve as potential therapeutic targets for atopic dermatitis.
Review
Biochemistry & Molecular Biology
Pamela Gallegos-Alcala, Mariela Jimenez, Daniel Cervantes-Garcia, Eva Salinas
Summary: This review summarizes the role of keratinocytes in atopic dermatitis (AD), discussing their involvement with genetic predisposition, environmental factors, inflammatory molecules, and signaling pathways in the pathophysiology of AD. It also analyzes the connections between keratinocytes, the microbiota, and the inflammatory response underlying acute and chronic skin lesions in AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Celine Try, Mona M. A. Abdel-Mottaleb, Arnaud Beduneau, Brice Moulari, Lionel Pazart, Chrystelle Vidal, Gaelle Brunotte, Florence Castelain, Alf Lamprecht, Philippe Humbert, Yann Pellequer
Summary: A major limitation in topical treatment for inflammatory skin disorders is the inability to target inflamed sites while minimizing exposure to healthy skin. This study investigated the use of polymeric nanoparticles to selectively deliver drugs to atopic dermatitis lesions. Results showed that the nanoparticles had higher deposition in the lesions with minimal accumulation in healthy or non-lesional skin. This suggests that polymeric nanoparticles could be a potential tool for targeted drug delivery in inflamed skin.
Article
Dermatology
Junichi Kumamoto, Koji Fujimoto, Yasuaki Kobayashi, Kota Ohno, Masaharu Nagayama, Mitsuhiro Denda
Summary: The study utilized computer simulations and in vitro experiments to demonstrate that a thick three-dimensional epidermal equivalent can be constructed on pillars with diameters ranging from 15 to 30 µm. Epidermal differentiation markers were expressed at the upper layer of the equivalent, and tight-junction proteins were expressed on cell membranes. The results suggest that mathematical modeling could be a useful tool for guiding biological studies.
SKIN RESEARCH AND TECHNOLOGY
(2021)
Article
Dermatology
Xiuju Dai, Jun Muto, Ken Shiraishi, Ryo Utsunomiya, Hideki Mori, Masamoto Murakami, Koji Sayama
Summary: Atopic dermatitis (AD) is an inflammatory skin disease characterized by skin barrier dysfunction. This study found that TSLP plays a promoting role in AD development by activating T helper type 2 responses and affecting the integrity of the epidermal barrier.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Allergy
Michelle F. Huffaker, Kanika Kanchan, Henry T. Bahnson, Ingo Ruczinski, Gautam Shankar, Donald Y. M. Leung, Carolyn Baloh, George Du Toit, Gideon Lack, Gerald T. Nepom, Rasika A. Mathias
Summary: This study found that deleterious variation in the epidermal differentiation complex (EDC) is associated with the severity of atopic dermatitis (AD) and the risk of peanut allergy (PA). Specifically, variations in the FLG gene are significantly associated with AD severity and the risk of PA.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yoshie Umehara, Juan Valentin Trujillo-Paez, Hainan Yue, Ge Peng, Hai Le Thanh Nguyen, Ko Okumura, Hideoki Ogawa, Francois Niyonsaba
Summary: Calcitriol has a positive therapeutic effect on atopic dermatitis by repairing the skin barrier and improving inflammatory symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Chieh-Chen Huang, Yuan-Hsin Lo, Yu-Jou Hsu, Yuan-Bin Cheng, Chia-Chi Kung, Cher-Wei Liang, Der-Chen Chang, Kang-Ling Wang, Chi-Feng Hung
Summary: Atopic dermatitis (AD, eczema) is a common skin condition that primarily affects children and adults, but current treatments have limited effectiveness and side effects. This study investigated the potential use of epi-oxyzoanthamine, a bioactive compound derived from Formosan zoanthid, for treating AD. In vitro and in vivo experiments showed that epi-oxyzoanthamine inhibited cytokine expression and reduced skin inflammation, indicating its potential as an alternative treatment for AD. Overall, the study highlights the importance of exploring new therapies for atopic dermatitis.
Article
Pharmacology & Pharmacy
Yuan Zhou, Jianxin Shi, Mingxin Qi, Xue Li, Yan Yang, Chan Zhu, Changming Wang, Zongxiang Tang, Yuxiang Ma, Guang Yu
Summary: Atopic dermatitis (AD) is a common chronic inflammatory skin disease that negatively affects quality of life. We investigated alterations in tight junction (TJ) related genes in AD and found that ZO-3 expression was significantly down-regulated. Knock-down of ZO-3 demonstrated its essential role in epidermal barrier function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Orsolya Somogyi, Zsolt Dajnoki, Lilla Szabo, Krisztian Gaspar, Zoltan Hendrik, Christos C. Zouboulis, Klaudia Docs, Peter Szucs, Katalin Dull, Daniel Torocsik, Aniko Kapitany, Andrea Szegedi
Summary: By comparing non-lesional HS skin, lesional HS skin, and healthy skin, the study found that none of the investigated molecules were significantly altered in non-lesional HS skin, while 11 molecules changed significantly in lesional HS skin. The study also showed that the permeability barrier function was not significantly damaged in HS skin, and permeability barrier alterations are not the driver factors of keratinocyte activation in this disease.
Article
Biochemistry & Molecular Biology
Yeon Kyung Nam, Mi Hye Kim, In Jin Ha, Woong Mo Yang
Summary: The study investigated the therapeutic effect of Derma-Hc on atopic dermatitis, finding that it significantly improved AD-like symptoms, inhibited skin lichenification, and regulated keratinocyte differentiation. This suggests that Derma-Hc has promising potential for treating chronic AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jamie M. L. Kok, Georgina C. Dowd, Jaydee D. Cabral, Lyn M. Wise
Summary: A lipid extract from Macrocystis pyrifera has anti-inflammatory and barrier-protective effects on keratinocytes, suggesting its potential benefits in the treatment of atopic dermatitis or other skin conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Geetha Samak, Rupa Rao, Radhakrishna Rao
Summary: The study found that Lactobacillus casei and epidermal growth factor (EGF) can ameliorate osmotic stress-induced disruption of apical junctional complexes and barrier dysfunction in the intestinal epithelium through distinct signaling mechanisms.
Article
Allergy
Jihyun Kim, Byung Eui Kim, Elena Goleva, Evgeny Berdyshev, Jaewoong Bae, Seokjin Kim, Hye-young Kim, Una Ha Lee, Myoung Shin Kim, Minyoung Jung, Hyunmi Kim, Jinyoung Lee, Donald Y. M. Leung, Kangmo Ahn
Summary: This study aimed to investigate the epidermal lipid profiles and their association with skin microbiome compositions in children with atopic dermatitis (AD). Skin tape stripping was used to obtain specimens from AD children and healthy subjects. The results showed that AD lesional skin had increased levels of certain ceramides, sphingomyelin, and lysophosphatidylcholine compared to nonlesional skin and control subjects. The lipid ratio and the proportions of certain bacteria were found to be associated with skin barrier dysfunction. These findings suggest that aberrant lipid profiles in pediatric AD skin are linked to microbial dysbiosis and cutaneous barrier dysfunction.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Christina M. Campion, Sandra Leon Carrion, Gayatri Mamidanna, Carrie Hayes Sutter, Thomas R. Sutter, Judith A. Cole
CHEMICO-BIOLOGICAL INTERACTIONS
(2016)
Article
Pharmacology & Pharmacy
Ryan S. Wible, Quynh T. Tran, Samreen Fathima, Carrie H. Sutter, Thomas W. Kensler, Thomas R. Sutter
MOLECULAR PHARMACOLOGY
(2018)
Article
Biology
Ryan S. Wible, Chidambaram Ramanathan, Carrie Hayes Sutter, Kristin M. Olesen, Thomas W. Kensler, Andrew C. Liu, Thomas R. Sutter
Article
Oncology
Quynh T. Tran, Lijing Xu, Vinhthuy Phan, Shirlean B. Goodwin, Mostafizur Rahman, Victor X. Jin, Carrie H. Sutter, Bill D. Roebuck, Thomas W. Kensler, E. Olusegun George, Thomas R. Sutter
Article
Environmental Sciences
Clarisse S. Muenyi, Sandra Leon Carrion, Lynn A. Jones, Lawrence H. Kennedy, Andrzej T. Slominski, Carrie H. Sutter, Thomas R. Sutter
ENVIRONMENTAL HEALTH PERSPECTIVES
(2014)
Article
Dermatology
Sandra Leon Carrion, Carrie Hayes Sutter, Thomas R. Sutter
EXPERIMENTAL DERMATOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Xiaoguang Ouyang, Quynh T. Tran, Shirlean Goodwin, Ryan S. Wible, Carrie Hayes Sutter, Thomas R. Sutter
FREE RADICAL BIOLOGY AND MEDICINE
(2011)
Article
Multidisciplinary Sciences
Carrie Hayes Sutter, Hong Yin, Yunbo Li, Jennifer S. Mammen, Sridevi Bodreddigari, Gaylene Stevens, Judith A. Cole, Thomas R. Sutter
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2009)
Article
Toxicology
Carrie H. Sutter, Sridevi Bodreddigari, Thomas R. Sutter, Erik A. Carlson, Jay B. Silkworth
TOXICOLOGICAL SCIENCES
(2010)
Article
Toxicology
Carrie Hayes Sutter, Sridevi Bodreddigari, Christina Campion, Ryan S. Wible, Thomas R. Sutter
TOXICOLOGICAL SCIENCES
(2011)
Article
Toxicology
Lawrence H. Kennedy, Carrie Hayes Sutter, Sandra Leon Carrion, Quynh T. Tran, Sridevi Bodreddigari, Elizabeth Kensicki, Robert P. Mohney, Thomas R. Sutter
TOXICOLOGICAL SCIENCES
(2013)
Article
Dermatology
Carrie Hayes Sutter, Kristin M. Olesen, Jyoti Bhuju, Zibiao Guo, Thomas R. Sutter
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Carrie Hayes Sutter, Haley M. Rainwater, Thomas R. Sutter
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Environmental Sciences
Jyoti Bhuju, Kristin M. Olesen, Clarisse S. Muenyi, Tejesh S. Patel, Robert W. Read, Lauren Thompson, Omar Skalli, Qi Zheng, Elizabeth A. Grice, Carrie Hayes Sutter, Thomas R. Sutter
Summary: Exposure to TCDD during pregnancy and lactation in mice resulted in skin effects such as acanthosis and chloracne-like sebaceous gland hypoplasia, which were reversible and did not cause long-term immunosuppression. Additionally, increased expression of CYP1A1 and CYP1B1 in the skin of exposed mice was observed, with co-localization with progenitor cells and stem cell niches.