Article
Cardiac & Cardiovascular Systems
Tobias J. Pfeffer, Manuel List, Julia H. Muller, Michaela Scherr, Johann Bauersachs, Denise Hilfiker-Kleiner, Melanie Ricke-Hoch
Summary: Peripartum cardiomyopathy (PPCM) is a pregnancy-associated cardiomyopathy characterized by heart failure due to systolic dysfunction. Treatment of PPCM complicated by CS is challenging, and the use of the glucose uptake-promoting drug perhexiline may help reduce the cardiotoxic side effects of beta-AR stimulation.
Review
Cell Biology
Ariadni Androvitsanea, Kostas Stylianou, Eleni Drosataki, Ioannis Petrakis
Summary: Research has shown that heat-shock proteins can have varying effects on the immune system, either triggering immune responses or alleviating them, which is important for studying and treating autoimmune diseases.
Article
Biochemistry & Molecular Biology
Lintong Men, Junyi Guo, Yu Cao, Bingyu Huang, Qian Wang, Shengqi Huo, Moran Wang, Dewei Peng, Lulu Peng, Wei Shi, Sheng Li, Li Lin, Jiagao Lv
Summary: Prolonged activation of PERK branch of UPR promotes cardiomyocytes apoptosis in response to chronic β-adrenergic stimulation. STAT3 plays a critical role in β-adrenergic functions in the heart. This study aimed to investigate whether STAT3 contributed to β-adrenoceptor-mediated PERK activation and how β-adrenergic signaling activates STAT3. Results showed that PERK phosphorylation was positively associated with STAT3 activation. Stimulation with isoproterenol produced an increase in IL-6 level and IL-6/gp130 signaling was involved in STAT3 and PERK activation.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Evren Onay Ucar, Aslihan Sengelen, Elif Mertoglu Kamali
Summary: The study reveals that heat shock response (HSR) is closely related to therapeutic resistance of gliomas. Resveratrol (RSV) shows potential as an experimental agent for glioblastoma (GB) therapy, but the role of heat shock proteins (Hsps) in RSV efficacy remains unclear. The findings suggest that silencing Hsp27, Hsp60, Hsp70, and Hsp90 makes glioma cells more sensitive to RSV treatment, making these Hsps potential therapeutic targets for GB treatment.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ayush Ranawade, Rati Sharma, Erel Levine
Summary: The Heat Shock Response (HSR) is a conserved genetic system that protects the proteome in organisms. Mathematical modeling has been crucial in understanding its regulation, but there are still many unanswered questions that can benefit from quantitative modeling.
Article
Multidisciplinary Sciences
Tsukumi Miwa, Hideki Taguchi
Summary: Research has shown that IbpA down-regulates the expression of multiple heat shock proteins (Hsps) by repressing the translation of the heat shock transcription factor sigma(32), and plays a crucial role in shutting down the heat shock response. These findings reveal an unknown role of IbpA in regulating the heat shock response at the translational level.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Plant Sciences
Fengxia Tian, Xiao-Li Hu, Tao Yao, Xiaohan Yang, Jin-Gui Chen, Meng-Zhu Lu, Jin Zhang
Summary: Global warming poses a threat to plant life, with heat shock response (HSR) playing a crucial role in protecting cellular homeostasis, especially for perennial trees. Understanding the molecular mechanisms of HSR in woody plants is essential for predicting how they will respond to climate changes.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Cell Biology
Mooud Amirkavei, Flavia Plastino, Anders Kvanta, Kai Kaarniranta, Helder Andre, Ari Koskelainen
Summary: Cells have stress-response pathways to cope with stress factors for homeostasis maintenance; low doses of stress may be beneficial; HHS was found to enhance autophagy gene expression and activation through HSF1.
Article
Microbiology
Felix Gruenberger, Georg Schmid, Zubeir El Ahmad, Martin Fenk, Katharina Vogl, Robert Reichelt, Winfried Hausner, Henning Urlaub, Christof Lenz, Dina Grohmann
Summary: This study investigated the transcriptomic and proteomic responses of hyperthermophilic archaea Pyrococcus furiosus to heat and cold shock stress. The results showed rapid and dynamic changes in gene and protein expression following these stress responses. The study also identified distinct short- and long-term responses at both the RNA and protein levels to cold shock. The findings contribute to our understanding of stress response mechanisms in extremophiles.
Article
Environmental Sciences
Milton Talukder, Shao-Shuai Bi, Mei-Wei Lv, Jing Ge, Cong Zhang, Jin-Long Li
Summary: Cadmium exposure induces neuronal damage in the chicken brain, triggering the heat shock response (HSR) pathway and apoptotic pathway in response to the damage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Plant Sciences
Yunzhuan Zhou, Fuxiang Xu, Yanan Shao, Junna He
Summary: As global warming intensifies, the earth's average temperature continues to rise. Plants have developed two main mechanisms, the heat stress response and the thermomorphogenesis response, to cope with elevated temperatures. This review summarizes recent progress in understanding these heat-responsive molecular regulatory pathways in plants and discusses future perspectives in this field.
Article
Cell Biology
Jin-Sook Kwon, Eric W. Barr, J. Kurt Chuprun, Walter J. Koch
Summary: Stimulation of alpha- or beta-adrenergic receptors in mice led to changes in the content of circulating blood EVs, with differential expression patterns of miRs. Pathway analysis revealed common and distinct pathways affected by PE and ISO treatment, indicating regulation of specific pathways by alpha- or beta-AR agonists. This study suggests that chronic sympathetic nervous system activation in heart failure may alter the content of EVs secreted from the heart and other organs, potentially impacting pathological remodeling.
Article
Environmental Sciences
Shao-Shuai Bi, Milton Talukder, Xue-Tong Sun, Mei-Wei Lv, Jing Ge, Cong Zhang, Jin-Long Li
Summary: This study assessed the neurotoxic effects of chronic cadmium (Cd) exposure on the chicken cerebellum and investigated the expression of genes related to the heat-shock response. The results showed that Cd exposure led to clinical symptoms of ataxia in the chickens, decreased the number of Purkinje cells, and induced degeneration of Purkinje cells. Cd exposure also affected the expression of heat-shock factors and proteins. These findings shed light on the toxic effects of Cd on the cerebellum and provide evidence for the health risks posed by Cd exposure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Oncology
Enzo M. Scutigliani, Yongxin Liang, Hans Crezee, Roland Kanaar, Przemek M. Krawczyk
Summary: Hyperthermia is a method of exposing tumors to elevated temperatures to enhance the effects of chemotherapy and radiotherapy. However, its efficacy is limited by factors such as heat stress response. Targeting this cellular defense mechanism may improve the effectiveness of hyperthermia-based therapies.
Article
Veterinary Sciences
Samuel A. Atkin, Abu Saleh Md Moin, Stephen L. Atkin, Alexandra E. Butler
Summary: This study investigated the effects of hypoglycemia on the heat shock-related protein pathway. The results showed that hypoglycemia significantly decreased the expression of HSP90, 70, 27, and ubiquitin proteins, which are important for the protective response against heat stress.
FRONTIERS IN VETERINARY SCIENCE
(2022)
