期刊
PHYSICS IN MEDICINE AND BIOLOGY
卷 55, 期 4, 页码 1189-1201出版社
IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/55/4/019
关键词
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资金
- National Institutes of Health Roadmap Initiative [NIBIB R21 EB005321, NIBIB R01 EB005221]
- National Science Foundation [BES 05-19920]
We present a new method for performing dynamic elastography of soft tissue samples. By sensing nanoscale displacements with optical coherence tomography, a chirped, modulated force is applied to acquire the mechanical spectrum of a tissue sample within a few seconds. This modulated force is applied via magnetic nanoparticles, named 'nanotransducers', which are diffused into the tissue, and which contribute negligible inertia to the soft tissue mechanical system. Using this novel system, we observed that excised tissues exhibit mechanical resonance modes which are well described by a linear damped harmonic oscillator. Results are validated by using cylindrical tissue phantoms of agarose in which resonant frequencies (30-400 Hz) are consistent with longitudinal modes and the sample boundary conditions. We furthermore show that the Young's modulus can be computed from their measured resonance frequencies, analogous to resonant ultrasound spectroscopy for stiff material analysis. Using this new technique, named magnetomotive resonant acoustic spectroscopy (MRAS), we monitored the relative stiffening of an excised rat liver during a chemical fixation process.
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