Article
Clinical Neurology
Konstantin Weise, William A. Wartman, Thomas R. Knoesche, Aapo R. Nummenmaa, Sergey N. Makarov
Summary: This study investigates the impact of the meningeal layers on the cortical electric field in transcranial electrical stimulation (TES) and transcranial magnetic stimulation (TMS). The results show that the presence of the meninges significantly increases the maximum electric fields in the cortex during TES, while the effect on TMS electric fields is minor. The findings provide a quantitative understanding of the influence of the meninges on TES and TMS and can contribute to the development of more accurate brain stimulation models.
Article
Neurosciences
Zsolt Turi, Nicholas Hananeia, Sina Shirinpour, Alexander Opitz, Peter Jedlicka, Andreas Vlachos
Summary: This study explored the effects of TMS in different cortical regions using multi-scale computational modeling and highlighted the limitations of conventional intensity selection methods. Personalized stimulation intensity selection could standardize the effects of TMS.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Neurosciences
Sybren Van Hoornweder, Marten Nuyts, Joana Frieske, Stefanie Verstraelen, Raf L. J. Meesen, Kevin A. Caulfield
Summary: This study examined different outcome measures used to report on tES and TMS induced E-fields, and found that outcome measure selection significantly impacts the locations and intensities of extracted E-field data. The suitability of different outcome measures depends on the target region, TMS/tES modality, individual anatomy, the analyzed E-field component, and the research question.
Article
Neurosciences
S. N. Makarov, W. A. Wartman, G. M. Noetscher, K. Fujimoto, T. Zaidi, E. H. Burnham, M. Daneshzand, A. Nummenmaa
Summary: The optimized TMS inverse problem solutions improve the focality of the electric field induced by TMS and reduce the size of the field hot spot near the target. Additionally, uncertainties in coil position/orientation, conductivity, and head segmentation accuracy affect the performance of TMS-IP.
Article
Clinical Neurology
Jaakko O. Nieminen, Heikki Sinisalo, Victor H. Souza, Mikko Malmi, Mikhail Yuryev, Aino E. Tervo, Matti Stenroos, Diego Milardovich, Juuso T. Korhonen, Lari M. Koponen, Risto J. Ilmoniemi
Summary: This study developed an mTMS system that allows adjusting the location and orientation of the maximum electric field within a cortical region. The system consists of a 5-coil transducer and electronics with independently controlled H-bridge circuits. Characterization and motor-mapping experiments demonstrated that the system performs as designed, enabling targeted brain stimulation within a cortical region.
Article
Engineering, Biomedical
Barna Ghosh, Khaleda Akhter Sathi, Md. Kamal Hosain, Md. Azad Hossain, M. Ali Akber Dewan, Abbas Z. Kouzani
Summary: A deep learning-based prediction model, called ViTab transformer, has been developed in this study to accurately predict the electric field and focus distance of transcranial magnetic stimulation. The proposed model outperforms the current state-of-the-art methods in terms of prediction accuracy.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Engineering, Multidisciplinary
Anna Susnjara, Ozbej Verhnjak, Dragan Poljak, Mario Cvetkovic, Jure Ravnik
Summary: This paper discusses the advantages of the Boundary Element method in modeling transcranial electric stimulation and its application in considering uncertainty. The results show the efficiency of the BE-SCM combination in simulating the stimulation process, with noticeably larger confidence intervals in interior tissues.
ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS
(2021)
Article
Neurosciences
Kathleen E. Mantell, Nipun D. Perera, Sina Shirinpour, Oula Puonti, Ting Xu, Jan Zimmermann, Arnaud Falchier, Sarah R. Heilbronner, Axel Thielscher, Alexander Opitz
Summary: The study examined the impact of anatomical details in NHP models on NIBS electric field calculations, highlighting the effects of muscle tissue and head field of view on TES and TMS simulation results. Opposing effects were found between TES and TMS when comparing full head models to cropped head models, with significant changes in electric field strength observed.
Article
Engineering, Biomedical
Samuel Nurmi, Jere Karttunen, Victor H. Souza, Risto J. Ilmoniemi, Jaakko O. Nieminen
Summary: This study investigated the relationship between the number of coils in an mTMS transducer, the focality of the induced E-field, and the extent of the cortical region within which the location and orientation of the maximum of the induced E-field can be controlled. The results showed that sacrificing E-field focality could lead to designing an mTMS transducer that can control the location and orientation of the peak of the induced E-field within a wider cortical region. This may simplify the electronically targeted TMS and accelerate the development of new clinical and research applications in the field.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Sergey N. Makaroff, Hieu Nguyen, Qinglei Meng, Hanbing Lu, Aapo R. Nummenmaa, Zhi-De Deng
Summary: This study presents an algorithm for modeling TMS coils with a magnetic core and validates it through simulations and experiments. The algorithm uses the boundary element fast multipole method and the successive substitution method, and outputs the coil inductances. The algorithm has a short execution time and can be used for practical coil design and core material selection.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Neurosciences
Basil C. Preisig, Alexis Hervais-Adelman
Summary: There is individual variability in the effectiveness of non-invasive brain stimulation. This study found evidence for a dose-response relationship between individual differences in electric fields and tACS-induced activity and connectivity changes, particularly in the right hemisphere.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Sina Shirinpour, Nicholas Hananeia, James Rosado, Harry Tran, Christos Galanis, Andreas Vlachos, Peter Jedlicka, Gillian Queisser, Alexander Opitz
Summary: NeMo-TMS is an open-source multi-scale toolbox that allows researchers to realistically model the physical and physiological effects of TMS with unprecedented detail and precision.
Article
Engineering, Biomedical
Mansour Alawi, Poh Foong Lee, Zhi-De Deng, Yong Kheng Goh, Paul E. Croarkin
Summary: This study investigated the impact of age on the electric fields induced by transcranial magnetic stimulation (TMS) in different anatomical regions of the brain. The results showed a negative correlation between age and electric field peaks in different brain tissues, with children exhibiting the widest distribution of electric fields. These findings underscore the importance of safety considerations for TMS applications and protocols in children.
JOURNAL OF NEURAL ENGINEERING
(2023)
Review
Biochemistry & Molecular Biology
Matteo Guidetti, Mattia Arlotti, Tommaso Bocci, Anna Maria Bianchi, Marta Parazzini, Roberta Ferrucci, Alberto Priori
Summary: Transcranial electrical stimulation techniques, such as tDCS and tACS, can induce neurophysiological and behavioral modifications by inducing electric fields in the brain. The estimation of these electric fields is mainly based on computational studies, but in vivo measurements have been used to further expand our current knowledge. This review summarizes the estimations of tDCS- and tACS-induced electric fields recorded in humans and non-human primates using intracerebral electrodes. The results suggest that even for deep brain structures, the injected current in clinical stimulation protocols can reach the brain, and the stimulation parameters and individual anatomy can determine the intensity and effects of the stimulation on neuronal and non-neuronal cell activity.
Article
Neurosciences
Yuanyuan Chen, Yihan Jiang, Zong Zhang, Zheng Li, Chaozhe Zhu
Summary: There are currently different kinds of TMS motor mapping algorithms available, but limited comparison studies have been conducted. This study compared the results of different algorithms using TMS and fMRI experiments and found that the association algorithm may be more advantageous in clinical applications and basic neuroscience research.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Mariam Ishaque, Janessa H. Manning, Mary D. Woolsey, Crystal G. Franklin, Elizabeth W. Tullis, Christian F. Beckmann, Peter T. Fox
HUMAN BRAIN MAPPING
(2017)
Article
Neurosciences
Thomas J. Vanasse, P. Mickle Fox, Daniel S. Barron, Michaela Robertson, Simon B. Eickhoff, Jack L. Lancaster, Peter T. Fox
HUMAN BRAIN MAPPING
(2018)
Article
Substance Abuse
Ashley Acheson, Crystal Franklin, Andrew J. Cohoon, David C. Glahn, Peter T. Fox, William R. Lovallo
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2014)
Review
Neurosciences
Peter T. Fox, Jack L. Lancaster, Angela R. Laird, Simon B. Eickhoff
ANNUAL REVIEW OF NEUROSCIENCE, VOL 37
(2014)
Article
Neurosciences
Peter Kochunov, Neda Jahanshad, Emma Sprooten, Thomas E. Nichols, Rene C. Mandl, Laura Almasy, Tom Booth, Rachel M. Brouwer, Joanne E. Curran, Greig I. de Zubicaray, Rali Dimitrova, Ravi Duggirala, Peter T. Fox, L. Elliot Hong, Bennett A. Landman, Herve Lemaitre, Lorna M. Lopez, Nicholas G. Martin, Katie L. McMahon, Braxton D. Mitchell, Rene L. Olvera, Charles P. Peterson, John M. Starr, Jessika E. Sussmann, Arthur W. Toga, Joanna M. Wardlaw, Margaret J. Wright, Susan N. Wright, Mark E. Bastin, Andrew M. McIntosh, Dorret I. Boomsma, Rene S. Kahn, Anouk den Braber, Eco J. C. de Geus, Ian J. Deary, Hilleke E. Hulshoff Pol, Douglas E. Williamson, John Blangero, Dennis van't Ent, Paul M. Thompson, David C. Glahn
Article
Neurosciences
S. Bludau, S. B. Eickhoff, H. Mohlberg, S. Caspers, A. R. Laird, P. T. Fox, A. Schleicher, K. Zilles, K. Amunts
Article
Clinical Neurology
Yun Wu, Yuan Zhong, Zijuan Ma, Xin Lu, Ning Zhang, Peter T. Fox, Chun Wang
PSYCHIATRY RESEARCH-NEUROIMAGING
(2018)
Review
Clinical Neurology
Nooshin Javaheipour, Niloofar Shandipour, Khadijeh Noori, Mojtaba Zarei, Julia A. Camilleri, Angela R. Laird, Peter T. Fox, Simon B. Eickhoff, Claudia R. Eickhoff, Ivana Rosenzweig, Habibolah Khazaie, Masoud Tahmasian
SLEEP MEDICINE REVIEWS
(2019)
Article
Biology
Thomas J. Vanasse, Peter T. Fox, P. Mickle Fox, Franco Cauda, Tommaso Costa, Stephen M. Smith, Simon B. Eickhoff, Jack L. Lancaster
Summary: Research indicates a high concordance between neuropsychiatric disorders and structural-functional networks, supporting the network degeneration hypothesis. There is a positive linear association between disease and behavioral entropy, suggesting nodal stress as a common mechanism.
COMMUNICATIONS BIOLOGY
(2021)
Article
Neurosciences
Tommaso Costa, Jordi Manuello, Mario Ferraro, Donato Liloia, Andrea Nani, Peter T. Fox, Jack Lancaster, Franco Cauda
Summary: This study introduces a new tool called BACON for reverse inference in functional and structural neuroimaging data, aiming to determine the extent of association between patterns of cerebral activation or alteration and specific mental functions or brain pathologies. BACON utilizes Bayes' factor and activation likelihood estimation derived-maps to obtain posterior probability distributions on evidence of specificity concerning a particular mental function or brain pathology.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Shalini Narayana, Crystal Franklin, Elizabeth Peterson, Eric J. Hunter, Donald A. Robin, Angela Halpern, Jennifer Spielman, Peter T. Fox, Lorraine O. Ramig
Summary: This study compared the acoustic and neural changes of two different treatment targets (voice or articulation) in speech therapies. The results showed that voice treatment significantly improved dysphonia and maintained the improvement at 7 months. Articulation treatment increased activity in specific brain regions and this effect was sustained at a 7-month follow-up. The study also found that intensive dosage contributed to the long-lasting effects of speech treatments.
HUMAN BRAIN MAPPING
(2022)
Article
Audiology & Speech-Language Pathology
John C. Moring, Patricia A. Resick, Alan L. Peterson, Fatima T. Husain, Carlos Esquivel, Stacey Young-McCaughan, Elsa Granato, Peter T. Fox
Summary: This study showed that veterans with comorbid bothersome tinnitus and PTSD experienced significant decreases in PTSD symptoms, tinnitus-related distress, and depression after receiving cognitive processing therapy. Clinical management addressing psychiatric distress, particularly associated with PTSD, may provide benefits for patients with bothersome tinnitus.
AMERICAN JOURNAL OF AUDIOLOGY
(2022)
Article
Clinical Neurology
M. Ishaque, J. H. Manning, M. D. Woolsey, C. G. Franklin, F. S. Salinas, P. T. Fox
AMERICAN JOURNAL OF NEURORADIOLOGY
(2017)
Meeting Abstract
Neurosciences
Emma E. M. Knowles, David R. McKay, Emma Sprooten, Jack W. Kent, Joanne E. Curran, Marcio A. A. de Almeida, Melanie A. Carless, Thomas D. Dyer, Harald H. Goring, Rene Olvera, Peter Fox, Laura Almasy, Ravi Duggirala, John Blangero, David C. Glahn
BIOLOGICAL PSYCHIATRY
(2014)
Meeting Abstract
Neurosciences
Thomas Nickl-Jockschat, Claudia Rottschy, Johanna Thommes, Frank Schneider, Angela R. Laird, Peter T. Fox, Simon B. Eickhoff
BIOLOGICAL PSYCHIATRY
(2014)