Article
Engineering, Biomedical
Yansong Zhu, Murat Bilgel, Yuanyuan Gao, Olivier G. Rousset, Susan M. Resnick, Dean F. Wong, Arman Rahmim
Summary: The partial volume effect caused by limited spatial resolution of PET degrades image quality, but anatomical information from MR images can be used to improve partial volume correction methods. The proposed post-reconstruction PVC method utilizes deconvolution with PLS regularization to incorporate anatomical information without requiring MR segmentation or assuming uniform PET distributions within regions, showing promising results for clinical imaging scenarios.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Neurosciences
Yihuan Lu, Takuya Toyonaga, Mika Naganawa, Jean-Dominique Gallezot, Ming-Kai Chen, Adam P. Mecca, Christopher H. van Dyck, Richard E. Carson
Summary: The purpose of the study is to reveal SV2A changes between Alzheimer's disease patients and cognitive normal participants using partial volume correction algorithms. In the hippocampus region, the IY algorithm increased the significance of group differences. MG algorithm may increase GM binding values to a greater extent. The results suggest that PVC is important for adjusting significant volume reduction.
Article
Acoustics
Syed M. Imaduddin, Charles G. Sodini, Thomas Heldt
Summary: Ultrasound-based blood flow monitoring is essential in the diagnosis and treatment of cardiovascular and neurologic conditions. This study proposes a resolution enhancement technique for reliable measurement of blood flow in small vessels.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuanyuan Gao, Yansong Zhu, Murat Bilgel, Saeed Ashrafinia, Lijun Lu, Arman Rahmim
Summary: This study introduces a partial volume correction (PVC) method using anatomical non-local means (NLMA) regularization to improve PET image quality. By incorporating MRI information and optimizing the LS objective function, better visual and quantitative performance improvements were achieved.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2021)
Article
Engineering, Mechanical
G. Totis, M. Sortino
Summary: High-end piezoelectric dynamometers with a wide frequency bandwidth are necessary for characterizing cutting mechanics during high-speed milling and micromilling applications. Current filters have limitations, prompting the development of a novel non-parametric filter that considers input force direction and location for improved results.
MECHANICAL SYSTEMS AND SIGNAL PROCESSING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Amirhossein Sanaat, Hossein Shooli, Andrew Stephen Bohringer, Maryam Sadeghi, Isaac Shiri, Yazdan Salimi, Nathalie Ginovart, Valentina Garibotto, Hossein Arabi, Habib Zaidi
Summary: A novel partial volume correction (PVC) technique using CycleGAN was proposed to overcome the adverse effects of partial volume effect on PET images. The technique directly maps non-PVC PET images to PVC PET images without the need for additional anatomical information or assumptions.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Biochemistry & Molecular Biology
Silvia Campanioni, Jose A. Gonzalez-Novoa, Laura Busto, Roberto Carlos Agis-Balboa, Cesar Veiga
Summary: Alzheimer's disease (AD) is the most common form of dementia, with confirmed epigenetic changes. Positron Emission Tomography (PET) is used for quantifying amyloid deposition in the brain tissues. This study aims to develop a new methodology for analyzing cognitive scores and PET features to identify multiple AD phenotypes. Using computational methods and various imaging techniques, the study successfully identifies three phenotypes and analyzes them under epigenetic conditions.
Article
Chemistry, Analytical
Jonghyun Kim, Kyeonghoon Jeong, Moon Gi Kang
Summary: In this paper, a crosstalk correction method for color filter array (CFA) image sensors based on L-p-regularized multi-channel deconvolution is proposed. The method improves color fidelity and spatial resolution and outperforms conventional methods.
Article
Geochemistry & Geophysics
Ronghuo Dai, Cheng Yin, Da Peng
Summary: Sparsity-regularized linear inverse problems are widely used in various fields, and the iterative hard thresholding algorithm and iterative soft thresholding algorithm are frequently used methods to solve them. This letter proposes a hybrid method that incorporates Davidon-Fletcher-Powell formulations into iterative thresholding-like algorithms to improve convergence rate. Numerical examples and real-life application demonstrate its effectiveness.
IEEE GEOSCIENCE AND REMOTE SENSING LETTERS
(2023)
Article
Multidisciplinary Sciences
Marie N. N. Hellem, Tua Vinther-Jensen, Lasse Anderberg, Esben Budtz-Jorgensen, Lena E. Hjermind, Vibeke Andree Larsen, Jorgen E. Nielsen, Ian Law
Summary: Huntington's disease (HD) is a progressive neurodegenerative disease with no cure, and studies have shown reduced striatal metabolism in HD gene-expansion carriers. The correlation between CAP(S) and striatal metabolism, corrected for partial volume effect, highlights the importance of accurate imaging biomarkers for interventions in HD.
Article
Computer Science, Information Systems
Vivek Narayanaswamy, Raja Ayyanar, Cihan Tepedelenlioglu, Devarajan Srinivasan, Andreas Spanias
Summary: Reconfiguring the connections of a photovoltaic array is a popular strategy to mitigate power production issues caused by partial shading. We propose a neural network based algorithm that uses panel-level sensor data to optimize the array's topology under arbitrary shading conditions, resulting in a power improvement of up to 11%.
Article
Neurosciences
Sebastian Schuster, Leonie Beyer, Carla Palleis, Stefanie Harris, Julia Schmitt, Endy Weidinger, Catharina Prix, Kai Boetzel, Adrian Danek, Boris-Stephan Rauchmann, Sophia Stoecklein, Simon Lindner, Marcus Unterrainer, Nathalie L. Albert, Lena M. Mittlmeier, Christian Wetzel, Rainer Rupprecht, Axel Rominger, Peter Bartenstein, Robert Perneczky, Johannes Levin, Guenter U. Hoeglinger, Matthias Brendel, Franziska J. Dekorsy
Summary: This study aimed to evaluate the use of partial volume effect correction (PVEC) in patients with corticobasal syndrome (CBS) and compare it with a control group. The results showed that after PVEC correction, patients with CBS had smaller regional volumes and increased positivity in TSPO PET.
Article
Physiology
Julien Poublanc, Reema Shafi, Olivia Sobczyk, Kevin Sam, Daniel M. Mandell, Lakshmikumar Venkatraghavan, James Duffin, Joseph A. Fisher, David J. Mikulis
Summary: Cerebrovascular reactivity (CVR) is effectively assessed using BOLD MRI in combination with end-tidal CO2 changes. Control values for CVR metrics were calculated in a cohort of healthy controls, revealing increases in gray matter and decreases in white matter.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Matthew R. Scott, Natalie C. Edwards, Michael J. Properzi, Heidi I. L. Jacobs, Julie C. Price, Cristina Lois, Michelle E. Farrell, Bernard J. Hanseeuw, Emma G. Thibault, Dorene M. Rentz, Keith A. Johnson, Reisa A. Sperling, Aaron P. Schultz, Rachel F. Buckley
Summary: Clinically normal females exhibit higher 18F-flortaucipir (FTP)-PET signal than males across the cortex. However, these sex differences may be explained by neuroimaging idiosyncrasies such as off-target extracerebral tracer retention or partial volume effects (PVEs).
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Mathematics, Applied
Moritz Ebeling-Rump, Dietmar Hoemberg, Robert Lasarzik
Summary: This study presents a new approach to produce optimal porous mesostructures and optimize the macro structure simultaneously. It utilizes a phase-field formulation of topology optimization and incorporates a local volume constraint (LVC). The novelty lies in the fact that the radius of the LVC can depend on both space and a local stress measure, allowing for the creation of optimal topologies with heterogeneous mesostructures that enforce desired spatial grading and accommodate stress concentrations.
COMPUTERS & MATHEMATICS WITH APPLICATIONS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Benjamin P. Lopez, David W. Jordan, Brad J. Kemp, Paul E. Kinahan, Charles R. Schmidtlein, Osama R. Mawlawi
Summary: This article summarizes the AAPM Task Group (TG) 126 report on acceptance and quality assurance (QA) testing of PET/CT systems, aiming to ensure optimal imaging and care for patients. The report outlines eight performance evaluations using common phantoms and freely available software, allowing clinical physicists to monitor each PET/CT system by comparing periodic Follow-Up Measurements to Baseline Measurements acquired during acceptance testing. It provides guidelines for periodic evaluations of most clinical PET/CT systems, simplifying procedures and facilitating performance comparisons across vendors, models, and institutions.
Review
Radiology, Nuclear Medicine & Medical Imaging
Mateos Bogoni, Juliano J. Cerci, Francois H. Cornelis, Cristina Nanni, Elena Tabacchi, Heiko Schoder, Paul B. Shyn, Constantinos T. Sofocleous, Stephen B. Solomon, Assen S. Kirov
Summary: This article discusses the rapid development of real-time molecular imaging using PET in combination with CT during interventional procedures over the past decade. It primarily focuses on the current workflows and clinical utility of PET/CT guided biopsies in cancer patients, as well as technological developments such as new PET tracers and robotic arms.
QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Assen S. Kirov, Heiko Schoder, Stephen B. Solomon, Bernhard Sattler
QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ryan P. Reddy, C. Ross Schmidtlein, Romina G. Giancipoli, Audrey Mauguen, Daniel LaFontaine, Heiko Schoder, Lisa Bodei
Summary: Ga-68-labeled somatostatin analog PET/CT is a standard component in the management of neuroendocrine tumors. However, the assessment of treatment response for these tumors still relies on morphologic size measurements, which may not accurately reflect the disease burden. This study aimed to test the accuracy of different methods for measuring functional tumor volume (FTV) using PET/CT and identify a reliable method for assessing tumor burden. The results showed that FTV determined with a thresholding approach had the strongest correlation with traditional morphologic volume measurements, indicating its potential use in determining disease extent and prognosis in patients with neuroendocrine tumors.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniel Lafontaine, C. Ross Schmidtlein, Assen Kirov, Ryan P. Reddy, Simone Krebs, Heiko Schoder, John L. Humm
Summary: The TriDFusion image viewer (3DF) is an open-source medical viewing platform that addresses unmet needs in nuclear medicine research. It provides a range of tools not available in commercial workstations, allowing for multi-modality image analysis and fusion.
Article
Computer Science, Interdisciplinary Applications
Jianfeng Guo, C. Ross Schmidtlein, Andrzej Krol, Si Li, Yizun Lin, Sangtae Ahn, Charles Stearns, Yuesheng Xu
Summary: We investigated the imaging performance of a fast convergent ordered-subsets algorithm with subiteration-dependent preconditioners (SDPs) for positron emission tomography (PET) image reconstruction. The study showed that the SDP-BSREM algorithms significantly improve the convergence rate compared to conventional BSREM and a vendor's implementation as Q.Clear, providing faster convergence to the same objective function value.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Harald Keller, Tina Shek, Brandon Driscoll, Yiwen Xu, Brian Nghiem, Sadek Nehmeh, Milan Grkovski, Charles Ross Schmidtlein, Mikalai Budzevich, Yoganand Balagurunathan, John J. Sunderland, Reinhard R. Beichel, Carlos Uribe, Ting-Yim Lee, Fiona Li, David A. Jaffray, Ivan Yeung
Summary: Characterizing the robustness of image-derived radiomics features is crucial for multicenter clinical studies. This study investigates the effectiveness of a simple harmonization strategy in improving feature robustness and agreement. The results show that the harmonization strategy significantly improves feature agreement and suggests a way to select suitable features for predictive models.
Article
Mathematics, Applied
Xinhuang Tang, Charles Ross Schmidtlein, Si Li, Yuesheng Xu
Summary: PET imaging is traditionally modeled as discrete systems, but the low accuracy of discrete models introduces irreducible modeling errors and limits the quality of reconstructed images. To address this, an integral equation model based on physical and geometrical considerations is proposed, which can be discretized using higher accuracy approximation methods. This new model significantly outperforms conventional discrete models in terms of consistency to simulated projection data and reconstructed image quality.
INTERNATIONAL JOURNAL OF NUMERICAL ANALYSIS AND MODELING
(2021)
Proceedings Paper
Engineering, Biomedical
C. Ross Schmidtlein, Eric S. Harmon, Michael Thompson, Andrzej Krol
Summary: The study extended the testing of non-cylindrical PET detectors by adding a polyethylene sphere and line-source channel to the standard cylindrical polyethylene phantom used in NEMA standards, proposing a method that uses known positions of line sources and detection points of LOR to estimate performance. The proposed modifications provided a consistent means to estimate NECR, SF, and sensitivity of non-cylindrical tomographs in line with NEMA methodology.
MEDICAL IMAGING 2021: PHYSICS OF MEDICAL IMAGING
(2021)
Proceedings Paper
Engineering, Biomedical
Eric S. Harmon, Michael O. Thompson, C. Ross Schmidtlein, James N. Turner, Andrzej Krol
Summary: The challenge of achieving a 10 ps Coincidence Timing Resolution (CTR) in time-of-flight (TOF) Positron Emission Tomography (PET) requires substantial improvements in PET detector blocks technology, such as increasing scintillator intensity and enhancing single photon timing resolution. The latest modeling results show a likelihood of reaching a 50 ps CTR in the near future, with indications that achieving a 10 ps CTR will be more challenging. The simulations align well with recent experimental results, demonstrating potential progress in the field of PET imaging.
MEDICAL IMAGING 2020: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL, AND FUNCTIONAL IMAGING
(2021)
Proceedings Paper
Computer Science, Artificial Intelligence
Eric S. Harmon, Michael O. Thompson, C. Ross Schmidtlein, Andrzej Krol
Summary: This research developed fast analytical methods to evaluate the impact of scintillator thickness on PET imaging system performance, providing an effective tool for preliminary system optimization.
MEDICAL IMAGING 2021: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL, AND FUNCTIONAL IMAGING
(2021)
Proceedings Paper
Computer Science, Artificial Intelligence
C. Ross Schmidtlein, Matthew Maroun, Andrzej Krol, Howard Gifford, Si Li, Lisa Bodei, Joesph O'Donoghue, Ida Haggstrom, Yuesheng Xu
Summary: Scintigraphy is a common nuclear medicine method used to image molecular targets, and a new image reconstruction-based method has been proposed to improve the quality of planar scintigraphic images. This new method outperforms conventional approaches, indicating its potential for further exploration and development in improving image quality.
MEDICAL IMAGING 2021: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL, AND FUNCTIONAL IMAGING
(2021)
Proceedings Paper
Engineering, Biomedical
Howard C. Gifford, C. Ross Schmidtlein, Andrzej Krol, Yuesheng Xu
MEDICAL IMAGING 2020: PHYSICS OF MEDICAL IMAGING
(2020)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Xingyu Nie, Ross Schmidtlein, Assen Kirov
JOURNAL OF NUCLEAR MEDICINE
(2020)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Ryan Reddy, Charles Schmidtlein, Romina Grazia Giancipoli, Audrey Mauguen, Heiko Schoder, Lisa Bodei
JOURNAL OF NUCLEAR MEDICINE
(2020)