期刊
VIRUS RESEARCH
卷 200, 期 -, 页码 19-23出版社
ELSEVIER
DOI: 10.1016/j.virusres.2015.01.018
关键词
Human metapneumovirus; Resveratrol; Quercetin
类别
资金
- [R01 AI062885]
- [P01 AI07924602]
- [P30 ES006676]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P01AI062885, R01AI079246] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES006676] Funding Source: NIH RePORTER
Human metapneumovirus (hMPV) is a major cause of respiratory tract infections in children, elderly and immunocompromised hosts, for which no vaccine or treatment are currently available. Oxidative stress and inflammatory responses represent important pathogenic mechanism(s) of hMPV infection. Here, we explored the potential protective role of dietary antioxidants in hMPV infection. Treatment of airway epithelial cells with resveratrol and quercetin during hMPV infection significantly reduced cellular oxidative damage, inflammatory mediator secretion and viral replication, without affecting viral gene transcription and protein synthesis, indicating that inhibition of viral replication occurred at the level of viral assembly and/or release. Modulation of proinflammatory mediator expression occurred through the inhibition of transcription factor nuclear factor (NF)-kappa B and interferon regulatory factor (IRF)-3 binding to their cognate site of endogenous gene promoters. Our results indicate the use of dietary antioxidants as an effective treatment approach for modulating hMPV induced lung oxidative damage and inflammation. (C) 2015 Elsevier B.V. All rights reserved.
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