期刊
VIRUS GENES
卷 51, 期 3, 页码 375-384出版社
SPRINGER
DOI: 10.1007/s11262-015-1256-z
关键词
PRRSV-Type 1; Chinese swine herds; Genetic variation
资金
- Swine Industry Technology System Building of Beijing [GWZJ-2009-05]
- National Basic Research Program of China [2008FY130100-2]
- Scientific Achievement Transformation Program [2009GB23260435]
Porcine reproductive and respiratory syndrome (PRRS) is an emerging disease that has caused serious economic losses to the swine industry worldwide. In 2011, a nation-wide surveillance program investigated the prevalence of PRRS viruses (PRRSV) in Chinese breeding swine farms, and four European genotype PRRSV (PRRSV-Type 1) were successfully isolated. To explore the genetic diversity of PRRSV-Type 1 in China, these 4 viral strains were subjected to genome sequencing and analysis. The four isolates shared 87.4-90.7 % nucleotide homology with the Lelystad strain (PRRSV-Type 1 stereotype strain). NSP2, ORF3, and ORF4 were the most variable regions and contained discontinuous deletions or insertions when compared to other PRRSV-Type 1 strains. All isolates fell into separate branches of the subtype 1 of PRRSV-Type 1 phylogenetic tree. This analysis of emerging PRRSV-Type 1 strains revealed previously unrecorded genetic diversity. Close attention should be paid to the prevention and control of this evolving virus.
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