Article
Immunology
Vasilis C. Pliasas, Peter J. Neasham, Maria C. Naskou, Rachel Neto, Philip G. Strate, J. Fletcher North, Stephen Pedroza, Strickland D. Chastain, Ian Padykula, S. Mark Tompkins, Constantinos S. Kyriakis
Summary: This study examined the immunogenicity and protective efficacy of different H1N1 influenza vaccine strategies against an H1N2 swine influenza virus. The results showed that heterologous prime-boost vaccination did not enhance cross-protection and worsened the clinical outcome and pathology.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Nutan Mytle, Sonja Leyrer, Jon R. Inglefield, Andrea M. Harris, Thomas E. Hickey, Jacob Minang, Hang Lu, Zhidong Ma, Hanne Andersen, Nathan D. Grubaugh, Tina Guina, Mario H. Skiadopoulos, Michael J. Lacy
Summary: Research demonstrates that utilizing combinations of conserved antigens of influenza A virus, such as NP and various forms of M2e, can generate broad immune protection in mice, reducing lung viral burden and weight loss.
Article
Virology
Min Dou, Wenjun Song, Yongping Lin, Qigao Chen, Chang Lu, Zhongmin Liu
Summary: The study analyzed clinical characteristics and viral genes in patients with severe pneumonia due to H1N1 influenza virus in Guangzhou in 2019. Risk factors for severe disease were identified as chronic lung disease and cardiovascular disease, with a significant rate of secondary infections in critically ill patients. Furthermore, serum IL-8 levels were significantly higher in critically ill patients compared to nonsevere patients and healthy controls.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Zach Menne, Vasilis C. Pliasas, Richard W. Compans, Sheniqua Glover, Constantinos S. Kyriakis, Ioanna Skountzou
Summary: The study demonstrates that vaccination with neuraminidase VLPs is protective against influenza challenge, and bivalent vaccination can effectively protect against lethal challenge from different subtypes of influenza viruses.
Article
Microbiology
Mengkai Cai, Ping Gan, Xiaokun Hu, Zhanzhuo Mai, Chihai Ji, Heyou Yi, Meidi Li, Shaofang Li, Yikuan Ji, Junmei Huang, Guihong Zhang, Lang Gong
Summary: This study developed a vaccine using virus-like particles (VLPs) that can protect against both EA H1N1 and human-like H3N2 infections. The vaccine induced strong immune responses in mice and provided partial or complete protection against different subtypes of the virus.
VETERINARY MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Zhannan Wang, Yingkai He, Wenfeng Wang, Yawen Tian, Chongbo Ge, Futing Jia, Tongyu Zhang, Gerui Zhang, Mingyue Wang, Jinshuo Gong, Haibin Huang, Jianzhong Wang, Chunwei Shi, Wentao Yang, Xin Cao, Yan Zeng, Nan Wang, Aidong Qian, Yanlong Jiang, Guilian Yang, Chunfeng Wang
Summary: The study demonstrates the importance of a dual dendritic cell targeting strategy in improving the effectiveness of influenza vaccines by enhancing the production of lung tissue-resident memory T cells. This research provides a novel approach for developing universal influenza vaccines.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Vaclav Brazda, Otilia Porubiakova, Alessio Cantara, Natalia Bohalova, Jan Coufal, Martin Bartas, Miroslav Fojta, Jean-Louis Mergny
Summary: The study identified multiple potential G-quadruplex forming sequences in the G4-EA-H1N1 genomes, which could serve as potential therapeutic targets.
Article
Biotechnology & Applied Microbiology
Mehrnaz Forqani, Seyed Masoud Hosseini, Behrokh Farahmand, Maryam Saleh, Hadiseh Shokouhi, Ali Torabi, Fatemeh Fotouhi
Summary: Influenza remains a significant threat, with the need for regular adaptation of vaccination strategies due to antigenic changes. The study showed that a combination of conserved influenza proteins NP and M2e supplemented with Alum adjuvant can efficiently induce immune responses in mice, leading to higher levels of specific antibodies and cytokine secretion compared to single antigens. This regimen demonstrated high efficacy with improved survival rates, suggesting its potential as a candidate for global vaccination against influenza.
BIOTECHNOLOGY LETTERS
(2021)
Article
Immunology
Yonghong Liu, Shirin Strohmeier, Irene Gonzalez-Dominguez, Jessica Tan, Viviana Simon, Florian Krammer, Adolfo Garcia-Sastre, Peter Palese, Weina Sun
Summary: By generating and sequentially vaccinating mice with inactivated influenza B viruses displaying mosaic HAs, researchers have successfully induced long-lasting and cross-protective antibody responses. These findings represent a significant step towards the development of a universal influenza B virus vaccine.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Sofia M. Buonocore, Robbert G. van der Most
Summary: This article reviews the association between the 2009-2010 H1N1 influenza pandemic and the increased risk of narcolepsy in children and adolescents after vaccination. Studies have suggested that immune responses and molecular mimicry may play a role in this association.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Chemical
Duy Tien Ta, Kai Ling Chu, Nur Izzati Bte Soonaan, Christine Chin, Say Kong Ng, Wei Zhang
Summary: A new and simplified anion exchange chromatographic process has been established for the purification of live and inactivated cell-grown influenza A H1N1 viruses. This process showed efficient, robust, cost-effective, and scalable characteristics, making it a promising alternative for cell-based influenza vaccine production.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Obstetrics & Gynecology
Nicola Vousden, Marian Knight
Summary: Influenza during pregnancy is associated with an increased risk of hospital admission, and there is variability in policies and uptake of immunization globally. Immunization is cost-effective and safe in preventing influenza in pregnant women and their infants.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Immunology
Krista Salo-Tuominen, Tamara Teros-Jaakkola, Laura Toivonen, Helena Ollila, Paivi Rautava, Minna Aromaa, Elina Lahti, Niina Junttila, Ville Peltola
Summary: The study investigated the association between parental socioeconomic and psychosocial factors and the uptake of the 2009 pandemic influenza vaccine in children. It found that children of younger and less educated mothers had a lower rate of vaccine uptake. However, the individual or relational psychosocial well-being of parents was not associated with children's vaccination.
Article
Microbiology
Jun Li, Rumeng Li, Qi Zhang, Peipei Peng, Xiaoquan Wang, Min Gu, Zenglei Hu, Xinan Jiao, Daxin Peng, Jiao Hu, Xiufan Liu
Summary: This study demonstrates that the H7N9 VLP vaccine provides complete clinical protection against HP H7N9 virus, significantly inhibits virus shedding, and abolishes viral replication in chickens. The VLP vaccine represents a promising alternative strategy for the development of novel H7N9 avian influenza vaccines for chickens.
VETERINARY MICROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Yuchong Wang, Xujun Zhang, Kefan Bi, Hongyan Diao
Summary: MicroRNAs play important roles in regulating virus replication and host antiviral response during H1N1 infection, with some defending against the virus and others promoting viral replication. They are involved in host-viral interactions and have versatile functions in this process.