Article
Medicine, General & Internal
Lei Chen, Funing Yang, Zhaoyan Qi, Jiandong Tai
Summary: Tumor budding (TB), a powerful predictor of colorectal cancer (CRC), was studied to develop a prediction model for lymph node metastasis (LNM) and local recurrence in pT1 CRC patients. Independent predictors for LNM and recurrence were identified and used to construct predictive nomograms for treatment decision-making. The models showed potential clinical application value and postoperative chemotherapy was associated with better outcomes in high-risk patients.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Jeong-ki Kim, Ye-Young Rhee, Jeong Mo Bae, Jung Ho Kim, Seong-Joon Koh, Hyun Jung Lee, Jong Pil Im, Min Jung Kim, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park, Ji Won Park, Gyeong Hoon Kang
Summary: The optimal tumor budding cut-off number for estimating LN metastasis in submucosal CRC was determined and a composite scoring system (CSS) was developed.
Article
Pathology
Adil Aziz Khan, Shaivy Malik, Sherrin Jacob, Durre Aden, Sana Ahuja, Sufian Zaheer, Sunil Ranga
Summary: Colorectal carcinoma is a common, highly fatal cancer. Although the staging system provides guidance for treatment, clinical outcomes can vary greatly among patients with the same stage. Additional prognostic markers are needed for better accuracy.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Pathology
John D. Paulsen, Alexandros D. Polydorides
Summary: Depth of invasion through the intestinal wall, categorized as primary tumor stage (pT), is an important prognostic factor in colorectal cancer. However, additional variables, such as tumor size, lymphovascular invasion, and lymph node stage, in pT2 colonic adenocarcinomas have not been thoroughly examined. Our study found that tumors extending to the outer muscularis propria (pT2b) were associated with older age, larger tumor size, higher likelihood of lymphovascular invasion, and higher lymph node stage compared to tumors limited to the inner muscle layer (pT2a). High-grade tumor budding was identified as an independent predictor of shorter progression-free survival in pT2 tumors. The presence of high-grade tumor budding was significantly associated with disease progression in cases that would not typically receive adjuvant treatment (pT2N0M0). These findings suggest the importance of considering specific variables, such as tumor size, pT stage, lymphovascular invasion, perineural invasion, and tumor budding, during the diagnosis of pT2 tumors for appropriate treatment decisions and patient prognostication.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Oncology
Gaoyan Yao, Yi Fang, Yangbo Fu, Jinghong Xu, Haojun Song, Hangqin Zhu, Mengli Gu, Xiaoyun Ding
Summary: Tumor budding is associated with tumor size, tumor histologic differentiation, depth of invasion, lymph node metastasis, lympho-vascular invasion, and early recurrence of early gastric cancer. High-grade tumor budding, especially, can predict lymph node metastasis in early gastric cancer and may be an important parameter for evaluating the prognosis of patients with early gastric cancer.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Kwangil Yim, Won Mo Jang, Sung Hak Lee
Summary: The study demonstrates that modified tumor budding (mTB) is a more accurate predictor of lymph node metastasis (LNM) in early gastric cancer patients compared to conventional tumor budding (TB). It enhances the predictive power of LNM, providing important information for patient treatment.
Article
Gastroenterology & Hepatology
Taketo Sasaki, Kohei Shigeta, Koji Okabayashi, Masashi Tsuruta, Ryo Seishima, Shimpei Matsui, Yuko Kitagawa
Summary: This study retrospectively analyzed 189 colorectal cancer patients who underwent curative resection, and found that horizontal spread of lymph node metastasis is an independent risk factor for recurrence.
COLORECTAL DISEASE
(2021)
Article
Medicine, General & Internal
Aura Jurescu, Adrian Vaduva, Octavia Vita, Adelina Gheju, Remus Cornea, Codruta Lazureanu, Anca Muresan, Marioara Cornianu, Sorina Taban, Alis Dema
Summary: This study aimed to evaluate the prognostic significance of classic and less-studied histopathological parameters in colorectal cancer (CRC). The findings showed that a high degree of malignancy, deep invasion of the intestinal wall, advanced stage of the disease, and other factors were positively correlated with lymph node metastases. The study highlighted the value of classic prognostic factors along with easily assessable parameters.
MEDICINA-LITHUANIA
(2023)
Article
Oncology
Ziyu Zhang, Li Li, Yang Gao, Xiaoxiong Xiao, Liyan Ji, Zhipeng Zhou, Juan Jiang, Shiqing Liu, Jian An, Pengbo Deng, Nannan Du, Pansong Li, Xuefeng Xia, Chengping Hu, Min Li
Summary: We investigated the immune environment in tumor-draining lymph nodes (TDLNs) of non-small cell lung cancer (NSCLC) patients with or without lymph node (LN) metastasis. Our findings suggest that LN metastasis facilitates tumor-specific antigen presentation in TDLNs and induces T cell priming, while existing tumor cells generate an immune-suppressive environment in metastasis-positive LNs.
Review
Multidisciplinary Sciences
Fengling Hu, Chutong Lin, Hongling Chu, Peng Ren, Jingdi Wang, Shaohua Ma
Summary: This study conducted a systematic review and meta-analysis to evaluate the survival difference between N1h and N1p in patients with pN1M0 NSCLC. The results showed that patients with N1p metastasis had a better prognosis compared to those with N1h metastasis.
SCIENTIFIC REPORTS
(2021)
Review
Gastroenterology & Hepatology
Mark A. Dykstra, Tamara I. Gimon, Paul E. Ronksley, W. Donald Buie, Anthony R. MacLean
Summary: This study identified 1500 μm as the depth most significantly associated with lymph node metastasis, while tumor budding and poorly differentiated clusters were also found to be significantly associated. These findings can help inform guidelines for risk stratification of T1 tumors and prompt further investigation into the contribution of poorly differentiated clusters to lymph node metastasis.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Oncology
Jun-Peng Pei, Rui Zhang, Nan-Nan Zhang, Yong-Ji Zeng, Zhe Sun, Si-Ping Ma, Jian-Guo Zhou, Xin-Xiang Li, Jin Fan, Ji Zhu, Masanobu Abe, Zu-Bing Mei, Gang Shi, Chun-Dong Zhang
Summary: The novel TLNR classification for colon cancer, which combines LNR and T stage, showed better prognostic discrimination, model-fitting ability, and net benefits compared to the AJCC 8th TNM classification in patients with operable stage I-III colon cancer. Further studies are needed to validate the novel TLNR classification.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, General & Internal
Xiang Zhang, Nan Feng, Bo Wu, Yiping Wei, Wenxiong Zhang
Summary: Lymph node ratio (LNR) is an important prognostic indicator in non-small-cell lung cancer (NSCLC), with higher LNR indicating worse prognosis. This study found that LNR and positive node category have predictive value for prognosis in stage III NSCLC patients.
Article
Critical Care Medicine
Hyungjin Kim, Hyewon Choi, Kyung Hee Lee, Sukki Cho, Chang Min Park, Young Tae Kim, Jin Mo Goo
Summary: Three robust definitions for central lung cancer that are associated with occult nodal metastasis were identified, but selecting candidates for invasive mediastinal staging solely based on tumor location is suboptimal.
Article
Oncology
Victor Lago, Beatriz Montero, Susana Lopez, Pablo Padilla-Iserte, Luis Matute, Tiermes Marina, Marta Gurrea, Guillermina Montoliu, Pilar Bello, Santiago Domingo
Summary: The objective of this study is to determine the role of sentinel lymph node ultrastaging in apparent early-stage ovarian cancer. The study shows that a uniform protocol for ultrastaging is essential for lower-volume metastasis detection and to provide reproducible information for future studies.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Emergency Medicine
Joel L. Lavanchy, Luciane Delafontaine, Tobias Haltmeier, Piotr Bednarski, Beat Schnuriger
Summary: The study in Switzerland found that higher hospital treatment volume was associated with a higher rate of successful non-operative management and shorter length of hospital stay for patients with splenic injuries, but not with reduced in-hospital mortality.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Pathology
Viktor Hendrik Koelzer, Rainer Grobholz, Inti Zlobec, Andrew Janowczyk
Summary: The survey suggests that the pandemic has accelerated the adoption of digital pathology, especially in centers with established workflows. However, institutions in the early stages of implementation face significant technical and organizational challenges.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Emergency Medicine
Christian T. J. Magyar, Piotr Bednarski, Dominik A. Jakob, Beat Schnuriger
Summary: This study found that severe penetrating trauma is very rare in Switzerland, with mortality rates ranging from 9% in stab wounds to 67% in self-inflicted gunshot wounds. Particularly in cases of torso injuries, reducing prehospital time may improve patient outcomes.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Oncology
Andreas Seeber, Francesca Battaglin, Kai Zimmer, Florian Kocher, Yasmine Baca, Joanne Xiu, Gilbert Spizzo, Veronica Novotny-Diermayr, Dietmar Rieder, Alberto Puccini, Jeff Swensen, Michelle Ellis, Richard M. Goldberg, Axel Grothey, Anthony F. Shields, John L. Marshall, Benjamin A. Weinberg, Paul E. Sackstein, Kiat Hon Lim, Gek San Tan, Chadi Nabhan, W. Michael Korn, Arno Amann, Zlatko Trajanoski, Martin D. Berger, Emil Lou, Dominik Wolf, Heinz-Josef Lenz
Summary: The molecular features of colorectal cancers with RSPOfp/RNF43 mutations were characterized in this study, revealing new RSPO fusion events and identifying additional mutations associated with RSPOfp and RNF43 mutations. The findings have important implications for the development of therapeutic strategies targeting these mutations.
CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Alberto Puccini, Kelsey Poorman, Fabio Catalano, Andreas Seeber, Richard M. Goldberg, Mohamed E. Salem, Anthony F. Shields, Martin D. Berger, Francesca Battaglin, Ryuma Tokunaga, Madiha Naseem, Wu Zhang, Philip A. Philip, John L. Marshall, W. Michael Korn, Heinz-Josef Lenz
Summary: Signet ring cell carcinoma (SRCC) is a rare subtype of gastric and colorectal cancer, associated with poor prognosis and unknown molecular characteristics. Analysis revealed that SRCCs harbor a similar molecular profile regardless of tumor location, potentially leading to tailored therapy for these patients.
Article
Oncology
Karlijn Hummelink, Vincent van der Noort, Mirte Muller, Robert D. Schouten, Ferry Lalezari, Dennis Peters, Willemijn S. M. E. Theelen, Viktor H. Koelzer, Kirsten D. Mertz, Alfred Zippelius, Michel M. van den Heuvel, Annegien Broeks, John B. A. G. Haanen, Ton N. Schumacher, Gerrit A. Meijer, Egbert F. Smit, Kim Monkhorst, Daniela S. Thommen
Summary: This study established PD-1T TILs as a predictive biomarker for clinical benefit to PD-1 blockade in patients with advanced NSCLC. The biomarker showed high sensitivity and specificity, and had a high negative predictive value in identifying patients without clinical benefit. Additionally, high levels of PD-1T TILs were associated with longer progression-free and overall survival.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Murielle N. Wahli, Stefanie Hayoz, Dennis Hoch, Christoph O. Ryser, Michele Hoffmann, Amina Scherz, Birgit Schwacha-Eipper, Simon Haefliger, Julian Wampfler, Martin D. Berger, Urban Novak, Berna C. Oezdemir
Summary: The role of immune checkpoint inhibitors (ICI) in clinical practice was investigated in this study, focusing on patient and tumor characteristics, survival rates, and toxicity rates by sex. The results showed that ICI treatment had an increasing importance in oncology, with higher incidence of adverse events in female patients and associated with longer overall survival.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Simone Benhamou, Evelyne Fournier, Giacomo Puppa, Thomas McKee, Frederic Ris, Laura Rubbia-Brandt, Valeria Viassolo, Thomas Zilli, Inti Zlobec, Pierre Olivier Chappuis, Elisabetta Rapiti
Summary: This study established a large cohort of colorectal cancer (CRC) patients and their relatives to investigate the impact of family history and tumor biomarkers on patient outcomes. The cohort includes 5499 patients and provides detailed clinical and molecular data. Future plans involve further research and correlation analysis with the latest follow-up data.
Review
Oncology
Alberto Puccini, Andreas Seeber, Martin D. Berger
Summary: This review provides an overview of established and potential promising biomarkers for guiding the treatment of metastatic colorectal cancer, aiming to further improve patient outcome.
Article
Pathology
Magdalena Skoworonska, Annika Blank, Irene Centeno, Caroline Hammer, Aurel Perren, Inti Zlobec, Tilman T. Rau
Summary: The standardized preanalytical code (SPREC) is a precise format for aggregating warm ischemia (WIT), cold ischemia (CIT), and fixation times (FIT). Through empirical research, the Tissue Bank Bern has developed a fully informative SPREC code and identified its dual role as a sample characteristic and a traceable process parameter. The study also reveals specific differences in WIT, CIT, and FIT values in various organs, as well as the potential to optimize the SPREC fixation and adapt its categories based on real-life data.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Oxana (Sachenkova) Lundstrom, Max Adriaan Verbiest, Feifei Xia, Helyaneh Ziaei Jam, Inti Zlobec, Maria Anisimova, Melissa Gymrek
Summary: Short tandem repeats (STRs), consisting of repeated one to six nucleotide motifs, have been shown to influence various traits in humans. However, the study of STRs has been limited due to technical challenges. Recent advancements in genome-wide analysis tools have enabled large-scale analysis of STR variations in populations.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Article
Neuroimaging
Morin Beyeler, Erich Rea, Loris Weber, Nebiyat Filate Belachew, Enrique Barvulsky Aleman, Moritz Kielkopf, Christoph C. Kurmann, Lorenz Grunder, Eike Immo I. Piechowiak, Thomas R. Meinel, Mirjam R. Heldner, David Seiffge, Sara Pilgram-Pastor, Tomas Dobrocky, Thomas Pabst, Martin D. Berger, Simon Jung, Marcel Arnold, Jan Gralla, Urs Fischer, Johannes Kaesmacher, Adnan Mujanovic
Summary: The absence of the susceptibility vessel sign (SVS) in patients treated with mechanical thrombectomy (MT) is associated with poor outcomes, and underlying conditions such as cancer may impact long-term prognosis.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Clinical Neurology
Morin Beyeler, Pasquale Castigliego, Joel Baumann, Victor Ziegler, Moritz Kielkopf, Madlaine Mueller, Stefan A. Bauer-Gambelli, Adnan Mujanovic, Thomas Raphael Meinel, Thomas Horvath, Urs Fischer, Johannes Kaesmacher, Mirjam R. Heldner, David Seiffge, Marcel Arnold, Thomas Pabst, Martin D. Berger, Babak B. Navi, Simon Jung, Philipp Bucke
Summary: Cancer-related transient ischemic attacks (TIA) are not uncommon and share similar biomarker changes with cancer-related stroke. Early identification of cancer-related TIA could lead to targeted treatment strategies and improved outcomes.
FRONTIERS IN NEUROLOGY
(2023)
Review
Chemistry, Medicinal
Linh Chi Tran, Berna C. Oezdemir, Martin D. Berger
Summary: This review provides an overview of the current state of immune checkpoint inhibitors (ICIs) in the treatment of metastatic pancreatic ductal adenocarcinoma (mPDAC). It discusses the biological rationale for implementing ICIs and explores preclinical studies and clinical trials in this field. The challenges of integrating ICIs into the treatment strategy of PDAC and potential future directions are also addressed.
Article
Pathology
Ana Leni Frei, Raphael Oberson, Elias Baumann, Aurel Perren, Rainer Grobholz, Alessandro Lugli, Heather Dawson, Christian Abbet, Ibai Lertxundi, Stefan Reinhard, Aart Mookhoek, Johann Feichtinger, Rossella Sarro, Gallus Gadient, Corina Dommann-Scherrer, Jessica Barizzi, Sabina Berezowska, Katharina Glatz, Susanne Dertinger, Yara Banz, Rene Schoenegg, Laura Rubbia-Brandt, Achim Fleischmann, Guenter Saile, Pierre Mainil-Varlet, Ruggero Biral, Luca Giudici, Alex Soltermann, Audrey Baur Chaubert, Sylvia Stadlmann, Joachim Diebold, Kristof Egervaril, Charles Beniere, Francesca Saro, Andrew Janowczyk, Inti Zlobec
Summary: Estimating tumor cell fraction (TCF) is a common clinical task with high variability among pathologists. This study evaluated the impact of using a tumor cell fraction computer-aided diagnostic (TCFCAD) tool to support pathologists' evaluation. The results showed that with the assistance of TCFCAD, interobserver variability decreased and estimates were closer to the ground truth. Pathologists also reported increased confidence in their assessments when aided by the TCFCAD tool.