期刊
VIRCHOWS ARCHIV
卷 467, 期 4, 页码 367-382出版社
SPRINGER
DOI: 10.1007/s00428-015-1818-4
关键词
CAFs; Tumour-environment; Biomimetics; Diagnostics; Therapy
类别
资金
- 'Stichting tegen Kanker' [2012-217]
- 'Vlaamse Liga tegen Kanker'
- Fund for Scientific Research-Flanders
- IWT [093153]
- Laurine Verset from Fonds Erasme
Cancer-associated fibroblasts (CAFs) are drivers of tumour progression and are considered as a target and a tool in cancer diagnostic and therapeutic applications. An increased abundance of CAFs or CAF signatures are recognized as a bad prognostic marker in several cancer types. Tumour-environment biomimetics strongly improve our understanding of the communication between CAFs, cancer cells and other host cells. Several experimental drugs targeting CAFs are in clinical trials for multiple tumour entities; alternatively, CAFs can be exploited as a tool to characterize the functionality of circulating tumour cells or to capture them as a tool to prevent metastasis. The continuous interaction between tissue engineers, biomaterial experts and cancer researchers creates the possibility to biomimic the tumour-environment and provides new opportunities in cancer diagnostics and management.
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