期刊
PHYSICAL REVIEW LETTERS
卷 108, 期 23, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.108.238102
关键词
-
资金
- NSF [MCB-0842871]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [0842871] Funding Source: National Science Foundation
The effect of surface hydration water on internal protein motion is of fundamental interest in molecular biophysics. Here, by decomposing the picosecond to nanosecond atomic motion in molecular dynamics simulations of lysozyme at different hydration levels into three components-localized single-well diffusion, methyl group rotation, and nonmethyl jumps-we show that the effect of surface hydration is mainly to increase the volume of the localized single-well diffusion. These diffusive motions are coupled in such a way that the hydration effect propagates from the protein surface into the dry core.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据