期刊
PHYSICAL REVIEW LETTERS
卷 107, 期 9, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.107.098102
关键词
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资金
- NSF [NSF CHE-0535616, EF-0623664]
- California Institute of Quantitative Biosciences [QB3]
- NIH [R01-GM062868, NSF-DMS-0900700, NSF-MCB-0954714]
To explain the observed dynamics in equilibrium single-molecule measurements of biomolecules, the experimental observable is often chosen as a putative reaction coordinate along which kinetic behavior is presumed to be governed by diffusive dynamics. Here, we invoke the splitting probability as a test of the suitability of such a proposed reaction coordinate. Comparison of the observed splitting probability with that computed from the kinetic model provides a simple test to reject poor reaction coordinates. We demonstrate this test for a force spectroscopy measurement of a DNA hairpin.
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