Article
Optics
Chaoyang Gong, Xi Yang, Shui-Jing Tang, Qian-Qian Zhang, Yanqiong Wang, Yi-Ling Liu, Yu-Cheng Chen, Gang-Ding Peng, Xudong Fan, Yun-Feng Xiao, Yun-Jiang Rao, Yuan Gong
Summary: This study reports the development of submonolayer lasers on optical fibers as ultrasensitive and disposable biosensors for biomarker detection, which offers great potential in early diagnosis.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Article
Chemistry, Applied
Wen-Juan Qu, Hao-Hang Yang, Jian-Peng Hu, Peng Qin, Xing-Xing Zhao, Qi Lin, Hong Yao, You-Ming Zhang, Tai-Bao Wei
Summary: This study presented a bi-acylhydrazone supramolecular gelator HT prepared by a simple Schiff base reaction, which could self-assemble into supramolecular gel HT-G and exhibit specially selective and ultrasensitive sensing property for CN-. The lowest detection limit of the gel for CN is 0.50 nM, making it a convenient and efficient tool for CN- detection.
Article
Multidisciplinary Sciences
Qingbin Zeng, Qianni Guo, Yaping Yuan, Baolong Wang, Meiju Sui, Xin Lou, Louis-S. Bouchard, Xin Zhou
Summary: A modular design approach was introduced to construct a molecular building block Xe probe for imaging intracellular biothiols, improving disease detection specificity. The probe had high signal-to-noise ratio and a low detection threshold of 100 pM, making it suitable for live cell detection. This strategy can be easily extended to detect other biomolecules, enhancing the development of low-cost multifunctional probes for molecular imaging.
Article
Engineering, Multidisciplinary
Hao Tian, Gang Liu, Zhanchao Liu, Lan Xiao
Summary: This study discusses the frequency shift phenomenon of 129Xe and 131Xe in NMR sensors caused by weak temperature gradients. A new model based on thermal diffusion and relative concentration is proposed to explain this phenomenon, and simulations are conducted using COMSOL software. The results show good agreement with experimental data, providing a valuable reference for analyzing the frequency shift of NMR sensors under weak temperature gradients.
Article
Chemistry, Physical
Xiaolan Lei, Yingyi Zou, Qingjian Liang, Weishao Xu, Shanshan Lao, Bin Yang, Ligui Li, Liting Yang, Hong Liu, Li-Jun Ma
Summary: A fluorescence enhancement probe with high selectivity and sensitivity for the detection of Al3+ was synthesized through a photoinduced electron transfer mechanism. The probe showed a fast response time, good photostability, wide measured range of pH, and high repeatability.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Chemistry, Applied
Yuting Wang, Yongkang Yue, Caixia Yin, Xiaoqing Li, Bin Huo, Fangjun Huo
Summary: This study reported a method based on an ultrasensitive fluorescent probe for simultaneous quantification of homocysteine and cysteine, which provides a highly accurate guidance for the clinical diagnosis and treatment of thiol-related cardiovascular and cerebrovascular diseases.
Editorial Material
Multidisciplinary Sciences
Sebastian Klembt
Summary: The strong coupling between confined organic molecules and light is shown to enhance photon detection at room temperature, highlighting the increasing significance of organic molecules in quantum-optics technologies.
Article
Multidisciplinary Sciences
Wanqi Mo, Zihao Zhu, Fanwei Kong, Xiaobai Li, Yu Chen, Huaqian Liu, Zhiyong Cheng, Hongwei Ma, Bin Li
Summary: In this study, a sensor design based on a conjugated microporous polymer film was proposed for the detection of nerve agent substitutes, with low detection limit and portability, providing new ideas for the future development of gas sensors.
NATURE COMMUNICATIONS
(2022)
Article
Agriculture, Multidisciplinary
Ruiyuan Pan, Jianghua Liu, Panxue Wang, Di Wu, Jian Chen, Yongning Wu, Guoliang Li
Summary: This study proposes an ultrasensitive surface-enhanced Raman scattering (SERS) biosensor driven by CRISPR/Cas12a for on-site nucleic acid detection. The biosensor achieves precise target DNA recognition and signal amplification through specific base pairing and efficient trans-cleavage capability of CRISPR/Cas12a. The strategy exhibits an ultralow detection limit and is successfully applied to milk authenticity detection.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Fengqin Li, Weiqiang Yang, Bingru Zhao, Shuai Yang, Qianyun Tang, Xiaojing Chen, Huili Dai, Peifeng Liu
Summary: Diagnostic testing of biological macromolecules is crucial for early warning of diseases and cancer. However, detecting macromolecules with high sensitivity using interface-based sensing methods remains challenging due to limited surface area and steric hindrance. In this study, a biphasic replacement electrochemical aptamer-based (BRE-AB) sensing strategy is introduced, which achieves ultrasensitive detection of luteinizing hormone (LH) by capturing biomacromolecules in a homogeneous solution and replacing them with small diameter single-stranded DNA to attach to the interface. Molecular Dynamics simulations are used to investigate the binding mechanism between the aptamer and target LH. Furthermore, the BRE-AB sensor demonstrates excellent sensing performance in whole blood and undiluted plasma, enabling successful quantification of LH concentrations in clinical samples, and identifying higher expression of LH in breast cancer patients. The sensor is also simple, low-cost, easy to regenerate and reuse, making it potentially applicable for point-of-care diagnostics of biological macromolecules.
Article
Chemistry, Analytical
Wenlong Sheng, Yamin Yu, Na Gao, Meng Jin, Lizhen Wang, Ning Li, Can Li, Huili Zhang, Yun Zhang, Kechun Liu
Summary: A novel fluorescent probe CP-Hg with high sensitivity and selectivity was successfully synthesized for the detection of mercury ions. The probe can react with mercury ions with a distinct color change and has been proven to have low toxicity, showing successful applications in detecting mercury in water samples, macrophages and zebrafish model.
ANALYTICAL METHODS
(2021)
Article
Chemistry, Analytical
Mengyuan Wang, Huixiao Li, Yadi Wang, Xiaodie Hu, Shujun Fang, Huili Ma, Wei Li, Dianlei Wang, Zhili Han
Summary: In this study, gold nanoclusters (AuNCs) were combined with a soft chitosan (CS) nanogel matrix (AuNCs@CS) using a simple one-pot approach. The resulting AuNCs@CS nanogels showed a 2.4-fold enhancement in electrochemiluminescence (ECL) intensity compared to bare AuNCs. This enhancement was attributed to increased Au(0) content, the confinement effect of the chitosan nanogels, and the prolonged excited state lifetime of AuNCs. The AuNCs@CS nanogels were used to develop a label-free ECL immunosensor for ultrasensitive detection of aflatoxin B1 (AFB1) with a significantly lower detection limit compared to previous ECL biosensors.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Shuo Meng, Dongmiao Qin, Yusheng Wu, Guichun Mo, Xiaohua Jiang, Biyang Deng
Summary: Researchers prepared a composite material MnCO3/poly(diallyl dimethyl ammonium chloride) (PDDA)/Ag with excellent electrochemiluminescence (ECL) performance and high biocompatibility by adding MnCO3 and PDDA to silver nanoparticles (AgNPs). MnCO3 and Au@SiO(2)NPs were used as ECL donors and acceptors, respectively, establishing an effective ECL-resonance energy transfer (RET) sensing platform. The system showed good response to the concentration of A beta(42) in serum samples.
Article
Engineering, Electrical & Electronic
Mingpan Bi, Yinping Miao, Wenjie Li, Chengwei Fei, Kailiang Zhang
Summary: In this study, an ultrasensitive microfiber sensor integrated with Nb2CTX nanosheets was proposed and designed, which showed temperature compensation and potential applications in biosensing and environmental pollution monitoring.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Zhou Li, David W. W. Gardner, Yong Xia, Sikai Zhao, Aifei Pan, Nishit Goel, Stephen Bart, Chen Liu, Jianxin Yi, Carlo Carraro, Roya Maboudian
Summary: Ordered porous thin films of reduced graphene oxide and tin oxide (rGO/SnO2) were synthesized and their gas-sensing properties were studied. The incorporation of rGO significantly improved the humidity sensitivity and electrical conductivity of the sensor. The rGO/SnO2 composite film also demonstrated fast response time and excellent selectivity towards humidity, and showed long-term stability compared to a commercial humidity sensor.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Review
Biochemistry & Molecular Biology
Jabadurai Jayapaul, Leif Schroder
Article
Chemistry, Medicinal
Martin Kunth, Christopher Witte, Leif Schroeder
Summary: Xenon magnetic resonance imaging (MRI) offers excellent sensitivity through the combination of spin hyperpolarization and chemical exchange saturation transfer (CEST), with molecular hosts like cryptophane-A or cucurbit[n]urils providing opportunities for switchable MRI reporters. Utilizing an internal reference host to resolve exchange kinetics information allows quantitative comparisons of different ultra-sensitive MRI reporters.
Article
Chemistry, Multidisciplinary
Olga Breitkreuz-Korff, Christian Tscheik, Giovanna Del Vecchio, Sophie Dithmer, Wolfgang Walther, Andrea Orthmann, Hartwig Wolburg, Reiner F. Haseloff, Leif Schroeder, Ingolf E. Blasig, Lars Winkler
Summary: M01, identified as a claudin-5 interaction inhibitor, transiently increases BBB permeability and enables enhanced delivery of neuropharmaceuticals to the brain by weakening cell-cell interactions.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jakob Ernst Luis Jordan, Gergely Bertalan, Tom Meyer, Heiko Tzschaetzsch, Anton Gauert, Luca Brame, Helge Herthum, Yasmine Safraou, Leif Schroeder, Juergen Braun, Anja I. H. Hagemann, Ingolf Sack
Summary: The zebrafish has become an important model in biomedical research, and there is increasing interest in mapping its viscoelastic properties using elastography methods. A study using microscopic multifrequency MR elastography showed distinct differences in stiffness and viscosity of different tissue regions in zebrafish, providing valuable information for neuromechanical and oncological research.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Biophysics
Jan Oliver Jost, Leif Schroeder
Summary: This study introduces liposomes with a HyperCEST-active lipopeptide to enhance the efficiency of Xe host, CrA-ma. Using depolarization time as a comparative measure, the researchers found that incorporating CrA-lipopeptides into liposomal carriers allows for significant image contrast even with lower saturation power.
NMR IN BIOMEDICINE
(2023)
Article
Multidisciplinary Sciences
Patrick Werner, Matthias Taupitz, Leif Schroeder, Patrick Schuenke
Summary: Gadolinium-based contrast agents have been used in clinical MRI for over 30 years, but evidence suggests their dissociation in vivo can lead to long-term deposition of gadolinium ions. In vitro experiments provide insight into the kinetics and thermodynamics of these processes. A new MRI relaxometry-based approach is developed to study the interactions of GBCAs with competing chelators, showing potential for identifying potent Gd-complexing macromolecular species.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Medicinal
Patrick Werner, Patrick Schuenke, Oxana Krylova, Heike Nikolenko, Matthias Taupitz, Leif Schroeder
Summary: This study investigates the interaction between glycosaminoglycans and gadolinium ions and its impact on clinical MR imaging contrast agents. The results highlight the crucial role of sulfate groups in the chelation process and suggest that GAGs with higher degrees of sulfation are more likely to engage in this mechanism.
Article
Multidisciplinary Sciences
Jabadurai Jayapaul, Sanna Komulainen, Vladimir V. Zhivonitko, Jiri Mares, Chandan Giri, Kari Rissanen, Perttu Lantto, Ville-Veikko Telkki, Leif Schroeder
Summary: Guest capture and release are essential properties of self-assembling nanostructures, with guests potentially transitioning between different environments to escape common spectroscopy techniques. This study uses spin-hyperpolarized Xe-129 hyper-CEST NMR to investigate an iron-based metal organic polyhedron's cavity, revealing unknown signals persisting under various perturbations, likely originating from Xe bound to three Fe-MOP diastereomers inducing steric effects. These findings have implications for selective spin manipulation in CEST MRI agents and processes occurring on a millisecond time scale.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Gergerly Bertalan, Julia Becker, Heiko Tzschaetzsch, Anna Morr, Helge Herthum, Mehrgan Shahryari, Ryan D. Greenhalgh, Jing Guo, Leif Schroeder, Christian Alzheimer, Silvia Budday, Kristian Franze, Juergen Braun, Ingolf Sack
Summary: The mechanical properties of brain tissue are complex and vary depending on species, region, measurement method, and in vivo or ex vivo conditions. Through various methods, we found that brain stiffness shows remarkable consistency across species, in vivo and ex vivo states, and different measurement techniques when considering viscoelastic dispersion properties combining equilibrium and non-equilibrium mechanical elements.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Lyndi Kiple, John Ballenger, Kristina Keating, Anagi M. M. Balachandra, Tyler Meldrum
Summary: Single-sided NMR instruments use inhomogeneous magnetic fields to probe physical properties of materials. We developed an algorithmic approach to position flat samples coplanar with the magnet's sensitive region. This positioning process improves the spatial resolution of single-sided NMR measurements for planar samples in research and industrial settings.
MAGNETIC RESONANCE IN CHEMISTRY
(2023)
Review
Nanoscience & Nanotechnology
Philip Saul, Leif Schroder, Andreas B. B. Schmidt, Jan-Bernd Hovener
Summary: Nanomaterials are crucial in the development and application of hyperpolarized materials for MRI. They can function as both directly imaged hyperpolarized materials, carriers for hyperpolarized gases, and catalysts for generating hyperpolarized substrates. This article provides an overview of recent developments in these three application possibilities, highlighting carbon-based materials for direct imaging. The importance of nanomaterials in MRI is discussed, including their biocompatibility and imaging experiments.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Applied
Lyndi Kiple, Tyler Lee, Gillian Zavaglia, Tyler Meldrum
Summary: In this study, single-sided 1H NMR relaxometry was used to characterize the molecular environments in both dry and wet acrylic paints by their molecular mobilities. Two different relaxation behaviors were identified in dry paint, indicating regions of greater and lesser mobility, attributed to amorphous and crystalline domains of the semi-crystalline acrylic polymer. In wet paint, two different relaxation behaviors were characterized, hypothesized to come from unique molecular environments in the acrylic binding medium, along with two simultaneous exchange processes involving aqueous solvent.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Chemistry, Physical
Hen-Amit Morik, Patrick Schuenke, Leif Schroeder
Summary: A serious limitation of high resolution Xe-129 chemical exchange saturation transfer (CEST) NMR spectroscopy is the long acquisition time due to step-wise encoding of the chemical shift dimension. This study presents a method of optimized use of Xe-129 spin magnetization to enable the accelerated and simultaneous acquisition of CEST spectra from multiple samples or regions. The method is applied to investigate the host-guest system of CB7 and xenon with competing guests, revealing that the observed CEST signal is from a CB6 impurity and that CB7 itself does not produce a CEST signal.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Md Sharif Ullah, Vladimir V. Zhivonitko, Anatoliy Samoylenko, Artem Zhyvolozhnyi, Sirja Viitala, Santeri Kankaanpaa, Sanna Komulainen, Leif Schroeder, Seppo J. Vainio, Ville-Veikko Telkki
Summary: Exosomes are a subset of lipid envelope-encapsulated extracellular vesicles of 50-150 nm diameter, with many smaller and larger nanoparticles co-isolated during purification processes. Diffusion ordered spectroscopy (DOSY) nuclear magnetic resonance (NMR) method enables the determination of a broad distribution of extracellular nanoparticles, ranging from 1 to 500 nm, showing the presence of smaller particles not visible in traditional analysis methods. Hyperpolarized chemical exchange saturation transfer (Hyper-CEST) with Xe-129 NMR also indicates the existence of smaller and larger nanoparticles in the EV samples, suggesting faster exchange rates in the EV pool compared to other nanoparticle pools.
Article
Chemistry, Multidisciplinary
Martin Kunth, Leif Schroeder
Summary: The study simplifies the behavior of spin-spin relaxation rates in different chemical environments using hyperpolarized Xe-129 as a reporter ligand. It was found that even in a diamagnetic system, detection of analyte concentrations can be achieved through large Larmor frequency jumps. This approach provides a way to measure exchange rates even in systems where direct measurements are challenging.
