Article
Multidisciplinary Sciences
Caroline Chylinski, Kristin Flogstad Degnes, Inga Marie Aasen, Sokratis Ptochos, Berit Marie Blomstrand, Karl-Christian Mahnert, Heidi Larsen Enemark, Stig Milan Thamsborg, Havard Steinshamn, Spiridoula Athanasiadou
Summary: This study assessed the impact of various factors on the antiparasitic activity of Norwegian conifers and found that tree species, extraction solvent, and seasonality significantly affect the efficacy of bark extracts. Furthermore, gastrointestinal nematodes showed species and stage-specific susceptibility to the extracts, and the presence of condensed tannins was associated with anthelmintic activity.
SCIENTIFIC REPORTS
(2023)
Article
Parasitology
S. Jouffroy, L. Bordes, C. Grisez, J. F. Sutra, T. Cazajous, J. Lafon, N. Dumont, M. Chastel, C. Vial-Novella, D. Achard, H. Karembe, M. Devaux, M. Abbadie, C. Delmas, A. Lespine, P. Jacquiet
Summary: In the pastoral systems of South Western France, the infection of sheep by gastrointestinal nematodes is a major cause of economic loss and degradation of welfare. This study monitored the efficacy of eprinomectin on farms in this area where a lack of anthelmintic efficacy was suspected. Resistance to eprinomectin was observed in Haemonchus contortus in dairy sheep farms. The study highlights the need for urgent changes in grazing and production systems in this important dairy region.
Article
Agriculture, Dairy & Animal Science
Waresi Tuersong, Xin Liu, Yifan Wang, Simin Wu, Peixi Qin, Shengnang Zhu, Feng Liu, Chunqun Wang, Min Hu
Summary: This study explored the metabolome of an IVM-resistant H. contortus strain and analyzed the role of metabolism in IVM resistance. The results showed that amino acid metabolism may be mediated by the uptake of IVM and related to IVM resistance in H. contortus. This study contributes to our understanding of the mechanisms of IVM resistance and may provide effective approaches to manage infection by resistant strains of H. contortus.
Article
Biotechnology & Applied Microbiology
Ricardo Jose Comans-Perez, Jose E. Sanchez, Laith Khalil Tawfeeq Al-Ani, Manases Gonzalez-Cortazar, Gloria Sarahi Castaneda-Ramirez, Pedro Mendoza-de Gives, Alma Delia Sanchez-Garcia, Jair Millan-Orozco, Liliana Aguilar-Marcelino
Summary: This study evaluated the morphology of ten strains of edible mushrooms and their anthelmintic activity against Haemonchus contortus larvae in vitro. The results showed that some fungi exhibited high toxicity against nematodes, making them potential candidates for future in vivo tests.
BIOLOGICAL CONTROL
(2021)
Review
Agriculture, Dairy & Animal Science
Isabella Adduci, Floriana Sajovitz, Barbara Hinney, Katharina Lichtmannsperger, Anja Joachim, Thomas Wittek, Shi Yan
Summary: This comprehensive review article summarizes the current control strategies, antigen engineering, and recent advances in anti-Haemonchus vaccine development for Haemonchus contortus, the most pathogenic blood-feeding parasitic nematode in sheep and goats. The review highlights the challenges and achievements in developing protective, efficient, and long-lasting vaccines to control H. contortus infection and discusses the potential of vaccines as an alternative control strategy. Novel developments addressing the challenge of glycosylation of putative vaccine candidates in recombinant form are also discussed.
Article
Agriculture, Dairy & Animal Science
Sophie Aguerre, Jean-Michel Astruc, Andres Legarra, Lea Bordes, Francoise Prevot, Christelle Grisez, Corinne Vial Novella, Francis Fidelle, Philippe Jacquiet, Carole Moreno-Romieux
Summary: This study investigated the genetic relationship between resistance to parasitic infections and milk production traits in the blond-faced Manech breed. The results showed that resistance to gastrointestinal parasites had a moderate heritability and a slightly unfavorable but low genetic correlation with milk production traits. These findings have important implications for breeding associations in incorporating resistance to parasites in the selection objective.
GENETICS SELECTION EVOLUTION
(2022)
Article
Multidisciplinary Sciences
T. Mafuna, P. Soma, A. M. Tsotetsi-Khambule, C. A. Hefer, F. C. Muchadeyi, O. M. M. Thekisoe, R. E. Pierneef
Summary: This study used metagenomic approach to investigate the gut microbiome of Haemonchus contortus field strains and its predilection site in Dohne Merino sheep. The research identified differences and similarities in bacterial composition between male and female H. contortus gut microbiomes, as well as the predominant genera in the abomasum of Dohne Merino sheep. The study provides insight into the complex interactions of different gastrointestinal nematode microbiomes with the host.
SCIENTIFIC REPORTS
(2021)
Article
Veterinary Sciences
Eva Varga-Visi, Gabor Nagy, Agnes Csivincsik, Tamas Toth
Summary: The study aimed to observe the impact of a feed supplement containing carvacrol and limonene on the performance and parasitological status of sheep. The results showed that the supplement had beneficial effects on the metabolic processes of lactating ewes and improved the weight gain of their twin suckling lambs. Additionally, it reduced the fecal egg count of gastrointestinal nematodes in fattening lambs. Further research is needed to investigate the effects of carvacrol and limonene against gastrointestinal parasites.
VETERINARY SCIENCES
(2023)
Article
Microbiology
Amanda C. Shaver, Janneke Wit, Clayton Dilks, Timothy Crombie, Hanchen Li, Raffi Aroian, Erik Andersen
Summary: Treatment of parasitic nematode infections in humans and livestock is becoming a challenge due to the increasing anthelmintic resistance. However, the use of Caenorhabditis elegans as a model organism has provided insights into the molecular targets of anthelmintic drugs. By studying genetically diverse strains of C. elegans, researchers were able to identify variations in anthelmintic responses and quantify the contribution of genetics to resistance. This study highlights the importance of using genetically diverse models to understand anthelmintic resistance.
Article
Agriculture, Dairy & Animal Science
Francelino Neiva Rodrigues, Jose Lindenberg Rocha Sarmento, Tania Maria Leal, Adriana Mello de Araujo, Luiz Antonio Silva Figueiredo Filho
Summary: The study revealed high heritability of worm resistance traits in sheep, along with significant correlations with egg count, hematocrit, body condition score, and Famacha score. Therefore, Famacha score is recommended as a criterion for genetic selection in sheep, particularly in terms of endoparasite resistance.
Article
Multidisciplinary Sciences
Christina D. Moon, Luis Carvalho, Michelle R. Kirk, Alan F. McCulloch, Sandra Kittelmann, Wayne Young, Peter H. Janssen, Dave M. Leathwick
Summary: Anthelmintic treatments, including a controlled release capsule (CRC) and a long-acting moxidectin injection (LAI), were found to significantly impact the rumen microbiota composition in adult ewes. The CRC treatment increased the relative abundances of specific archaeal species, while the LAI treatment led to minor changes in the bacterial and fungal communities. Overall, the anthelmintic treatments resulted in few but highly significant changes to the rumen microbiota composition.
SCIENTIFIC REPORTS
(2021)
Article
Parasitology
M. M. Kebeta, B. C. Hine, S. W. Walkden-Brown, L. P. Kahn, D. P. Piedrafita, S. Bailey, E. K. Doyle
Summary: This study investigated the effect of co-administration of Barbervax (R) (Bvax) with Haemonchus contortus surface larval antigen (HcsL3) on the protective efficacy and duration of protection against H. contortus infection in weaner Merino sheep. The results showed that Bvax and combined vaccination induced an antibody response against HcsL3, but only the booster vaccination with Bvax reduced worm egg count. The HcsL3 vaccine did not reduce worm egg count in this experiment and co-administration with Bvax did not improve the efficacy and duration of protection against H. contortus infection.
VETERINARY PARASITOLOGY
(2022)
Article
Parasitology
Waresi Tuersong, Caixian Zhou, Simin Wu, Peixi Qin, Chunqun Wang, Wenda Di, Lu Liu, Hui Liu, Min Hu
Summary: This study identified differentially expressed genes (DEGs) in Ivermectin (IVM)-resistant Haemonchus contortus compared to susceptible strains, providing insights into the molecular mechanisms of IVM resistance. The study revealed potential new target genes related to lipid metabolism, cuticle structure, and important pathways such as antigen processing, lysosome, autophagy, apoptosis, and NOD1-like receptor signaling pathways. These findings contribute to a better understanding of IVM resistance in H. contortus.
PARASITES & VECTORS
(2022)
Article
Parasitology
Zaira M. Estrada-Reyes, D. Owen Rae, Raluca G. Mateescu
Summary: Florida Native sheep is an ancient breed well-adapted to humid and hot climates, with superior ability to regulate nematode burdens. Both additive and non-additive genetic effects play important roles in resistance to natural Haemonchus contortus infections in Florida Native sheep, with potential genetic markers identified.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2021)
Article
Microbiology
Barbara Hinney, Sandra Wiedermann, Waltraud Kaiser, Juergen Kruecken, Anja Joachim
Summary: The study provides updated information about the spread of anthelmintic resistance in caprine parasites in Austria. It identifies the presence of resistance to eprinomectin and moxidectin in trichostrongyloids, posing a serious threat to dairy goat farming. The findings also highlight the need for immediate action to prevent further spread of resistance.