Article
Parasitology
Daniel E. Snyder, Scott Wiseman, Elizabeth Crawley, Kim Wallace, Dwight D. Bowman, Craig R. Reinemeyer
Summary: The study demonstrated that orally administered Credelio Plus combination tablet was highly effective in treating immature stages of A. caninum in experimentally infected dogs, with efficacy exceeding 97.3% against L4 larval stage and over 98.7% against immature adult (L5) stage.
PARASITES & VECTORS
(2021)
Article
Parasitology
Lisa M. Young, Scott Wiseman, Elizabeth Crawley, Dwight D. Bowman, Craig R. Reinemeyer, Daniel E. Snyder
Summary: The study showed that the Credelio Plus combination tablet was highly effective against experimental infections of immature stages of T. canis, with worm counts exceeding 98.6% and 96.8% in the two dose confirmation studies.
PARASITES & VECTORS
(2021)
Article
Parasitology
Angela Di Cesare, Simone Morelli, Giulia Morganti, Giulia Simonato, Fabrizia Veronesi, Mariasole Colombo, Michele Berlanda, Wilfried Lebon, Matilde Gallo, Frederic Beugnet, Donato Traversa
Summary: The study demonstrated that NEXGARD SPECTRA(R) was safe and highly effective in reducing Capillaria aerophila and Capillaria boehmi eggs in dogs after one treatment, with complete reduction of egg output and recovery from respiratory signs after the second administration.
PARASITES & VECTORS
(2021)
Article
Parasitology
Kari L. Riggs, Scott Wiseman
Summary: The combination of milbemycin oxime (MO) and lotilaner (Credelio® Plus) demonstrated wide safety margin when administered monthly to puppies and dogs at the high end of the commercial dose band, as shown in three target animal safety studies.
PARASITES & VECTORS
(2021)
Article
Pharmacology & Pharmacy
Marlene Drag, Eric Tielemans, Elizabeth Mitchell
Summary: The safety of oral Afoxolaner, alone or in combination with milbemycin oxime, was investigated in homozygous MDR1-deficient collie dogs, and no significant adverse reactions were observed.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2022)
Article
Chemistry, Analytical
Sarju Adhikari, Abu M. Rustum
Summary: In this study, a comprehensive forced degradation study was conducted on Milbemycin oxime (MO) drug substance to identify and characterize its major degradation products. The study provides a basis for further understanding the stability and quality control of the drug.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Parasitology
Brad Hayes, Scott Wiseman, Daniel E. Snyder
Summary: This study demonstrated the efficacy (>= 97.2% reduction), safety and tablet acceptance of a combination of milbemycin oxime and lotilaner (Credelio Plus) administered orally to dogs with natural intestinal infections of T. canis, A. caninum and T. vulpis.
PARASITES & VECTORS
(2021)
Article
Veterinary Sciences
Shiting Xie, Yixing Lu, Jun Wang, Changcheng Lin, Peiyu Ye, Xiaolin Liu, Wenguang Xiong, Zhenling Zeng, Dongping Zeng
Summary: A selective and sensitive LC-MS/MS method was developed and validated for the simultaneous quantification of MBO, PZQ, C-4-OH-PZQ, and T-4-OH-PZQ in cat plasma. The method showed good precision, accuracy, recovery, and linearity.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Microbiology
Lucie A. Zanen, Johannes G. Kusters, Paul A. M. Overgaauw
Summary: This study confirms the potential risk of zoonotic pathogen transmission from pets that sleep with their owners, especially during direct contact. Pet owners should be informed about these risks and educated on how to interact with their pets in a more responsible way.
Article
Veterinary Sciences
Deborah Cruciani, Manuela Papini, Sayra Broccatelli, Francesco Agnetti, Sara Spina, Ylenia Natalini, Silvia Crotti
Summary: This case report described a kerion caused by N. gypsea in a 2-year-old boy, where the contagion was likely secondary to domestic healthy carrier dogs. A One-Health approach involving human dermatologists and veterinarians, combined with conventional and molecular-based techniques, allowed tracing the epidemiological chain and effectively managing treatment and prevention to avoid recurrence.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Parasitology
Lisa M. Young, Scott Wiseman, Elizabeth Crawley, Kim Wallace, Daniel E. Snyder
Summary: The study demonstrated the effectiveness of the combination product in preventing heartworm disease and its good tolerability in dogs; all treated dogs remained heartworm negative, showing 100% prevention efficacy.
PARASITES & VECTORS
(2021)
Article
Parasitology
Sophie Forster, Scott Wiseman, Daniel E. Snyder
Summary: A pivotal European field study demonstrated the excellent effectiveness and safety of a combination of lotilaner and milbemycin oxime (Credelio Plus®) administered orally to dogs naturally infested with fleas and/or ticks.
PARASITES & VECTORS
(2021)
Article
Public, Environmental & Occupational Health
Senait Belay, Mirutse Giday, Tsegahun Manyazewal
Summary: Conducting clinical trials on zoonotic diseases in Ethiopia faces challenges such as unclear ethics and regulatory frameworks, limited trial experts, and inadequate financial resources. Strengthening institutional and human resources capacity is crucial for enhancing the efficiency of clinical trials.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Parasitology
Katharine Costa dos Santos, Eric Tielemans, Andre Antonio Cutolo, Paula Elisa Brandao Guedes, Tatiani Vitor Harvey, Jamille Bispo de Carvalho Teixeira, Rebeca Costa Vitor, Anaia da Paixao Seva, Adan William de Melo Navarro, Ana Carolina Ribeiro Lima, Karin Denise Botteon, Thammy Vieira Bittar, George Rego Albuquerque, Fernando de Almeida Borges, Frederic Beugnet, Renata Santiago Alberto Carlos
Summary: This study assessed the efficacy of NexGard Spectra (R) against canine tungiasis and proved its high effectiveness. In addition to benefiting the health and welfare of treated dogs, the use of this product may have a one-health benefit on human cases by controlling the main reservoir of sand fleas.
PARASITES & VECTORS
(2023)
Article
Microbiology
Leszek Rolbiecki, Joanna N. Izdebska, Marta Franke, Lech Iliszko, Slawomira Fryderyk
Summary: Thelazia callipaeda is a zoonotic nematode transmitted by drosophilid flies, causing ocular disease. This study reports the first occurrence of this parasite in a dog in south-east Poland.