Article
Multidisciplinary Sciences
Xi Liu, Zhi Qiao, Yuming Chai, Zhi Zhu, Kaijie Wu, Wenliang Ji, Daguang Li, Yujie Xiao, Lanqun Mao, Chao Chang, Quan Wen, Bo Song, Yousheng Shu
Summary: Midinfrared stimulation (MIRS) is a potential neuromodulation approach that exerts nonthermal, long-distance, and reversible modulatory effects on ion channel activity, neuronal signaling, and sensorimotor behavior. This method provides gain control over spiking activities and modulates startle responses, making it suitable for clinical application.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Martin Kruse, Rayne J. Whitten
Summary: Phosphoinositides, despite being a minor component of cell lipids, play essential roles in regulating neuronal activities. Activation of neurotransmitter receptors can rapidly deplete phosphoinositide levels, significantly impacting neuronal behavior. A comprehensive model has been developed to study the connection between muscarinic acetylcholine signaling, phosphoinositide metabolism, and action potential firing in sympathetic neurons.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Hannah Scheiblich, Joern R. Steinert
Summary: Regulation of neuronal activity through nitric oxide (NO) involves suppression of potassium and sodium channel activities, leading to decreased excitability. NO mediates these effects via redox signaling on ion channels, with an additional cGMP-mediated component specifically for sodium currents. The study provides new insights into nitrergic activities in modulating neuronal function following nNOS activation.
Review
Neurosciences
Pablo Gimenez-Gomez, Timmy Le, Gilles E. Martin
Summary: Drug use is a serious threat to global health systems, with alcohol being the most consumed substance leading to 3 million deaths (5.3% of all deaths) and 132.6 million disability-adjusted life years. This review provides an updated summary of the global impact of binge alcohol drinking on brain health and cognitive function development, as well as the preclinical models used to study its effects on brain neurobiology. It also discusses the current understanding of the molecular and cellular mechanisms underlying the effects of binge drinking on neuronal excitability and synaptic plasticity, with a focus on the meso-cortico limbic neurocircuitry.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Rohit Pal, Bhupinder Kumar, Md. Jawaid Akhtar, Pooja A. Chawla
Summary: Voltage-gated sodium channel blockers are important targets for managing central nervous system diseases such as epilepsy, chronic pain, psychiatric disorders, and spasticity. These drugs work by reducing excitotoxicity and improving symptoms, with several new drugs in development to target abnormal neuronal excitability. Despite extensive research, there has been no groundbreaking discovery yet in controlling seizures through sodium channel blockers, and ongoing efforts are focused on developing more potent anticonvulsant drugs with minimized toxicity.
BIOORGANIC CHEMISTRY
(2021)
Article
Biology
Andres De la Rossa, Marine H. Laporte, Simone Astori, Thomas Marissal, Sylvie Montessuit, Preethi Sheshadri, Eva Ramos-Fernandez, Pablo Mendez, Abbas Khani, Charles Quairiaux, Eric B. Taylor, Jared Rutter, Jose Manuel Nunes, Alan Carleton, Michael R. Duchen, Carmen Sandi, Jean-Claude Martinou
Summary: Neuronal excitation relies on ATP from oxidative phosphorylation, and deficient oxidative phosphorylation can lead to hyperexcitability in neurons. Inhibiting GABA activity in mice with deficient mitochondrial pyruvate carrier (MPC) led to seizures and death, but providing ketone bodies restored energy and attenuated seizures. These findings provide insights into epilepsy and other neuropathologies associated with energy deficits.
Review
Biochemistry & Molecular Biology
Cole Malloy, Maisie Ahern, Lin Lin, Dax A. Hoffman
Summary: The coordinated action of voltage-gated ion channels, often associated with auxiliary subunits, is crucial for controlling neuronal physiology and circuit function in the brain. Dipeptidyl aminopeptidase-like protein 6 (DPP6), an auxiliary subunit expressed in multiple brain regions, interacts with A-type K+ channels to regulate their distribution and gating properties, as well as plays an independent role in synaptic formation and maintenance. Dysfunction of DPP6 is associated with various neurological disorders. Understanding the contribution of DPP6 to these disorders is an active area of research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Alexandra A. Adams, Ying Li, Haesun A. Kim, Bryan J. Pfister
Summary: In vitro models of traumatic brain injury commonly use neurons from the central nervous system, but there are limitations with primary cortical cultures. This study aimed to compare the response of cortical and DRGN axons to mechanical stretch injury associated with TBI. The results showed that both types of axons exhibited similar morphological changes, elongation, recovery, and degeneration after injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Bokyung Song, Sung-Joong Lee, Chong-Hyun Kim
Summary: In a ATP-induced cortical injury model, ATP and cytokine TNF-alpha significantly affect the physiological activities of neurons and microglia at day 3 post-injection, while IL-10 and IL-4 effectively suppress these changes in both cell types.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Shashank Pant, Jiaren Zhang, Eung Chang Kim, Kin Lam, Hee Jung Chung, Emad Tajkhorshid
Summary: Research using molecular dynamics simulations and electrophysiology has revealed the allosteric role of phosphatidylinositol-4,5-bisphosphate (PIP2) in the activation of K(v)7.2 channels, influencing protein conformation and correlated motions.
COMMUNICATIONS BIOLOGY
(2021)
Article
Physiology
Jamie S. S. Lindner, Salil R. R. Rajayer, Briana J. J. Martiszus, Stephen M. M. Smith
Summary: The calcium-sensing receptor agonist, cinacalcet, regulates neuronal excitability by modulating the voltage-dependence of voltage-gated sodium channel (VGSC) currents. This regulation is achieved by shifting the voltage-dependence of VGSC currents and involves an unidentified inhibitory molecule that is G-protein dependent.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Clinical Neurology
Benjamin Clennell, Tom G. J. Steward, Kaliya Hanman, Tom Needham, Janette Benachour, Mark Jepson, Meg Elley, Nathan Halford, Kate Heesom, Eunju Shin, Elek Molnar, Bruce W. Drinkwater, Daniel J. Whitcomb
Summary: This study reveals the regulation of neuronal excitability and synaptic function by ultrasound stimulation. Ultrasound stimulation can increase whole-cell potassium currents and excitatory synaptic transmission. Activation of ionotropic glutamate receptors is required for ultrasound-induced modulation of neuronal potassium currents. These findings have important implications for the application of ultrasound stimulation in experimental and therapeutic settings, but further research is needed to understand the underlying molecular mechanisms.
Article
Chemistry, Multidisciplinary
Laura Matino, Anna Mariano, Chiara Ausilio, Raghav Garg, Tzahi Cohen-Karni, Francesca Santoro
Summary: The correct wiring of a neural network requires neurons to integrate cues from their extracellular environment, and biologically inspired micro- and nanostructured substrates can regulate axonal outgrowth. Graphene, as a conductive neural interface, has the potential to enhance cell adhesion and neural sprouting. This study found that nanoscale protruding features influenced neuronal growth and branching, and the integrin-mediated contact adhesion points and plasma membrane curvature processes played a crucial role in neurons-to-graphene coupling.
Article
Clinical Neurology
Antonia S. Carroll, James Howells, Cindy S. Y. Lin, Susanna B. Park, Neil Simon, Mary M. Reilly, Steve Vucic, Matthew C. Kiernan
Summary: This study compares the excitability differences of motor and sensory axons in the main upper limb nerves and provides guidance for future research on human diseases. The results demonstrate that the excitability parameters are most comparable between the median and ulnar nerves.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Neurosciences
Sandesh Mohan, Manindra Nath Tiwari, Marija Stanojevic, Yoav Biala, Yoel Yaari
Summary: Stimulation of muscarinic receptors on hippocampal neurons activates multiple signaling pathways that inhibit Na+/K+-ATPase activity, leading to increased intrinsic neuronal excitability through enhanced enzyme phosphorylation. This novel mechanism contributes to cholinergic modulation of hippocampal activity in spatial navigation, learning and memory.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Engineering, Mechanical
Xinlin Song, Hengtong Wang, Yong Chen
NONLINEAR DYNAMICS
(2018)
Article
Physics, Multidisciplinary
Zhao-Xia Niu, Tao Huang, Yong Chen
FRONTIERS OF PHYSICS
(2018)
Article
Multidisciplinary Sciences
Huawei Fan, Yafeng Wang, Hengtong Wang, Ying-Cheng Lai, Xingang Wang
SCIENTIFIC REPORTS
(2018)
Article
Engineering, Mechanical
Xinlin Song, Hengtong Wang, Yong Chen
NONLINEAR DYNAMICS
(2019)
Article
Engineering, Mechanical
Miaomiao Xing, Xinlin Song, Zhuoqin Yang, Yong Chen
NONLINEAR DYNAMICS
(2020)
Article
Mathematics, Interdisciplinary Applications
Miaomiao Xing, Xinlin Song, Hengtong Wang, Zhuoqin Yang, Yong Chen
Summary: This work studies the response dynamics of a two-neuron network motif composed of class-1 and class-3 Morris-Lecar neurons under an external directional current. The study finds that the two neurons exhibit frequency locking and complete frequency synchronization with increases in coupling strength and input current. The class-3 neuron in the motif can produce various excitabilities with appropriate coupling strength and input current, including tonic and phasic spiking.
CHAOS SOLITONS & FRACTALS
(2022)
Article
Physics, Multidisciplinary
Jian Zhang, Tao Huang, Guoqing Xu, Yong Chen
Summary: In this study, the density fluctuation in two-dimensional mixtures of active and passive particles was investigated using Brownian dynamics simulations. The boundary of motility-induced phase separation was determined by the transition from unimodal to bimodal density distribution. It was observed that the fluctuation exponent rapidly increases near the boundary of phase separation in the plane of density and Peclet number. When phase separation occurs, the fluctuation exponent remains approximately constant at 0.85.
COMMUNICATIONS IN THEORETICAL PHYSICS
(2022)
Article
Engineering, Mechanical
Miaomiao Xing, Zhuoqin Yang, Yong Chen
Summary: This study investigates the effect of temperature on the bursting discharge behavior of temperature-sensitive ion channels in neurons. The results show that an increase in temperature can promote the generation of bursting discharge, but eventually the bursting discharge phenomenon disappears. It is also found that even if the dynamic paths are consistent, the bursting discharge types and waveforms may be different, and vice versa.
NONLINEAR DYNAMICS
(2023)
Article
Physics, Multidisciplinary
Tao Huang, Chunhua Zeng, Yong Chen
Summary: This study investigates the collective diffusion behavior of a two-dimensional anisotropic liquid system through molecular dynamics simulations. The results show that the long-time diffusion behavior of nearly spherical anisotropic particles is similar to that of isotropic liquids, while their anisotropic properties are mainly reflected in the spatial correlation of particle orientations and mid-range diffusion behavior.
COMMUNICATIONS IN THEORETICAL PHYSICS
(2022)
Article
Physics, Fluids & Plasmas
Tao Huang, Chunhua Zeng, Hua Wang, Yong Chen, Yilong Han
Summary: This study reveals that Janus particles can rotate collectively and form polycrystalline orientational domains as the temperature increases, while the lattice structure remains unchanged. The transition is induced by internal strains, and the orientation-position coupling plays a crucial role in it. The research findings are important for understanding solid-solid transitions.
Article
Chemistry, Physical
Guoqing Xu, Tao Huang, Yilong Han, Yong Chen
Summary: The study investigates the interface morphology in mixtures of active and passive particles, revealing different types of interfaces and anomalous scaling behavior in the propagation stage. Additionally, similarities and differences between active-inactive interfaces and passive interfaces provide insights into the interfacial growth of active matter.
Article
Physics, Fluids & Plasmas
Xinlin Song, Hengtong Wang, Yong Chen, Ying-Cheng Lai
Article
Chemistry, Physical
Tao Huang, Yilong Han, Yong Chen
