期刊
VETERINARY JOURNAL
卷 206, 期 1, 页码 105-107出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tvjl.2015.04.012
关键词
Coagulation; Inflammation; Recurrent airway obstruction
资金
- Pfizer Clinical Research Fund
- Canadian Institutes of Health Research [MIF79636]
- AllerGen National Center of Excellence, a member of the Networks of Centers of Excellence of Canada
As inflammation and coagulation are intertwined processes, the efficiency of blood coagulation of heaves-affected horses and controls were compared in an observational case-control study, using thrombelastography. In experiment I (Exacerbation, six heaves, five controls), horses were housed indoors and fed hay. Thrombelastography, functional fibrinogen, platelet count, hematology, and antithrombin were measured. In experiment 2 (Remission, eight heaves, 11 controls), horses were housed in a low-dust environment for at least a month when thrombelastography was performed. Heaves-affected horses in exacerbation had greater maximum amplitude and higher functional fibrinogen than controls. Heaves-affected horses in clinical remission had greater maximum amplitude than controls. The hypercoagulable state and systemic inflammation of horses with heaves may be a consequence of pulmonary inflammation and may contribute to the perpetuation of airway dysfunction. (C) 2015 Elsevier Ltd. All rights reserved.
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