期刊
PHYSICAL REVIEW E
卷 79, 期 4, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevE.79.041928
关键词
biorheology; elasticity; molecular biophysics; proteins; shear deformation
资金
- NSF [DMR-0602684, CTS-0505929]
- Harvard MRSEC [DMR-0820484]
- NSF
- European Marie Curie [FP62002-Mobility-6B, 8526]
- National Heart, Lung, and Blood Institute [1 F33 HL083684-01]
- Harvard Center for Nanoscale Systems
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [820484] Funding Source: National Science Foundation
Networks of the biopolymer actin, cross-linked by the compliant protein filamin, form soft gels. They can, however, withstand large shear stresses due to their pronounced nonlinear elastic behavior. The nonlinear elasticity can be controlled by varying the number of cross-links per actin filament. We propose and test a model of rigid filaments decorated by multiple flexible linkers that is in quantitative agreement with experiment. This allows us to estimate loads on individual cross-links, which we find to be less than 10 pN.
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