期刊
PHYSICAL REVIEW E
卷 80, 期 4, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevE.80.041917
关键词
DNA; genetics; molecular biophysics; molecular configurations
资金
- Hong Kong Research Grant Council [123408]
- City University of Hong Kong [9610034]
DNA rigidity is an important physical property originating from the DNA three-dimensional structure. Although the general DNA rigidity patterns in human promoters have been investigated, their distinct roles in transcription are largely unknown. In this paper, we discover four highly distinct human promoter groups based on similarity of their rigidity profiles. First, we find that all promoter groups conserve relatively rigid DNAs at the canonical TATA box [a consensus TATA(A/T)A(A/T) sequence] position, which are important physical signals in binding transcription factors. Second, we find that the genes activated by each group of promoters share significant biological functions based on their gene ontology annotations. Finally, we find that these human promoter groups correlate with the tissue-specific gene expression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据