期刊
PHYSICAL REVIEW E
卷 78, 期 2, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevE.78.021907
关键词
-
资金
- AFRL
- AFOSR
- NSF
Viruses have traditionally been studied as pathogens, but in recent years they have been adapted for applications ranging from drug delivery and gene therapy to nanotechnology, photonics, and electronics. Although the structures of many viruses are known, most of their biophysical properties remain largely unexplored. Using Brillouin light scattering, we analyzed the mechanical rigidity, intervirion coupling, and vibrational eigenmodes of Wiseana iridovirus (WIV). We identified phonon modes propagating through the viral assemblies as well as the localized vibrational eigenmode of individual viruses. The measurements indicate a Young's modulus of similar to 7 GPa for single virus particles and their assemblies, surprisingly high for soft materials. Mechanical modeling confirms that the DNA core dominates the WIV rigidity. The results also indicate a peculiar mechanical coupling during self-assembly of WIV particles.
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