Article
Medicine, Research & Experimental
Mohammad Afsar Khan, Deepti Singh, Amin Arif, Kushneet Kaur Sodhi, Dileep Kumar Singh, Sk Najrul Islam, Absar Ahmad, Kafil Akhtar, Hifzur R. Siddique
Summary: The biosynthesized SeNP conjugated with DOX showed a protective effect against DOX-induced toxicities by reducing reactive oxygen and nitrogen species, DNA damage, and lipid peroxidation, and restoring antioxidant defense systems and cytoarchitectures.
Article
Virology
Francisco Noe Fonseca, Vanessa Haach, Franciana Volpato Bellaver, Gabrielly Bombassaro, Danielle Gava, Luciano Paulino da Silva, Lana Flavia Baron, Mayara Simonelly, Wanessa Araujo Carvalho, Rejane Schaefer, Ana Paula Bastos
Summary: A polyvalent virosome influenza vaccine containing hemagglutinin and neuraminidase proteins derived from swine influenza A viruses (swIAVs) was developed and shown to induce efficient immune response and provide long-lasting immunity in mice.
Article
Chemistry, Multidisciplinary
Maya Holay, Nishta Krishnan, Jiarong Zhou, Yaou Duan, Zhongyuan Guo, Weiwei Gao, Ronnie H. Fang, Liangfang Zhang
Summary: This study presents the development of an adjuvanted nanotoxoid vaccine based on macrophage membrane-coated nanoparticles, which generates long-lasting immunity in a murine model to protect against anthrax toxins.
Article
Immunology
Gregory P. Howard, Nicole G. Bender, Prachi Khare, Borja Lopez-Gutierrez, Vincent Nyasembe, William J. Weiss, Jerry W. Simecka, Timothy Hamerly, Hai-Quan Mao, Rhoel R. Dinglasan
Summary: This study developed a nanoparticle-based malaria transmission blocking vaccine that successfully induced an immune response blocking parasite transmission by co-delivering UF6b and CpG oligodeoxynucleotide immunostimulatory sequence 1018. This nanovaccine platform allows for antigen dose-sparing and achieves immunopotentiation of AnAPN1 through direct lymph node targeting.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Wen-Hung Wang, Aspiro Nayim Urbina, Chih-Yen Lin, Zih-Syuan Yang, Wanchai Assavalapsakul, Arunee Thitithanyanont, Po-Liang Lu, Yen-Hsu Chen, Sheng-Fan Wang
Summary: The development of dengue vaccines is crucial in preventing and controlling the global health threat caused by Dengue virus. Current approved vaccines have demonstrated low efficacy in certain populations, leading to ongoing investigation and development of novel strategies for dengue vaccines.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Tuksin Jearanaiwitayakul, Panya Sunintaboon, Runglawan Chawengkittikul, Jitra Limthongkul, Panuwat Midoeng, Preamrudee Chaisuwirat, Saradee Warit, Sukathida Ubol
Summary: The study demonstrates that the use of TMC nanoparticles as both a vaccine carrier and adjuvant can enhance the internalization of UV-inactivated DENV2 into MoDCs, drive the maturation of MoDCs, and induce higher levels of antibodies and T cells with stronger neutralizing activity against DENV-2 in mice.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Bilal Onur, Kultrgin Cavusoglu, Emine Yalcin, Ali Acar
Summary: This study investigated the toxicity of Paraquat herbicide in Swiss albino mice. The results showed that the dose of Paraquat was closely associated with changes in physiological, biochemical, oxidative stress and genetic parameters.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Swamita Arora, Sangeetha Gupta, Wasim Akram, Ahmed E. Altyar, Priti Tagde
Summary: This study aimed to investigate the effect of a TLR3/dsRNA complex inhibitor on Poly(I:C)-induced airway inflammation following TLR3 activation and to explore a potential pathway for the treatment of asthma through TLR3 inhibition.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Ana Sara Cordeiro, Yogita Patil-Sen, Maitreyi Shivkumar, Ronak Patel, Abdulwahhab Khedr, Mohamed A. Elsawy
Summary: This article discusses the main vaccine delivery systems and associated challenges, as well as the recent success in developing nanomaterials-based and advanced delivery systems. It emphasizes the importance of effective vaccine delivery for immunization effectiveness, stability, and mass immunization.
Article
Chemistry, Multidisciplinary
Jinrong Long, Changxiao Yu, Yiming Cao, Yiqi Miao, Huisheng Sun, Zhen Zhang, Jierui Mai, Xin Wang, Yingying Mao, Hongwei Li, Jing Yang, Shengqi Wang
Summary: Rabies is a deadly viral disease and vaccinations are the most effective way to prevent and control it. Researchers have developed an mRNA-based vaccine that can be produced quickly and in large quantities. This vaccine has shown robust immune responses and long-term protection in mice and dogs.
Article
Chemistry, Medicinal
Nada H. Aljarba, Huma Ali, Saad Alkahtani
Summary: This study evaluated the chemopreventive effect of a combined drug sample containing stigmasterol and palmatine, finding that it was more effective than individual drugs in reducing tumor size and number, and improving oxidative enzyme levels.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Hongxia Zhang, Xiaojun Xia
Summary: mRNA-based cancer vaccines are a popular approach for developing personalized and effective antitumor immunotherapy, delivering tumor antigen-encoding mRNA into dendritic cells for antigen presentation and stimulating innate immune response as an adjuvant effect. A minimalist nanovaccine formulation called C1 has shown significant antitumor efficacy on tumor mouse models, highlighting the potential of mRNA vaccines targeting the immunosuppressive tumor microenvironment.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Review
Infectious Diseases
Chung-Hao Huang, Yu-Te Tsai, Seng-Fan Wang, Wen-Hung Wang, Yen-Hsu Chen
Summary: Development of efficient dengue vaccines is still lacking despite the presence of licensed vaccines like CYD-TDV. Efforts are being made to improve vaccine efficacy and eliminate the risk of severe dengue through heterologous prime-boost regimens. Additionally, the absence of an ideal animal model remains a challenge in dengue vaccine development.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2021)
Review
Biotechnology & Applied Microbiology
Tanzeel Zohra, Faryal Saeed, Aamer Ikram, Tariq Khan, Siyab Alam, Muhammad Adil, Ayesha Gul, Saud Almawash, Muhammad Ayaz
Summary: This review explores the role of nanomedicine-based therapeutic agents against dengue virus and introduces a potential method for better treatment.
Article
Fisheries
Yu-Ming Gong, Xue-Feng Wei, Guo-Qing Zhou, Ming -Zhu Liu, Peng-Fei Li, Bin Zhu
Summary: In this study, a biomimetic nanodelivery system using modified erythrocyte membrane as a DNA vaccine carrier was constructed. The nanoparticles showed sustained and efficient expression of plasmid DNA in muscle and spleen tissue. Immunization of tilapia with the vaccine resulted in high levels of serum antibody production and immune-related gene expression. The vaccine also provided high protection against TiLV challenge.