Article
Immunology
Laure F. Pittet, Lianne Cox, Bridget Freyne, Susie Germano, Rhian Bonnici, Kaya Gardiner, Susan Donath, Clare L. Collins, Dan Casalaz, Roy Robins-Browne, Katie L. Flanagan, Nicole L. Messina, Nigel Curtis
Summary: The co-administration of BCG and HBV vaccines during neonatal vaccination has an impact on immune responses, with BCG vaccine reducing cytokine responses to unrelated pathogens. The co-administration of HBV vaccine with BCG vaccine influences immune responses to neonatal BCG vaccination in a sex-differential manner.
Review
Biochemistry & Molecular Biology
Anne-Cathrine S. Vogt, Tasneem Arsiwala, Mona Mohsen, Monique Vogel, Vania Manolova, Martin F. Bachmann
Summary: Iron is crucial for biological processes and is mainly bound to hemoglobin in red blood cells. It is recycled from senescent cells by macrophages and regulated by hormones like hepcidin. Key proteins like DMT1 and FPN play crucial roles in iron uptake and transport.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Long-Xia Li, Fang-Fang Guo, Hong Liu, Tao Zeng
Summary: Ethanol exposure can promote iron overload in the liver, exacerbating the damage in alcoholic liver disease (ALD).
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Pediatrics
Fredrik Baeckstroem, Anna Chmielewska, Magnus Domelloef, Staffan K. Berglund
Summary: This study aimed to assess the ERFE serum concentrations and its predictors in infants, and found that ERFE concentrations increase gradually during the first year of life in infants, but lack correlation to iron status and markers of erythropoiesis.
PEDIATRIC RESEARCH
(2023)
Article
Physiology
Yihang Li, Ian Miller, Princy Prasad, Nisha Ajit George, Nermi L. Parrow, Robert E. Fleming
Summary: This study investigates the role of transferrin in the erythropoietic response to iron deficiency and iron deficiency anemia. The results demonstrate that transferrin not only plays a role in iron delivery but also affects iron homeostasis and erythropoiesis. Administration of exogenous iron-loaded transferrin restores iron levels and influences the expression of regulatory proteins involved in erythropoiesis. In iron deficiency anemia, transferrin treatment increases erythropoietin sensitivity, highlighting its importance in the recovery from iron deficiency anemia.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Sung Yeon Ham, Ji Hae Jun, Hye-Bin Kim, Jae-Kwang Shim, Gisong Lee, Young-Lan Kwak
Summary: This study investigated the activities of key regulators affecting erythropoiesis in a rat model of iron deficiency anemia with inflammation. The results showed that IV iron therapy exacerbated inflammation and oxidative stress and did not resolve anemia.
Article
Biochemistry & Molecular Biology
Cansu Kahraman, Faruk Turgay, Oya Yigitturk, Aykut Eren Canuzmez, Burak Durmaz, Semih Asikovali
Summary: This study investigated the role of TMPRSS6 C > T polymorphism on the effects of chronic aerobic training on main hematological parameters in male soccer referees. The results suggest that TMPRP can modify the endurance training effects on iron and RBC count.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Poonam Sagar, Stanzin Angmo, Rajat Sandhir, Vikas Rishi, Hariom Yadav, Nitin Kumar Singhal
Summary: Iron is essential for mammals but its homeostasis must be accurately regulated for proper physiological functioning. Hepcidin plays a crucial role in maintaining iron balance in the body, while inflammatory disorders can disrupt this balance. Therapeutic approaches targeting the hepcidin-FPN axis have been developed to address iron-related disorders.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Biology
Edouard Charlebois, Carine Fillebeen, Angeliki Katsarou, Aleksandr Rabinovich, Kazimierz Wisniewski, Vivek Venkataramani, Bernhard Michalke, Anastasia Velentza, Kostas Pantopoulos
Summary: This study investigates how iron affects inflammatory hepcidin levels and the subsequent hypoferremic response, revealing the antagonistic effect of iron on hepcidin induction and the critical role of de novo ferroportin synthesis in serum iron levels.
Review
Oncology
Artur Slomka, Monika Lecka, Jan Styczynski
Summary: This systematic review provides an overview of observational studies on the association between hepcidin and acute leukemia (AL) or hematopoietic cell transplantation (HCT). The review highlights the need for more extensive research as iron metabolism disturbances are common in AL and HCT, and hepcidin seems to play a significant role in their modulation.
Review
Food Science & Technology
Mauricio Restrepo-Gallego, Luis E. Diaz, Patricia H. C. Rondo
Summary: Iron deficiency is the leading cause of anemia, and assessing iron nutritional status requires consideration of various laboratory tests and indicators. Using multiple indicators in combination may be the best practice due to the influence of different factors on these indicators. Constant validation, improvement of assessment methods, and identification of new indicators are key to refining the assessment of iron nutritional status and selecting appropriate treatment for improvement.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Daniela Marin-Hernandez, Douglas F. Nixon, Nathaniel Hupert
Summary: Traditional vaccines are designed to target specific pathogens, but there are known off-target effects that can impact unrelated pathogen infections. Heterologous vaccines, like BCG, can induce non-specific effects through trained immunity.
MOLECULAR MEDICINE
(2021)
Article
Food Science & Technology
Anatoly Skalny, Yordanka Gluhcheva, Olga P. Ajsuvakova, Ekaterina Pavlova, Emilia Petrova, Pavel Rashev, Ivelin Vladov, Roza A. Shakieva, Michael Aschner, Alexey A. Tinkov
Summary: The study found that cobalt exposure could lead to accumulation of copper, iron, manganese, and zinc in tissue of immature mice, and alter serum hepcidin levels. The effect was most pronounced in 25-day-old mice.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Veterinary Sciences
Z. Vizi, D. Hotchkiss, K. Lanyi, A. Sterczer
Summary: The aim of this research was to study whether more than one isoform of canine hepcidin-25 exists. The study demonstrated that two isoforms of canine hepcidin-25 exist, and both may be synthesized by dogs together. No statistically significant correlations were found between the measured concentrations of the two canine hepcidin-25 isoforms and the measured serum iron parameters in the sampled dogs, irrespective of the measurements were made in serum or urine.
RESEARCH IN VETERINARY SCIENCE
(2023)
Article
Endocrinology & Metabolism
Sandro Altamura, Katja Muedder, Andrea Schlotterer, Thomas Fleming, Elena Heidenreich, Ruiyue Qiu, Hans-Peter Hammes, Peter Nawroth, Martina U. Muckenthaler
Summary: The study reveals that hepatic iron accumulation may exacerbate symptoms related to metabolic syndrome and type 2 diabetes. It suggests that iron depletion strategies in combination with anti-diabetic drugs could potentially improve insulin resistance and diabetic late complications.
MOLECULAR METABOLISM
(2021)
Article
Medicine, Research & Experimental
Sarah Prentice, Emily L. Webb, Hazel M. Dockrell, Pontiano Kaleebu, Alison M. Elliott, Stephen Cose
Article
Immunology
Patrice Akusa Mawa, Emily L. Webb, Abdelali Filali-Mouhim, Gyaviira Nkurunungi, Rafick-Pierre Sekaly, Swaib Abubaker Lule, Sarah Prentice, Stephen Nash, Hazel M. Dockrell, Alison M. Elliott, Stephen Cose
Review
Immunology
Sarah Prentice
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Immunology
Sarah Prentice, Zephyrian Kamushaaga, Stephen B. Nash, Alison M. Elliott, Hazel M. Dockrell, Stephen Cose
Article
Anthropology
Sarah Prentice, Antony J. Fulford, Landing M. A. Jarjou, Gail R. Goldberg, Ann Prentice
ANNALS OF HUMAN BIOLOGY
(2010)
Article
Multidisciplinary Sciences
Sarah Prentice, Amadou T. Jallow, Edrissa Sinjanka, Momodou W. Jallow, Ebrima A. Sise, Noah J. Kessler, Rita Wegmuller, Carla Cerami, Andrew M. Prentice
SCIENTIFIC REPORTS
(2019)
Correction
Medicine, Research & Experimental
Sarah Prentice, Emily L. Webb, Hazel M. Dockrell, Pontiano Kaleebu, Alison M. Elliott, Stephen Cose
Editorial Material
Medicine, Research & Experimental
S. Prentice, H. M. Dockrell
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Infectious Diseases
Sarah Prentice, Beatrice Nassanga, Emily L. Webb, Florence Akello, Fred Kiwudhu, Hellen Akurut, Alison M. Elliott, Rob J. W. Arts, Mihai G. Netea, Hazel M. Dockrell, Stephen Cose
Summary: BCG vaccination in neonates reduces non-tuberculous infectious disease incidence, and prioritizing BCG on the first day of life in high-mortality settings may have significant public health benefits.
LANCET INFECTIOUS DISEASES
(2021)
Editorial Material
Immunology
Sarah Prentice, Hazel M. Dockrell
JOURNAL OF INFECTIOUS DISEASES
(2021)