Article
Immunology
Laura M. Canaday, Jessica D. Resnick, Hsuan Liu, Harrison Powell, Alyssa M. McCoy, Dat Nguyen, Andrew Pekosz
Summary: The replication differences between two isogenic LAIVs with different HA segments were evaluated using nasal epithelial cell cultures. The study found that the HA segment alone could impact LAIV replication and that physiologically relevant temperatures and primary cell cultures are necessary to demonstrate efficient replication, which is a crucial property for effective vaccines.
Article
Pediatrics
Andrew G. Sokolow, Amy P. Stallings, Carolyn Kercsmar, Theresa Harrington, Natalia Jimenez-Truque, Yuwei Zhu, Katherine Sokolow, M. Anthony Moody, Elizabeth P. Schlaudecker, Emmanuel B. Walter, Mary Allen Staat, Karen R. Broder, C. Buddy Creech
Summary: This study found that among children with asthma aged 5 to 17 years, LAIV4 was not associated with an increased frequency of asthma exacerbations or asthma-related symptoms compared to IIV4. There were no significant differences in asthma symptoms or lung function changes within 14 days post-vaccination between the two groups.
Review
Immunology
Yo Han Jang, Baik L. Seong
Summary: Influenza virus infection poses a major public health challenge, with current vaccines potentially compromised by viral antigenic changes. Efforts are underway to develop a universal influenza vaccine that provides long-lasting and broad protection. Immune responses induced by live attenuated influenza vaccines (LAIVs), including neutralizing antibodies, T cell responses, and mucosal immunity, show promising potential for serving as attractive platforms for a universal influenza vaccine.
Article
Immunology
Pia S. Pannaraj, Andre Guilherme da Costa-Martins, Chiara Cerini, Fan Li, Sook-San Wong, Youvika Singh, Alysson H. Urbanski, Patricia Gonzalez-Dias, Juliana Yang, Richard J. Webby, Helder Nakaya, Grace M. Aldrovandi
Summary: Breastfeeding provides protection against mucosal infections in infants. The study investigated the mechanisms of immune response in human milk following maternal infection with mucosal pathogens. It was found that both live attenuated influenza vaccination (LAIV) and inactivated influenza vaccination (IIV) induced the production of influenza-specific IgA in human milk. However, LAIV resulted in a higher upregulation of innate immunity pathways compared to IIV. This innate immunity in human milk may offer timely protection against mucosal infections in breastfed infants until antigen-specific immunity develops.
MUCOSAL IMMUNOLOGY
(2022)
Article
Health Care Sciences & Services
Jessica R. Cataldi, Laura P. Hurley, Megan C. Lindley, Sean T. O'Leary, Carol Gorman, Michaela Brtnikova, Brenda L. Beaty, Lori A. Crane, David K. Shay, Allison Kempe
Summary: The study examined family physicians' and general internal medicine physicians' perceptions, knowledge, and practices regarding high-dose inactivated influenza vaccine (HD-IIV) and live attenuated influenza vaccine (LAIV). Many physicians believed HD-IIV is more effective for patients >= 65 years, and there was a misconception that ACIP had preferential recommendations for HD-IIV.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Article
Virology
Joao P. P. L. Bonifacio, Nathalia Williams, Laure Garnier, Stephanie Hugues, Mirco Schmolke, Beryl Mazel-Sanchez
Summary: This study proposes a safer live attenuated influenza vaccine (optiLAIV) by modifying a nonstructural protein of the currently licensed LAIV. The results show that optiLAIV exhibits better efficacy in both mouse models and a human nasal mucosal model compared to the existing LAIV. This research is important for expanding the application of live attenuated vaccines and reducing the burden of influenza in high-risk populations.
JOURNAL OF VIROLOGY
(2022)
Article
Infectious Diseases
Lalit Dar, Anand Krishnan, Ramesh Kumar, Shivram Dhakad, Avinash Choudekar, Sumedha Bagga, Amrit Sharma, Amit Kumar, Jyoti Jethani, Siddhartha Saha, Ritvik Amarchand, Rakesh Kumar, Aashish Choudhary, Venkatesh Vinayak Narayan, Giridara Gopal, Kathryn E. E. Lafond, Stephen Lindstrom
Summary: This study investigated the efficacy of trivalent LAIV and inactivated influenza vaccines in rural north India. The results showed that on day 2 post-vaccination, approximately 71.2% of LAIV recipients shed vaccine virus strains, but this decreased to 42.3% on day 4. In the second year, the shedding rate of vaccine viruses was lower compared to the first year.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2023)
Review
Immunology
Subhan Ullah, Ted M. Ross
Summary: Influenza virus is a major cause of seasonal epidemics and intermittent pandemics. Despite the current molecular biology and vaccine development, influenza virus infection is a significant burden. Vaccines are considered an essential countermeasure for effective control and prevention of influenza virus infection.
EXPERT REVIEW OF VACCINES
(2022)
Article
Biochemical Research Methods
Ji Chen, Jinyu Wang, Hongyu Zhu, Yang Zhang, Jin Sun, Wei Wang, Congwen Wei, Hui Zhong, Mingxin Dong
Summary: Researchers report a novel method to construct recombinant influenza A virus regulated by small molecules. By inserting 4-hydroxytamoxifen (4-HT)-dependent intein into the polymerase acidic (PA) protein of IAV, a series of 4-HT-dependent recombinant viruses were generated and screened. The attenuated viruses showed excellent replication characteristics and elicited robust immunity against homologous viruses.
ACS SYNTHETIC BIOLOGY
(2023)
Review
Immunology
Kenneth Sik-Kwan Chan, Charlene Hoi-Lam Wong, Horace Cheuk-Wai Choi
Summary: This study assessed the cost-effectiveness of pediatric influenza vaccination with the intranasal live-attenuated influenza vaccine (LAIV). It found that the implementation of LAIV vaccination in the pediatric population is cost-effective when compared to other strategies. Factors such as the efficacy of LAIV for children, vaccination coverage, vaccine prices, and herd immunity were significant contributors to the cost-effectiveness.
Review
Immunology
Giulia Perego, Giacomo Pietro Vigezzi, Giulia Cocciolo, Federica Chiappa, Stefano Salvati, Federica Balzarini, Anna Odone, Carlo Signorelli, Vincenza Gianfredi
Summary: This study conducted a systematic review and meta-analysis on the efficacy and safety of spray live attenuated influenza vaccine (LAIV), finding that LAIV was associated with a higher probability of seroconversion for the A/H1N1 serotype, and had no significant association with systemic adverse events, with only rhinorrhea, nasal congestion, and sore throat being significantly associated with LAIV compared to the placebo.
Review
Immunology
Jue Hou, Weijian Ye, Jianzhu Chen
Summary: Dengue is a common mosquito-borne disease caused by four closely related viruses. Developing a vaccine that can protect against all four virus strains without adverse effects is a challenge. Several tetravalent live attenuated vaccine candidates have entered clinical trials.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Wei Ran, Jacob Schoen, Kevin Ciminski, Julian Kraft, Susanne Kessler, Sophie Euchner, Donata Hoffmann, Anne Pohlmann, Martin Beer, Martin Schwemmle, Sebastian Giese
Summary: This study demonstrates the potential of a chimeric bat H17N10 virus as a live influenza vaccine. The virus was passaged in eggs and chickens to improve its suitability for mammalian usage. The vaccine induced a strong antibody response and provided full protection against avian influenza virus in mice.
MICROBIOLOGY SPECTRUM
(2022)
Article
Veterinary Sciences
Lila M. Zarski, Wendy E. Vaala, D. Craig Barnett, Fairfield T. Bain, Gisela Soboll Hussey
Summary: The study showed that Flu Avert treatment modulated interferons, cytokines, and chemokines in equine respiratory epithelial cells, leading to a reduction in EHV-1 replication. The optimal antiviral response occurred at days 5-8 post-treatment.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Immunology
Sumedha Bagga, Anand Krishnan, Lalit Dar
Summary: Seasonal influenza epidemics cause significant pediatric mortality and morbidity worldwide. Live attenuated influenza vaccines (LAIVs) have the potential to be an attractive option for young children in developing countries due to their intranasal administration, broad immune response, and higher manufacturing yields compared to inactivated influenza vaccines (IIVs). However, recent studies evaluating LAIV efficacy in developing countries have reported contradictory results, highlighting the need for a better understanding of the factors influencing LAIV effectiveness in these settings. Assessing replicative fitness and antigenicity when selecting components for LAIV formulations is essential for optimal vaccine performance.
Article
Multidisciplinary Sciences
Lars Ketscher, Ronny Hannss, David J. Morales, Anja Basters, Susana Guerra, Tobias Goldmann, Annika Hausmann, Marco Prinz, Ronald Naumann, Andrew Pekosz, Olaf Utermoehlen, Deborah J. Lenschow, Klaus-Peter Knobeloch
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Physiology
Jackye Peretz, Andrew Pekosz, Andrew P. Lane, Sabra L. Klein
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2016)
Article
Obstetrics & Gynecology
Shriddha Nayak, Jun Lei, Andrew Pekosz, Sabra Klein, Irina Burd
SEMINARS IN REPRODUCTIVE MEDICINE
(2016)
Article
Public, Environmental & Occupational Health
J. H. Leibler, K. Dalton, A. Pekosz, G. C. Gray, E. K. Silbergeld
ZOONOSES AND PUBLIC HEALTH
(2017)
Article
Microbiology
Olivia J. Hall, Nathachit Limjunyawong, Meghan S. Vermillion, Dionne P. Robinson, Nicholas Wohlgemuth, Andrew Pekosz, Wayne Mitzner, Sabra L. Klein
Article
Virology
Leigh M. Howard, Monika Johnson, Ana I. Gil, Andrew Pekosz, Marie R. Griffin, Kathryn M. Edwards, Claudio F. Lanata, Carlos G. Grijalva, John V. Williams
JOURNAL OF CLINICAL VIROLOGY
(2017)
Article
Virology
Hsuan Liu, Michael L. Grantham, Andrew Pekosz
JOURNAL OF VIROLOGY
(2018)
Article
Immunology
Nicholas Wohigemuth, Yang Ye, Katherine J. Fenstermacher, Hsuan Liu, Andrew P. Lane, Andrew Pekosz
Article
Immunology
Adriana Forero, Katherine Fenstermacher, Nicholas Wohlgemuth, Andrew Nishida, Victoria Carter, Elise A. Smith, Xinxia Peng, Melissa Hayes, Doreen Francis, John Treanor, Juliet Morrison, Sabra L. Klein, Andrew Lane, Michael G. Katze, Andrew Pekosz
Article
Multidisciplinary Sciences
Meghan S. Vermillion, Jun Lei, Yahya Shabi, Victoria K. Baxter, Nathan P. Crilly, Michael McLane, Diane E. Griffin, Andrew Pekosz, Sabra L. Klein, Irina Burd
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Thomas E. Sussan, Sachin Gajghate, Rajesh K. Thimmulappa, Jinfang Ma, Jung-Hyun Kim, Kuladeep Sudini, Nicola Consolini, Stephania A. Cormier, Slawo Lomnicki, Farhana Hasan, Andrew Pekosz, Shyam Biswal
Article
Microbiology
Jessica D. Resnick, Michael A. Beer, Andrew Pekosz
Summary: This study investigated the effect of temperature on host responses in human nasal epithelial cells during respiratory virus infections. The results showed that temperature affected SARS-CoV-2, but not influenza A virus, replication fitness, and SCV2-infected cultures had a slower infection-induced response. Furthermore, temperature not only changed the basal transcriptomic landscape of the cells but also impacted the response to infection. Overall, these findings provide new insights into the innate immune response to respiratory infections and may aid in the development of novel treatment strategies.
Article
Virology
Jo L. Wilson, Elgin Akin, Ruifeng Zhou, Anne Jedlicka, Amanda Dziedzic, Hsuan Liu, Katherine Z. J. Fenstermacher, Richard E. Rothman, Andrew Pekosz
Summary: Understanding influenza B virus infections is crucial for controlling severe influenza and related diseases. Recent research has found that the two genetic lineages of influenza B virus differ not only in their antigenic structure but also in their ability to induce host immune responses.
Article
Health Care Sciences & Services
Anna Russell, Edbert B. Hsu, Katherine Z. J. Fenstermacher, Erin P. Ricketts, Gabriella Dashler, Allison Chen, Kathryn Shaw-Saliba, Patrizio P. Caturegli, Andrew Pekosz, Richard E. Rothman
Summary: This study investigated the prevalence of SARS-CoV-2 infection among emergency department healthcare workers in Baltimore during the early stage of the COVID-19 pandemic. The results showed that the infection rate was relatively low and most infected individuals did not require hospitalization. The study also found that the absenteeism among healthcare workers was not significant.
