The rapid antidepressant effect of ketamine in rats is associated with down-regulation of pro-inflammatory cytokines in the hippocampus

Serum Interleukin-6 Is a Predictive Biomarker for Ketamine’s Antidepressant Effect in Treatment-Resistant Patients With Major Depression

(2015) Jian-jun Yang et al.   BIOLOGICAL PSYCHIATRY

A role for inflammatory metabolites as modulators of the glutamate N-methyl-d-aspartate receptor in depression and suicidality

(2015) Cecilie Bay-Richter et al.   BRAIN BEHAVIOR AND IMMUNITY

Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder

(2015) Jonathan Savitz et al.   BRAIN BEHAVIOR AND IMMUNITY

Requirement of AMPA receptor stimulation for the sustained antidepressant activity of ketamine and LY341495 during the forced swim test in rats

(2014) Hiroyuki Koike et al.   BEHAVIOURAL BRAIN RESEARCH

A single infusion of ketamine improves depression scores in patients with anxious bipolar depression

(2014) Dawn F Ionescu et al.   BIPOLAR DISORDERS

Decreased quinolinic acid in the hippocampus of depressive patients: evidence for local anti-inflammatory and neuroprotective responses?

(2014) Mandy Busse et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Inflammatory Markers and the Pathogenesis of Pediatric Depression and Suicide

(2014) Jae-Won Kim et al.   JOURNAL OF CLINICAL PSYCHIATRY

Putative Neuroprotective and Neurotoxic Kynurenine Pathway Metabolites Are Associated with Hippocampal and Amygdalar Volumes in Subjects with Major Depressive Disorder

(2014) Jonathan Savitz et al.   NEUROPSYCHOPHARMACOLOGY

Association of Serum Interleukin 6 and C-Reactive Protein in Childhood With Depression and Psychosis in Young Adult Life

(2014) Golam M. Khandaker et al.   JAMA Psychiatry

Effects of Brilliant Blue G on Serum Tumor Necrosis Factor-α Levels and Depression-like Behavior in Mice after Lipopolysaccharide Administration

(2014) Min Ma et al.   Clinical Psychopharmacology and Neuroscience

Ketamine: synaptogenesis, immunomodulation and glycogen synthase kinase-3 as underlying mechanisms of its antidepressant properties

(2013) P A Zunszain et al.   MOLECULAR PSYCHIATRY

NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice

(2013) Adam K Walker et al.   NEUROPSYCHOPHARMACOLOGY

Does Intraoperative Ketamine Attenuate Inflammatory Reactivity Following Surgery? A Systematic Review and Meta-Analysis

(2012) Ola Dale et al.   ANESTHESIA AND ANALGESIA

Replication of Ketamine's Antidepressant Efficacy in Bipolar Depression: A Randomized Controlled Add-On Trial

(2012) Carlos A. Zarate et al.   BIOLOGICAL PSYCHIATRY

A meta-analysis of differences in IL-6 and IL-10 between people with and without depression: Exploring the causes of heterogeneity

(2012) Sarah A. Hiles et al.   BRAIN BEHAVIOR AND IMMUNITY

Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression

(2012) Hyangin Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

The Epidemiology of Depression and the Evolution of Treatment

(2012) Robert M. A. Hirschfeld   JOURNAL OF CLINICAL PSYCHIATRY

Neuroinflammation and Depression

(2012) M. Elizabeth Sublette et al.   PSYCHOSOMATIC MEDICINE

Acute administration of ketamine in rats increases hippocampal BDNF and mTOR levels during forced swimming test

(2012) Chun Yang et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes

(2012) S J Sukoff Rizzo et al.   Translational Psychiatry

Effects of Ketamine on Endotoxin and Traumatic Brain Injury Induced Cytokine Production in the Rat

(2011) Jeremy L. Ward et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

(2010) M. Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression

(2010) Michael Maes   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Inflammation-associated depression: From serotonin to kynurenine

(2010) Robert Dantzer et al.   PSYCHONEUROENDOCRINOLOGY

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

(2009) Andrew H. Miller et al.   BIOLOGICAL PSYCHIATRY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Induction of IDO by Bacille Calmette-Guerin Is Responsible for Development of Murine Depressive-Like Behavior

(2009) J. C. O'Connor et al.   JOURNAL OF IMMUNOLOGY

Peripheral Inflammation is Associated with Altered Substantia Nigra Activity and Psychomotor Slowing in Humans

(2008) Lena Brydon et al.   BIOLOGICAL PSYCHIATRY

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

Corticolimbic Transcriptome Changes are State-Dependent and Region-Specific in a Rodent Model of Depression and of Antidepressant Reversal

(2008) Alexandre Surget et al.   NEUROPSYCHOPHARMACOLOGY