Article
Microbiology
Min-A Lee, Usharani Jayaramaiah, Su-Hwa You, Eun-Gyeong Shin, Seung-Min Song, Lanjeong Ju, Seok-Jin Kang, Bang-Hun Hyun, Hyang-Sim Lee
Summary: This study collected serum and tissue samples between 2018 and 2022 to analyze the PRRSV types in Korea. Subgroup A was the most prevalent, followed by lineage 1, lineage 5, LKC, LKB, and subtype 1C. Highly virulent lineages 1 and 8 were detected, which can mutate or recombine with other viruses. The current vaccine in Korea offers limited protection, emphasizing the need for ongoing surveillance and region-specific immunization programs to reduce PRRSV infections.
Article
Microbiology
Lujia Zhou, Yang Yang, Qiqi Xia, Zhixin Guan, Junjie Zhang, Beibei Li, Yafeng Qiu, Ke Liu, Donghua Shao, Zhiyong Ma, Xiaodu Wang, Jianchao Wei
Summary: PRRS is an immunosuppressive disease in pigs caused by PRRSV, leading to reproductive and respiratory disorders. The predominant strain in Eastern China is still highly pathogenic PRRSV, with an increasing proportion of NADC30-like and NADC34-like strains. This study enriches the epidemiological data and provides a theoretical basis for the development of vaccines and prevention and control of the disease.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Li Du, Honglei Wang, Fang Liu, Zeyu Wei, Changjiang Weng, Jun Tang, Wen-hai Feng
Summary: Highly pathogenic PRRSV infection leads to up-regulation of COX-2 and PGE2 production in microglia through NSP2 protein interaction with 14-3-3 zeta, essential amino acid residues identified for this process. Mutant viruses lacking these residues show impaired ability to induce fever and clinical symptoms in pigs, suggesting potential for development of attenuated vaccines.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Veterinary Sciences
Mengmeng Zhao, Huiyang Sha, Hang Zhang, Ruining Wang
Summary: This study found that TRIM4 gene inhibits the proliferation of PRRSV through ubiquitination and degradation of the NSP2 protein, providing a new insight for the development of new antiviral targets.
BMC VETERINARY RESEARCH
(2022)
Article
Infectious Diseases
Giovanni Franzo, Giulia Faustini, Matteo Legnardi, Mattia Cecchinato, Michele Drigo, Claudia Maria Tucciarone
Summary: This study investigates the molecular epidemiology patterns and determinants of porcine reproductive and respiratory syndrome virus (PRRSV) in Europe, with live pig trade identified as the major determinant of viral spread.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Veterinary Sciences
Akshay Chadha, Rozita Dara, David L. Pearl, Daniel Gillis, Thomas Rosendal, Zvonimir Poljak
Summary: Since the early 1990s, porcine reproductive and respiratory syndrome (PRRS) virus outbreaks have been reported globally. This study aimed to evaluate baseline machine learning algorithms for the clinical impact classification of PRRSV sequences and demographic data. The classifiers showed improvements in accuracy for abortion and pre-weaning mortality, but not for sow mortality. Consensus voting ensemble techniques helped stabilize performance metrics but did not substantially improve overall accuracy.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Virology
Seung-Chai Kim, Chang-Gi Jeong, Gyeong-Seo Park, Ji-Young Park, Hye-Young Jeoung, Go-Eun Shin, Mi-Kyeong Ko, Seoung-Hee Kim, Kyoung-Ki Lee, Won-Il Kim
Summary: The most important pathogen in the Korean swine industry, Porcine reproductive and respiratory syndrome virus (PRRSV), continues to circulate and evolve despite efforts to control it. Through genetic analysis, different lineages of PRRSV have been identified in Korea, with vaccine-like subgroups being predominant. The increasing population of lineage 1 among PRRSV2 isolates indicates the need for ongoing surveillance and potential issues with current vaccination strategies.
ARCHIVES OF VIROLOGY
(2021)
Article
Microbiology
Dike Jiang, Teng Tu, You Zhou, Yanwei Li, Yan Luo, Xueping Yao, Zexiao Yang, Meishen Ren, Yin Wang
Summary: This study investigated the PRRSV epidemic situation in Sichuan province, China, and identified HP-PRRSV as the predominant strain. A new PRRSV strain named SCSN2020 was isolated and characterized, showing high genomic similarity to the JXA1 strain. The study also demonstrated the pathogenicity of the SCSN2020 strain in piglets.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Infectious Diseases
Xingdong Zhou, Sushu Bian, Enxi Kan, Lujia Zhou, Xiaohui Zhang, Min Xiao, Chang Lu, Ji Hua, Yuan Wu, Cheng Zhang, Yingshan Zhou, Wanyu Dong, Jing Du, Xiaodu Wang, Houhui Song
Summary: A new strain of PRRSV, PRRSV-HQ-2020, was discovered in nursery piglets in Yunnan Province, China in 2020. Genetic analysis revealed that PRRSV-HQ-2020 is a result of natural recombination events among three lineages of PRRSV-2 in Chinese swine herds. This recombination has led to the emergence of unique genetic properties and provides a basis for developing better PRRSV prevention strategies.
TRANSBOUNDARY AND EMERGING DISEASES
(2023)
Article
Immunology
Chang-zhan Xie, Zheng Wang, Zhuo Ha, Ying Zhang, Yu-biao Xie, He Zhang, Fu-long Nan, Jin-yong Zhang, Guan-yu Zhao, Zhuo-xin Li, Cheng-hui Li, Cheng-dong Yu, Ping Zhang, Hui-jun Lu, Ning-yi Jin
Summary: The study identified a new PRRSV strain, PRRSV-HB-16-China-2019, in China, which is a novel NSP2-deletion NADC30-like strain with specific deletions and mutations. This strain, recombined between a NADC30-like strain and a vaccine strain, poses a challenge to PRRSV prevention in China.
MICROBIAL PATHOGENESIS
(2021)
Article
Veterinary Sciences
Chang-Zhan Xie, Yi-Mo Tao, Zhuo Ha, Ping Zhang, Ying Zhang, He Zhang, Ning-Yi Jin, Hui-Jun Lu
Summary: This study provides valuable evidence for understanding the genomic characteristics and potential pathogenicity of the NADC34-like strain 2020-Acheng-1.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Virology
Shuangyun Wang, Yanling Liu, Linyang Yu, Tairun Liang, Pengfei Zhang, Jianguo Dong, Leyi Zhang, Pengshuai Liang, Lei Wang, Zheng Xu, Changxu Song
Summary: In this study, a highly pathogenic PRRSV strain was isolated and a full-length infectious cDNA clone was constructed, providing an effective reverse genetics platform for further research on viral pathogenesis.
ARCHIVES OF VIROLOGY
(2021)
Article
Veterinary Sciences
Wang Zhai, Siyu Yu, Pengxuan Zhang, Yuan Lin, Shenghu Ge, Taojie Zhang, Kun Zhang, Shicheng He, Qiaoyun Hu, Xiaomin Tang, Zhi Peng, Changjian Wang
Summary: This study investigated the epidemiological characteristics of PRRSV in Hunan and Hebei provinces of China in 2021. The results showed high prevalence of PRRSV, with diverse lineages, including NADC30-like and HP-PRRSV strains. A novel sublineage 1.8 strain recombinant was also identified. This study provides updated information on the epidemiology and genetic characteristics of PRRSV in the investigated regions.
VETERINARY SCIENCES
(2023)
Article
Veterinary Sciences
Monica Guzman, Ronald Melendez, Carlos Jimenez, Marta Piche, Emily Jimenez, Bernal Leon, Juan M. Cordero, Lisbeth Ramirez-Carvajal, Alberto Uribe, Arie Van Nes, Arjan Stegeman, Juan Jose Romero
Summary: In Costa Rica, PRRS virus has three distinct origins, with PRRSV-2 being the only species detected. Sequencing and phylogenetic analysis revealed three clusters, with some samples closely related to historical lineages while others forming a separate clade. Epitope analysis of field isolates showed similarities to previously described immunogenic regions. Future studies will explore the impact of vaccines on the evolutionary change of circulating field strains.
BMC VETERINARY RESEARCH
(2021)
Article
Virology
Feifei Diao, Juan Bai, Chenlong Jiang, Yangyang Sun, Yanni Gao, Hans Nauwynck, Ping Jiang, Xing Liu
Summary: This study reveals that stimulator of interferon genes (STING) suppresses the replication of porcine reproductive and respiratory syndrome virus (PRRSV) through type I interferon signaling. However, PRRSV can inhibit STING function by impeding its translocation. Moreover, the nonstructural protein 2 (Nsp2) of PRRSV interacts with STING and disrupts its function. Additionally, PRRSV Nsp2 retains STING at the endoplasmic reticulum by increasing the level of STIM1 protein.
JOURNAL OF VIROLOGY
(2023)
Article
Immunology
Siyeon Yang, Taehwan Oh, Hyejean Cho, Chanhee Chae
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2020)
Article
Veterinary Sciences
Siyeon Yang, Taehwan Oh, Josuke Mago, Akihiro Iwakuma, Chanhee Chae
VETERINARY MEDICINE AND SCIENCE
(2020)
Article
Veterinary Sciences
Taehwan Oh, Su-Jin Park, Hyejean Cho, Siyeon Yang, Hee Jin Ham, Chanhee Chae
VETERINARY MEDICINE AND SCIENCE
(2020)
Article
Virology
Kee Hwan Park, Taehwan Oh, Hyejean Cho, Siyeon Yang, Chanhee Chae
ARCHIVES OF VIROLOGY
(2020)
Article
Veterinary Sciences
Siyeon Yang, Taehwan Oh, Kee Hwan Park, Hyejean Cho, Chanhee Chae
FRONTIERS IN VETERINARY SCIENCE
(2020)
Article
Infectious Diseases
Kee Hwan Park, Chanhee Chae
Summary: The study aimed to determine the prevalence of porcine circovirus type 2e (PCV2e) compared to other PCV2 genotypes in lymph nodes of slaughter pigs. Results showed PCV2d as the dominant genotype, with PCV2e being the least prevalent. Multiple infections were rare, with PCV2a+PCV2d being the most common combination.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Veterinary Sciences
Siyeon Yang, Yongjun Ahn, Taehwan Oh, Hyejean Cho, Kee Hwan Park, Chanhee Chae
Summary: Vaccination with the bivalent vaccine significantly improved growth performance, reduced clinical scores, decreased PCV2d and M. hyopneumoniae loads, elicited higher levels of protective immunity, and lowered the scores of M. hyopneumoniae-induced pneumonia and PCV2-associated lymphoid lesions compared to unvaccinated animals under field conditions.
VETERINARY MEDICINE AND SCIENCE
(2021)
Review
Immunology
Chanhee Chae
Summary: PRRSV is a challenging viral pathogen in the global pork industry, with MLV vaccines being the principal strategy for control. The efficacy of the vaccines is often unpredictable and depends heavily on the field virus.
Article
Immunology
Hyungmin Um, Siyeon Yang, Taehwan Oh, Keehwan Park, Hyejean Cho, Jeongmin Suh, Kyung-Duk Min, Chanhee Chae
Summary: This study compared two combined vaccines for porcine circovirus type 2 (PCV2) and Mycoplasma hyopneumoniae in herds with subclinical PCV2d infection and enzootic pneumonia, finding that the trivalent vaccine containing PCV2a, 2b, and M. hyopneumoniae showed better growth performance and reduction of pathogens compared to the bivalent vaccine. No statistical differences were observed between one- and two-dose trivalent-vaccinated groups.
Article
Veterinary Sciences
Taehwan Oh, Duy Tien Do, Hung Van Vo, Hyeok-il Kwon, Seung-Chul Lee, Min Ho Kim, Dung Thi Thu Nguyen, Quang Tin Vinh Le, Tan Minh Tran, Toan Tat Nguyen, Joo Young Lee, Chanhee Chae
Summary: The use of renal-derived swine macrophages as a novel primary cell candidate offers a solution to ethical constraints and consistency problems in ASFV propagation. These primary cells are proven to be permissive to both cell adapted ASFV and wild-type ASFV, making them useful for virus isolation and propagation. Additionally, compared to commercial cell lines, renal-derived macrophages demonstrate consistent molecular characteristics and are more suitable for isolating field viruses.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Yongjun Ahn, Siyeon Yang, Taehwan Oh, Kee Hwan Park, Hyejean Cho, Jeongmin Suh, Chanhee Chae
Summary: The study demonstrated that the new single-dose bivalent vaccine effectively protected pigs against dual PCV2b and M. hyopneumoniae challenge by significantly increasing neutralizing antibodies and cell-mediated immunity, reducing viremia and nasal shedding, and decreasing the severity of lung and lymphoid lesions associated with the infections.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Microbiology
Siyeon Yang, Taehwan Oh, Kee Hwan Park, Hyejean Cho, Jeongmin Suh, Chanhee Chae
Summary: The experimental study evaluated the efficacy of a new trivalent vaccine containing PCV2a/b and Mycoplasma hyopneumoniae. Results showed that vaccinated pigs had a significant amount of protective immunity and reduced viral load compared to unvaccinated pigs. The trivalent vaccination provided good protection against single and dual challenges of PCV2d and M. hyopneumoniae.
VETERINARY MICROBIOLOGY
(2021)
Article
Veterinary Sciences
Duy Tien Do, Khanh Doan Vinh Tran, Anh Tuyet Quach, David Lee, Frank C. J. Chang, Carol P. Y. Wu, Toan Nguyen Tat, Chanhee Chae
Summary: The study demonstrated that the CIRCOQ porcine circovirus type 2 (PCV2) subunit vaccine is effective in protecting piglets with high maternally derived antibodies against disease caused by natural infection with PCV2d. Vaccinated pigs showed lower signs of respiratory disorder and dermatitis, lower mortality rates, and higher body weight and productivity compared to unvaccinated pigs.
CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE
(2021)
Article
Veterinary Sciences
SooHwan Kim, Taehwan Oh, Siyeon Yang, Hyejean Cho, Chanhee Chae
Summary: This study evaluated the efficacy of a new Mycoplasma hyopneumoniae bacterin in Korean pigs under experimental conditions. The vaccinated pigs showed a strong cell-mediated immunity and reduced nasal shedding and lung lesions compared to the unvaccinated pigs. Overall, the evaluated vaccine was effective in controlling M. hyopneumoniae infection.
CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE
(2021)
Article
Veterinary Sciences
Joo Young Lee, Kee Hwan Park, Taehwan Oh, Siyeon Yang, Jeongmin Suh, Hee Jin Ham, Chanhee Chae
Summary: The study aimed to reproduce severe pneumonic lesions by dual inoculation of pigs with porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae at 6 weeks of age, followed by inoculation with porcine circovirus type 2. Results demonstrated that this triple pathogen inoculation can lead to severe interstitial pneumonia with peribronchial or peribronchiolar lymphoid hyperplasia and fibrosis.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)
