Article
Obstetrics & Gynecology
Erika Bonacina, Pablo Garcia-Manau, Monica Lopez, Sara Caamina, Angels Vives, Eva Lopez-Quesada, Marta Ricart, Anna Maroto, Laura de Mingo, Elena Pintado, Laura Castillo-Ribelles, Lourdes Martin, Alicia Rodriguez-Zurita, Esperanza Garcia, Mar Pallarols, Laia Vidal-Sagnier, Mireia Teixidor, Carmen Orizales-Lago, Adela Perez-Gomez, Vanesa Ocana, Linda Puerto, Pilar Millan, Merce Alsius, Sonia Diaz, Nerea Maiz, Elena Carreras, Anna Suy, Manel Mendoza
Summary: The study aimed to assess whether aspirin treatment could be discontinued in pregnancies with a normal uterine artery pulsatility index (≤90th percentile) at 24-28 weeks. The results showed that discontinuing aspirin treatment was non-inferior to continuing aspirin treatment for preventing preterm pre-eclampsia in women with a uterine artery pulsatility index ≥90th percentile at 24-28 weeks.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Medicine, General & Internal
Nadia Shahid, Mehar Masood, Zakia Bano, Urooj Naz, Syeda Fariha Hussain, Adnan Anwar, Atif A. Hashmi
Summary: This study aimed to determine the role of Doppler U/S in predicting PE among high-risk women. The overall sensitivity of Doppler U/S in predicting PE was found to be 71.4%, with notching of uterine arteries showing better specificity compared to high RI.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Acoustics
N. Gana, M. Sarno, N. Vieira, A. Wright, M. Charakida, K. H. Nicolaides
Summary: This study aimed to evaluate the potential value of ophthalmic artery Doppler at 11-13 weeks' gestation as a predictive marker for pre-eclampsia (PE) and compare it with other first-trimester biomarkers. The results showed that ophthalmic artery PSV ratio may be helpful in predicting the development of preterm PE. However, larger studies are still needed to validate this finding.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Acoustics
I Sapantzoglou, A. Wright, M. Gallardo Arozena, R. Vallenas Campos, M. Charakida, K. H. Nicolaides
Summary: The study showed that the ophthalmic artery PSV ratio at 19-23 weeks' gestation could be used to predict the development of PE, especially preterm PE. Combining the PSV ratio with other biomarkers improved the accuracy of predicting PE, but larger studies are needed to validate these findings.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Review
Medicine, General & Internal
Serena Resta, Gaia Scandella, Ilenia Mappa, Maria Elena Pietrolucci, Pavjola Maqina, Giuseppe Rizzo
Summary: The number of pregnancies achieved through IVF is increasing globally, with improved chances of success due to technological advances. However, pregnancies conceived through IVF have a higher risk of adverse maternal and perinatal outcomes, mainly related to hypertensive diseases, pre-eclampsia, and fetal growth restriction. Advances in ultrasound technology allow for the evaluation of placental volume and hemodynamics, with differences observed between fresh and frozen-thawed embryos.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Acoustics
M. Sarno, A. Wright, N. Vieira, I Sapantzoglou, M. Charakida, K. H. Nicolaides
Summary: The study indicates that maternal ophthalmic artery Doppler combined with established biomarkers can enhance the prediction of pre-eclampsia at 35-37 weeks of gestation, especially for imminent pre-eclampsia within 3 weeks after assessment. Further validation studies are needed to confirm this finding.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
K. Phan, Y. H. Gomez, J. Gorgui, A. El-Messidi, R. Gagnon, H. A. Abenhaim, E. Rahme, S. S. Daskalopoulou
Summary: This study aimed to evaluate the ability of arterial stiffness parameters to predict pre-eclampsia early compared with peripheral blood pressure, uterine artery Doppler, and established angiogenic biomarkers. The results showed that arterial stiffness predicted pre-eclampsia more accurately than blood pressure, ultrasound indices, and angiogenic biomarkers.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Meng Li, Chaoyan Yue
Summary: This study aims to evaluate whether abnormal uterine artery Doppler ultrasound during weeks 21-23 of pregnancy is associated with an increased risk of pre-eclampsia. The results suggest that abnormal uterine artery ultrasound indices are closely associated with the development of pre-eclampsia.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Anna Meroni, Margaret Mascherpa, Monica Minopoli, Benjamin Lambton, Rawan Elkalaawy, Alexander Frick, Basky Thilaganathan
Summary: Routine mid-gestational uterine artery Doppler can modify the risk for preterm pre-eclampsia after first-trimester combined pre-eclampsia screening. Women at low risk in the first trimester but with high mid-gestational uterine artery Doppler resistance had a higher prevalence of preterm pre-eclampsia. This suggests that pregnancy care should not be de-escalated for women at high risk in the first trimester with low mid-gestational uterine artery Doppler resistance, and escalation of care may be justified for women at low risk but with high mid-gestational uterine artery Doppler resistance.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Acoustics
E. Hwuang, P. H. Wu, A. Rodriguez-Soto, M. Langham, F. W. Wehrli, M. Vidorreta, B. Moon, K. Kochar, S. Parameshwaran, N. Koelper, M. D. Tisdall, J. A. Detre, W. Witschey, N. Schwartz
Summary: This study recruited 87 pregnant women with a singleton pregnancy to measure UtA hemodynamics using 4D flow MRI. The results showed that MRI blood flow rate and pulsatility index were associated with pregnancy outcomes. The potential of MRI-flow and MRI-PI in predicting pre-eclampsia and small-for-gestational-age neonates was highlighted.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Acoustics
D. L. Rolnik, A. Syngelaki, N. O'Gorman, D. Wright, L. C. Poon, K. H. Nicolaides
Summary: This study aimed to investigate the effects of aspirin on mean arterial pressure (MAP) and mean uterine artery pulsatility index (UtA-PI) in women at increased risk of preterm pre-eclampsia. The results showed that aspirin did not significantly affect MAP, but it was associated with a significant decrease in mean UtA-PI, particularly before 20 weeks of gestation.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Acoustics
C. Russo, S. Camilli, F. G. Martire, A. Di Giovanni, L. Lazzeri, M. Malzoni, E. Zupi, C. Exacoustos
Summary: The study aimed to correlate the ultrasound appearance of highly vascularized uterine myomas with histopathological diagnosis, highlighting the importance of combining lesion characteristics and patient age for differential diagnosis of typical myomas, benign variants, and malignant lesions.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Acoustics
E. Gibbone, I. Sapantzoglou, M. E. Nunez-Cerrato, A. Wright, K. H. Nicolaides, M. Charakida
Summary: This study aimed to investigate the association between the PSV ratio and maternal cardiovascular function in an unselected population at 19-23 weeks' gestation. It found weak associations between the PSV ratio and most cardiovascular indices in the total population, except for mean arterial pressure. However, in the subgroup that developed PE, a moderately strong association between the PSV ratio and left ventricular mass indexed for body surface area was noted.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Acoustics
M. Litwinska, E. Litwinska, K. Lisnere, A. Syngelaki, A. Wright, K. H. Nicolaides
Summary: The study aimed to evaluate the predictive value of uterine artery pulsatility index (UtA-PI) at 19-24 weeks' gestation for pre-eclampsia (PE) and to stratify pregnancy care based on estimated risks of PE from UtA-PI and combinations of maternal factors with UtA-PI and mean arterial pressure (MAP). The findings suggest that early screening for PE at 20 weeks can help identify subgroups for additional monitoring, and screening by a combination of maternal factors and MoM values of UtA-PI and MAP is superior to other screening methods.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Lina Gong, Meng Liu, Haiheng Shi, Ying Huang
Summary: This study found a significant association between uterine fibroids and pre-eclampsia (PE), with pregnant women with uterine fibroids in early pregnancy having three times higher odds for PE. The association between uterine fibroids and PE was stronger in pregnant women aged ≥ 35 years and multiparas.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Editorial Material
Obstetrics & Gynecology
Pedro Castro, Heron Werner, Gerson Ribeiro, Jorge Lopes, Edward Araujo Jr
JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA
(2023)
Article
Clinical Neurology
Alexandre Kim Sangalan Sasaoka, Antonio Fernandes Moron, Edward Araujo, Adriana Sanudo, Mauricio Mendes Barbosa, Herbene Jose Figuinha Milani, Stephanno Gomes Pereira Sarmento, Sergio Cavalheiro
Summary: This study aimed to analyze the evolution of uterine scar thickness after open fetal surgery for myelomeningocele and establish a cut-off point for uterine scar thickness associated with high risk of uterine rupture. The results showed that thinner uterine scars were significantly associated with increased likelihood of thinning during pregnancy follow-up. A cut-off point of ≤3.0 mm in scar thickness may be useful for decision-making regarding the risk of uterine rupture and indication of caesarean section.
CHILDS NERVOUS SYSTEM
(2023)
Article
Acoustics
E. M. M. Yamaguti, E. T. Sontag dos Reis, W. P. Martins, M. N. Nadai, N. F. Soares, F. da Silva Costa, C. S. Vieira
Summary: This study describes the feasibility of an ultrasound-guided repositioning technique for partially expelled intrauterine devices (IUDs) without sedation. The results showed that the procedure was successful in majority of the cases with no serious complications.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Review
Acoustics
Darlei Neves Carneiro, Isabela Rossi, Nagibe Tayfour Oliveira, Lorena de Moraes Oliveira, Mariana Rodrigues, Edward Araujo Junior, Rodrigo Ruano, Alberto Borges Peixoto, Marina Carvalho Paschoini
Summary: This study describes the ultrasonographic characteristics, outcomes, and evolution of congenital porto-systemic venous shunts (CPSS) diagnosed during pregnancy. The data shows that the majority of fetuses were diagnosed with intra-hepatic CPSS at 33 weeks. Preterm delivery, fetal growth restriction, and postnatal treatment were common issues.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Review
Acoustics
Renato Silveira Ximenes, Nathalie Jeanne Bravo-Valenzuela, David Baptista Silva Pares, Edward Araujo Junior
Summary: This study aims to explore ultrasound features that could allow early diagnosis of major congenital heart diseases (CHDs). High resolution ultrasound images of various CHDs were evaluated to provide useful tools for assessment. Results show that early ultrasound detection of most major CHDs is feasible. Safety concerns, findings on early fetal cardiovascular hemodynamics, and progressive cardiac lesions during pregnancy were also discussed.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Editorial Material
Acoustics
Pedro Teixeira Castro, Gerson Ribeiro, Tatiana Fazecas, Fernando Maia Peixoto-Filho, Edward Araujo Junior, Heron Werner
Summary: In this case report, we present two cases of fetal liver giant hemangioma assessed using ultrasound, magnetic resonance imaging and three-dimensional reconstructions. We also discuss their respective postnatal outcomes.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Article
Obstetrics & Gynecology
Caroline Cervante Chagas, Ana Leticia Siqueira Pontes, Nathalie Jeanne Bravo-Valenzuela, Alberto Borges Peixoto, Ilenia Mappa, Clementina Viscardi, Giuseppe Rizzo, Edward Araujo Junior
Summary: Reference curves for fetal aortic and pulmonary valve annulus area were determined using three-dimensional ultrasonography with STIC, and their applicability in CHD was confirmed. The results showed a strong correlation between the areas of the valve annuli and CHD. Overall, the study received a rating of 9 out of 10.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Medicine, General & Internal
Karina da Rocha Mariano, Giovanna Calixto Andrade, Maria Laura Costa Louzada, Mary Uchiyama Nakamura, Edward Araujo Junior, Eduardo Souza
Summary: The study aimed to assess the consumption of ultra-processed foods by Brazilian pregnant women and its impact on the nutritional quality of their diet. Data from the 2017-2018 Family Budgets Survey were used to measure food consumption, and the foods were categorized using the NOVA classification. The results showed that ultra-processed foods accounted for 20.9% of the total calories in the diet of Brazilian pregnant women. Higher consumption of ultra-processed foods was associated with reduced intake of nutrients and decreased nutritional quality of their diet.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2023)
Article
Medicine, General & Internal
Thaisa de Souza Lima, Flavia Mariane Pagani, Carolina Bianchini Borges, Caetano Galvao Petrini, Marina Carvalho Paschoini, Edward Araujo Junior, Alberto Borges Peixoto
Summary: The aim of this study was to evaluate the association between antibiotic prophylaxis and adverse perinatal outcomes in pregnant women with premature rupture of membranes. The results showed that there was no association found between antibiotic prophylaxis and the presence of adverse perinatal outcomes. There were significant effects observed in patients with premature rupture of membranes using prophylactic antibiotics regarding various factors.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Eduardo Felix Martins Santana, Ana Maria Faria Esteves, Daniella Guerra Delorenzo, Celso Hygino, Heron Werner, Edward Araujo Junior
Summary: Tuberous sclerosis complex (TSC) is a genetic disorder caused by mutations in TSC1 or TSC2, leading to the development of tumors in various organs. Prenatal diagnosis of TCS can be done through ultrasound and MRI, specifically identifying fetal cardiac tumors and brain subependymal nodules. We present two case reports of prenatal TCS diagnosis using both ultrasound and MRI, which were later confirmed postnatally.
INDIAN JOURNAL OF RADIOLOGY AND IMAGING
(2023)
Article
Pediatrics
Joao Victor Jacomele Caldas, Antonio Fernandes Moron, David Baptista da Silva Pares, Sergio Cavalheiro, Italo Capraro Suriano, Edward Araujo Junior
Summary: Occipital encephalocele is a rare neural tube defect that requires surgical repair after birth. Intrauterine surgery aims to minimize brain herniation and improve perinatal outcomes. This study presents the first experience of fetal open surgery for occipital encephalocele in Brazil, highlighting the importance of postnatal follow-up to evaluate the benefits.
JOURNAL OF PEDIATRIC NEUROLOGY
(2023)
Letter
Obstetrics & Gynecology
Rodrigo Manieri Rocha, Jose Vitor Zanardi, Wellington de Paula Martins
FERTILITY AND STERILITY
(2023)
Review
Obstetrics & Gynecology
Nienke E. van Hoogenhuijze, Gemma Lahoz Casarramona, Sarah Lensen, Cindy Farquhar, Mohan S. Kamath, Aleyamma T. Kunjummen, Nick Raine-Fenning, Sine Berntsen, Anja Pinborg, Shari Mackens, Zeynep Ozturk Inal, Ernest H. Y. Ng, Jennifer S. M. Mak, Sachin A. Narvekar, Wellington P. Martins, Mia Steengaard Olesen, Helen L. Torrance, Ben W. Mol, Marinus J. C. Eijkemans, Rui Wang, Frank J. M. Broekmans
Summary: This meta-analysis based on individual participant data suggests that endometrial scratching may improve live birth rates in women undergoing IVF/ICSI. However, the effectiveness of scratching may vary in different subgroups, and the timing of the procedure may also play a role. Therefore, the use of endometrial scratching in clinical practice should be done cautiously and patients should be informed about the level of evidence and uncertainties.
HUMAN REPRODUCTION UPDATE
(2023)
Review
Acoustics
Gabriele Tonni, Alberto Borges Peixoto, Heron Werner, Gianpaolo Grisolia, Rodrigo Ruano, Francisco Sepulveda, Waldo Sepulveda, Edward Araujo Jr
Summary: Cleft lip is a common congenital anomaly, and micrognathia is a rare facial malformation. Prenatal ultrasound is the standard method for screening orofacial abnormalities, but adjunct imaging modalities like fetal MRI can enhance prenatal diagnosis. This review discusses the role of ultrasound and fetal MRI in assessing abnormalities of the upper lip, palate, and mandible.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Article
Cardiac & Cardiovascular Systems
Alberto Borges Peixoto, Nathalie Jeanne Bravo-Valenzuela, Wellington P. Martins, Gabriele Tonni, Antonio Fernandes Moron, Rosiane Mattar, Rodrigo Ruano, Liliam Cristine Rolo, Edward Araujo Junior
Summary: This study aimed to assess the impact of overweight and obesity in the second and third trimesters of pregnancy on fetal cardiac function parameters. The results showed that overweight and obese pregnant women had higher fetal left ventricular modified myocardial performance index (Mod-MPI) and right ventricular E' compared to normal weight pregnant women. However, there were no differences between the groups in terms of 5-min APGAR score < 7, neonatal intensive care unit admission, hypoglycemia and hyperglobulinemia.
CARDIOLOGY IN THE YOUNG
(2023)