Article
Immunology
Marwa Ben Ali Gannoun, Meriem Mehdi, Hedia Zitouni, Manel Boussabah, Ines Zouari, Ali Jlali, Wassim Y. Almawi
Summary: This study tested the link between altered PlGF and sFLT-1 levels, and their ratio with PE and PE-associated features, and found that increased sFlt-1 levels and sFlt-1/PlGF ratio are independent risk factors for PE.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Acoustics
K. Lau, A. Wright, M. Sarno, N. A. Kametas, K. H. Nicolaides
Summary: This study compared the predictive performance of serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1)/PlGF ratio with the competing-risks model utilizing maternal risk factors, mean arterial pressure (MAP), and ophthalmic artery peak systolic velocity (PSV) ratio for predicting pre-eclampsia (PE) delivery. The results showed that ophthalmic artery Doppler combined with maternal risk factors and blood pressure could potentially replace the measurement of PlGF and sFlt-1/PlGF ratio in predicting imminent PE.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Medicine, General & Internal
Katarzyna Kosinska-Kaczynska, Ewa Malicka, Iwona Szymusik, Norbert Dera, Michal Pruc, Stepan Feduniw, Zubaid Rafique, Lukasz Szarpak
Summary: COVID-19 infection in pregnant women is associated with an increased risk of adverse pregnancy outcomes, including preeclampsia. This meta-analysis found that pregnant women with COVID-19 have higher sFlt-1/PlGF ratios compared to those without COVID-19. Severe COVID-19 and SARS-CoV-2 infection in hypertensive pregnant women were also associated with significantly higher sFlt-1/PlGF ratios.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Sama Hussein, Weina Ju, Stephanie Pizzella, Michael Flory, Chu Chu, Yong Wang, Nanbert Zhong
Summary: The study found that the expression of sFLT-1 and PlGF was reduced in preterm birth cases, while the sFLT-1/PlGF ratio was increased in EVs-EXs, indicating a potential biomarker for predicting preterm birth.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Peripheral Vascular Disease
Rugina Neuman, Langeza Saleh, Koen Verdonk, Anton H. van den Meiracker, Henk Russcher, Herold J. Metselaar, Willy Visser, A. H. Jan Danser
Summary: The study indicates that PlGF production is significantly upregulated in AFLP patients, mainly originating from the placenta. Compared to other disease groups, AFLP patients have significantly elevated levels of PlGF, which rapidly decline postpartum.
Review
Biochemistry & Molecular Biology
Nataliia Sergeevna Karpova, Olga Pavlovna Dmitrenko, Tatyana Sergeevna Budykina
Summary: One of the main causes of maternal and neonatal morbidity and mortality is pre-eclampsia, characterized by a high sFlt1/PlGF ratio. Pregestational diseases in mothers may increase the risk, but few studies have looked at the connection between maternal comorbidities and the sFlt1/PlGF ratio. This review summarizes the latest information on the association between maternal pregestational diseases and the ratio of sFlt1/PlGF, as well as the link between changes in pregnancy hormones/metabolites and a high sFlt1/PlGF ratio. Debate remains on the association between the ratio and maternal disorders, calling for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Laura Bremner, Carolyn Gill, Paul T. Seed, Frances Conti-Ramsden, Louise Webster, Jessica Fleminger, Lucy C. Chappell, Andrew Shennan, Kate Bramham
Summary: This study aimed to explore and validate thresholds for Placental growth factor (PlGF) and soluble fms-like tyrosine-kinase 1 (s-Flt-1) to diagnose pre-eclampsia in women. The results showed that using PlGF alone could be a cost-effective alternative to dual biomarker testing, with comparable performance to sFlt-1: PlGF ratio, but reduced performance in women with Kidney Disease.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Review
Medicine, Research & Experimental
Alexandros Velegrakis, Elisavet Kouvidi, Persefoni Fragkiadaki, Stavros Sifakis
Summary: Preeclampsia (PE) is a serious complication of pregnancy with a high incidence rate and causes significant maternal and fetal health risks. Studies have shown that differences in maternal serum levels of angiogenic factors can be used as biomarkers to predict the development of PE. Specifically, the sFlt-1/PlGF ratio has been identified as the optimal predictive tool. However, further research is needed to enhance its clinical applicability and provide universal guidelines for consistent management of PE.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Obstetrics & Gynecology
M. Wind, M. E. van den Akker-van Marle, B. E. P. B. Ballieux, C. M. Cobbaert, T. J. Rabelink, J. M. M. van Lith, Y. K. O. Teng, M. Sueters
Summary: This study investigated the clinical value of adding the sFlt-1/PlGF ratio to the spot urine protein/creatinine ratio (PCr) in women with suspected pre-eclampsia. The results showed that this combined test could improve the selection of low-risk pregnant women and reduce hospital care for women with suspected pre-eclampsia.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Medicine, General & Internal
Szymon Kozlowski, Anna Stelmaszczyk-Emmel, Iwona Szymusik, Aleksandra Saletra-Bielinska, Robert Brawura-Biskupski-Samaha, Pawel Pietruski, Agnieszka Osinska, Katarzyna Kosinska-Kaczynska
Summary: In this study, it was found that the concentration of sFlt-1 is higher in dichorionic twin pregnancies compared to monochorionic pregnancies. PlGF and sEng levels did not significantly differ between mono- and dichorionic gestation. Additionally, the concentrations of PlGF, sFlt-1 and sEng increased significantly during gestation and were much higher in the third trimester compared to the first trimester.
Article
Developmental Biology
Fengyuan Zhang, Mengqi Gu, Pengzheng Chen, Shuting Wan, Qian Zhou, Yuan Lu, Lei Li
Summary: This study found that the concentrations of sFlt-1 and PLGF, as well as the sFlt-1/PLGF ratio, can help distinguish patients with placenta accreta from those with placenta previa.
Article
Biochemistry & Molecular Biology
Isabelle Hernandez, Audrey Chissey, Jean Guibourdenche, Roger Atasoy, Xavier Coumoul, Thierry Fournier, Jean-Louis Beaudeux, Amal Zerrad-Saadi
Summary: The study demonstrates the involvement of NADPH oxidase in the secretion of sFlt-1 and PlGF in first trimester chorionic villi, and indicates the participation of p38 MAPK pathway in sFlt-1 production and Nox activation. Additionally, the research highlights the major role of placental NADPH oxidase in mediating the signal transduction cascade of sFlt-1 production, as well as the involvement of p38 activation in first trimester placental Nox activity.
Article
Acoustics
J. Binder, E. Kalafat, P. Palmrich, P. Pateisky, A. Khalil
Summary: This study aimed to investigate the value of angiogenic marker assessment in women with chronic hypertension and suspected superimposed PE. The study found that adding angiogenic markers to the traditional diagnostic criteria significantly improved the prediction of adverse outcomes for both mothers and infants. Therefore, the assessment of angiogenic markers should be considered when evaluating pregnant women with chronic hypertension.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Review
Developmental Biology
Wenjing Chen, Qing Wei, Qian Liang, Shurong Song, Jia Li
Summary: This study systematically investigated the diagnostic capacity of the sFlt-1/PlGF ratio in fetal growth restriction (FGR). The results revealed that an sFlt-1/PlGF ratio > 33 could predict FGR, and the group with an sFlt-1/PlGF ratio ≥85 had higher diagnostic accuracy. However, more studies are needed to support these findings.
Article
Obstetrics & Gynecology
Alan Wright, Peter von Dadelszen, Laura A. Magee, Argyro Syngelaki, Ranjit Akolekar, Dave Wright, Kypros H. Nicolaides
Summary: This study examined the effect of self-declared race on serum placental growth factor (PlGF) and sFlt-1/PlGF ratio and its impact on the prediction of pre-eclampsia (PE). The results showed that compared to white women, black, South Asian, East Asian, and mixed race women had higher mean PlGF levels and lower sFlt-1/PlGF ratios.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Obstetrics & Gynecology
Rick Enste, Patrick Cricchio, Pierre-Yves Dewandre, Thorsten Braun, Christopher O. Leonards, Phil Niggemann, Claudia Spies, Wolfgang Henrich, Lutz Kaufner
Summary: Placenta accreta spectrum (PAS) is a condition where the placenta abnormally adheres to the uterine wall, leading to postpartum hemorrhage and maternal complications. Effective management strategies, such as specialized centers, multidisciplinary teams, novel diagnostics/pharmaceuticals, and innovative surgical/interventional approaches, are crucial.
JOURNAL OF PERINATAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Rick Enste, Patrick Cricchio, Pierre-Yves Dewandre, Thorsten Braun, Christopher O. Leonards, Phil Niggemann, Claudia Spies, Wolfgang Henrich, Lutz Kaufner
Summary: This two-part review summarizes challenging aspects in the management of placenta accreta spectrum (PAS) and provides evidence-based recommendations to improve management strategies and outcomes.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Cecilia Villalain, Enery Gomez-Montes, Eva Felipe, David Escribano, Enrique Garcia-Torres, Miguel Angel Granados, Ignacio Herraiz, Alberto Galindo
Summary: A retrospective cohort study found that CAT can be accurately diagnosed by experts, but it still has a high perinatal mortality rate. The association with other anomalies is the most important prognostic factor.
FETAL DIAGNOSIS AND THERAPY
(2023)
Article
Obstetrics & Gynecology
Alexander Paping, Clara Basler, Kerstin Melchior, Loreen Ehrlich, Mario Thiele, Georg N. Duda, Wolfgang Henrich, Thorsten Braun
Summary: The study aimed to evaluate the reliability of intraoperative ultrasound in identifying histologically confirmed uterine scar tissue. The results showed that intraoperative ultrasound was more accurate in identifying scar tissue compared to preoperative ultrasound. This is important for studying uterine wound healing and preventing uterine wall rupture.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Acoustics
J. Rodriguez-Calvo, C. Villalain, P. I. Gomez-Arriaga, M. S. Quezada, I. Herraiz, A. Galindo
Summary: The study aimed to analyze the ability to predict perinatal survival and severe neonatal morbidity in cases of early-onset fetal growth restriction (eoFGR) using maternal variables, ultrasound parameters, and angiogenic markers at the time of diagnosis. The results showed that a model combining estimated fetal weight and maternal serum PlGF accurately predicts perinatal survival in eoFGR cases diagnosed before 28 weeks of gestation.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Dorota Sroka, Lisa-Antonia Lorenz-Meyer, Valerie Scherfeld, Julie Thoma, Andreas Busjahn, Wolfgang Henrich, Stefan Verlohren
Summary: A retrospective study found that integrating the soluble fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio with other markers in a multi-marker regression model had better predictive performance for adverse maternal and fetal outcomes related to preeclampsia in women beyond 34 weeks of gestation.
FETAL DIAGNOSIS AND THERAPY
(2023)
Article
Obstetrics & Gynecology
Paula I. Gomez-Arriaga, Noemi Nunez, Berta Zamora, Cecilia Villalain, Beatriz Risco, Constanza Liebana, Ignacio Herraiz, Alberto Galindo
Summary: This study investigated the intrauterine evolution, associated anomalies, and neurodevelopmental outcome of fetuses with isolated mild ventriculomegaly. The results showed that 53% of the children had abnormal neurodevelopmental test scores at 2-6 years of age, but only 30% of them were diagnosed with neurological disorders.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Review
Acoustics
C. Villalain, A. J. Moon-Grady, U. Herberg, J. Strainic, J. L. Cohen, A. Shah, D. S. Levi, E. Gomez-Montes, I. Herraiz, A. Galindo
Summary: This study evaluated the accuracy of published models for predicting postnatal circulation in cases of pulmonary atresia/critical stenosis with intact ventricular septum (PA/CS-IVS). The results showed that multiparametric models performed well in predicting biventricular repair, but had low sensitivity in predicting univentricular circulation.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Medicine, General & Internal
Selina Balke, Petra Weid, Laura Fangmann, Paul Rostin, Wolfgang Henrich, Josefine Theresia Koenigbauer
Summary: This study analyzed data from 1664 patients with gestational diabetes (GDM) and found a strong correlation between glucose levels in the 75 g oGTT and adverse perinatal fetomaternal outcomes. Three subtypes of GDM were identified based on glucose levels, and significant differences were observed in baseline characteristics, insulin therapy, mode of delivery, and fetal growth among the subgroups. The findings suggest the need for individualized prenatal care after a GDM diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Larry Hinkson, Vanessa Ande Ruan, Madeleine Schauer, Pimrapat Gebert, Boris Tutschek, Wolfgang Henrich
Summary: The study aimed to assess the prevalence of uterine anomalies in breech presentation and its impact on external cephalic version, delivery options, and perinatal outcomes. The results showed a higher rate of newly diagnosed uterine anomalies in the third trimester with breech compared to the diagnosis prior to pregnancy. Vaginal breech delivery had a success rate of 55.5% while external cephalic version was unsuccessful.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Florence Vibert, Guel Schmidt, Kerstin Loeffler, Adam Gasiorek-Wiens, Wolfgang Henrich, Stefan Verlohren
Summary: The purpose of this study was to determine the accuracy of prenatal ultrasound in classifying facial clefts. The study found that prenatal ultrasound had a high accuracy of 88.9% in diagnosing facial clefts, which can help guide parents in postnatal care and surgical treatment.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Pediatrics
Joachim Carsten Will, Nina Siedentopf, Oliver Schmid, Teresa Mira Gruber, Wolfgang Henrich, Christoph Hertzberg, Bernhard Weschke
Summary: Cardiac rhabdomyomas can potentially indicate the presence of Tuberous Sclerosis Complex (TSC). Though they usually regress without intervention, they can grow and disrupt heart function, posing a threat to the child's life. Administering rapalogs, like sirolimus, to a pregnant mother with TSC can effectively stop the growth of cardiac tumors and cause them to shrink. This article presents a successful case of treating a fetal cardiac rhabdomyoma in a TSC patient using sirolimus.
Article
Obstetrics & Gynecology
Charlotte K. Metz, Anna S. Skof, Jalid Sehouli, Jan-Peter Siedentopf, Pimrapat Gebert, Fabian Weiss, Irene Alba Alejandre, Michaela Heinrich-Rohr, Katharina Weizsaecker, Wolfgang Henrich, Andreas M. Kaufmann, Irena Rohr
Summary: The purpose of this study was to investigate the influence of HIV infection and pregnancy on HR-HPV infection and progression. The study found that a high HIV viral load and a low CD4 T cell count were associated with a higher prevalence of HR-HPV infections and multiple infections. It is recommended to perform more attentive and comprehensive HPV screening and cytological examination for pregnant women with HIV infection.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Review
Obstetrics & Gynecology
Max Hackeloeer, Leon Schmidt, Stefan Verlohren
Summary: Preeclampsia, a multisystem disorder, is a major cause of maternal morbidity and mortality in pregnancy. In recent decades, there have been successful improvements in screening and prediction, including the use of biomarkers such as the sFlt-1/PlGF ratio. The traditional definition of preeclampsia has been expanded based on new insights into the pathophysiology and the ability of angiogenic biomarkers to improve detection of adverse events. Digital solutions, such as decision support algorithms and remote monitoring devices, offer opportunities for further improvement in care.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Madeleine Schauer, Elisabetta Latartara, Maria Alonso-Espias, Emma Rossetti, Pimrapat Gebert, Wolfgang Henrich, Larry Hinkson
Summary: This study found that women with breech presentation do not have higher levels of psychological distress compared to women with cephalic presentation. However, they still experience symptoms of potential mental disorders. Younger women and multiparous women may need additional support and should be assessed using a standardized screening tool for perinatal psychological distress.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)