Article
Biochemistry & Molecular Biology
Runjie Yu, Fuyin Xie, Qiguo Tang
Summary: This study characterized the brain lipid profiles of Tibetan chickens (TBCs) and dwarf laying chickens (DLCs) under hypoxia and normoxia conditions. The results showed that TBCs have a better adaptation to hypoxia than DLCs, with distinct cell membrane composition and nervous system development. Specific lipid species were identified as potential markers for distinguishing between TBCs and DLCs under hypoxia.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Caroline Cros, Matthieu Douard, Sebastien Chaigne, Come Pasqualin, Gilles Bru-Mercier, Alice Recalde, Caroline Pascarel-Auclerc, Thomas Hof, Michel Haissaguerre, Meleze Hocini, Pierre Jais, Olivier Bernus, Fabien Brette
Summary: Cardiac excitation-contraction coupling can vary between different regions of the heart, including the left atrium. This study introduces a new method to isolate atrial cardiac myocytes from four different regions of the left atrium in a relevant animal model, sheep. The results show regional differences in calcium transients and t-tubule density across the left atria, which may play a crucial role in the development of atrial fibrillation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Domitilla Pulcini, David Meo Zilio, Francesco Cenci, Cesare Castellini, Monica Guarino Amato
Summary: This study aimed to identify genetic lines of broilers adapted to organic production and provide valuable information by analyzing the correlation between bone shape and walking capability.
Article
Multidisciplinary Sciences
Ratna Dwi Wulandari, Agung Dwi Laksono, Nikmatur Rohmah, Hadi Ashar
Summary: This study analyzes regional differences in primary healthcare utilization in the Java Region of Indonesia. The results show that people in Jakarta are more likely to utilize primary healthcare than those in Banten, while people in East Java are less likely to utilize it. Overall, the level of utilization in the Java Region is highest in Jakarta, followed by Yogyakarta, East Java, Central Java, Banten, and West Java.
Article
Environmental Sciences
Ylva Sjoberg, Benoit Dessirier, Navid Ghajarnia, Fernando Jaramillo, Jerker Jarsjo, Davood Moshir Panahi, Diandian Xu, Liangchao Zou, Stefano Manzoni
Summary: Water bodies, such as lakes and reservoirs, provide important ecosystem services. This study compares the morphometric features of natural lakes and reservoirs using a global dataset. The results show that natural lakes have a larger volume-area scaling exponent and cover a wider range of volumes compared to reservoirs. Additionally, the scaling relations of lakes are more influenced by land cover and terrain compared to reservoirs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Nutrition & Dietetics
Xiaohong Huang, Jiaying Hu, Haining Peng, Heng-wei Cheng
Summary: Maternal metabolic disorder during early pregnancy may lead to emotional and behavioral disorders in children, making them vulnerable to bullying. Excessive gestational tryptophan intake may affect children's development through modulating the microbiota-gut-brain axis, which lays the foundation for their mental status.
Article
Biochemistry & Molecular Biology
Rosario Baltazar-Lara, Janeth Mora Zenil, Martha Carranza, Jose Avila-Mendoza, Carlos G. Martinez-Moreno, Carlos Aramburo, Maricela Luna
Summary: This study found that growth hormone (GH) can cross the blood-brain barrier and reach the cerebellum under hypoxic conditions, exerting antiapoptotic, antioxidative, anti-inflammatory, neuroprotective, and neuroregenerative effects. In addition, hypoxia caused changes in the size and structure of cerebellar layers, which could be restored by GH treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Davide Marengo, Kenneth L. Davis, Gokce Ozkarar Gradwohl, Christian Montag
Summary: The Affective Neuroscience Personality Scales (ANPS) measure individual differences in six primary emotional systems and have consistent relationships with Big Five personality traits, indicating that these emotional systems are ancient foundations of human personality evolution.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Bei Feng, Jiang Cao, YaPing Yu, HaiYan Yang, YangHongYan Jiang, Ying Liu, Rong Wang, Qian Zhao
Summary: This study aimed to investigate gender-related differences in brain metabolism among healthy individuals of different ages using 18F-FDG PET/CT. The study found significant differences in brain metabolism between males and females, with a general decline in metabolism starting around the age of 60, and a more pronounced decrease in males after the age of 70.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Kyung Min Jung, Kyung Je Park, Young Min Kim, Jae Yong Han
Summary: This study compared the CMV promoter with three neuron-specific promoters (cCaMKII, cNestin, and human synapsin I) to explore the possibility of manipulating gene expression in chicken embryonic brain cells. The results showed that two neuron-specific promoters (cCaMKII and cNestin) successfully expressed transgenes in cultured brain cells and had comparable or higher expression levels in brain cells than the ubiquitous CMV promoter. Overexpression of the FOXP2 gene driven by the cNestin promoter significantly affected the expression levels of target genes, CNTNAP2 and ELAVL4.
Article
Geriatrics & Gerontology
Chia-Fen Tsai, Chia-Hsien Chuang, Yen-Po Wang, Ya-Bo Lin, Pei-Chi Tu, Pei-Yi Liu, Po-Shan Wu, Chung-Yen Lin, Ching-Liang Lu
Summary: This study found significant differences in the gut microbial composition between late-life depression (LLD) patients and healthy controls. The gut microbiota associated with depressive symptoms were negatively correlated with brain structural signatures in regions related to memory, somatosensory integration, and emotional processing/cognition/regulation. These findings suggest that gut microbes may play a role in the symptomatology of LLD patients, offering a potential avenue for therapeutic strategies targeting gut microbiota in the treatment of elderly depressed patients.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yeonsil Moon, Changmok Lim, Yeahoon Kim, Won-Jin Moon
Summary: The study revealed that females may have better BBB integrity in the cingulate and occipital cortices, and sex-related differences in BBB integrity are attenuated with aging or cognitive decline.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Antonio Dono, Takeshi Takayasu, Yuanqing Yan, Bethany E. Bundrant, Octavio Arevalo, Carlos A. Lopez-Garcia, Yoshua Esquenazi, Leomar Y. Ballester
Summary: This study reveals significant differences in genomic alterations between brain metastases and primary tumors, with certain genes mutated at increased frequencies in brain metastases. Some gene mutations in brain metastases are associated with worse prognosis, highlighting the potential for targeted therapies and personalized management in these patients.
Article
Geriatrics & Gerontology
Xianxiao Zhou, Jiqing Cao, Li Zhu, Kurt Farrell, Minghui Wang, Lei Guo, Jialiang Yang, Andrew McKenzie, John F. Crary, Dongming Cai, Zhidong Tu, Bin Zhang
Summary: This integrative network biology study identifies molecular signatures and networks underlying brain regional vulnerability to aging in males and females. The findings pave the way for understanding the molecular mechanisms of gender differences in developing neurodegenerative diseases such as Alzheimer's disease (AD).
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Chen Li, Ye Liu
Summary: This study aimed to assess the behaviors of fascicles and tendinous tissue in different regions of the biceps femoris long head (BFLH) during dynamic knee and hip tasks. The results showed that the fascicles changed less in length and contributed less to BFLH length change in the knee-dominant Nordic hamstring exercise (NHE) compared to the hip-dominant Romanian deadlift (RDL). Moreover, the distal region of BFLH had higher activation and greater pennation angle changes in both tasks. These findings suggest potential regional differences in mechanical function of BFLH during dynamic tasks.
JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY
(2023)
Article
Engineering, Biomedical
Matthew McGarry, Elijah Van Houten, Charlotte Guertler, Ruth Okamoto, Daniel Smith, Damian Sowinski, Curtis Johnson, Philip Bayly, John Weaver, Keith Paulsen
Summary: In this study, a numerical implementation of a NITI FE model for MR elastography of fibrous soft tissue was described, with heterogeneity and anisotropy accounted for. Simulation results showed that the NLI algorithm performed well in simple isotropic cases, while LDI exhibited significant artifacts due to violation of local homogeneity assumptions. Additionally, isotropic NLI inversion of anisotropic data produced undesirable wavefield-dependent mechanical property maps.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Engineering, Biomedical
Zuoxian Hou, Charlotte A. Guertler, Ruth J. Okamoto, Hong Chen, Joel R. Garbow, Ulugbek S. Kamilov, Philip Bayly
Summary: This study utilizes artificial neural networks to estimate parameters of a transversely isotropic material model using data from MRE and DTI. The inputs include strain ratios, shear-wave speeds, and fiber direction, and ensembles of neural networks are used to obtain parameter estimates. The robustness of this approach is evaluated.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Computer Science, Artificial Intelligence
Matthew McGarry, Elijah Van Houten, Damian Sowinski, Dhrubo Jyoti, Daniel R. Smith, Diego A. Caban-Rivera, Grace McIlvain, Philip Bayly, Curtis L. Johnson, John Weaver, Keith Paulsen
Summary: This paper presents a model-based transverse isotropic implementation for non-linear inversion (TI-NLI) that accurately reconstructs shear modulus, damping ratio, shear anisotropy, and tensile anisotropy in in vivo brain tissue. The accuracy and repeatability of TI-NLI were validated using synthetic and real data, demonstrating its potential for clinical research on anisotropic tissues such as the brain and muscle.
MEDICAL IMAGE ANALYSIS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dhrubo Jyoti, Matthew McGarry, Elijah Van Houten, Damian Sowinski, Philip Bayly, Curtis L. Johnson, Keith Paulsen
Summary: In this study, a new data quality metric for magnetic resonance elastography (MRE) was developed based on a generalized calculation method. The metric can quickly and reliably predict the accuracy of material property reconstructions and shows promise for point-of-care evaluation of data quality.
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS
(2022)
Article
Engineering, Multidisciplinary
Kshitiz Upadhyay, Dimitris G. Giovanis, Ahmed Alshareef, Andrew K. Knutsen, Curtis L. Johnson, Aaron Carass, Philip Bayly, Michael D. Shields, K. T. Ramesh
Summary: Computational models of the human head play a crucial role in predicting traumatic brain injury, but they are associated with uncertainty and variability. This study proposes a data-driven framework for uncertainty quantification of computational head models, which reduces computational cost while providing accurate approximations. The framework employs manifold learning techniques and surrogate models to quantify uncertainty and variability in the simulated strain fields. The results highlight significant spatial variation in model uncertainty and reveal differences in uncertainty among strain-based brain injury predictor variables.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2022)
Article
Cell Biology
Adam W. J. Soh, Louis G. Woodhams, Anthony D. Junker, Cassidy M. Enloe, Benjamin E. Noren, Adam Harned, Christopher J. Westlake, Kedar Narayan, John S. Oakey, Philip Bayly, Chad G. Pearson
Summary: Hydrodynamic flow produced by multiciliated cells is critical for fluid circulation and cell motility. Cilia coupling through fluid flow and basal body connections play important roles in cilia beating and fluid flow.
MOLECULAR BIOLOGY OF THE CELL
(2022)
Article
Cell Biology
Anthony D. Junker, Louis G. Woodhams, Adam W. J. Soh, Eileen T. O'Toole, Philip Bayly, Chad G. Pearson
Summary: Research shows that the forces exerted by cilia on basal bodies affect their bending patterns, and environmental conditions can also impact ciliary waveforms. Striated fibers play a crucial role in coupling ciliary forces between basal bodies, while the loss of the basal body stability protein Poc1 disrupts normal distribution of basal bodies and ciliary bending patterns.
MOLECULAR BIOLOGY OF THE CELL
(2022)
Article
Multidisciplinary Sciences
Jung Hoon Cho, Zipeng A. Li, Lifei Zhu, Brian D. Muegge, Henry F. Roseman, Eun Young Lee, Toby Utterback, Louis G. Woodhams, Philip V. Bayly, Jing W. Hughes
Summary: Primary cilia in pancreatic islets have both sensory and motile function, and play a regulatory role in insulin secretion.
Article
Engineering, Biomedical
Daniel Yoon, Margrethe Ruding, Charlotte A. Guertler, Ruth J. Okamoto, Philip Bayly
Summary: The study aims to design, fabricate, and characterize hydrogel lattice structures with consistent, controllable, anisotropic mechanical properties. Lattices made of three different unit-cell types were printed using stereolithography (SLA) of polyethylene glycol diacrylate (PEGDA). The mechanical properties of the scaled lattices were measured in shear and compression and compared to those of the unscaled lattices.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Biomedical
Daniel R. Smith, Diego A. Caban-Rivera, L. Tyler Williams, Elijah E. W. Van Houten, Phil Bayly, Keith D. Paulsen, Matthew D. J. McGarry, Curtis L. Johnson
Summary: This study used magnetic resonance elastography (MRE) and a nonlinear inversion algorithm (TI-NLI) to analyze the anisotropic mechanical response of calf muscles and investigate the role of muscle fiber stiffening under load. The study found that in passive tension, there was a significant increase in fiber shear stiffness (mu(1)), shear anisotropy (phi), and tensile anisotropy (zeta) with increasing muscle length. In active tension, there was an increase in substrate shear stiffness (mu(2)) and a decrease in phi and zeta, indicating less anisotropy, especially when the muscles acted as agonists.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Mingyang Cui, Susan K. Dutcher, Philip V. Bayly, J. Mark Meacham
Summary: We present a label-free acoustic microfluidic method to confine cilia-driven swimming cells in space. Our platform integrates a surface acoustic wave (SAW) actuator and bulk acoustic wave (BAW) trapping array, achieving high spatial resolution and strong trapping forces. We use this platform to study ciliary beating and cell body motion, and investigate the effects of environmental variables. Acoustic confinement offers a compelling alternative to traditional methods of cell holding and allows for mechanical perturbation of cells via rapid acoustic positioning.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Shuaihu Wang, Charlotte A. Guertler, Ruth J. Okamoto, Curtis L. Johnson, Matthew D. J. McGarry, Philip V. Bayly
Summary: This study used MRE and DTI data to estimate anisotropic mechanical properties in six young female Yucatan minipigs. The results showed that white matter is more dissipative and anisotropic than gray matter, and brain development has a significant impact on brain stiffness and structural anisotropy.
Article
Multidisciplinary Sciences
Kshitiz Upadhyay, Ahmed Alshareef, Andrew K. Knutsen, Curtis L. Johnson, Aaron Carass, Philip V. Bayly, Dzung L. Pham, Jerry L. Prince, K. T. Ramesh
Summary: Computational head models are promising tools for understanding and predicting traumatic brain injuries. However, current head models suffer from uncertainty and poor accuracy in capturing the nonlinear brain tissue response. To address these issues, a framework for developing subject-specific head models using magnetic resonance imaging and elastography is proposed. The models employ a nonlinear visco-hyperelastic constitutive model to capture the brain tissue response.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2022)
Proceedings Paper
Computer Science, Interdisciplinary Applications
Ahmed Alshareef, Curtis L. Johnson, Aaron Carass, Andrew K. Knutsen, Peyton L. Delgorio, Grace McIlvain, Alexa M. Diano, K. T. Ramesh, Phillip Bayly, Dzung L. Pham, Jerry L. Prince
Summary: Modeling the brain tissue mechanics is crucial in understanding traumatic brain injury. This study collected a dataset of 23 subjects and performed analyses to investigate the potential influence of cerebral vessels on brain mechanical properties. The results showed regional differences in brain stiffness and damping ratio, but no dependence on vessel density. However, different correlations were observed in different brain regions. The findings contribute to a better understanding of brain biomechanics and the development of computational models for brain injury.
MEDICAL IMAGING 2022: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL, AND FUNCTIONAL IMAGING
(2022)
Article
Multidisciplinary Sciences
Louis G. Woodhams, Yenan Shen, Philip V. Bayly
Summary: By constructing a mathematical model of the axoneme, researchers have proposed a new mechanism for ciliary beating, suggesting that dynamic instability without dynamic dynein regulation is a plausible and robust mechanism for generating propulsion.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2022)