Article
Toxicology
Jelle Mertens, Anissa Alami, Katrien Arijs
Summary: Silver and silver compounds, including massive and powder forms, are widely used in various applications. However, the toxicokinetic profiles of different forms of silver and their oral bioavailability are not well understood. In this study, rats were exposed to different forms of silver via oral gavage for 28 days. The results showed that silver acetate and silver nitrate had the highest bioavailability, followed by nanosilver, while silver powder had very limited oral bioavailability. These findings provide important information for hazard assessment of silver compounds.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Toxicology
Nikola Pluym, Nadine Roegner, Oliver Peschel, Edgar Leibold, Gerhard Scherer, Max Scherer
Summary: In this study, a human biomonitoring method was developed to detect TMDD. Through metabolism study and urine analysis, 1-OH-TMDD was identified as a biomarker of exposure, and it was found that TMDD is rapidly metabolized and mainly excreted via urine. This method can be applied for biomonitoring of the general population.
ARCHIVES OF TOXICOLOGY
(2023)
Review
Medicine, General & Internal
Jee Yoon Park, Hosub Lim, Jianhua Qin, Luke P. Lee
Summary: Organs-on-chips or organoids microphysiological analysis platforms (MAP) have become a focus of attention in disease models, drug discovery, and developmental biology. Reproducing human pregnancy through bioengineering devices is significant and has made progress in cell cultures, reproductive organ reconstruction, and diseases research.
Article
Biochemistry & Molecular Biology
Jin Yu, Soo-Jin Choi
Summary: The study investigated the absorption and metabolic fate of ZnO particles in rats as well as their impact on gene expression in the liver. The results showed no significant acute toxicity after oral administration of ZnOs, but different forms of ZnO had varying effects on the transcriptomic responses in the liver.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Zhoumeng Lin, Santosh Aryal, Yi-Hsien Cheng, Andre J. Gesquiere
Summary: This review article critically evaluates existing studies on in vivo pharmacokinetic properties, in vitro cellular uptake and release kinetics, and whole-body physiologically based pharmacokinetic (PBPK) modeling studies of different nanomaterials (NMs). It discusses methods for simulating in vitro and in vivo dosimetry of NMs and shares perspectives on current challenges and future directions. The article proposes a Nano-IVIVE-PBPK framework for high-throughput screening of target dosimetry and potential toxicity of NMs.
Review
Cell Biology
Bum-Kyu Lee, Jonghwan Kim
Summary: Understanding the molecular mechanisms of early human placenta development is crucial for maternal and fetal health. Recent advancements in human trophoblast models offer new opportunities, but the application of high-throughput omics tools in this field remains limited. Integration of omics approaches with human in vitro model systems has the potential to enhance our understanding of placental development and associated complications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Xinlu Liu, Gang Wang, Haiqin Huang, Xin Lv, Yanru Si, Lixia Bai, Guohui Wang, Qinghua Li, Weiwei Yang
Summary: The placenta plays a crucial role in pregnancy by facilitating nutrient and gas exchange between the mother and fetus. Abnormalities in placental development can lead to pregnancy-related disorders and have long-term effects on maternal health. In vitro models, particularly trophoblast stem cell culture and organoids, have been used to study placental development and pregnancy-related diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Miyuki Breen, Caroline L. Ring, Anna Kreutz, Michael-Rock Goldsmith, John F. Wambaugh
Summary: This review discusses the use of generic physiologically based toxicokinetic (PBTK) models and high-throughput PBTK modeling for in vitro-in vivo extrapolation (IVIVE). The 'httk' tool is highlighted as a useful resource for chemical risk assessors to support rapid screening and prioritization, as well as to provide TK modeling for large numbers of chemicals using limited data. The modular and open-source design of httk allows for continuous improvement by a broad user community to facilitate rapid hazard assessments.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Article
Environmental Sciences
Alan Valdiviezo, Yuki Kato, Erin S. Baker, Weihsueh A. Chiu, Ivan Rusyn
Summary: The evaluation of exposure to multiple contaminants in a mixture poses challenges, including the characterization of chemical metabolism and the development of suitable models. This study used various in vitro models to assess the metabolism of a mixture of 20 pesticides. The results showed that iHep-based suspension assays exhibit higher metabolic activity and ion mobility spectrometry-mass spectrometry can characterize the formation of metabolites, providing a comprehensive evaluation of in vitro chemical metabolism.
Article
Toxicology
Jin Kwon Kim, Hoi Pin Kim, Jung Duck Park, Kangho Ahn, Woo Young Kim, Mary Gulumian, Gunter Oberdorster, Il Je Yu
Summary: The results showed that the clearance of silver nanoparticles follows a two-phase model, while the clearance of gold nanoparticles could be described by a one-phase model. In the co-exposure of gold and silver nanoparticles, the clearance of silver nanoparticles was altered by the presence of gold, possibly due to some interaction affecting the dissolution and clearance of silver nanoparticles in vivo.
PARTICLE AND FIBRE TOXICOLOGY
(2021)
Review
Environmental Sciences
Alexander East, Daniel E. Dawson, Sydney Brady, Daniel A. Vallero, Rogelio Tornero-Velez
Summary: This scoping effort aims to map the current landscape of PFAS toxicokinetic models by categorizing different trends and similarities. The assessment reveals that PFOA and PFOS are the most studied PFAS, with the majority of models using one-compartment models.
Article
Chemistry, Multidisciplinary
Ali Doryab, Juergen Groll
Summary: As chronic respiratory diseases become one of the leading causes of mortality post-COVID, the lack of predictive in vitro lung models hinders pulmonary preclinical drug development. Current cutting-edge models are compromised in technological and biological aspects, with limited translation to clinical settings. On the other hand, cellular and molecular studies mostly rely on simplistic and unrealistic in vitro models. This article discusses the current challenges and potential strategies for developing truly biomimetic lung models.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Physical
Aleksandr Kakinen, Ibrahim Javed, Thomas P. Davis, Pu Chun Ke
Summary: Amyloid diseases are global epidemics with limited solutions for diagnosis, treatment, and prevention;
The research on amyloidosis inhibition has evolved into a new frontier in nanomedicine, offering interdisciplinary research opportunities in materials, chemistry, and biophysics;
Due to the complex and overlapping physiopathologies of amyloid diseases, there is a crucial need for appropriate in vitro and in vivo models to validate novel anti-amyloidosis nanomedicines, and the development of new animal models reflecting the behavioral, symptomatic, and cross-talk hallmarks of amyloid diseases such as Alzheimer's, Parkinson's, and type 2 diabetes.
NANOSCALE HORIZONS
(2021)
Article
Biochemistry & Molecular Biology
Shane Forde, Giulianna Vozza, David J. Brayden, Hugh J. Byrne, Jesus M. Frias, Sinead M. Ryan
Summary: In order to address the challenges of oral administration of SeMet, researchers encapsulated it in zein-coated nanoparticles made from chitosan using an ionic gelation formulation. The SeMet-NPs showed high stability and minimal cytotoxicity, as well as antioxidant properties. Additionally, they exhibited increased intestinal permeability compared to free SeMet. These findings suggest the potential of SeMet-NPs for further development as an oral supplement.
Article
Nanoscience & Nanotechnology
Kirsty Meldrum, Stephen J. Evans, Ulla Vogel, Lang Tran, Shareen H. Doak, Martin J. D. Clift
Summary: Exposure to engineered nanomaterials can pose health risks, and this study aimed to determine the level of hazard using in vitro lung cell cultures. The results showed that DQ(12) caused pro-inflammatory responses, while TiO2 and BaSO4 did not. These findings highlight the importance of considering the appropriateness of positive controls, cell culture model, exposure time, and type when determining the response to specific ENMs.
Article
Nanoscience & Nanotechnology
Ashraf Abdelkhaliq, Meike van der Zande, Anna K. Undas, Ruud J. B. Peters, Hans Bouwmeester
Article
Toxicology
Kornphimol Kulthong, Loes Duivenvoorde, Huiyi Sun, Samuel Confederat, Jiaqing Wu, Bert Spenkelink, Laura de Haan, Victor Marin, Meike van der Zande, Hans Bouwmeester
TOXICOLOGY IN VITRO
(2020)
Review
Nanoscience & Nanotechnology
Christina Giannakou, Margriet V. D. Z. Park, Irene E. M. Bosselaers, Wim H. de Jong, Jan Willem van der Laan, Henk van Loveren, Rob J. Vandebriel, Robert E. Geertsma
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2020)
Article
Chemistry, Physical
Elisa Giubilato, Virginia Cazzagon, Monica J. B. Amorim, Magda Blosi, Jacques Bouillard, Hans Bouwmeester, Anna Luisa Costa, Bengt Fadeel, Teresa F. Fernandes, Carlos Fito, Marina Hauser, Antonio Marcomini, Bernd Nowack, Lisa Pizzol, Leagh Powell, Adriele Prina-Mello, Haralambos Sarimveis, Janeck James Scott-Fordsmand, Elena Semenzin, Burkhard Stahlmecke, Vicki Stone, Alexis Vignes, Terry Wilkins, Alex Zabeo, Lang Tran, Danail Hristozov
Review
Biochemistry & Molecular Biology
C. Frieke Kuper, Raymond H. H. Pieters, Jolanda H. M. van Bilsen
Summary: This article discusses the important role of the serosal immune system in the thoracic and peritoneal cavities, as well as the effects of nanomaterials on this system. ILCs are crucial in the first defense against pathogenic viruses and bacteria, and exposure to NMs may reduce resistance to pathogens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Pim de Haan, Milou J. C. Santbergen, Meike van der Zande, Hans Bouwmeester, Michel W. F. Nielen, Elisabeth Verpoorte
Summary: A novel, integrated, in vitro gastrointestinal system was developed for studying oral bioavailability parameters of small molecules. By mimicking the processes of the mouth, stomach, and intestine, as well as the absorption barrier model of the intestinal epithelium, the system enabled analysis of compound metabolism and absorption. The system has potential for future research in pharmacology, toxicology, and nutrition.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Kornphimol Kulthong, Guido J. E. J. Hooiveld, Loes Duivenvoorde, Ignacio Miro Estruch, Victor Marin, Meike van der Zande, Hans Bouwmeester
Summary: Dynamic culture conditions in gut-on-chip devices can mimic the in vivo intestinal environment and impact the gene expression of Caco-2 cells. The study shows that under dynamic culture conditions, gene expression patterns similar to those of the intestines in vivo were observed.
SCIENTIFIC REPORTS
(2021)
Article
Nanoscience & Nanotechnology
Kornphimol Kulthong, Guido J. E. J. Hooiveld, Loes P. M. Duivenvoorde, Ignacio Miro Estruch, Hans Bouwmeester, Meike van der Zande
Summary: The study utilized a gut-on-chip in vitro system and found that under dynamic conditions, intestinal epithelial cells showed increased sensitivity to TiO2 and ZnO nanomaterials, with significantly different gene expression levels. This suggests that shear stress may be a major factor in cell susceptibility.
Article
Toxicology
Menno Grouls, Meike van der Zande, Laura de Haan, Hans Bouwmeester
Summary: In various in vitro intestinal models, exposure to flagellin triggered an increase in IL-8 secretion as a pro-inflammatory response, while other TLR agonists did not induce a similar response, suggesting a lack of presence or functionality of specific TLRs in these models.
TOXICOLOGY IN VITRO
(2022)
Article
Pathology
Tracey L. Papenfuss, Lauren Himmel, C. Frieke Kuper, Sunish Mohanan, Johannes Harleman, Susan A. Elmore
Summary: The evaluation of changes in the immune system is important for determining the effectiveness and potential adverse effects of new products. Toxicologic pathologists play critical roles in identifying immune system changes and assessing immunosafety. The recent growth in immunomodulatory therapies presents challenges in evaluating the clinical relevance and potential adversity of immune system changes.
TOXICOLOGIC PATHOLOGY
(2023)
Article
Medicine, Research & Experimental
Ans Punt, Hans Bouwmeester, Bas J. Blaauboer, Sandra Coecke, Betty Hakkert, Delilah F. G. Hendriks, Paul Jennings, Nynke Kramer, Sibylle Neuhoff, Rosalinde Masereeuw, Alicia Paini, Ad A. C. M. Peijnenburg, Martijn Rooseboom, Michael L. Shuler, Ian Sorrell, Bart Spee, Marije Strikwold, Andries D. Van der Meer, Meike Van der Zande, Mathieu Vinken, Huan Yang, Peter M. J. Bos, Minne B. Heringa
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
(2020)
Review
Chemistry, Multidisciplinary
Meike van der Zande, Anita Jemec Kokalj, David J. Spurgeon, Susana Loureiro, Patricia V. Silva, Zahra Khodaparast, Damjana Drobne, Nathaniel J. Clark, Nico W. van den Brink, Marta Baccaro, Cornelis A. M. van Gestel, Hans Bouwmeester, Richard D. Handy
ENVIRONMENTAL SCIENCE-NANO
(2020)
Article
Biochemical Research Methods
Milou J. C. Santbergen, Meike Van der Zande, Arjen Gerssen, Hans Bouwmeester, Michel W. F. Nielen
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2020)
Article
Medicine, Research & Experimental
Miaoying Shi, Sebastiaan Wesseling, Hans Bouwmeester, Ivonne M. C. M. Rietjens
Summary: The study successfully predicted the cardiotoxicity of the neuroprotective drug ibogaine and its metabolites using an in vitro-in silico method, demonstrating the effectiveness of this new approach methodology.
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
(2021)