Review
Biochemistry & Molecular Biology
Yoshinori Harada, Yasutoshi Murayama, Tetsuro Takamatsu, Eigo Otsuji, Hideo Tanaka
Summary: 5-Aminolevulinic acid (5-ALA) is a natural amino acid that can accumulate in cancer cells and be used for tumor visualization. However, its diagnostic applicability is challenging due to interference from tissue autofluorescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Martin Kiening, Norbert Lange
Summary: Most cancer research focuses on targeting specific types of cancer, but this can be limiting as not all cancers or patients express the necessary antigens for certain therapies. Combination therapies are promising but require personalized treatment and can be expensive. In this study, the researchers investigated the use of aminolevulinate-based photodynamic diagnosis and therapy for breast cancer and found that a novel derivative showed potential in accumulating the fluorescent protoporphyrin IX, which could aid in guided resection and destruction of cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Yo Shinoda, Daitetsu Kato, Ryosuke Ando, Hikaru Endo, Tsutomu Takahashi, Yayoi Tsuneoka, Yasuyuki Fujiwara
Summary: The study reviewed and analyzed the effectiveness of 5-ALA PDT in vitro experiments for different cancer cell types, finding that the sensitivity to 5-ALA PDT varies across cancer classifications, with stomach cancer showing significantly higher sensitivity compared to other cancers. The analysis suggests the need for a standardized in vitro experimental protocol for 5-ALA PDT in future research.
Review
Biochemistry & Molecular Biology
Martin Kiening, Norbert Lange
Summary: Mitochondria play essential roles in energy production, iron metabolism, apoptosis, and heme synthesis. Specifically, the accumulation of protoporphyrin IX photosensitizer has been observed in neoplastic cells, suggesting a selective mechanism. This report aims to provide an overview of mitochondrial heme metabolism and potential explanations for the selectivity towards cancer cells, including the involvement of enzymes and transporters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
K. M. Tewari, R. Dondi, E. Yaghini, C. Pourzand, A. J. MacRobert, I. M. Eggleston
Summary: A novel peptide-targeted dendrimeric prodrug of 5-aminolevulinic acid (ALA) was successfully synthesized, which can effectively deliver ALA to specific cancer cell types. The prodrug system showed sustained and enhanced production of protoporphyrin IX (PpIX) in cancer cell lines over-expressing the epidermal growth factor receptor (EGFR+). This study provides proof of concept for the development of new generation prodrugs for ALA-based photodynamic therapy with enhanced ALA payload delivery to specific tissue types.
BIOORGANIC CHEMISTRY
(2021)
Article
Oncology
Bernhard Gillissen, Antje Richter, Frank Essmann, Wolfgang Kemmner
Summary: The combination of Alectinib with photodynamic therapy was found to increase the accumulation of protoporphyrin-IX and induce cell death in tumor cell lines of different origins. This suggests that Alectinib could enhance the effectiveness of photodynamic therapy and potentially serve as a new strategy for the treatment of disseminated carcinomas.
Article
Biochemistry & Molecular Biology
Jaroslava Joniova, Cyrus Kazemiraad, Emmanuel Gerelli, Georges Wagnieres
Summary: Studies have shown that photobiomodulation with red or near-infrared light significantly enhances the production of PpIX, improving the efficacy of PDT.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)
Review
Oncology
Hung Wei Lai, Taku Nakayama, Shun-ichiro Ogura
Summary: Studies have shown that administration of aminolevulinic acid can lead to the formation and accumulation of protoporphyrin IX in cancer cells, resulting in photocytotoxicity upon light irradiation. Transporters play a crucial role in regulating the amount of substrates, with their expression levels influenced by factors such as oxygen availability and iron ions.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hao Zhang, Yingnan Zhu, Yi Li, Xiaoyu Qi, Jing Yang, Haishan Qi, Qingsi Li, Yiming Ma, Ye Zhang, Xu Zhang, Lei Zhang
Summary: A bifunctional photodynamic dental therapy (PDDT) strategy based on ZMP has been developed for tooth whitening and biofilm eradication, showing superior ROS output and ability to disintegrate extracellular polymeric substances compared to PP. This new approach highlights the potential of ZMP as a photosensitizer for clinical dentistry in addressing tooth whitening and biofilm-induced dental diseases.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemical Research Methods
Pratheeba Palasuberniam, Daniel Kraus, Matthew Mansi, Richard Howley, Alexander Braun, Kenneth Myers, Bin Chen
Summary: The study demonstrates that clinically used kinase inhibitors can enhance the application of aminolevulinic acid (ALA) in tumor fluorescence imaging and photodynamic therapy (PDT). Among the kinase inhibitors tested, lapatinib showed the most significant enhancement in PpIX fluorescence and PDT response, particularly in tumors with high ABCG2 activity, suggesting its potential for therapeutic enhancement in combination with ALA.
JOURNAL OF BIOMEDICAL OPTICS
(2021)
Article
Biochemical Research Methods
Michelle Barreto Requena, Andi Dian Permana, Jose Dirceu Vollet-Filho, Patricia Gonzalez-Vazquez, Marlon Rodrigues Garcia, Clara Maria Goncalves De Faria, Sebastiao Pratavieira, Ryan F. Donnelly, Vanderlei Salvador Bagnato
Summary: The study developed and characterized dissolving microneedles for enhanced drug delivery, showing promising results for treating thicker skin lesions with topical photodynamic therapy.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Materials Science, Multidisciplinary
Jie Zhang, Zihuayuan Yang, Yan-Hong Li, Samran Durrani, Ai-Ping Pang, Yichen Gao, Fu-Gen Wu, Fengming Lin
Summary: This study presented super-stable carboxymethyl chitosanpolyethyleneimine-protoporphyrin IX nanoparticles (CMCS-PEI-PpIX NPs) for effective photodynamic inactivation of bacteria and fungi with excellent biocompatibility. The NPs exhibited exceptional photoinactivation toward a broad range of microbes with record low minimal bactericidal concentrations, showing high stability and negligible cytotoxicity. The development of CMCS-PEI-PpIX NPs provides a promising route for improving microbicidal PDT efficacy in clinic treatment of microbial infections.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Stephane Desgranges, Petras Juzenas, Vlada Vasovic, Odrun Arna Gederaas, Mikael Lindgren, Trond Warloe, Qian Peng, Christiane Contino-Pepin
Summary: Photodynamic therapy (PDT) is a non-invasive treatment that utilizes a photosensitive molecule and visible light to achieve therapeutic effects. Researchers have developed a series of compounds with improved water solubility and photodynamic properties compared to the original photosensitizer, PpIX.
Article
Biochemistry & Molecular Biology
Federica Foglietta, Patrizia Panzanelli, Loredana Serpe, Roberto Canaparo
Summary: Sonodynamic therapy (SDT) is a noninvasive cancer treatment method that utilizes ultrasound to activate a sonosensitizer, resulting in reactive oxygen species (ROS) generation and cancer cell death. In this research, SDT was found to significantly decrease cell proliferation and induce ROS generation, apoptosis, cytochrome c release, and DNA damage in various cancer cell lines. The efficacy of SDT in halting tumor proliferation was confirmed in 3D cancer spheroids. This study suggests that SDT is a valuable and innovative approach for cancer treatment.
Article
Biochemical Research Methods
Shakir Khan, Bofan Song, Srivalleesha Mallidi, Shaobai Li, Hui Liu, M. A. Bilal Hussain, Shaista Siddiqui, Amjad P. Khan, Kafil Akhtar, Shahid Ali Siddiqui, Syed Abrar Hasan, Colin Hopper, Stephen G. Bown, Rongguang Liang, Tayyaba Hasan, Jonathan P. Celli
Summary: India has a high incidence of oral squamous cell carcinoma (OSCC), but lacks medical infrastructure and routine screening, especially in rural areas. This study aims to use a hand-held smartphone-coupled intraoral imaging device for detection and photodynamic therapy (PDT) of oral cancer. The results suggest the utility of this low-cost device for image-guided PDT and treatment monitoring.
JOURNAL OF BIOMEDICAL OPTICS
(2023)
