期刊
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
卷 9, 期 4, 页码 310-318出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.pdpdt.2012.03.003
关键词
Topical photodynamic therapy; Oral precancerous lesions; 5-Aminolevulinic acid; 7,12-Dimethylbenz(a) anthracene; Hamster buccal pouch precancer
类别
资金
- National Science Council, Taipei, Taiwan, ROC [NSC 99-2622-E-033-014-CC3, NSC 100-2221-E-033-021]
Background: Our previous studies found that topical 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (ALA-PDT) with a light dose of 100J/cm(2) is very effective for human oral precancerous lesions. Methods: In this study, 20 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch precancerous lesions were treated by topical ALA-PDT with a light dose of either 75 J/cm(2) (n=10) or 100 J/cm(2) (n=10) using a 640-nm light-emitting diode (LED) light to test which light dose could achieve a better clinical outcome. Results: The 10 precancerous lesions treated by 75-J ALA-PDT showed complete response in 8 after an average of 3.4 (range, 2-6) treatments and partial response in 2. The 10 precancerous lesions treated by 100-J ALA-PDT demonstrated complete response in 7 after an average of 4.4 (range, 3-6) treatments and partial response in 3. Fisher exact test showed no significant difference in clinical outcome between these two treatment modalities (p=1.000). One complete-response precancerous lesion in the 75-J ALA-PDT group recurred at the end of 19-week follow-up and another complete response precancerous lesion in the 100-J ALA-PDT group recurred at the end of 16-week follow-up. Both recurrence lesions were treated by the original topical ALA-PDT regimen and demonstrated complete response after 3 PDT treatments. Furthermore, the 5 partial-response precancerous lesions developed into squamous cell carcinomas after 30-week follow-up. Conclusion: Our findings indicate that both the 75-J and 100-J topical ALA-PDT treatment modalities are very effective for DMBA-induced hamster buccal pouch precancerous lesions and no significant difference in clinical outcome between these two treatment modalities. Crown Copyright (C) 2012 Published by Elsevier B.V. All rights reserved.
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