Review
Engineering, Biomedical
Yinglin Xu, Haolin Chen, Yifen Fang, Jun Wu
Summary: Combining hydrogels with phototherapy shows great potential for wound healing, overcoming the shortcomings of traditional treatment methods. Phototherapy can effectively treat bacterial infections, while hydrogels provide a moist environment for wound healing.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Huiqun Hu, Danni Zhong, Wanlin Li, Xiuhui Lin, Jian He, Yuchao Sun, Yuan Wu, Minqi Shi, Xiaoyuan Chen, Feng Xu, Min Zhou
Summary: A multifunctional quorum sensing (QS) inhibitor based on a bioactive hydrogel system was developed to accelerate wound healing. The gel was found to synergistically inhibit the QS of bacteria, destroy biofilm formation, and promote wound healing by releasing specific substances and generating reactive oxygen species.
Article
Chemistry, Multidisciplinary
Meiyu Shao, Yaqian Fan, Kai Zhang, Yang Hu, Fu-Jian Xu
Summary: A new bifunctional nanosystem (HPT-RP) was developed for the treatment of infected wounds, with high antibacterial and gene delivery capabilities. By conjugating photosensitizers and bacterium/cell-affinity phenylboronic acid onto hyper branched polyaminoglycosides, HPT-RP showed great potential in combating infections and promoting gene transfection.
Article
Chemistry, Multidisciplinary
Kangkang Zha, Wenqian Zhang, Weixian Hu, Meijun Tan, Shengming Zhang, Yongsheng Yu, Shuangquan Gou, Pengzhen Bu, Bikun Zhou, Yanan Zou, Yuan Xiong, Bobin Mi, Guohui Liu, Qian Feng, Kaiyong Cai
Summary: A bilayered gelatin/acryloyl & beta;-cyclodextrin hydrogel loaded with humic acids and astragaloside IV in the lower layer and verteporfin in the upper layer was developed to treat bacteria-infected cutaneous wounds. The hydrogel alleviates oxidative stress, promotes M2 macrophage polarization and angiogenesis during the inflammation and early proliferation phases, and inhibits excessive vessel growth during the late proliferation and remodeling phases.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Jiaying Li, Shuxuan Zhang, Chang He, Jue Ling
Summary: In this study, a silk fibroin-based electrospun fiber composite film was successfully fabricated, demonstrating good mechanical properties and hemocompatibility. The material was capable of generating ROS under near infrared irradiation, effectively killing Staphylococcus aureus and promoting wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Nanoscience & Nanotechnology
Wenshang Zhang, Bingjie Wang, Guangli Xiang, Tianze Jiang, Xia Zhao
Summary: To enhance the healing of infected wounds without using antibiotics, a new strategy combining zinc-metal-organic framework (MOF) with photodynamic therapy (PDT) was developed. The strategy involved using a Chlorin e6 (Ce6)-loaded zinc-MOF hydrogel (Ce6@MOF-Gel) to release Ce6 in an acid-responsive manner, improving antibacterial effects and promoting wound healing. The Ce6@MOF-Gel showed enhanced stability, solubility, and photodynamic properties of Ce6, reducing inflammation and facilitating collagen deposition and re-epithelialization for accelerated healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Xiaoxuan Tang, Xiaoli Chen, Siming Zhang, Xinyi Gu, Ronghua Wu, Tingting Huang, Zhihao Zhou, Cheng Sun, Jue Ling, Mei Liu, Yumin Yang
Summary: A silk-based hydrogel system has been developed for improved cancer therapy and enhanced wound healing, showing promising results in suppressing tumor recurrence and promoting tissue regeneration.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Youzhun Fan, Zhengao Wang, Weizhou Ren, Guangyu Liu, Jun Xing, Taizhong Xiao, Wei Li, Yongjin Li, Peng Yu, Chengyun Ning, Zhiguo Song
Summary: A core-shell structured nanocomposite, consisting of polypyrrole (PPy) nanosheets synthesized in the restricted area of layered bismuth oxychloride (BiOCl) nanosheets, demonstrates excellent photothermal and photodynamic synergistic antibacterial activity under near-infrared (NIR) light irradiation. The atomic-level interface contact and bonding between PPy and BiOCl improve the light-to-heat conversion capabilities of PPy and enhance the transmission of photogenerated charge carriers. These nanocomposites exhibit deep tissue penetration, good biocompatibility, and accelerated wound healing through antimicrobial activity and skin repair function.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
M. C. Linju, M. R. Rekha
Summary: The present study developed a L-proline conjugated chitosan scaffold for wound healing. The scaffold was characterized by various tests and showed no cytotoxicity. In vitro experiments demonstrated that the modified scaffold promoted wound closure and collagen deposition. These findings suggest that the L-proline conjugated scaffold has potential as a wound dressing to improve wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Katieli da Silva Souza Campanholi, Ranulfo Combuca da Silva Jr, Renato Sonchini Goncalves, Mariana Carla de Oliveira, Magali Soares dos Santos Pozza, Angela Tiago Leite, Leandro Herculano da Silva, Luis Carlos Malacarne, Marcos Luciano Bruschi, Leandro Dalcin Castilha, Tatiana Carlesso dos Santos, Wilker Caetano
Summary: Chronic wound healing is a significant financial burden on healthcare systems, and using natural products as alternative therapy can reduce costs and maintain effectiveness. A study developed phytotherapeutic gels for use in photodynamic therapy, which showed significant antibiotic potential and promising results in animal experiments, making them a viable alternative for future pharmaceutical applications.
Article
Nanoscience & Nanotechnology
Aurelie Francois, Luca Dirheimer, Alicia Chateau, Henri-Pierre Lassalle, Ilya Yakavets, Lina Bezdetnaya
Summary: The study aimed to develop a 3D human heterotypic model to study the interactions between immune cells and cancer cells, as well as investigate the behavior of Foslip (R) in a macrophage-enriched 3D model. The results showed that the microenvironment could significantly modulate photo-induced cell death in the context of photodynamic therapy with Foslip (R).
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Engineering, Biomedical
Haoyu Chen, Lijuan Wu, Tianyi Wang, Fenglan Zhang, Junyao Song, Jun Fu, Xiaoying Kong, Jinsheng Shi
Summary: Antibiotics have shown limited effectiveness in destroying biofilms and lead to the emergence of antibiotic-resistant bacteria and chronic infections. Photodynamic therapy (PDT) and photothermal therapy (PTT) have emerged as potential alternatives to antibiotics by effectively activating the immune system and promoting wound tissue proliferation. However, there is still debate on whether the success of PDT/PTT in antimicrobial and wound healing depends solely on the cytotoxic effects or also on host immune system activation. This study investigates the dependence of PDT/PTT-induced microbial apoptosis and wound healing on immune activation and macrophage phenotype transformation and highlights the significant role of macrophage phenotype transformation in improving wound healing.
ACTA BIOMATERIALIA
(2023)
Article
Biotechnology & Applied Microbiology
Solmaz Saghebasl, Hassan Amini, Abbas Nobakht, Sanya Haiaty, Hesam Saghaei Bagheri, Parisa Hasanpour, Morteza Milani, Sepideh Saghati, Ozra Naturi, Mehrdad Farhadi, Reza Rahbarghazi
Summary: This study investigated a nanofibrous matrix for promoting wound healing, which showed good cytocompatibility, antibacterial activity, and enhanced healing potential. The addition of an antibacterial agent and a drug release system improved the therapeutic effect of the matrix.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Yongping Liang, Jiahui He, Baolin Guo
Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.
Article
Nanoscience & Nanotechnology
Nayanika Chakraborty, Diksha Jha, Vijay Pal Singh, Pradeep Kumar, Navin Kumar Verma, Hemant Kumar Gautam, Indrajit Roy
Summary: This article presents the preparation and antibacterial efficacy of chitosan-coated Prussian blue nanoparticles loaded with the photosensitizer fluorescein isothiocyanate-dextran (CHPB-FD). The nanoparticles effectively eradicate drug-resistant bacteria and promote wound healing in both in vitro and in vivo experiments. The presence of white light further enhances the antibacterial efficacy of CHPB-FD nanoparticles.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Oncology
T. Sorin, J. P. Fyad, E. Delay, P. Rouanet, F. Rimareix, J. L. Houpeau, J. M. Classe, I. Garrido, C. Tunon De Lara, J. Dauplat, C. Bendavid, G. Houvenaeghel, K. B. Clough, I. Sarfati, N. Leymarie, M. Trudel, J. Salleron, F. Guillemin, G. Oldrini, M. Brix, G. Dolivet, E. Simon, J. L. Verhaeghe, F. Marchal
Article
Obstetrics & Gynecology
S. Yaribakht, F. Guillemin, V. Harter, C. Malartic, F. Marchal
GYNECOLOGIE OBSTETRIQUE & FERTILITE
(2015)
Review
Oncology
Jean-Louis Houpeau, Marie-Pierre Chauvet, Francois Guillemin, Cecile Bendavid-Athias, Helene Charitansky, Andrew Kramar, Sylvia Giard
JOURNAL OF SURGICAL ONCOLOGY
(2016)
Editorial Material
Oncology
F. Guillemin
Editorial Material
Oncology
F. Guillemin
Editorial Material
Oncology
F. Guillemin, M. Schneider
Article
Computer Science, Artificial Intelligence
Sharib Ali, Christian Daul, Ernest Galbrun, Francois Guillemin, Walter Blondel
PATTERN RECOGNITION
(2016)
Article
Oncology
Alexandre Doussot, David Fuks, Jean-Marc Regimbeau, Olivier Farges, Antonio Sa-Cunha, Francois-Rene Pruvot, Rene Adam, Francis Navarro, Daniel Azoulay, Bruno Heyd, Patrick Pessaux, Cyril Cosse, Delphine Lignier, Julien Barbieux, Emilie Lermite, Antoine Hamy, Francois Mauvais, Christophe Laurent, Laurence Chiche, Irchid Al Naasan, Jacques Belghiti, Chady Salloum, Philippe Compagnon, Chetana Lim, Mohammed Sbai Idrissi, Frederic Martin, Jerome Atger, Emmanuel Boleslawski, Jacques Baulieux, Benjamin Darnis, Jean Yves Mabrut, Vahan Kepenekian, Julie Perinel, Mustapha Adham, Olivier Glehen, Michel Rivoire, Jean Hardwigsen, Anais Palen, Emilie Gregoire, Yves Patrice Le Treut, Jean Robert Delpero, Olivier Turrini, Astrid Herrero, Fabrizio Panaro, Ahmet Ayav, Laurent Bresler, Philippe Rauch, Francois Guillemin, Frederic Marchal, Jean Gugenheim, Antonio Iannelli, Stephane Benoist, Antoine Brouquet, Marc Pocard, Rea Lo Dico, Brice Gayet, Olivier Scatton, Olivier Soubrane, Jean-Christophe Vaillant, Tullio Piardi, Daniele Sommacale, Reza Kianmanesh, Michel Comy, Philippe Bachellier, Elie Oussoultzoglou, Pietro Addeo, Dimitrios Ntourakis, Didier Mutter, Jacques Marescaux, Loic Raoux, Bertrand Suc, Fabrice Muscari, Georges Elhomsy, Maximiliano Gelli, Denis Castaing, Gabriella Pittau, Oriana Ciacio, Eric Vibert, Daniel Cherqui, Dominique Elias, Diane Goere, Fabrizio Vittadello
Article
Optics
Marine Amouroux, Julia Salleron, Cecile Huin-Schohn, Sharib Ali, Stephane Berthaud, Philippe Rizo, Sylvain Schneider, Christine Vever-Bizet, Genevieve Bourg-Heckly, Francois Guillemin, Patricia Le Coupanec, Ernest Galbrun, Joel Daouk, Christian Daul, Walter Blondel, Pascal Eschwege
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION
(2019)
Editorial Material
Medicine, Research & Experimental
Francois Guillemin
M S-MEDECINE SCIENCES
(2020)
Article
Oncology
Clement Dabiri, Judicael Hotton, Karl Wehbe, Hugo Gornes, Christian Garbar, Francois Guillemin, Vivien Ceccato
Summary: The Grisotti technique is an easily reproducible procedure without major complications, allowing for satisfactory central lumpectomy, correction of central glandular defect, and reconstruction of a new areola. Postoperative satisfaction rates for both patients and surgeons are high, especially in the appearance of the breasts after radiotherapy.
Article
Business, Finance
Francois Guillemin
RESEARCH IN INTERNATIONAL BUSINESS AND FINANCE
(2020)
Article
Business, Finance
Francois Guillemin, Maria Semenova
Article
Oncology
F. Guillemin, F. Marchal, M. Geffroy
Article
Economics
Herve Alexandre, Francois Guillemin, Catherine Refait-Alexandre
