Review
Oncology
Nabil F. F. Saba, Saagar Pamulapati, Bhamini Patel, Mayur Mody, Primoz Strojan, Robert Takes, Antti A. A. Maekitie, Oded Cohen, Pia Pace-Asciak, Jan B. B. Vermorken, Carol Bradford, Arlene Forastiere, Yong Teng, Andreas Wieland, Alfio Ferlito
Summary: Head and neck cancer (HNC) is a common malignancy, with oropharyngeal squamous cell carcinoma (OPSCC) being the majority of cases. The incidence of HPV-related OPSCC, caused by human papillomavirus (HPV), is increasing rapidly. Immunotherapy has shown promise in managing recurrent and metastatic HNC, leading to interest in its application for HPV-related OPSCC. This review focuses on the immune characteristics and potential for immunotherapy in this virus-driven cancer.
Article
Materials Science, Multidisciplinary
Miaochen Wang, Fan Li, Tingwei Lu, Ruoyi Wu, Shengbing Yang, Wantao Chen
Summary: This study aimed to develop a drug carrier, ZIF-8@ssPDA, for head and neck cancer treatment. The ZIF-8 structure efficiently loaded the photosensitizer Ce6, while the ssPDA structure could rupture in response to the tumor microenvironment, consuming glutathione and inactivating GPX4 to exert an anti-cancer effect through ferroptosis. Furthermore, the Ce6@ZIF-8 structure could release Ce6 in the acidic tumor microenvironment, generating singlet oxygen under near-infrared laser excitation for photodynamic therapy.
MATERIALS & DESIGN
(2022)
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Pharmacology & Pharmacy
Chia-Hsien Yeh, Juan Chen, Gang Zheng, Leaf Huang, Yih-Chih Hsu
Summary: This study combined novel nanoparticle-based photodynamic therapy and gene therapy to effectively treat head and neck cancer. Results showed significant tumor volume reduction and effective inhibition of EGFR expression with the combined therapy, suggesting potential clinical applications in the future.
Article
Nutrition & Dietetics
Zalina Abu Zaid, May Kay Neoh, Zulfitri Azuan Mat Daud, Nor Baizura Md Yusop, Zuriati Ibrahim, Zuwariah Abdul Rahman, Norshariza Jamhuri, Aishah Zafirah Abdul Azim
Summary: This study aimed to evaluate the weight loss during and post-treatment among head and neck cancer patients. The study found that the average weight loss during treatment was 7.4%, and post-treatment weight loss was 2.1%. One month after treatment completion, patients showed significant improvements in nutrition status and muscle mass, but there was a decrease in oral nutritional supplement intake.
Article
Multidisciplinary Sciences
Xianghua Ye, Dazhou Guo, Jia Ge, Senxiang Yan, Yi Xin, Yuchen Song, Yongheng Yan, Bing-shen Huang, Tsung-Min Hung, Zhuotun Zhu, Ling Peng, Yanping Ren, Rui Liu, Gong Zhang, Mengyuan Mao, Xiaohua Chen, Zhongjie Lu, Wenxiang Li, Yuzhen Chen, Lingyun Huang, Jing Xiao, Adam P. Harrison, Le Lu, Chien-Yu Lin, Dakai Jin, Tsung-Ying Ho
Summary: In this study, we propose an automated and highly effective stratified OAR segmentation system using deep learning (SOARS) that precisely delineates a comprehensive set of 42 H&N OARs. The results show that SOARS consistently outperforms other state-of-the-art methods in evaluations across different institutions, reducing workload significantly. Moreover, the segmentation and dosimetric accuracy are within or smaller than the inter-user variation.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Sarah Weppler, Harvey Quon, Colleen Schinkel, Adam Yarschenko, Lisa Barbera, Nabhya Harjai, Wendy Smith
Summary: The study aimed to reduce toxicity incidence among head and neck cancer patients through adaptive radiation therapy (ART). Results showed a strong association between patient-reported dysphagia symptoms and the delivered dose to the pharyngeal constrictor.
FRONTIERS IN ONCOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Mina Guirguis, Chanda Bhandari, Junjie Li, Menitte Eroy, Sushant Prajapati, Ryan Margolis, Navadeep Shrivastava, Kenneth Hoyt, Tayyaba Hasan, Girgis Obaid
Summary: This study evaluates the impact of different chemical properties and conformations on the functionality of NIR-activable liposomes, showing that membrane composition is crucial for their effectiveness as tumor-selective PDT platforms. Different lipid conformations exhibit significant differences in photodynamic generation, phototriggered release, and cell phototoxicity.
Article
Pharmacology & Pharmacy
Laureline Lamy, Manon Francois, Lina Bezdetnaya, Ilya Yakavets
Summary: Photodynamic therapy is a multi-stage treatment that destroys cancerous and precancerous cells through light activation of a drug. The role of drug penetration in therapy has been unexplored until recently. This study demonstrates that nanosponges based on hypercrosslinked beta-cyclodextrin polymer can increase drug penetration in multicellular spheroids, providing a potential candidate for effective PDT.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Wojciech Domka, Dorota Bartusik-Aebisher, Wiktoria Mytych, Klaudia Dynarowicz, David Aebisher
Summary: Head-neck cancers, particularly squamous cell carcinoma, have a high incidence rate worldwide and pose challenges in treatment. Photodynamic therapy (PDT) shows promise as a therapeutic approach for head, neck, and brain diseases, as it can induce apoptosis and necrosis in tumor cells through the generation of singlet oxygen or reactive oxygen radicals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychology, Multidisciplinary
Melissa Henry, Justine G. Albert, Saul Frenkiel, Michael Hier, Anthony Zeitouni, Karen Kost, Alex Mlynarek, Martin Black, Christina MacDonald, Keith Richardson, Marco Mascarella, Gregoire B. Morand, Gabrielle Chartier, Nader Sadeghi, Christopher Lo, Zeev Rosberger
Summary: This longitudinal study identifies patients who are more susceptible to experience body image disturbance following head and neck cancer. It emphasizes the importance of clinicians paying attention to body image concerns upon cancer diagnosis, physical symptom burden, and neuroticism, and suggests targeting these factors in future preventive interventions.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Oncology
Simon Boeke, David Monnich, Janita E. van Timmeren, Panagiotis Balermpas
Summary: In recent years, the development of new hybrid machines consisting of an MRI and a linear accelerator, MRgRT has revolutionized the field of radiotherapy, especially for HNC patients. However, its application is still in its infancy, and future challenges in terms of new technical, clinical, and logistic aspects need to be addressed.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Qi Zhan, Chenzhou Wu, Haoran Ding, Yingzhao Huang, Zhou Jiang, Nailin Liao, Kunyu Wang, Yi Li
Summary: This bibliometric analysis provides a visual analysis of photodynamic therapy in head and neck cancer, revealing that the current research in this field mainly focuses on the study of photosensitizers, particularly nanomaterials and targeted therapies.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Oncology
Won Jin Cho, David Kessel, Joseph Rakowski, Brian Loughery, Abdo J. Najy, Tri Pham, Seongho Kim, Yong Tae Kwon, Ikuko Kato, Harold E. Kim, Hyeong-Reh C. Kim
Summary: This study aims to understand the molecular basis of radiotherapy resistance in advanced head and neck squamous cell carcinoma (HNSCC) and found that autophagy pathway is upregulated in therapy-resistant HNSCC. Additionally, photodynamic therapy (PDT) directed at the endoplasmic reticulum (ER)/mitochondria can promote radiotoxicity by inducing programmed cell death. Furthermore, the study suggests that ER/mitochondria-targeted PDT can serve as a radiosensitizer in intrinsically radioresistant HNSCC with increased autophagic flux.
Article
Oncology
Linda Sharp, Laura-Jayne Watson, Liya Lu, Sam Harding, Katrina Hurley, Steve J. Thomas, Joanne M. Patterson
Summary: This study investigated cancer-related fatigue (CRF) in head and neck cancer patients using data from the Head and Neck 5000 prospective clinical cohort. The findings revealed a high prevalence of CRF, indicating the need for additional interventions and supports for affected patients.
Article
Dermatology
Waseem Jerjes, Zaid Hamdoon, Colin Hopper
SKIN RESEARCH AND TECHNOLOGY
(2020)
Article
Dermatology
Zaid Hamdoon, Waseem Jerjes, Colin Hopper
SKIN RESEARCH AND TECHNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Waseem Jerjes, Zaid Hamdoon, Kristian Berg, Anders Hogset, Colin Hopper
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2020)
Article
Oncology
Waseem Jerjes, Zaid Hamdoon, Aamr A. Yousif, Natheer H. Al-Rawi, Cohn Hopper
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2019)
Review
Medicine, General & Internal
Waseem Jerjes, Theodossis A. Theodossiou, Henry Hirschberg, Anders Hogset, Anette Weyergang, Pal Kristian Selbo, Zaid Hamdoon, Colin Hopper, Kristian Berg
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Multidisciplinary Sciences
Zaid Hamdoon, Nazhat Mahmood, Wael Talaat, Abier Abdul Sattar, Karrar Naeim, Ahmed Qais, Waad Kheder, Waseem Jerjes
Summary: Surgical removal of displaced dental implants from the maxillary sinus requires appropriate surgical approach based on the location of the implant and the surrounding vital anatomical structures. Different levels of surgical challenges may be encountered during the removal, with more difficulties when dealing with implants located near the floor of the orbit.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Waseem Jerjes, Zaid Hamdoon, Dara Rashed, Abier Abdul Sattar, Colin Hopper
Summary: This study used in vivo optical coherence tomography (OCT) technology to describe the morphologic features of normal and pathologic skin conditions. It found qualitative differences in OCT image features of skin with varying degrees of pathology, and between normal and pathological skin. In vivo OCT shows promise as a useful optical diagnostic technique in diagnosing skin pathologies, with impressive sensitivity and specificity based on this small sample size.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Zaid Hamdoon, Wael Talaat, Ahmed Aziz, Abier Abdul Sattar, Waad Kheder, Waseem Jerjes
Summary: Root damage after dental implant surgery varies in type and severity, with periodic clinical and radiographical examinations necessary to monitor root resorption, implant integration, and to rule out pulp necrosis.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2021)
Article
Oncology
Waseem Jerjes, Zaid Hamdoon, Kristian Berg, Anders Hogset, Colin Hopper
Summary: This case demonstrates the potential of PCI as a clinically relevant technique in the treatment of squamous cell cancer, avoiding the need for radical intervention.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Oncology
Zaid Hamdoon, Waseem Jerjes, Dara Rashed, Sausan Kawas, Abier abdul Sattar, Rani Samsudin, Colin Hopper
Summary: This study demonstrated the technical feasibility of using OCT to map tumor margins and monitor skin changes post-PDT, as well as optimize treatment efficacy. OCT images showed distinct microstructural differences between different skin tissues, providing valuable information for histological analysis of skin lesions.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Review
Medicine, General & Internal
Daniele Ramsay, Harvey Stevenson, Waseem Jerjes
Summary: Head and neck cancers, largely squamous cell carcinomas, are commonly treated with surgical intervention, chemotherapy, and radiotherapy which may cause damage to healthy tissues. Photodynamic therapy has been shown to be effective in treating head and neck malignancies and vascular tumors without causing harm to underlying structures. Recent studies have demonstrated the efficacy of photodynamic therapy compared to traditional treatments with minimal adverse effects.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Waseem Jerjes, Harvey Stevenson, Daniele Ramsay, Zaid Hamdoon, Colin Hopper
Summary: Healthcare related quality of life is defined as the impact one's health and well-being has on physical, mental, spiritual, and social functions. Photodynamic therapy (PDT) is increasingly used for head and neck cancer treatment, with mTHPC-PDT showing improvement in patients' QoL. Pain was the main reported issue post-treatment, but significant improvements in various aspects of life were observed in the weeks following PDT.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Letter
Primary Health Care
Waseem Jerjes
EDUCATION FOR PRIMARY CARE
(2023)
Letter
Engineering, Biomedical
Waseem Jerjes
LASERS IN MEDICAL SCIENCE
(2023)
Review
Dentistry, Oral Surgery & Medicine
Sausan Al Kawas, Natheer Al-Rawi, Wael Talaat, Zaid Hamdoon, Basheer Salman, Saad Al Bayatti, Waseem Jerjes, A. B. Rani Samsudin