Article
Polymer Science
Abdechakour Elkihel, Charlotte Vernisse, Tan-Sothea Ouk, Romain Lucas-Roper, Vincent Chaleix, Vincent Sol
Summary: This study presents a synthesis method for light-triggered antibacterial hydrogels based on xylan chains chemically bound to meso-tetra(4-carboxyphenyl)porphyrin (TCPP). TCPP not only acts as an efficient photosensitizer against Gram-positive bacteria, but also serves as a cross-linking agent for the hydrogels. The hydrogels were characterized using infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM), and swelling and rheological tests. Under visible light irradiation, the hydrogels showed interesting antimicrobial activity against Staphylococcus aureus and Bacillus cereus, suggesting their potential for the treatment of skin bacterial infections through photodynamic antimicrobial chemotherapy (PACT).
Article
Oncology
Ticiane da Rosa Pinheiro, Carolina Gonzalez Urquhart, Thiago Vargas Acunha, Roberto Christ Vianna Santos, Bernardo Almeida Iglesias
Summary: This manuscript presents the first report on antimicrobial photo-inactivation in vitro using tetra-cationic porphyrins with peripheral platinum(II) bipyridyl complexes against Gram-positive bacteria. Two isomeric tetracationic porphyrins (3TPyP and 4TPyP) were tested against clinically important bacterial species. The antimicrobial activity assays were performed at specific photosensitizer (PS) concentrations under dark and white-light LED irradiation conditions for 120 min.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Sara R. D. Gamelas, Catia Vieira, Maria Bartolomeu, Maria A. F. Faustino, Joao P. C. Tome, Augusto C. Tome, Adelaide Almeida, Leandro M. O. Lourenco
Summary: This study evaluated the PDI effect of novel SiPcs photosensitizers with ammonium cationic units on Escherichia coli and Staphylococcus aureus. The results demonstrated high photodynamic efficiency of these PSs against both Gram-negative and Gram-positive bacteria.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Article
Chemistry, Applied
L. Collen Makola, Sithi Mgidlana, Tebello Nyokong
Summary: This study focuses on the synthesis, characterization, and application of indium porphyrins linked to silver core-shell magnetic nanoparticles for in vitro photodynamic antimicrobial chemotherapy. The research compares the photophysicochemical properties and activities of different indium porphyrin complexes based on their structure and charges, and examines the hydrophilic and hydrophobic characteristics of the amphiphilic porphyrins by comparing different alkyl halides quaternizing agents. Furthermore, the porphyrin complexes are linked to magnetic nanoparticles to enhance antimicrobial synergy and allow for recovery after use, resulting in high Log reduction values.
Article
Multidisciplinary Sciences
Aliya Fazal, Sajida Ara, Muhammad Tayab Ishaq, Kalsoom Sughra
Summary: The study focuses on the green synthesis of copper oxide nanoparticles using vegetable peels, with an ecofriendly approach and low fabrication temperature. It also explores the antibacterial efficacy of the nanoparticles, showing a more significant biocidal effect on Gram-negative bacteria compared to Gram-positive bacteria. The research highlights the potential of utilizing biowaste for the production of useful products.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2022)
Article
Microbiology
Ryan Waite, Candace T. Adams, David R. Chisholm, C. H. Cole Sims, Joshua G. Hughes, Eva Dias, Emily A. White, Kathryn Welsby, Stanley W. Botchway, Andrew Whiting, Gary J. Sharples, Carrie A. Ambler
Summary: The emergence of antibiotic resistance poses a growing threat to human health, and the search for alternatives is urgent. A new fluorescent photoactivatable diarylacetylene has been discovered, showing a preference for eliminating Gram-positive bacteria. Experimental evidence suggests that the outer surface of Gram-negative bacteria and oxidative damage repair pathways affect the sensitivity and antibacterial activity of this compound. This new finding holds promise for the treatment of skin infections.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Sarabjot Kaur, Rushikesh Tambat, Vikas Pathania, Hemraj Nandanwar, Sanjeev Soni
Summary: This study demonstrates that photo-thermally enhanced triangular silver nanoplates have strong antimicrobial efficacy and can eradicate various pathogens in a short period of time, which is significant for a wide range of antibacterial and antifungal applications.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Chemistry, Applied
Le Wang, Xiaohong Pan, Shuzhi Tang, Yaqi Wang, Haixing Shi, Huanhuan Wang, Wenzhen Liu, Zhuo Chen
Summary: The skin microbiota is an important component of the skin barrier and plays a role in the stability of the barrier function and the development of skin diseases. Researchers have developed a negatively charged photosensitizer TPA-3NBA that can selectively stain and effectively kill Gram-positive cocci, allowing for quick identification of bacterial infections.
Article
Oncology
Grazille Guidolin Rossi, Kevim Bordignon Guterres, Kelly Schneider Moreira, Thiago Augusto Lima Burgo, Marli Matiko Anraku de Campos, Bernardo Almeida Iglesias
Summary: Antimicrobial photodynamic therapy has shown potential in treating noninvasive infections, with positively charged porphyrins, especially the 3-PdTPyP derivative, demonstrating the most efficient bactericidal activity against fast-growing mycobacterial strains.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Chemistry, Medicinal
Rubina Chowdhary, Mohamad Mosa Mubarak, Hadiya A. A. Kantroo, Junaid ur Rahim, Abbass Malik, Aminur Rahman Sarkar, Gulnaz Bashir, Zahoor Ahmad, Rajkishor Rai
Summary: The development of new antibiotics is urgently needed due to the increasing resistance against conventional antibiotics. Antimicrobial peptides have potential as small antibiotic molecules. The stability of peptides is a concern, but introducing beta-amino acids into peptide sequences can help prevent degradation. In this study, the synthesis, characterization, and antimicrobial activity of ultra-short cationic beta-peptides (P1-P4) were described. P3 exhibited the most potent antimicrobial activity against various bacteria and showed time- and concentration-dependent bactericidal activities. P3 also disrupted the cell membrane of E. coli and had inhibitory effects on biofilm production. Additionally, P3 showed synergy with certain antibiotics and high cell viability in different cell lines.
ACS INFECTIOUS DISEASES
(2023)
Article
Agriculture, Multidisciplinary
Hongyan Yang, Lan Wang, Libo Yuan, Heng Du, Boyuan Pan, Kui Lu
Summary: In this study, a series of hybrid peptides were designed by connecting an antimicrobial peptide Ce(1-8) with a lipopolysaccharide-targeting peptide Lf(28-34) via different linkers. The results showed that the linkers played a crucial role in the antimicrobial activity of the hybrid peptides against Gram-negative bacteria. Among these hybrid peptides, peptide CL5 with a dipeptide rigid linker exhibited excellent activity and selectivity against Gram-negative bacteria. It was found that the interaction of the peptides with LPS was crucial for their antimicrobial activity. Mechanistic studies revealed that peptide CL5 disrupted the integrity of bacterial membranes, leading to the death of Gram-negative bacterial cells. This study highlights the importance of linker selection in the design of hybrid peptides and provides a foundation for the development of antimicrobial peptides.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Microbiology
Ana Silva-Dias, Blanca Perez-Viso, Ines Martins-Oliveira, Rosario Gomes, Acacio G. Rodrigues, Rafael Canton, Cidalia Pina-Vaz
Summary: The FASTinov flow cytometry kits were assessed in two locations for direct evaluation, demonstrating high sensitivity for positive blood cultures and the ability to provide rapid and personalized antibiotic management.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Guobin Qi, Yufu Tang, Leilei Shi, Jiahao Zhuang, Xianglong Liu, Bin Liu
Summary: This study discovers a new antimicrobial agent, a water-soluble porphyrin-cored hyperbranched conjugated polyelectrolyte (PorHP), which exhibits high photodynamic bactericidal activity against Gram-negative bacteria and low cytotoxicity toward mammalian cells.
Article
Chemistry, Medicinal
Rongcui Zhong, Haizhou Li, Hongxia Li, Shanfang Fang, Jiayong Liu, Yongzhi Chen, Shouping Liu, Shuimu Lin
Summary: Compound 25, a newly designed amphiphilic coumarin derivative, showed potent antibacterial activity against Gram-positive bacteria, including MRSA, with low hemolytic activity and toxicity. It can quickly kill bacteria by disrupting cell membranes and demonstrated excellent efficacy in a murine corneal infection caused by Staphylococcus aureus. This suggests that compound 25 has great potential as a potent antimicrobial agent for treating drug-resistant Gram-positive bacterial infections.
ACS INFECTIOUS DISEASES
(2021)
Article
Immunology
Marlane Geribone Seeger, Bernardo Almeida Iglesias, Fernanda Silveira Flores Vogel, Juliana Felipetto Cargnelutti
Summary: Infectious bovine keratoconjunctivitis (IBK) is a significant eye disease in ruminants worldwide. The bacteria Moraxella bovis and Moraxella bovoculi, frequently isolated from affected animals, can form biofilm. The use of antimicrobials to treat IBK has limited success, and photodynamic therapy using porphyrins is considered as an alternative method to eliminate microorganisms and biofilms. In this study, the antibacterial activity of a zinc(II) metalloporphyrin (ZnTMeP) against M. bovis and M. bovoculi biofilms was evaluated. The results showed that ZnTMeP reduced biofilm formation and partially destroyed consolidated biofilms of M. bovoculi.
MICROBIAL PATHOGENESIS
(2023)
Article
Chemistry, Inorganic & Nuclear
Meliha Aliosman, Ivan Angelov, Yavor Mitrev, Ivan Iliev, Mahmut Durmus, Vanya Mantareva
Article
Biochemistry & Molecular Biology
Vanya Mantareva, Cem Gol, Vesselin Kussovski, Mahmut Durmus, Ivan Angelov
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
(2019)
Article
Chemistry, Multidisciplinary
Oxana Semyachkina-Glushkovskaya, Ekaterina Borisova, Vanya Mantareva, Ivan Angelov, Ivelina Eneva, Andrey Terskov, Aysel Mamedova, Alexander Shirokov, Alexander Khorovodov, Maria Klimova, Ilana Agranovich, Inna Blokhina, Nikita Lezhnev, Jurgen Kurths
APPLIED SCIENCES-BASEL
(2020)
Article
Chemistry, Multidisciplinary
Suneesh C. Karunakaran, Brian J. Cafferty, Kyan S. Jain, Gary B. Schuster, Nicholas Hud
Article
Chemistry, Physical
Meliha Syuleyman, Ivan Angelov, Yavor Mitrev, Mahmut Durmus, Vanya Mantareva
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Asem Alenaizan, Carlos H. Borca, Suneesh C. Karunakaran, Amy K. Kendall, Gerald Stubbs, Gary B. Schuster, C. David Sherrill, Nicholas Hud
Summary: Equimolar mixtures of TAP and CyCo6 self-assemble into gel-forming supramolecular polymers with unique molecular structures. The polymers exhibit different helical structures, suggesting a potential role as recognition units for nucleic acids before the emergence of RNA.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
David M. Fialho, Suneesh C. Karunakaran, Katherine W. Greeson, Isaac Martinez, Gary B. Schuster, Ramanarayanan Krishnamurthy, Nicholas Hud
Summary: The mechanism of how informational polymers formed on the early earth is still unknown. Research on depsipeptide nucleic acids (DepsiPNA) suggests that it could be a potential candidate for proto-RNA due to its attractive properties.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Gary B. Schuster, Brian J. Cafferty, Suneesh C. Karunakaran, Nicholas Hud
Summary: The hypothesis that RNA and DNA are products of chemical and biological evolution has led to the search for alternative nucleic acids in the emergence of life. Investigations have revealed ancestral nucleobases that self-assemble into hexameric rosettes in water, forming long, rigid supramolecular polymers. These structures provide robust solutions to the search for prebiotic synthesis of nucleic acids and offer insight into the principles that govern water-soluble supramolecular polymers.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Physical
Irem Kulu, Vanya Mantareva, Vesselin Kussovski, Ivan Angelov, Mahmut Durmus
Summary: Four novel tetra non-peripheral 2-hydroxypyridine substituted palladium (II) and nickel (II) phthalocyanines and their quaternized derivatives were synthesized and fully characterized. The quaternized phthalocyanines showed good solubility and singlet oxygen generation properties. The palladium (II) phthalocyanine complex demonstrated good uptake and inactivation capabilities towards Gram (+) Methicillin-resistant Staphylococcus aureus (MRSA) while the newly synthesized nickel (II) phthalocyanine lacked inactivation towards both bacterial strains.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Vanya N. Mantareva, Vesselin Kussovski, Petya Orozova, Lyudmila Dimitrova, Irem Kulu, Ivan Angelov, Mahmut Durmus, Hristo Najdenski
Summary: PhotoDynamic Therapy (PDT) is an effective strategy to combat antimicrobial multidrug resistance (AMR) in pathogenic bacteria. This study demonstrates the efficacy of new Pd(II)- and Zn(II)-phthalocyanine complexes in inactivating Gram-negative bacteria, independent of their antibiotic sensitivity.
Article
Biochemistry & Molecular Biology
Vanya Mantareva, Ivan Iliev, Inna Sulikovska, Mahmut Durmus, Ivan Angelov
Summary: Photodynamic therapy (PDT) is an effective cancer treatment with minimal side effects. In this study, zinc(II) phthalocyanines (3ZnPc and 4ZnPc) and hydroxycobalamin (Cbl) were tested on breast cancer cell lines, showing enhanced photocytotoxicity and reduced dark toxicity when Cbl was added to 3ZnPc. This suggests that the addition of Cbl can improve the efficiency of phthalocyanines for anticancer PDT applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Vanya Mantareva, Vesselin Kussovski, Petya Orozova, Ivan Angelov, Mahmut Durmus, Hristo Najdenski
Summary: Antimicrobial photodynamic therapy (aPDT) is a promising method to combat the multidrug resistance of pathogenic bacteria. This study evaluates the effectiveness of photodynamic inactivation using synthesized palladium phthalocyanines (PdPcs) on Gram-negative Flavobacterium hydatis strains. The results show significant photodynamic inactivation for both resistant and sensitive strains, indicating the potential of aPDT with phthalocyanines as an alternative to antibiotics in aquaculture. Furthermore, zinc phthalocyanine demonstrated optimal photocytotoxicity for inactivating the bacteria.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Sreejith Mangalath, Suneesh C. Karunakaran, Gary Newnam, Gary B. Schuster, Nicholas Hud
Summary: The goal of supramolecular chemistry is to create covalent polymers of precise composition and stereochemistry from complex mixtures through reversible assembly before covalent bond formation. By studying short oligomers of deoxyadenosine monophosphate and their assemblies with cyanuric acid, researchers demonstrate the power of this approach. The results show that this method allows for self-sorting of racemic monomers and covalent bond formation exclusively in homochiral assemblies.
CHEMICAL COMMUNICATIONS
(2021)
Proceedings Paper
Engineering, Electrical & Electronic
I Agranovich, Al Khorovodov, M. Kanevsky, Ts Genova, Al Gisbrecht, I Angelov, V Mantareva, N. Navolokin, O. Semyachkina-Glushkovskaya, E. Borisova
Summary: In this study, exogenous fluorescent markers such as phthalocyanine compounds were used for diagnosing gastrointestinal adenocarcinoma in laboratory animals. Significant fluorescence signals were observed from the neoplastic lesions, which allows for fluorescence discrimination and imaging of the investigated lesions, particularly useful for clinical applications.
XXI INTERNATIONAL CONFERENCE AND SCHOOL ON QUANTUM ELECTRONICS: LASER PHYSICS AND APPLICATIONS
(2021)
Proceedings Paper
Engineering, Biomedical
E. Borisova, Ts Genova, A. Yakimansky, V Mantareva, I Angelov, A. Gisbrecht, Al Khorovodov, I Agranovich, M. Klimova, O. Semyachkina-Glushkovskaya
SARATOV FALL MEETING 2019: OPTICAL AND NANO-TECHNOLOGIES FOR BIOLOGY AND MEDICINE,
(2020)