期刊
PHOTOCHEMISTRY AND PHOTOBIOLOGY
卷 86, 期 2, 页码 397-402出版社
WILEY
DOI: 10.1111/j.1751-1097.2009.00684.x
关键词
-
资金
- Malaysian Ministry of Science, Technology and Innovation (MOSTI)
- Cancer Research Initiatives Foundation (CARIF)
In this study, the photodynamic therapy (PDT) induced efficacy of a semi-synthesized analogue 151-hydroxypurpurin-7-lactone dimethyl ester or G2, in terms of chick chorioallantoic membrane blood vessel occlusion was evaluated in reference to verteporfin. Early formulation studies showed that G2 prepared in a system of cremophor EL 2.5% and ethanol 2.5% in saline was biocompatible up to 20 mu L volume of injection. Following injection, G2 accumulation peaked within the first minute and its extravasation from intra- to extra-vascular occurred somewhat slower as compared with verteporfin. In the PDT study, closure of capillaries and small neovessels was observed with 4 mu g per embryo of G2 and a light dose of 20 J cm-2 at a fluence rate of 40 mW cm-2 filtered at 400-440 nm-a result that may be considered optimum for the treatment of age-related macular degeneration (AMD). Also, partial occlusion of the large vessels was observed using the same dose of G2 and light-an effect which is desirable for cancer treatment. From this study, we conclude that G2 has the potential to be developed as a therapeutic agent for photodynamic treatment for AMD and cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据