Review
Endocrinology & Metabolism
Jeffrey B. Travers, Joyce G. Rohan, Ravi P. Sahu
Summary: PAF, a glycerophosphocholine lipid mediator, plays a crucial role in pathologic processes and can be transmitted through MVP to activate the PAF receptor and generate more PAF. Studying the PAF family of lipid mediators is essential for understanding the relationship among diverse cutaneous, cancerous, neurologic, and systemic pathologic processes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shuang Gao, Keke Guo, Yu Chen, Jungang Zhao, Rongrong Jing, Lusheng Wang, Xuenan Li, Zhenlin Hu, Nuo Xu, Xiaokun Li
Summary: KGF-2 can mitigate UVB-induced skin damage by inhibiting apoptosis, reducing oxidative stress, and preventing DNA damage and mitochondrial dysfunction through regulating the AhR/Nrf2 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Jordi Roca-Ferrer, Maria Perez-Gonzalez, Isam Alobid, Valeria Tubita, Mireya Fuentes, Marina Bantula, Rosa Munoz-Cano, Antonio Valero, Inaki Izquierdo, Joaquim Mullol, Jacopo Galli
Summary: This study aimed to assess the role of the Platelet-Activating Factor (PAF)/receptor (PAFR) system in chronic rhinosinusitis with nasal polyps (CRSwNP). The study found that PAFR protein was expressed in nasal mucosa and nasal polyps, and Lyso-PAF concentrations were higher in nasal polyps of asthmatic patients. These findings suggest that the PAF/PAFR system may play a role in CRSwNP pathogenesis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Kohei Kawasaki, Atsushi Kasamatsu, Toshiaki Ando, Tomoaki Saito, Takafumi Nobuchi, Ryunosuke Nozaki, Manabu Iyoda, Katsuhiro Uzawa
Summary: PAFR is a therapeutic target for modulating CDDP sensitivity in oral squamous cell carcinoma (OSCC) cells. The specific inhibitor of PAFR, ginkgolide B (GB), can enhance chemosensitivity to CDDP and promote apoptosis. GB may serve as a novel drug to enhance combination chemotherapy with CDDP for OSCC patients.
Review
Nutrition & Dietetics
Rajendran Harishkumar, Sakshi Hans, Janelle E. Stanton, Andreas M. Grabrucker, Ronan Lordan, Ioannis Zabetakis
Summary: This review discusses the role of platelet-activating factor (PAF) and its receptor in inflammatory diseases and atherosclerotic cardiovascular diseases, with a focus on how inhibiting PAF-R can reduce cardiovascular disease risk. Research suggests that dietary factors may modulate PAF metabolism and PAF-R function to regulate disease development.
Article
Biochemistry & Molecular Biology
Lone A. Nazir, Malik A. Tanveer, Sheikh A. Umar, Sharma Love, Gupta Divya, Sheikh A. Tasduq
Summary: The study investigated the therapeutic potential of the natural agent Trigonelline (TG) against UV-B radiation induced skin photodamage, showing that TG alleviates various harmful effects caused by UV-B radiation on human skin cells and Balb/c skin mice. TG treatment significantly prevents oxidative stress, inflammation, collagen degradation, and apoptosis, potentially through modulation of the ROS-MAPKs-NF-kappa B axis.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kavita Vats, Oleg Kruglov, Alicia Mizes, Svetlana N. Samovich, Andrew A. Amoscato, Vladimir A. Tyurin, Yulia Y. Tyurina, Valerian E. Kagan, Yuri L. Bunimovich
Summary: This research indicates that UVB-induced skin inflammation is primarily mediated by ferroptosis in epidermal keratinocytes, rather than apoptosis or pyroptosis. Inhibition of ferroptosis can prevent inflammation and has implications for the prevention and treatment of various skin diseases induced by UVB.
Article
Biochemistry & Molecular Biology
Ewan Eadie, Paul O'Mahoney, Louise Finlayson, Isla Rose Mary Barnard, Sally Helen Ibbotson, Kenneth Wood
Summary: This study compares the DNA damage caused by far-UVC and sunlight exposure in different climatic conditions, revealing that sunlight exposure poses greater risk for DNA damage compared to far-UVC. It should be noted that the photochemical reactions and consequences of high-energy far-UVC photons absorbed by the stratum corneum remain unknown.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tuba M. Ansary, Md. Razib Hossain, Koji Kamiya, Mayumi Komine, Mamitaro Ohtsuki
Summary: Skin is the largest and most complex organ in the human body, composed of different types of cells. Various environmental stressors, such as UVR, can accelerate skin aging by stimulating inflammatory molecules. UVR-induced skin aging is characterized by loss of elasticity, among other factors, and aged skin serves as a source of circulatory inflammatory molecules that further accelerate aging and contribute to aging-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Eileen Deuster, Ivi Hysenaj, Maja Kahaly, Elisa Schmoeckel, Doris Mayr, Susanne Beyer, Thomas Kolben, Anna Hester, Fabian Kraus, Anca Chelariu-Raicu, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch, Bastian Czogalla
Summary: In patients with ovarian cancer, high expression of PAFR affects overall and recurrence-free survival, while rupatadine, an antagonist, effectively inhibits proliferation and migration of ovarian cancer cells.
Article
Biochemistry & Molecular Biology
Evelyn Andrades, Miquel Claros, Juan Vicente Torres, Lara Nonell, Monica Gonzalez, Laia Curto-Barredo, Eduardo Rozas-Munoz, Ramon Gimeno, Carlos Barranco, Ramon M. Pujol, Inaki Izquierdo, Ana M. Gimenez-Arnau
Summary: The objective of this study was to assess the role of Platelet Activating Factor (PAF) in chronic spontaneous urticaria (CSU) and its relevance to treatment. The results showed that PAF plays a significant role in the pathogenesis of urticaria, and the serum PAF-AH/PAF ratio may serve as a potential biomarker for treatment refractoriness in urticaria.
Article
Cell Biology
Fu Lv, Yingxin He, Hongde Xu, Yongchun Li, Lipei Han, Lijie Yan, Hui Lang, Yafei Zhao, Zhanzheng Zhao, Yuanyuan Qi
Summary: CD36 plays an important role in podocyte injury in lupus nephritis by activating NLRP3 inflammasome and inhibiting autophagy, and enhancing autophagy can decrease NLRP3 inflammasome and alleviate podocyte injury.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Junke Liu, Hengmin Tang, Chanjuan Xu, Shengnan Zhou, Xunying Zhu, Yuanyuan Li, Laurent Prezeau, Tao Xu, Jean-Philippe Pin, Philippe Rondard, Wei Ji, Jianfeng Liu
Summary: This study reveals that the assembly of platelet-activating factor receptor (PAFR) into dimers and oligomers can significantly influence its signaling mode. Oligomerization enhances G protein coupling, while restraining beta-arrestin recruitment and internalization.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Israr Ahmad, Tahseen H. Nasti, Heba M. Rihan, Hugo Jimenez, Craig A. Elmets, Nabiha Yusuf
Summary: Experimental findings suggest a crucial role of TLR4 in UVB-induced skin cancer development, with TLR4-deficient mice showing lower tumor incidence and shorter tumor latency compared to TLR4-proficient mice. The inflammatory response and immune cell levels were higher in TLR4-proficient mice than in TLR4-deficient mice.
MOLECULAR CARCINOGENESIS
(2021)
Review
Immunology
George Fromm, Suresh de Silva, Taylor H. Schreiber
Summary: The extracellular domain of tumor necrosis factor receptors (TNFR) needs to assemble into a homotrimeric quaternary structure in order to initiate signaling. Synthetic agonists targeting TNF receptors have potential clinical benefits in amplifying immune responses, but their translation into human clinical studies has been limited and raised questions about the biology of TNF receptors.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jesus A. Ocana, Eric Romer, Ravi Sahu, Sven-Christian Pawelzik, Garret A. FitzGerald, Mark H. Kaplan, Jeffrey B. Travers
JOURNAL OF IMMUNOLOGY
(2018)
Article
Dermatology
Michael G. Kemp, Smita Krishnamurthy, Michael N. Kent, David L. Schumacher, Priyanka Sharma, Katherine J. D. A. Excoffon, Jeffrey B. Travers
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Article
Dermatology
Jeffrey B. Travers, Michael G. Kemp, Nathan M. Weir, Elizabeth Cates, Abdulrahman M. Alkawar, Avinash S. Mahajan, Dan F. Spandau
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2020)
Article
Dermatology
Roy Chen, Jeffrey J. Wargo, Amy Williams, Elizabeth Cates, Dan F. Spandau, Christina Knisely, Jeffrey B. Travers
LASERS IN SURGERY AND MEDICINE
(2020)
Review
Oncology
Anita Thyagarajan, Mamdouh Salman A. Alshehri, Kelly L. R. Miller, Catherine M. Sherwin, Jeffrey B. Travers, Ravi P. Sahu
Review
Nutrition & Dietetics
Patrick J. McCullough, William P. McCullough, Douglas Lehrer, Jeffrey B. Travers, Steven J. Repas
Summary: Vitamin D, sunshine, and UVB phototherapy have been reported to effectively treat psoriasis, controlling the disease without complications. Changes in serum 25(OH)D concentrations before and after treatment are crucial for assessing the therapeutic effects. Further research is needed to fully understand the impact of these treatments on psoriasis patients.
Article
Biochemistry & Molecular Biology
Pariksha Thapa, Shweta Bhadri, Christina Borchers, Langni Liu, Yanfang Chen, Christine M. Rapp, Jeffrey B. Travers
Summary: Studies have shown that UVB exposure leads to the generation of MVP, and pretreatment with PAFR agonist/phorbol ester can significantly increase MVP levels at low fluences of UVB, suggesting a potential role of MVP in combinatorial pathological processes involving UVB.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Review
Dermatology
Zafer Sattouf, Steven J. Repas, Jeffrey B. Travers, Craig A. Rohan
Summary: Actinic keratoses are precancerous skin lesions caused by long-term UV exposure, and intervening before they progress to skin cancer is crucial. Recent advancements in AK treatment have raised questions about current treatment paradigms and the role of the immune system in field therapies. Studies suggest a key interplay between vitamin D and cancer immunity in improving field therapy approaches.
JOURNAL OF SKIN CANCER
(2021)
Article
Biochemistry & Molecular Biology
Jinju Wang, Kartheek Pothana, Shuzhen Chen, Harshal Sawant, Jeffrey B. Travers, Ji Bihl, Yanfang Chen
Summary: The study reveals that UVB stimulates the release of exosomes from keratinocyte HaCaT cells and affects the content of microRNA in these exosomes under diabetic conditions.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Article
Toxicology
Azeezat A. Awoyemi, Christina Borchers, Langni Liu, Yanfang Chen, Christine M. Rapp, Chad A. Brewer, Ramzi Elased, Jeffrey B. Travers
Summary: Ethanol has been found to modulate the generation and release of larger microvesicle particles, providing a novel mechanism for ethanol-mediated effects, which could be relevant in the significant toxicity associated with thermal burn injury.
TOXICOLOGY LETTERS
(2022)
Article
Nutrition & Dietetics
Avinash S. Mahajan, Venkata S. Arikatla, Anita Thyagarajan, Tetyana Zhelay, Ravi P. Sahu, Michael G. Kemp, Dan F. Spandau, Jeffrey B. Travers
Summary: Dermal fibroblasts produce collagen and IGF-1, regulating cell proliferation and responses to stressors. The study shows that H2O2 induces cell senescence, while pretreatment with Cr or NAM can protect fibroblasts from this senescence. These findings suggest a potential strategy for preventing stress-induced senescence in aging skin.
Article
Biochemistry & Molecular Biology
Anita Thyagarajan, Krishna Awasthi, Christine M. Rapp, R. Michael Johnson, Yanfang Chen, Kelly L. R. Miller, Jeffrey B. Travers, Ravi P. Sahu
Summary: Chemotherapy is the main treatment for various types of cancers, including skin cancer. However, it is limited by adverse effects. Recent studies have found that chemotherapy drugs can induce the generation of extracellular vesicles called microvesicle particles (MVP), which may involve specific receptors and enzymes. Experiments showed that topical application of gemcitabine can induce MVP generation in human and murine skin, and this process is dependent on specific receptors and enzymes.
Review
Biochemistry & Molecular Biology
Carson J. Rohan, Rushabh P. Lohade, Chad Brewer, Jeffrey B. Travers
Summary: Thermal burn injuries in alcohol-intoxicated patients result in greater morbidity and mortality. This review highlights the roles of platelet-activating factor (PAF) and subcellular microvesicle particle (MVP) release in the pathology of intoxicated thermal burn injury (ITBI). The review provides a mechanism and potential therapeutic approaches for the increased toxicity and immunosuppressive outcomes of TBI in the presence of acute ethanol exposure.
Letter
Dermatology
Ericson John V. Torralba, Shikshita Singh, Robert F. Short, Christine M. Rapp, Karen M. Henkels, Ravi P. Sahu, Jeffrey B. Travers
SKIN RESEARCH AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shreepa J. Chauhan, Anita Thyagarajan, Yanfang Chen, Jeffrey B. Travers, Ravi P. Sahu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)