期刊
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
卷 10, 期 5, 页码 792-801出版社
SPRINGERNATURE
DOI: 10.1039/c0pp00326c
关键词
-
资金
- US-NIH [R01AI050875, R01CA/AI838801]
- Center for Integration of Medicine and Innovative Technology [DAMD17-02-20006]
- CDMRP Program in TBI [W81XWH-09-1-0514]
- Air Force Office of Scientific Research [FA9950-04-1-0079]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI050875] Funding Source: NIH RePORTER
Photodynamic therapy (PDT) has been used as a cancer therapy for forty years but has not advanced to a mainstream cancer treatment. Although it has been shown to be an efficient way to destroy local tumors by a combination of non-toxic dyes and harmless visible light, it is its additional effects in mediating the stimulation of the host immune system that gives PDT great potential to become more widely used. Although the stimulation of tumor-specific cytotoxic T-cells that can destroy distant tumor deposits after PDT has been reported in some animal models, it remains the exception rather than the rule. This realization has prompted several investigators to test various combination approaches that could potentiate the immune recognition of tumor antigens that have been released after PDT. This review will cover these combination approaches using immunostimulants including various microbial preparations that activate Toll-like receptors and other receptors for pathogen-associated molecular patterns, cytokines growth factors, and approaches that target regulatory T-cells. We believe that by understanding the methods employed by tumors to evade immune response and neutralizing them, more precise ways of potentiating PDT-induced immunity can be devised.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据