Article
Cell Biology
Marjan Khorsand, Sahar Khajeh, Mahboobeh Eslami, Navid Nezafat, Younes Ghasemi, Vahid Razban, Zohreh Mostafavi-Pour
Summary: This study aimed to investigate the effects of Telmisartan, a novel N-cadherin antagonist, on cell migration of cancer cells. The results showed that Telmisartan and ADH-1 significantly reduced cell attachment to N-cadherin coated plate in different cancer cell lines. Telmisartan and Docetaxel also showed significant inhibitory effects on cell migration. Moreover, Telmisartan exerted its anti-proliferation and anti-migration effects by targeting antagonistically N-cadherin, suggesting its potential use as an alternative to ADH-1 in enhancing the anticancer effects of Docetaxel.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Oncology
Zhenfeng Liu, Guanghua Wen, Yuqiao Huang, Yanzhao Dong, Zewei Wang, Ahmad Alhaskawi, Shuyi Zhang, GuoLin Wang, Qianni Ye, Haiying Zhou, Hui Lu, Mengjie Dong
Summary: In this study, [F-18]AlF-NOTA-ADH-1 was synthesized and its targeting ability for N-cadherin in tumors was evaluated through in vitro cell binding test, biodistribution, and microPET imaging. The results showed that [F-18]AlF-NOTA-ADH-1 could effectively bind to N-cadherin expressing tumors.
FRONTIERS IN ONCOLOGY
(2023)
Review
Cell Biology
Orest W. Blaschuk
Summary: This review focuses on the molecular mechanisms and intracellular signaling pathways of neural cadherin (N-cadherin), a cell adhesion molecule. It discusses N-cadherin antagonists and agonists and their potential therapeutic applications in treating fibrotic diseases, cancer, manipulating vascular function, and tissue regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Joman Javadi, Ghazal Heidari-Hamedani, Angelika Schmalzl, Tunde Szatmari, Muzaffer Metintas, Pontus Aspenstrom, Anders Hjerpe, Katalin Dobra
Summary: SDC-1 is a transmembrane proteoglycan that regulates the binding of growth factors and cytokines, impacting angiogenesis. Overexpression of SDC-1 inhibits proliferation, wound healing, and tube formation in endothelial cells in malignant mesothelioma. Silencing SDC-1 affects wound healing but not tube formation.
Article
Multidisciplinary Sciences
Tobias Wijshake, Zhongju Zou, Beibei Chen, Lin Zhong, Guanghua Xiao, Yang Xie, John G. Doench, Lynda Bennett, Beth Levine
Summary: The study revealed previously unrecognized cooperation between Beclin 1 and E-cadherin in mediating tumor suppression in breast cancer cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Guanglin Cui, Hanzhe Liu, Jann-Birger Laugsand
Summary: Enhanced angiogenesis is critical for colorectal cancer invasion and metastasis. Studies suggest that tumor endothelial cells not only respond to proangiogenic factors, but also produce proangiogenic factors themselves. This review summarizes the potential role of interleukins released by microvascular endothelial cells in driving tumor angiogenesis and discusses their potential as a novel antiangiogenic target for colorectal cancer treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Daniel Delgado-Bellido, F. J. Oliver, Maria Victoria Vargas Padilla, Laura Lobo-Selma, Antonio Chacon-Barrado, Juan Diaz-Martin, Enrique de alava
Summary: Tumor growth can be facilitated by the expansion of blood vessels or the development of vasculogenic mimicry (VM), a novel pathway involving aggressive tumor cells expressing endothelial cell markers. VM is associated with high tumor grade, cancer cell invasion, metastasis, and reduced survival. This review summarizes studies on angiogenesis and aberrant angiogenesis by tumor cells, discusses the intracellular signaling mechanisms involved in VM formation, and explores the implications for tumor angiogenesis and targeted therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Developmental Biology
Minkyoung Lee, Charles Betz, Jianmin Yin, Ilkka Paatero, Niels Schellinx, Adam N. Carte, Christopher W. Wilson, Weilan Ye, Markus Affolter, Heinz-Georg Belting
Summary: Rasip1 plays essential roles during blood vessel formation by regulating various cellular behaviors such as cell pairing, tricellular junction stability, and apical membrane organization. Loss of Rasip1 function results in defects in sprouting angiogenesis, anastomosis, and lumen formation, highlighting the importance of Rasip1 in maintaining proper multicellular organization and junction formation during vascular development.
Article
Oncology
Yuxian Wu, Jinghai Gao, Xiaojun Liu
Summary: The study showed that upregulation of ANGPTL4 in ovarian cancer cells led to increased tumor angiogenesis, growth, and metastasis inhibition. Inactivation of VEGFR2 Y949 phosphorylation eliminated the tumor-suppressive effects of ANGPTL4 inhibition in spontaneous ovarian carcinoma.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Kumaravel Mohankumar, Rupesh Shrestha, Stephen Safe
Summary: The study revealed that PSPC1 is crucial in cancer cells, with NR4A1 acting as a key regulator of PSPC1. NR4A1 antagonists inhibit tumor growth by downregulating PSPC1 and suppressing pro-oncogenic activities.
MOLECULAR CARCINOGENESIS
(2022)
Article
Oncology
Tzu-Yin Lin, Chi-Hwa Yang, Hsiao-Chin Chou, Chun-Mei Cheng, Ya-Wen Liu, Jiz-Yuh Wang, Li-Rung Huang, Shih-Feng Tsai, Shiu-Feng Huang, Yi-Rong Chen
Summary: This study identified CLEC11A as a novel factor in tumor angiogenesis, with endothelial trophic and tumor-promoting activities. CLEC11A was over-expressed in lung cancer cells with EGFR mutation and in lung adenocarcinoma tissues. It enhanced angiogenesis triggered by VEGF-A or basic FGF and increased tumorigenic ability in mouse models. CLEC11A exhibited chemotactic ability towards endothelial cells and increased levels of active integrin beta 1 in these cells.
Article
Oncology
Yanfen Cui, Hui Liu, Zhaosong Wang, He Zhang, Jianfei Tian, Zhiyong Wang, Weijie Song, Hui Guo, Liming Liu, Ruinan Tian, Xiaoyan Zuo, Sixin Ren, Fei Zhang, Ruifang Niu
Summary: High fructose intake is associated with increased risk of multiple cancers. Fructose can enhance the biological function of vascular endothelial cells (VECs) and promote angiogenesis by activating the Akt and Src signaling pathways. It can also upregulate production of reactive oxygen species (ROS) in colorectal cancer cells, indirectly enhancing the function of VECs. These findings have been validated in clinical colorectal cancer tissues and mouse models.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Kinga Wilkus, Klaudia Brodaczewska, Arkadiusz Kajdasz, Claudine Kieda
Summary: The study found significant differences in protein expression, differentiation status, adhesion properties, and barrier formation of endothelial cells derived from tumors compared to normal tissues. Functional assays revealed impaired angiogenesis and increased permeability in tumor-derived endothelial cells, along with enhanced VEGF production in response to hypoxia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Evangelia Papadimitriou, Vasiliki K. Kanellopoulou
Summary: Protein tyrosine phosphatase receptor zeta 1 (PTPRZ1) is highly expressed during embryonic development but limited in adulthood. It plays a role in oligodendrocytes' survival and maturation in the central nervous system. In gliomas, PTPRZ1 is significantly upregulated and studied as a potential cancer driver and therapy target. However, its functional significance and tumor-suppressor role in other cancer types need further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Xia Meng, Anwei Zhou, Yu Huang, Yu Zhang, Yurui Xu, Kaifeng Shao, Xinghai Ning
Summary: Nanoengineered multivalent N-cadherin antagonist ADH-AuNPs were developed to enhance the reprogramming efficiency of iPSCs by driving cell MET, showing higher inhibitory activity than monovalent ADH-1 and promoting the conversion of cell state towards epithelial lineages. Particularly, reprogramming efficiency was improved by over 7-fold after introduction of four Yamanaka factors, and iPSCs generated by ADH-AuNPs exhibited high stemness and pluripotency in vitro and in vivo, providing a cooperative strategy for enhancing iPSC generation efficacy.