Primitive endoderm differentiation: from specification to epithelium formation

Initiation of Hippo signaling is linked to polarity rather than to cell position in the pre-implantation mouse embryo

(2014) Shihadeh Anani et al.   DEVELOPMENT

Oct4 is required for lineage priming in the developing inner cell mass of the mouse blastocyst

(2014) G. C. Le Bin et al.   DEVELOPMENT

Limited predictive value of blastomere angle of division in trophectoderm and inner cell mass specification

(2014) T. Watanabe et al.   DEVELOPMENT

GATA6 Levels Modulate Primitive Endoderm Cell Fate Choice and Timing in the Mouse Blastocyst

(2014) Nadine Schrode et al.   DEVELOPMENTAL CELL

Single-Cell RNA-Seq Reveals Dynamic, Random Monoallelic Gene Expression in Mammalian Cells

(2014) Q. Deng et al.   SCIENCE

Cell adhesion and sorting in embryoid bodies derived from N- or E-cadherin deficient murine embryonic stem cells

(2014) R. Moore et al.   Biology Open

Differential requirement for Dab2 in the development of embryonic and extra-embryonic tissues

(2013) Robert Moore et al.   BMC DEVELOPMENTAL BIOLOGY

A molecular basis for developmental plasticity in early mammalian embryos

(2013) A. M. Arias et al.   DEVELOPMENT

Atypical protein kinase C couples cell sorting with primitive endoderm maturation in the mouse blastocyst

(2013) N. Saiz et al.   DEVELOPMENT

FGF4 is a limiting factor controlling the proportions of primitive endoderm and epiblast in the ICM of the mouse blastocyst

(2013) Dayana Krawchuk et al.   DEVELOPMENTAL BIOLOGY

Allocation of inner cells to epiblast vs primitive endoderm in the mouse embryo is biased but not determined by the round of asymmetric divisions (8→16- and 16→32-cells)

(2013) Magdalena Krupa et al.   DEVELOPMENTAL BIOLOGY

Oct4 Cell-Autonomously Promotes Primitive Endoderm Development in the Mouse Blastocyst

(2013) Tristan Frum et al.   DEVELOPMENTAL CELL

A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo

(2013) D. V. Do et al.   GENES & DEVELOPMENT

Sox Transcription Factors Require Selective Interactions with Oct4 and Specific Transactivation Functions to Mediate Reprogramming

(2013) Irene Aksoy et al.   STEM CELLS

PDGF signaling is required for primitive endoderm cell survival in the inner cell mass of the mouse blastocyst

(2013) Jérôme Artus et al.   STEM CELLS

The differential response to Fgf signalling in cells internalized at different times influences lineage segregation in preimplantation mouse embryos

(2013) S. A. Morris et al.   Open Biology

Atypical protein kinase C in cell motility

(2012) Helan Xiao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The roles of FGF and MAP kinase signaling in the segregation of the epiblast and hypoblast cell lineages in bovine and human embryos

(2012) E. W. Kuijk et al.   DEVELOPMENT

FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse

(2012) M. Kang et al.   DEVELOPMENT

Loss of Oct4 expression during the development of murine embryoid bodies

(2012) Abdulrahim A. Sajini et al.   DEVELOPMENTAL BIOLOGY

Fibroblast Growth Factor Receptor 2 Homodimerization Rapidly Reduces Transcription of the Pluripotency GeneNanogwithout Dissociation of Activating Transcription Factors

(2012) Katherine E. Santostefano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of ground-state pluripotency by allelic regulation of Nanog

(2012) Yusuke Miyanari et al.   NATURE

Differential plasticity of epiblast and primitive endoderm precursors within the ICM of the early mouse embryo

(2011) J. B. Grabarek et al.   DEVELOPMENT

Lineage mapping the pre-implantation mouse embryo by two-photon microscopy, new insights into the segregation of cell fates

(2011) Katie McDole et al.   DEVELOPMENTAL BIOLOGY

Human hypoblast formation is not dependent on FGF signalling

(2011) Mila Roode et al.   DEVELOPMENTAL BIOLOGY

Primitive Endoderm Differentiates via a Three-Step Mechanism Involving Nanog and RTK Signaling

(2011) Stephen Frankenberg et al.   DEVELOPMENTAL CELL

The regulatory role of histone deacetylase inhibitors in Fgf4 expression is dependent on the differentiation state of pluripotent stem cells

(2011) Guilai Shi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cell fate in the early mouse embryo: sorting out the influence of developmental history on lineage choice

(2011) Samantha A. Morris   REPRODUCTIVE BIOMEDICINE ONLINE

Simulating the Mammalian Blastocyst - Molecular and Mechanical Interactions Pattern the Embryo

(2011) Pawel Krupinski et al.   PLoS Computational Biology

Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2

(2010) A. Ralston et al.   DEVELOPMENT

FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst

(2010) Y. Yamanaka et al.   DEVELOPMENT

Nanog is required for primitive endoderm formation through a non-cell autonomous mechanism

(2010) Daniel M. Messerschmidt et al.   DEVELOPMENTAL BIOLOGY

Nodal cis-regulatory elements reveal epiblast and primitive endoderm heterogeneity in the peri-implantation mouse embryo

(2010) Céline Granier et al.   DEVELOPMENTAL BIOLOGY

The primitive endoderm lineage of the mouse blastocyst: Sequential transcription factor activation and regulation of differentiation by Sox17

(2010) Jérôme Artus et al.   DEVELOPMENTAL BIOLOGY

Resolution of Cell Fate Decisions Revealed by Single-Cell Gene Expression Analysis from Zygote to Blastocyst

(2010) Guoji Guo et al.   DEVELOPMENTAL CELL

Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal

(2010) K. K. Niakan et al.   GENES & DEVELOPMENT

Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo

(2010) S. A. Morris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanog Is the Gateway to the Pluripotent Ground State

(2009) Jose Silva et al.   CELL

Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo

(2009) J. Nichols et al.   DEVELOPMENT

Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse

(2009) J. Rossant et al.   DEVELOPMENT

Lgl2 and E-cadherin act antagonistically to regulate hemidesmosome formation during epidermal development in zebrafish

(2009) M. Sonawane et al.   DEVELOPMENT

Active cell movements coupled to positional induction are involved in lineage segregation in the mouse blastocyst

(2009) Sigolène M. Meilhac et al.   DEVELOPMENTAL BIOLOGY

Cell adhesive affinity does not dictate primitive endoderm segregation and positioning during murine embryoid body formation

(2009) Robert Moore et al.   GENESIS

Integrins are required for the differentiation of visceral endoderm

(2009) J. Liu et al.   JOURNAL OF CELL SCIENCE

NANOG Is a Direct Target of TGFβ/Activin-Mediated SMAD Signaling in Human ESCs

(2008) Ren-He Xu et al.   Cell Stem Cell

Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst

(2008) B. Plusa et al.   DEVELOPMENT

The Endoderm of the Mouse Embryo Arises by Dynamic Widespread Intercalation of Embryonic and Extraembryonic Lineages

(2008) Gloria S. Kwon et al.   DEVELOPMENTAL CELL

Dynamic GATA6 expression in primitive endoderm formation and maturation in early mouse embryogenesis

(2008) Kathy Q. Cai et al.   DEVELOPMENTAL DYNAMICS

The ground state of embryonic stem cell self-renewal

(2008) Qi-Long Ying et al.   NATURE

Dynamic expression of Lrp2 pathway members reveals progressive epithelial differentiation of primitive endoderm in mouse blastocyst

(2007) François Gerbe et al.   DEVELOPMENTAL BIOLOGY