Microbial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us?

Interrogation of Related Clinical Pan-Azole-Resistant Aspergillus fumigatus Strains: G138C, Y431C, and G434C Single Nucleotide Polymorphisms incyp51A, Upregulation ofcyp51A, and Integration and Activation of TransposonAtf1in thecyp51APromoter

(2011) Ahmed M. Albarrag et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Impact of Recently Emerged Sterol 14α-Demethylase (CYP51) Variants of Mycosphaerella graminicola on Azole Fungicide Sensitivity

(2011) Hans J. Cools et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

New Nystatin-Related Antifungal Polyene Macrolides with Altered Polyol Region Generated via Biosynthetic Engineering of Streptomyces noursei

(2011) Trygve Brautaset et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Terminal Olefin (1-Alkene) Biosynthesis by a Novel P450 Fatty Acid Decarboxylase fromJeotgalicoccusSpecies

(2011) Mathew A. Rude et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Rational Domain Swaps Decipher Programming in Fungal Highly Reducing Polyketide Synthases and Resurrect an Extinct Metabolite

(2011) Katja M. Fisch et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Double Oxidation of the Cyclic Nonaketide Dihydromonacolin L to Monacolin J by a Single Cytochrome P450 Monooxygenase, LovA

(2011) Jorge Barriuso et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A stable yeast strain efficiently producing cholesterol instead of ergosterol is functional for tryptophan uptake, but not weak organic acid resistance

(2011) Cleiton M. Souza et al.   METABOLIC ENGINEERING

The versatility of the fungal cytochrome P450 monooxygenase system is instrumental in xenobiotic detoxification

(2011) Ljerka Lah et al.   MOLECULAR MICROBIOLOGY

Molecular Modelling of the Emergence of Azole Resistance in Mycosphaerella graminicola

(2011) Jonathan G. L. Mullins et al.   PLoS One

CYP5122A1, a Novel Cytochrome P450 Is Essential for Survival of Leishmania donovani

(2011) Smriti Verma et al.   PLoS One

Microaerobic steroid biosynthesis and the molecular fossil record of Archean life

(2011) J. R. Waldbauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Plant Cell Wall-Decomposing Machinery Underlies the Functional Diversity of Forest Fungi

(2011) D. C. Eastwood et al.   SCIENCE

Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis

(2011) Hugues Ouellet et al.   TRENDS IN MICROBIOLOGY

Identification and Characterization of Four Azole-Resistant erg3 Mutants of Candida albicans

(2010) C. M. Martel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Expression, Purification, and Characterization of Aspergillus fumigatus Sterol 14-  Demethylase (CYP51) Isoenzymes A and B

(2010) A. G. S. Warrilow et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Azole Binding Properties of Candida albicans Sterol 14-  Demethylase (CaCYP51)

(2010) A. G. S. Warrilow et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (Sterol 14 -Demethylase) Doxycycline-Regulated Mutant and Screening of the Azole Sensitivity of Aspergillus fumigatus Isoenzymes CYP51A and CYP51B

(2010) C. M. Martel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanism of Binding of Prothioconazole toMycosphaerella graminicolaCYP51 Differs from That of Other Azole Antifungals

(2010) Josie E. Parker et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Heterologous Expression of Mutated Eburicol 14 -Demethylase (CYP51) Proteins of Mycosphaerella graminicola To Assess Effects on Azole Fungicide Sensitivity and Intrinsic Protein Function

(2010) H. J. Cools et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Molecular characterization and isolation of cytochrome P450 genes from the filamentous fungus Aspergillus oryzae

(2010) K. H. M. Nazmul Hussain Nazir et al.   ARCHIVES OF MICROBIOLOGY

Genome-to-function characterization of novel fungal P450 monooxygenases oxidizing polycyclic aromatic hydrocarbons (PAHs)

(2010) Khajamohiddin Syed et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Breakthrough in P450 bioelectrochemistry and future perspectives

(2010) Sheila J. Sadeghi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

LICRED: A Versatile Drop-In Vector for Rapid Generation of Redox-Self-Sufficient Cytochrome P450s

(2010) Federico Sabbadin et al.   CHEMBIOCHEM

The CYPome of Sorangium cellulosum So ce56 and Identification of CYP109D1 as a New Fatty Acid Hydroxylase

(2010) Yogan Khatri et al.   CHEMISTRY & BIOLOGY

Cytochromes P450-mediated degradation of  fuel oxygenates by environmental isolates

(2010) Cédric Malandain et al.   FEMS MICROBIOLOGY ECOLOGY

The Actinomycin Biosynthetic Gene Cluster of Streptomyces chrysomallus: a Genetic Hall of Mirrors for Synthesis of a Molecule with Mirror Symmetry

(2010) U. Keller et al.   JOURNAL OF BACTERIOLOGY

Structural Characterization of OxyD, a Cytochrome P450 Involved in β-Hydroxytyrosine Formation in Vancomycin Biosynthesis

(2010) Max J. Cryle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of a steroid 11α-hydroxylase from Rhizopus oryzae and its biotechnological application

(2010) Š. Petrič et al.   JOURNAL OF BIOTECHNOLOGY

Structural Basis of Human CYP51 Inhibition by Antifungal Azoles

(2010) Natallia Strushkevich et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular characterization and expression analysis of a suite of cytochrome P450 enzymes implicated in insect hydrocarbon degradation in the entomopathogenic fungus Beauveria bassiana

(2010) N. Pedrini et al.   MICROBIOLOGY-SGM

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

Various players in the nitrogen cycle: Diversity and functions of the microorganisms involved in nitrification and denitrification

(2010) Masahito Hayatsu et al.   SOIL SCIENCE AND PLANT NUTRITION

Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole

(2010) Chiung-Kuang Chen et al.   PLoS Neglected Tropical Diseases

Echinocandins: The Newest Class of Antifungals

(2009) Allana J Sucher et al.   ANNALS OF PHARMACOTHERAPY

Special relationship between sterols and oxygen: Were sterols an adaptation to aerobic life?

(2009) Anne M. Galea et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phylogenomics of Sterol Synthesis: Insights into the Origin, Evolution, and Diversity of a Key Eukaryotic Feature

(2009) Elie Desmond et al.   Genome Biology and Evolution

The Structure of Mycobacterium tuberculosis CYP125

(2009) Kirsty J. McLean et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of PpoA fromAspergillus nidulansas a Fusion Protein of a Fatty Acid Heme Dioxygenase/Peroxidase and a Cytochrome P450

(2009) Florian Brodhun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures of Trypanosoma brucei Sterol 14α-Demethylase and Implications for Selective Treatment of Human Infections

(2009) Galina I. Lepesheva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Albaflavenone Monooxygenase Containing a Moonlighting Terpene Synthase Active Site

(2009) Bin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Azole resistance in Aspergillus fumigatus: a side-effect of environmental fungicide use?

(2009) Paul E Verweij et al.   LANCET INFECTIOUS DISEASES

Molecular cloning and functional characterization of two CYP619 cytochrome P450s involved in biosynthesis of patulin in Aspergillus clavatus

(2009) M. P. Artigot et al.   MICROBIOLOGY-SGM

Fossil steroids record the appearance of Demospongiae during the Cryogenian period

(2009) Gordon D. Love et al.   NATURE

Deep phylogeny, ancestral groups and the four ages of life

(2009) T. Cavalier-Smith   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Identification, Characterization, and Azole-Binding Properties of Mycobacterium smegmatis CYP164A2, a Homolog of ML2088, the Sole Cytochrome P450 Gene of Mycobacterium leprae

(2008) A. G. S. Warrilow et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Differential Azole Antifungal Efficacies Contrasted Using a Saccharomyces cerevisiae Strain Humanized for Sterol 14 -Demethylase at the Homologous Locus

(2008) J. E. Parker et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vivo Evolution of Butane Oxidation by Terminal Alkane Hydroxylases AlkB and CYP153A6

(2008) D. J. Koch et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Soil Formate Regulates the Fungal Nitrous Oxide Emission Pathway

(2008) W. K. Ma et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The sterols of calcareous sponges (Calcarea, Porifera)

(2008) Andrea Hagemann et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Importance of the cytochrome P450 monooxygenase CYP52 family for the sophorolipid-producing yeastCandida bombicola

(2008) Inge N.A. Van Bogaert et al.   FEMS YEAST RESEARCH

The CYPome (Cytochrome P450 complement) of Aspergillus nidulans

(2008) Diane E. Kelly et al.   FUNGAL GENETICS AND BIOLOGY

Biosynthesis of the Sesquiterpene Antibiotic Albaflavenone inStreptomyces coelicolorA3(2)

(2008) Bin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression and Characterization of CYP51, the Ancient Sterol 14-demethylase Activity for Cytochromes P450 (CYP), in the White-Rot Fungus Phanerochaete chrysosporium

(2008) Andrew Warrilow et al.   LIPIDS

Reassessing the first appearance of eukaryotes and cyanobacteria

(2008) Birger Rasmussen et al.   NATURE

QoI resistance emerged independently at least 4 times in European populations ofMycosphaerella graminicola

(2008) Stefano FF Torriani et al.   PEST MANAGEMENT SCIENCE

Sterols in a unicellular relative of the metazoans

(2008) R. B. Kodner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome

(2008) D. A. Sela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA