Article
Biochemistry & Molecular Biology
Tatyana Y. Postnikova, Sergey L. Malkin, Maria Zakharova, Ilya Smolensky, Olga E. Zubareva, Aleksey Zaitsev
Summary: Disruption of glutamate clearance in the synaptic cleft can lead to synaptic dysfunction and neurological diseases, potentially causing excitotoxicity. Increased glutamate clearance has been shown to reduce long-term synaptic potentiation (LTP). Treatment with the enhancer of glutamate transporter 1 expression, ceftriaxone, weakened LTP in the hippocampus of young rats, likely due to reduced spillover of glutamate leading to decreased activation of synapses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Tatyana Y. Postnikova, Dmitry V. Amakhin, Alina M. Trofimova, Natalia L. Tumanova, Nadezhda M. Dubrovskaya, Daria S. Kalinina, Anna A. Kovalenko, Anastasiia D. Shcherbitskaia, Dmitry S. Vasilev, Aleksey V. Zaitsev
Summary: Maternal hyperhomocysteinemia during pregnancy leads to memory impairments in rats, associated with reduced long-term potentiation (LTP) and altered NMDA receptor desensitization in the hippocampus. Expression of glutamate receptor subunits is unaffected except for GluN1. Additionally, delayed hippocampal maturation and decreased synaptopodin-positive spines were observed in offspring.
Article
Behavioral Sciences
Frank Raven, Iris W. Riemersma, Martha F. Olthuis, Ieva Rybakovaite, Elroy L. Meijer, Peter Meerlo, Eddy A. van der Zee, Robbert Havekes
Summary: Many organisms in the animal kingdom have the ability to form and retrieve memories. Synaptic plasticity is crucial for memory storage. Overactivating cofilin improves short-term memory formation.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Neurosciences
Magdalena Pereyra, Ana Belen de Landeta, Juliana Fatima Dalto, Cynthia Katche, Jorge H. Medina
Summary: The study shows that the activity of mTORC1 signaling pathway is crucial for the normal expression of aversive and non-aversive long-term memories during memory retrieval. Specifically, the de novo synthesis of GluA1 and GluA2 AMPAR subunits plays an important role in memory retrieval, with mTORC1 potentially regulating AMPAR trafficking during this process.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Cell Biology
Luca Franchini, Jennifer Stanic, Marta Barzasi, Elisa Zianni, Daniela Mauceri, Monica Diluca, Fabrizio Gardoni
Summary: This study demonstrates a key role for Rph3A in the modulation of structural synaptic plasticity at hippocampal synapses, which correlates with its interactions with both NMDARs and AMPARs.
Article
Biochemistry & Molecular Biology
Julia L. Ergina, Dmitry Amakhin, Tatyana Y. Postnikova, Elena B. Soboleva, Aleksey Zaitsev
Summary: The increase in excitability of hippocampal neural networks after epileptiform activity is primarily achieved through postsynaptic mechanisms, while the intrinsic membrane properties of neurons and the probability of glutamate release from presynaptic terminals are not affected.
Article
Multidisciplinary Sciences
Benjamin Compans, Come Camus, Emmanouela Kallergi, Silvia Sposini, Magalie Martineau, Corey Butler, Adel Kechkar, Remco Klaassen, Natacha Retailleau, Terrence J. Sejnowski, August B. Smit, Jean-Baptiste Sibarita, Thomas M. Bartol, David Perrais, Vassiliki Nikoletopoulou, Daniel Choquet, Eric Hosy
Summary: Long-term depression (LTD) of synaptic strength is associated with circuit remodeling, memory encoding, and erasure. P2XR- and NMDAR-dependent LTD are linked to distinct molecular modifications that lead to specific changes in synapse function.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Alen Eapen, Diego Fernandez-Fernandez, John Georgiou, Zuner A. Bortolotto, Stafford Lightman, David E. Jane, Arturas Volianskis, Graham L. Collingridge
Summary: The study demonstrates the involvement of GluN2D-containing NMDARs in both short-term potentiation (STP) and long-term potentiation (LTP) in the mouse hippocampus, highlighting the important role of GluN2D subunits in synaptic plasticity.
Review
Physiology
Roger A. Nicoll, Howard Schulman
Summary: This article reviews the relationship between CaMKII and LTP, as well as the role of new technologies in research. It proposes a model for synaptic memory and discusses the steps involved in driving this process, along with the supporting evidence for each step. Despite the lengthy research journey, the prospect of a cellular and molecular understanding of learning and memory is within reach.
PHYSIOLOGICAL REVIEWS
(2023)
Article
Multidisciplinary Sciences
Xiumin Chen, Yuko Fukata, Masaki Fukata, Roger A. Nicoll
Summary: This study reveals the essential role of the MAGUK family of synaptic scaffolding proteins in LTP, with PSD-95 requiring binding to ADAM22 for synaptic transmission enhancement. Additionally, an alternative pathway involving SAP102 is proposed, independent of ADAM22.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Tatyana Y. Postnikova, Alina M. Trofimova, Maria Zakharova, Olga Nosova, Alexey R. Brazhe, Dmitry E. Korzhevskii, Alexey Semyanov, Aleksey Zaitsev
Summary: This study examined the long-term effects of pentylenetetrazole-induced generalized seizures in three-week-old rats. The seizures resulted in neuronal loss in several hippocampal regions and impaired long-term synaptic potentiation. The mechanism of plasticity induction was altered, and the function of core-located NMDA receptors was weakened, likely due to disturbed glutamate clearance from the synaptic cleft.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Jenni Harvey
Summary: It has been well established that leptin plays a crucial role in controlling energy homeostasis by signaling to specific hypothalamic nuclei. However, recent studies have revealed that leptin also acts on hippocampal synapses and significantly impacts cognitive processes, particularly hippocampal-dependent learning and memory.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Randa Kassab
Summary: This article introduces a new method for modeling the CA3 network, focusing on the impact of long-term potentiation (LTP) on CA3 functional connectivity. The study found that only a small fraction of active synapses should be connected to activated cells to achieve optimal performance. This control of connectivity is achieved by acetylcholine modulating the trafficking and adjustment of the AMPA receptors.
Article
Biochemistry & Molecular Biology
Tatyana Y. Postnikova, Alexandra Griflyuk, Dmitry Amakhin, Anna A. Kovalenko, Elena B. Soboleva, Olga E. Zubareva, Aleksey Zaitsev
Summary: Febrile seizures in early life can cause slight morphological disturbances in the hippocampus, but lead to significant functional impairments, particularly in the activity of NMDARs and LTP in synapses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Computer Science, Interdisciplinary Applications
Haonan He, Liangyu Chen, Shanyong Wang
Summary: Accurate demand forecasting is crucial for airlines to cope with competition and increase revenue. This paper presents adaptive frameworks based on LSTM network for predicting flight booking demand, achieving superior performance and handling irregular data patterns effectively.
COMPUTERS & INDUSTRIAL ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Pojeong Park, John Georgiou, Thomas M. Sanderson, Kwang-Hee Ko, Heather Kang, Ji-il Kim, Clarrisa A. Bradley, Zuner A. Bortolotto, Min Zhuo, Bong-Kiun Kaang, Graham L. Collingridge
Summary: Long-term potentiation at hippocampal CA1 synapses can be achieved by increasing the number and/or single-channel conductance of AMPA receptors, with CaMKII and PKA working together to increase single-channel conductance.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Pojeong Park, Heather Kang, John Georgiou, Min Zhuo, Bong-Kiun Kaang, Graham L. Collingridge
Summary: The study demonstrates that calcium-permeable AMPA receptors are crucial for heterosynaptic metaplasticity. Results show that significant metaplasticity occurs when a strong TBS precedes a weak TBS, and pausing stimulation can largely eliminate this metaplasticity.
Article
Orthopedics
Rahul Gawri, Ryszard Bielecki, Eric W. Salter, Alena Zelinka, Toshikazu Shiba, Graham Collingridge, Andras Nagy, Rita A. Kandel
Summary: Inorganic polyphosphates (polyP) require calcium influx to regulate chondrocyte matrix production, likely through activating calcium signaling pathway. These findings help in the clinical translation of polyP into a therapeutic agent for cartilage repair.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Neurosciences
Qi-Yu Chen, Xu-Hui Li, Jing-Shan Lu, Yinglu Liu, Jung-Hyun Alex Lee, Yu-Xin Chen, Wantong Shi, Kexin Fan, Min Zhuo
Summary: This study found that GluN2C/2D subunits are expressed in the pyramidal cells of the ACC in adult mice. A selective antagonist of GluN2C/2D, UBP145, significantly reduced NMDAR-mediated currents without affecting synaptically evoked EPSCs. UBP145 also did not impact postsynaptic long-term potentiation (post-LTP), presynaptic LTP (pre-LTP), or LTD, but did decrease the frequency of miniature EPSCs (mEPSCs) without affecting their amplitude.
Article
Neurosciences
Jung-Hyun Alex Lee, Zhuang Miao, Qi-Yu Chen, Xu-Hui Li, Min Zhuo
Summary: The anterior cingulate cortex (ACC) is crucial for processing pain-related information in the brain, with studies on synaptic connections within the ACC shedding light on basic cellular and molecular mechanisms underlying brain functions such as pain, emotion, and cognition. A new mapping technique combining single neuron whole-cell patch-clamp recording with multi-channel field potential recording was developed to investigate excitatory inputs into ACC neurons, revealing heterogeneous excitatory synaptic innervations from different ACC subregions. Pyramidal neurons in the ACC show faster conduction velocity with increasing stimulation distance, while different types of interneurons exhibit varying inactivation and activation properties in response to synaptic transmission modulation.
Article
Neurosciences
G. France, R. Volianskis, R. Ingram, N. Bannister, R. Rotharmel, M. W. Irvine, G. Fang, E. S. Burnell, K. Sapkota, B. M. Costa, D. A. Chopra, S. M. Dravid, A. T. Michael-Titus, D. T. Monaghan, J. Georgiou, Z. A. Bortolotto, D. E. Jane, G. L. Collingridge, A. Volianskis
Summary: This passage discusses how different types of memory rely on different types of synaptic plasticity and the potential use of positive allosteric modulators (PAMs) of NMDA receptors as cognitive enhancers. It also presents experimental findings that show PAMs can differently regulate distinct forms of NMDAR-dependent synaptic plasticity based on their subtype selectivity.
Review
Neurosciences
Qi-Yu Chen, Xu-Hui Li, Min Zhuo
Summary: The anterior cingulate cortex plays a critical role in pain modulation and pain-related emotional disorders. Long-term potentiation and long-term depression are key mechanisms underlying chronic pain and emotional disorders, with NMDARs playing important roles in these processes. Inhibiting NMDAR subtypes may offer potential drug targets for these conditions.
Article
Neurosciences
Alen Eapen, Diego Fernandez-Fernandez, John Georgiou, Zuner A. Bortolotto, Stafford Lightman, David E. Jane, Arturas Volianskis, Graham L. Collingridge
Summary: The study demonstrates the involvement of GluN2D-containing NMDARs in both short-term potentiation (STP) and long-term potentiation (LTP) in the mouse hippocampus, highlighting the important role of GluN2D subunits in synaptic plasticity.
Article
Neurosciences
Yeseul Lee, Zuner A. Bortolotto, Clarrisa A. Bradley, Thomas M. Sanderson, Min Zhuo, Bong-Kiun Kaang, Graham L. Collingridge
Summary: Inhibition of GSK-3 improves learning speed in behavioral tasks and enhances the accuracy of long-term spatial memory.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Thomas M. Sanderson, Liam T. Ralph, Mascia Amici, Ai Na Ng, Bong-Kiun Kaang, Min Zhuo, Sang Jeong Kim, John Georgiou, Graham L. Collingridge
Summary: In hippocampal area CA1, mGluR-LTD can be expressed by a decrease in neurotransmitter release probability or a change in postsynaptic AMPA receptor number. The determinant of expression locus is still unknown. Using different concentrations of DHPG, we found that low concentration DHPG induces presynaptic LTD that requires NMDA receptor co-activation, while high concentration DHPG induces postsynaptic LTD that is independent of NMDA receptor activation. Our results reveal an unexpected complexity to mGluR-mediated synaptic plasticity in the hippocampus.
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Matthew T. Birnie, Alen Eapen, Yvonne M. Kershaw, David Lodge, Graham L. Collingridge, Becky L. Conway-Campbell, Stafford L. Lightman
Summary: More than 50% of depressed patients exhibit hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis. Ketamine, a rapid-acting antidepressant, has a significant impact on HPA axis function. The timing of ketamine administration may be crucial for its glucocorticoid-mediated action in depression.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Article
Chemistry, Organic
Lisa-Maria Recnik, Robert J. Thatcher, Shahida Mallah, Craig P. Butts, Graham L. Collingridge, Elek Molnar, David E. Jane, Christine L. Willis
Summary: (-)-Arctigenin and new analogues showed antagonist activity at both AMPA and kainate receptors, with spirocyclic analogue 6c acting as a non-competitive antagonist. Molecular docking studies suggest they bind in a similar manner to known AMPA receptor antagonists, indicating potential as novel leads for epilepsy treatment drug development.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Review
Neurosciences
Jing-Shan Lu, Qi-Yu Chen, Xiang Chen, Xu-Hui Li, Zhaoxiang Zhou, Qin Liu, Yuwan Lin, Miaomiao Zhou, Ping-Yi Xu, Min Zhuo
Summary: Parkinson's disease is the second most common neurodegenerative disorder after Alzheimer's disease, often accompanied by chronic pain. Degeneration of dopaminergic neurons is the key mechanism of Parkinson's disease, leading to dysfunction in the nociceptive system.
