C-terminal interactions mediate the quaternary dynamics of  B-crystallin

Dissecting Heterogeneous Molecular Chaperone Complexes Using a Mass Spectrum Deconvolution Approach

(2012) Florian Stengel et al.   CHEMISTRY & BIOLOGY

Linking structural change with functional regulation—insights from mass spectrometry

(2012) Nina Morgner et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Binding determinants of the small heat shock protein, αB-crystallin: recognition of the ‘IxI’ motif

(2012) Scott P Delbecq et al.   EMBO JOURNAL

The family of mammalian small heat shock proteins (HSPBs): Implications in protein deposit diseases and motor neuropathies

(2012) Alessandra Boncoraglio et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

sHSP in the eye lens: Crystallin mutations, cataract and proteostasis

(2012) Alice R. Clark et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Measurement of the signs of methyl 13C chemical shift differences between interconverting ground and excited protein states by R 1ρ : an application to αB-crystallin

(2012) Andrew J. Baldwin et al.   JOURNAL OF BIOMOLECULAR NMR

Structural Studies on the Oligomeric Transition of a Small Heat Shock Protein, StHsp14.0

(2012) Yuya Hanazono et al.   JOURNAL OF MOLECULAR BIOLOGY

Probing Dynamic Conformations of the High-Molecular-Weight αB-Crystallin Heat Shock Protein Ensemble by NMR Spectroscopy

(2012) Andrew J. Baldwin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reliable Determinations of Protein–Ligand Interactions by Direct ESI-MS Measurements. Are We There Yet?

(2012) Elena N. Kitova et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Two decades of studying non-covalent biomolecular assemblies by means of electrospray ionization mass spectrometry

(2012) G. R. Hilton et al.   Journal of the Royal Society Interface

Atomic View of a Toxic Amyloid Small Oligomer

(2012) Arthur Laganowsky et al.   SCIENCE

Charge state and adduct reduction in electrospray ionization–mass spectrometry using solvent vapor exposure

(2011) Jonathan T.S. Hopper et al.   ANALYTICAL BIOCHEMISTRY

Binding of the Molecular Chaperone αB-Crystallin to Aβ Amyloid Fibrils Inhibits Fibril Elongation

(2011) Sarah L. Shammas et al.   BIOPHYSICAL JOURNAL

Mass spectrometry: come of age for structural and dynamical biology

(2011) Justin LP Benesch et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Quaternary Dynamics of αB-Crystallin as a Direct Consequence of Localised Tertiary Fluctuations in the C-Terminus

(2011) Andrew J. Baldwin et al.   JOURNAL OF MOLECULAR BIOLOGY

αB-Crystallin Polydispersity Is a Consequence of Unbiased Quaternary Dynamics

(2011) Andrew J. Baldwin et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structure of R120G Disease Mutant of Human αB-Crystallin Domain Dimer Shows Closure of a Groove

(2011) A.R. Clark et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

N-terminal domain of  B-crystallin provides a conformational switch for multimerization and structural heterogeneity

(2011) S. Jehle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple molecular architectures of the eye lens chaperone  B-crystallin elucidated by a triple hybrid approach

(2011) N. Braun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Polydispersity of αB-Crystallin Is Rationalized by an Interconverting Polyhedral Architecture

(2011) Andrew J. Baldwin et al.   STRUCTURE

Small heat shock proteins and α-crystallins: dynamic proteins with flexible functions

(2011) Eman Basha et al.   TRENDS IN BIOCHEMICAL SCIENCES

Alternate Dissociation Pathways Identified in Charge-Reduced Protein Complex Ions

(2010) Kevin Pagel et al.   ANALYTICAL CHEMISTRY

Collision Cross Sections of Proteins and Their Complexes: A Calibration Framework and Database for Gas-Phase Structural Biology

(2010) Matthew F. Bush et al.   ANALYTICAL CHEMISTRY

The Interaction of αB-Crystallin with Mature α-Synuclein Amyloid Fibrils Inhibits Their Elongation

(2010) Christopher A. Waudby et al.   BIOPHYSICAL JOURNAL

The Quaternary Organization and Dynamics of the Molecular Chaperone HSP26 Are Thermally Regulated

(2010) Justin L.P. Benesch et al.   CHEMISTRY & BIOLOGY

Selective degradation of aggregate-prone CryAB mutants by HSPB1 is mediated by ubiquitin–proteasome pathways

(2010) Huali Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Heat Shock Response: Life on the Verge of Death

(2010) Klaus Richter et al.   MOLECULAR CELL

Solid-state NMR and SAXS studies provide a structural basis for the activation of αB-crystallin oligomers

(2010) Stefan Jehle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Quaternary dynamics and plasticity underlie small heat shock protein chaperone function

(2010) F. Stengel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-3D domain swapped crystal structure of truncated zebrafish alphaA crystallin

(2010) A. Laganowsky et al.   PROTEIN SCIENCE

Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function

(2010) Arthur Laganowsky et al.   PROTEIN SCIENCE

Role of conformational sampling in computing mutation-induced changes in protein structure and stability

(2010) Elizabeth H. Kellogg et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structure and Mechanism of Protein Stability Sensors: Chaperone Activity of Small Heat Shock Proteins

(2009) Hassane S. Mchaourab et al.   BIOCHEMISTRY

Crystal Structures of α-Crystallin Domain Dimers of αB-Crystallin and Hsp20

(2009) C. Bagnéris et al.   JOURNAL OF MOLECULAR BIOLOGY

Fundamentals of Traveling Wave Ion Mobility Spectrometry

(2008) Alexandre A. Shvartsburg et al.   ANALYTICAL CHEMISTRY

Crystallin proteins and amyloid fibrils

(2008) H. Ecroyd et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Real-Time Monitoring of Protein Complexes Reveals their Quaternary Organization and Dynamics

(2008) Alexander J. Painter et al.   CHEMISTRY & BIOLOGY

Alpha crystallin: The quest for a homogeneous quaternary structure

(2008) Joseph Horwitz   EXPERIMENTAL EYE RESEARCH

Truncation of αB-Crystallin by the Myopathy-causing Q151X Mutation Significantly Destabilizes the Protein Leading to Aggregate Formation in Transfected Cells

(2008) Victoria H. Hayes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Heat Shock Protein Activity Is Regulated by Variable Oligomeric Substructure

(2008) Justin L. P. Benesch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allostery: Absence of a Change in Shape Does Not Imply that Allostery Is Not at Play

(2008) Chung-Jung Tsai et al.   JOURNAL OF MOLECULAR BIOLOGY

αB-Crystallin: A Hybrid Solid-State/Solution-State NMR Investigation Reveals Structural Aspects of the Heterogeneous Oligomer

(2008) Stefan Jehle et al.   JOURNAL OF MOLECULAR BIOLOGY

Collisional activation of protein complexes: Picking up the pieces

(2008) Justin L. P. Benesch   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Native mass spectrometry: a bridge between interactomics and structural biology

(2008) Albert J R Heck   NATURE METHODS

Ion mobility–mass spectrometry analysis of large protein complexes

(2008) Brandon T Ruotolo et al.   Nature Protocols

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

Interactive sequences in the molecular chaperone, human αB crystallin modulate the fibrillation of amyloidogenic proteins

(2007) Joy G. Ghosh et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY