期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 366, 期 1580, 页码 2853-2856出版社
ROYAL SOC
DOI: 10.1098/rstb.2011.0133
关键词
prebiotic chemistry; self-assembling systems; RNA world; ribozymes; ribosome
类别
资金
- MRC [MC_UP_A024_1009] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [B17092] Funding Source: researchfish
- Cancer Research UK [11722] Funding Source: researchfish
- Medical Research Council [MC_UP_A024_1009] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [B17092] Funding Source: Medline
- Cancer Research UK [11722] Funding Source: Medline
- Medical Research Council [MC_UP_A024_1009] Funding Source: Medline
Can we look at contemporary biology and couple this with chemical insight to propose some plausible mechanisms for the origin of life on the planet? In what follows, we examine some promising chemical reactions by which the building blocks for nucleic acids might have been created about a billion years after the Earth formed. This could have led to self-assembling systems that were based on an all-RNA metabolism, where RNA is both catalytic and informational. We consider the breadth of RNA enzymes presently existing in biology, and to what extent these might have covered a wider range of chemistry in the RNA world. Ultimately, the RNA world would probably have given way to protein-based life quite quickly, and the origins of peptidyl transferase activity are discussed below.
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