期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 365, 期 1551, 页码 2383-2395出版社
ROYAL SOC
DOI: 10.1098/rstb.2009.0322
关键词
spinal cord; locomotion; central pattern generator; mouse; networks
类别
资金
- Natural Sciences and Engineering Research Council of Canada
- Canadian Institutes of Health Research
Rhythmic activity is responsible for numerous essential motor functions including locomotion, breathing and chewing. In the case of locomotion, it has been realized for some time that the spinal cord contains sufficient circuitry to produce a sophisticated stepping pattern. However, the central pattern generator for locomotion in mammals has remained a 'black box' where inputs to the network were manipulated and the outputs interpreted. Over the last decade, new genetic approaches and techniques have been developed that provide ways to identify and manipulate the activity of classes of interneurons. The use of these techniques will be critically discussed and related to current models of network function.
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