Article
Business
Jbid Arsenyan, Agata Mirowska, Anke Piepenbrink
Summary: Virtual agent research has formed a substantial body of work, with fragmented structure and overlapping definitions and results. This study used Latent Dirichlet Allocation to analyze 1865 publications from 1995 to 2022, revealing 16 topics that represent the current research landscape. By organizing these topics into a Human-Virtual Agent Coexistence Framework, this study identifies current trends and future research opportunities.
TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
(2023)
Review
Medicine, Research & Experimental
Parichehr Hassanzadeh
Summary: The emergence of nanotechnology has allowed for the development of multifunctional nanobiomaterials, particularly in the biomedical field. By incorporating nanomaterials into biomaterials, beneficial effects such as site-specific drug delivery or tissue engineering can be achieved. However, challenges such as inappropriate distribution or penetration into cells, bio-nano interface complexity, and loss of targeting ability still exist.
Review
Chemistry, Multidisciplinary
Doudou Hu, Tiandong Li, Wen'an Liang, Yeyuan Wang, Min Feng, Jingchen Sun
Summary: Silk sericin, produced by silkworms, has gained increasing attention in the field of biomedical applications due to its excellent biocompatibility, biodegradability, and pharmacological activities resulting from its unique amino acid compositions. This review summarizes the biological properties of silk sericin, including its potential in curing specific diseases, promoting tissue regeneration, and the underlying mechanisms. The antioxidant activity of silk sericin is considered a fundamental property, despite the exact mechanisms remaining unknown.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Biochemical Research Methods
K. H. Brian Lam, Kevin Faust, Richard Yin, Clare Fiala, Phedias Diamandis
Summary: This article introduces an integrated online portal, the Brain Protein Atlas (BPA), aimed at accelerating the biological understanding of the brain and various diseases. The portal contains mass-spectrometry-based proteomic datasets and provides built-in analytical tools for users to explore and evaluate the spatiotemporal patterns of proteins of interest.
Article
Computer Science, Artificial Intelligence
Chanachok Chokwitthaya, Yimin Zhu, Weizhuo Lu
Summary: This study proposes a virtual human-building interaction experimentation ontology (VHBIEO) to standardize virtual reality experiments. VHBIEO is developed based on state-of-the-art ontology development approaches and is made machine-readable, accessible, and processable using Semantic Web technologies. It also includes an application view (APV) to support the inclusion of unique information for specific applications.
ADVANCED ENGINEERING INFORMATICS
(2023)
Article
Computer Science, Information Systems
Prateek Chhikara, Prabhjot Singh, Rajkumar Tekchandani, Neeraj Kumar, Mohsen Guizani
Summary: Change is essential for existence, and utilizing technological advances is crucial for human development; the pandemic has exposed vulnerabilities and the need to adapt to the new normal; the proposed solution combining federated learning and emotion analysis can enhance work culture and promote mental health post-pandemic.
IEEE INTERNET OF THINGS JOURNAL
(2021)
Article
Engineering, Biomedical
Alicia Fernandez-Colino, Fabian Kiessling, Ioana Slabu, Laura De Laporte, Payam Akhyari, Saskia K. Nagel, Julia Stingl, Stefanie Reese, Stefan Jockenhoevel
Summary: By studying the construction rules of living organisms, it is possible to develop biomimetic materials and biomedical systems. The article highlights recent advances in transformative biohybrid systems for tissue regeneration and biomedicine, as well as the progress in computational simulations and data-driven predictions. The ongoing development of imaging methods is also essential for validating computational models and enabling longitudinal monitoring. The challenges and future prospects of lifelike biohybrid materials are discussed.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Multidisciplinary Sciences
Buket Coskun, Sevket Ay, Duygun Erol Barkana, Hilal Bostanci, Ismail Uzun, Ayse Betul Oktay, Basak Tuncel, Devrim Tarakci
Summary: This study introduces a new dataset AKTIVES, which is used for evaluating stress detection and game reaction methods using physiological signals. The data was collected from 25 children with different conditions, including obstetric brachial plexus injury, dyslexia, and intellectual disabilities, as well as typically developed children during game therapy. Physiological data (BVP, EDA, ST) and facial expressions of the children were recorded. Three experts labeled the data as Stress/No Stress and Reaction/No Reaction based on the videos, and the technical validation showed good quality and consistency among the experts.
Article
Multidisciplinary Sciences
Andreas Angourakis, Jonas Alcaina-Mateos, Marco Madella, Debora Zurro
Summary: The origin of agricultural societies and the domestication of plants has been a widely debated topic. This article presents the Human-Plant Coevolution (HPC) model, which captures different factors and conditions that may have contributed to the development of agriculture and domestication.
Article
Robotics
Andrea Bajcsy, Somil Bansal, Ellis Ratner, Claire J. Tomlin, Anca D. Dragan
Summary: Designing human motion predictors for robots operating in close physical proximity to people is a challenge, as it requires balancing safety and efficiency. One approach is to use robust control predictors, which can be too conservative, while another is through intent-driven predictors, which can lead to unsafe maneuvers if intent models are misspecified. A novel predictor combining robust control and intent-driven human modeling is proposed to provide robustness against misspecified models while reducing conservatism, demonstrated through simulation and hardware tests.
IEEE ROBOTICS AND AUTOMATION LETTERS
(2021)
Article
Neurosciences
Jiamin Fan, Xiaomeng Li, Xing Su
Summary: Construction equipment teleoperation is a promising solution for hazardous site environments. However, operator's limited situational awareness is a major hurdle. Virtual annotations (VAs) can convey operating clues to improve operator's situational awareness without cognitive overload. This study investigates the effect of VA on teleoperation performance in excavating tasks and provides insights into human vision in virtual or augmented reality, informing the design of user-friendly teleoperation systems.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Sara Stabile, Francesca Palermo, Inna Bukreeva, Daniela Mele, Vincenzo Formoso, Roberto Bartolino, Alessia Cedola
Summary: This study utilizes X-ray phase contrast tomography to unlock the secrets of the ancient Herculaneum papyrus scrolls, paving the way for further investigation despite challenges in the unfolding process.
SCIENTIFIC REPORTS
(2021)
Review
Ecology
Kathryn Wilsterman, Mallory A. Ballinger, Caroline M. Williams
Summary: Animals across different taxonomic groups exhibit similar phenotypes during programmed dormancy in highly seasonal environments, but research on dormancy has been historically limited by phylogenetic barriers. A broad comparative approach could provide new insights into the evolution of programmed dormancy.
FUNCTIONAL ECOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Farhah Amaliya Zaharuddin, Nazrita Ibrahim, Azmi Mohd Yusof
Summary: This study proposed a framework for designing virtual environments for stress therapy, incorporating design requirements from psychology and information technology. The effectiveness, usability, ease of use, and usefulness of the system implementing the framework concept were evaluated through four methods, and the results showed positive findings in stress reduction and usefulness of design elements.
APPLIED SCIENCES-BASEL
(2022)
Editorial Material
Multidisciplinary Sciences
David A. Leopold
Summary: The human brain's motor cortex is traditionally seen as a linear map controlling different body parts. However, the discovery of additional functions suggests a different kind of mapping.
Article
Cardiac & Cardiovascular Systems
Ana Simon-Chica, Marbely C. Fernandez, Eike M. Wuelfers, Achim Lother, Ingo Hilgendorf, Gunnar Seemann, Ursula Ravens, Peter Kohl, Franziska Schneider-Warme
Summary: This study characterized the electrophysiological properties of cardiac resident MΦ in mice and explored their potential impact on cardiomyocytes. The research findings provide insights into the involvement of MΦ in cardiac conduction and pave the way for further understanding their role in the heart.
CARDIOVASCULAR RESEARCH
(2022)
Article
Engineering, Biomedical
Alessandra Aldieri, Mara Terzini, Alberto L. Audenino, Cristina Bignardi, Margaret Paggiosi, Richard Eastell, Marco Viceconti, Pinaki Bhattacharya
Summary: The thickness of passive soft tissues surrounding the trochanteric region is related to hip fracture risk. Personalized measurement of thickness using computed tomography scans can improve the accuracy of fracture classification based on absolute risk values.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Article
Biology
Barbara de Melo Quintela, Silvia Hervas-Raluy, Jose Manuel Garcia-Aznar, Dawn Walker, Kenneth Y. Wertheim, Marco Viceconti
Summary: This article discusses the factors affecting solid tumor growth and the importance of constructing personalized mathematical models. In order to address the wide range of scales in solid tumors, a multiscale model is proposed, which separates scales based on experimental and computational limitations.
JOURNAL OF THEORETICAL BIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Peter Kohl, Joachim Greiner, Eva A. Rog-Zielinska
Summary: This Review discusses the latest insight into the 3D nanostructure of the heart and its impact on cellular function during contraction and relaxation. Technological breakthroughs in biological sample preparation, 3D imaging, and data analysis have provided access to new data and driven the development of smart image-analysis algorithms. The authors highlight the scientific discovery and potential clinical relevance of understanding 3D cardiac nanodynamics, as well as predict further progress in the next decade.
NATURE REVIEWS CARDIOLOGY
(2022)
Article
Engineering, Biomedical
Antonino A. La Mattina, Fabio Baruffaldi, Mark Taylor, Marco Viceconti
Summary: This study explored the use of statistical aliasing to expand patient cohorts while retaining original biomechanical characteristics. By simulating a clinical trial on a large cohort of virtual patients and monitoring biomarkers of interest, it offers a novel solution to address the limitations of prospective studies on osteoporosis-related hip fragility fractures.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Cristina Curreli, Valentina Di Salvatore, Giulia Russo, Francesco Pappalardo, Marco Viceconti
Summary: This study develops a computer simulation environment that can predict the dose-response of new therapeutic vaccines against tuberculosis, supporting the optimal design of clinical trials. Before using this in silico methodology, it is important to assess the credibility of the predictive model and a risk-informed credibility assessment plan is presented.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Vinicius Varella, Barbara de M. Quintela, Marek Kasztelnik, Marco Viceconti
Summary: This study explores the simplest particularisation/homogenisation scheme that can couple a model predicting the growth of a solid tumor with a tissue-scale model of cell-tissue biology. The study finds that even a simple algorithm can significantly reduce computational costs with negligible approximation errors.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Giorgio Davico, Francesca Bottin, Alberto Di Martino, Vanita Castafaro, Fabio Baruffaldi, Cesare Faldini, Marco Viceconti
Summary: This study evaluates the repeatability of manual segmentation of hip muscle volumes on clinical MRI data and finds that repeated manual segmentations are highly similar to each other. However, shape and surface similarity decrease when muscle extremities are included in the segmentations.
JOURNAL OF DIGITAL IMAGING
(2023)
Editorial Material
Neurosciences
T. Alexander Quinn, Peter Kohl
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Medicine, General & Internal
Marco Viceconti, Maria Tome, Wilhelmus Dartee, Igor Knezevic, Sabina Hernandez Penna, Claudia Mazza, Brian Caulfield, Judith Garcia-Aymerich, Clemens Becker, Walter Maetzler, Thierry Troosters, Basil Sharrack, Giorgio Davico, Solange Corriol-Rohou, Lynn Rochester
Summary: Loss of mobility is common in various health conditions and affects the quality of life. Recent advancements in technology now allow accurate monitoring of mobility in real-world settings, even for pathological populations. However, regulatory qualification is necessary before employing these methods in clinical trials. The Mobilise-D Consortium presents their experience with the European regulator, proposing a refined qualification strategy for using digital mobility outcome measures as biomarkers in drug trials.
FRONTIERS IN MEDICINE
(2022)
Editorial Material
Neurosciences
Peter Kohl
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Computer Science, Information Systems
Francesco Pappalardo, John Wilkinson, Francois Busquet, Antoine Bril, Mark Palmer, Barry Walker, Cristina Curreli, Giulia Russo, Thierry Marchal, Elena Toschi, Rossana Alessandrello, Vincenzo Costignola, Ingrid Klingmann, Martina Contin, Bernard Staumont, Matthias Woiczinski, Christian Kaddick, Valentina Di Salvatore, Alessandra Aldieri, Liesbet Geris, Marco Viceconti
Summary: In Silico Trials methodologies will have a significant impact on the development and risk reduction of medical devices in the future. The regulatory pathway for Digital Patient and Personal Health Forecasting solutions is clear, but more complex for In Silico Trials solutions. It is suggested that the European regulatory system should start an innovation process to avoid companies focusing on other markets like the USA.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2022)
Editorial Material
Neurosciences
Yoshihiro Kubo, Peter Kohl
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Review
Cardiac & Cardiovascular Systems
Ana Simon-Chica, Eike M. Wuelfers, Peter Kohl
Summary: This review provides an overview of heterocellular electrical communication in the heart, highlighting the roles of cardiac fibroblasts and macrophages in cardiac electrophysiology and arrhythmogenesis.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Orthopedics
Domenico Alesi, Barbara Bordini, Stefano Fratini, Cristina Ancarani, Piero Agostinone, Alberto Grassi, Giulio Maria Marcheggiani Muccioli, Marco Viceconti, Stefano Zaffagnini
Summary: This study investigated the differences in survivorship between medial and lateral unicompartmental knee arthroplasty (UKA) using data analysis from an Italian regional registry. The results showed that lateral UKA had a significantly higher survival rate compared to medial UKA.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
