期刊
PHARMACOTHERAPY
卷 30, 期 2, 页码 169-176出版社
WILEY
DOI: 10.1592/phco.30.2.169
关键词
angiogenesis; 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors; HMG-CoA; statins; stroke; myocardial infarction; diabetic retinopathy; cancer
资金
- American Heart Association Southeast Affiliate
- Pfizer
- Veterans Affairs Merit Review
- National Institutes of Health
- Juvenile Diabetes Research Foundation
Angiogenesis is an important process for a variety of physiologic and pathologic conditions. Different angiogenic modulating targets are under extensive investigation both experimentally and clinically The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are the first-line agents used in hypercholesterolemia. They are also characterized by having other benefits apart from their lipid-lowering effects. Among these pleiotropic effects are the pro- and antiangiogenic properties of statins. The pleiotropic effects of statins and how they modulate new blood vessel formation are discussed in this review. The currently available data from both animal and human studies regarding the effects of statins on angiogenesis in ischemic heart disease, stroke, ocular diseases, and cancer are also reviewed. Statins are safe, orally available agents that may acquire novel therapeutic indications through their angiogenic modulating effects.
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