Article
Clinical Neurology
Bing Chen, Jiangang Xu, Simiao Chen, Tingting Mou, Ying Wang, Haojun Wang, Zhihan Zhang, Feifan Ren, Zheng Wang, Kangyu Jin, Jing Lu
Summary: This study found that dysregulation of the dopamine system contributes to depressive-like behaviors in rats, and the neurological functions regulated by hypocretin are severely affected in depression. It also found that suvorexant plays a role in alleviating depression by affecting the dopamine system.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Multidisciplinary Sciences
Nace Mikus, Christoph Eisenegger, Christoph Mathys, Luke Clark, Ulrich Mueller, Trevor W. Robbins, Claus Lamm, Michael Naef
Summary: The study investigates the impact of the D2/D3 dopamine receptor antagonist sulpiride on learning about other people's prosocial attitudes. The results show that sulpiride increases the volatility of beliefs, leading to higher precision weights on prediction errors. This effect is more significant in participants with genetically conferred higher dopamine availability and remains even after controlling for working memory performance. The findings demonstrate the importance of D2 receptors in regulating belief updating in a social context.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Seongsik Yun, Ben Yang, Justin D. Anair, Madison M. Martin, Stefan W. Fleps, Arin Pamukcu, Nai-Hsing Yeh, Anis Contractor, Ann Kennedy, Jones G. Parker
Summary: Psychosis is associated with elevated dopamine transmission, and antipsychotic drugs are thought to rebalance the output by blocking D2 receptors. However, this study found that the efficacy of antipsychotic drugs is associated with the reversal of abnormal D1-SPN dynamics, not D2-SPN dynamics. The findings suggest that D1-SPN modulation plays an important role in the mechanism of antipsychotic drugs.
NATURE NEUROSCIENCE
(2023)
Article
Neuroimaging
Philippe Pfeifer, Alexandra Sebastian, Hans Georg Buchholz, Christoph P. Kaller, Gerhard Gruender, Christoph Fehr, Mathias Schreckenberger, Oliver Tuescher
Summary: This study investigated the relationship between D-2/D-3 dopamine receptor availability and response inhibition, finding a positive correlation between striatal and extrastriatal dopamine receptor availability and stopping-related brain activity. The findings highlight the importance of these receptors in the fronto-striatal neural circuit for response inhibition.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Neurosciences
Mia I. Allen, Angela N. Duke, Susan H. Nader, Adrienne Adler-Neal, Kiran Solingapuram K. Sai, Beth A. Reboussin, H. Donald Gage, Ronald J. Voll, Akiva Mintz, Mark M. Goodman, Michael A. Nader
Summary: Brain imaging studies using PET have shown that long-term cocaine use is associated with lower levels of dopamine D2/D3 receptors and inconsistent effects on dopamine transporter availability. This study used PET imaging to examine the effects of cocaine self-administration on D2/D3 receptor availability and dopamine transporter availability in female monkeys. The results demonstrated sex differences in the relationship between D2/D3 receptor availability and vulnerability to long-term cocaine use, with baseline D2/D3 receptor availability only correlated with cocaine self-administration in the first week of exposure.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Dean F. Wong, Arash Raoufinia, Patricia Bricmont, James R. Brasic, Robert D. McQuade, Robert A. Forbes, Tetsuro Kikuchi, Hiroto Kuwabara
Summary: The study aimed to assess the D-2/D-3 receptor occupancy induced by brexpiprazole at different doses, showing a dose-dependent increase in occupancy up to 77-88%. Multiple doses of brexpiprazole are expected to result in an efficacious brexpiprazole concentration consistent with clinically active doses.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Seth C. Hopkins, Scott Wilkinson, Taryn J. Corriveau, Hiroyuki Nishikawa, Keiko Nakamichi, Antony Loebel, Kenneth S. Koblan
Summary: In the treatment of bipolar depression, balancing the reduction of side effects with retaining therapeutic effects is crucial. Amisulpride's potential antidepressant effects through 5-HT7R antagonism can be maximized with a nonracemic ratio, reducing side effects and retaining benefits.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Igor D. Grachev, Philipp M. Meyer, Georg A. Becker, Marcus Bronzel, Doug Marsteller, Gina Pastino, Ole Voges, Laura Rabinovich, Helena Knebel, Franziska Zientek, Michael Rullmann, Bernhard Sattler, Marianne Patt, Thilo Gerhards, Maria Strauss, Andreas Kluge, Peter Brust, Juha-Matti Savola, Mark F. Gordon, Michal Geva, Swen Hesse, Henryk Barthel, Michael R. Hayden, Osama Sabri
Summary: Pridopidine demonstrates high affinity for the S1R in clinical trials, with near complete occupancy at a clinically relevant single dose of 90 mg. Minimal occupancy is seen at the D2/D3R, indicating pridopidine's selectivity as an S1R ligand. The dose-S1R occupancy relationship suggests cooperative binding of pridopidine to the S1R.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Clinical Neurology
Hironori Nishibe, Amane Tateno, Takeshi Sakayori, Masahiro Yamamoto, WooChan Kim, Hiroyoshi Kakuyama, Yoshiro Okubo
Summary: Transdermal antipsychotic patch formulations, specifically blonanserin patches at doses of 40 mg/d and 80 mg/d, exhibit lower diurnal variability in occupancy compared to blonanserin tablets at doses of 8 mg/d and 16 mg/d, indicating that patches may be a suitable alternative for patients with schizophrenia. The study suggests that blonanserin patches could potentially offer a new treatment option for these patients.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Psychiatry
Linda M. Bonnekoh, Stephanie Seidenbecher, Katrin Knigge, Anne-Kathrin Huenecke, Coraline D. Metzger, Claus Tempelmann, Martin Kanowski, Joern Kaufmann, Gabriela Meyer-Lotz, Konstantin Schlaaff, Henrik Dobrowolny, Leonardo Tozzi, Dorothee M. Gescher, Johann Steiner, Clemens Kirschbaum, Thomas Frodl
Summary: This study investigated metabolic alterations in the anterior cingulate cortex (ACC) of patients with major depression and comorbid anxiety disorder. It found a relationship between N-acetylaspartate metabolism in the ACC and activity of the hypothalamic-pituitary-adrenal axis (HPA) as represented by long-term cortisol output.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kambiz Rahbar, Markus Essler, Kim M. Pabst, Matthias Eiber, Christian la Fouge, Vikas Prasad, Philipp Rassek, Ergela Hasa, Helmut Dittmann, Ralph A. Bundschuh, Wolfgang P. Fendler, Milena Kurtinecz, Anja Schmall, Frank Verholen, Oliver Sartor
Summary: The RALU study evaluated the feasibility of using sequential a and b emitters in patients with bone-predominant metastatic castration-resistant prostate cancer. The study found that treatment with 177Lu-PSMA after 223Ra was feasible and led to a prolongation of overall survival. Few adverse events, mainly anemia and thrombocytopenia, were observed during treatment.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Behavioral Sciences
Saskia Therese Schirmer, Fienne-Elisa Beckmann, Hanna Gruber, Konstantin Schlaaff, Denise Scheermann, Stephanie Seidenbecher, Coraline Danielle Metzger, Claus Tempelmann, Thomas Frodl
Summary: This study compared resting-state functional connectivity (RSFC) in patients with major depressive disorder (MDD) and childhood trauma (CT) history versus MDD without CT, as well as healthy controls. The results showed decreased RSFC in MDD patients compared to controls in multiple brain networks. Patients with CT history exhibited more aberrant RSFC. This suggests that CT may be a significant factor in the etiology of MDD, contributing to dysregulated neural circuits and distinct pathophysiology.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Clinical Neurology
Joy Read, Sarah Cable, Gergely Bartl, Charlotte Loefqvist, Susanne Iwarsson, Anette Schrag
Summary: This study aims to understand the experiences and satisfaction of family caregivers in providing care for late-stage Parkinson's patients. The findings revealed the need for continuous support, unmet service provision needs, and the burden of coordinating various aspects of care. Family caregivers also reported assuming new roles and experiencing multiple losses, but they were able to mitigate some of the challenges through support from professionals and organized and informal support.
PARKINSONS DISEASE
(2023)
Article
Geriatrics & Gerontology
Rowena K. Merritt, Sarah Hotham, Anette Schrag
Summary: This study investigated the support needs of carers of People with Parkinson's (PwP) in 11 European countries. Results showed that carers often felt the need to help patients get a diagnosis and deal with the impact of the diagnosis on the family. Information on medication was particularly important for carers, and many felt their informational needs differed from that of the patients. Many carers also felt the need to be present at all appointments to request referrals or ask for medication changes. Carers of patients in later stages of the disease often reported feeling isolated and having no time for themselves.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2023)
Article
Clinical Neurology
Harry Costello, Yumeya Yamamori, Suzanne Reeves, Anette-Eleonore Schrag, Robert Howard, Jonathan P. Roiser
Summary: This study found that dopaminergic dysfunction in the midbrain is associated with motivational symptoms such as apathy and anhedonia in Parkinson's disease (PD), and this association becomes evident as the disease progresses. These findings can inform intervention strategies for improving the treatment of PD patients.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Anna Held, Dariush Henning, Carina Jiang, Christoph Hoeschen, Thomas Frodl
Summary: The study aimed to confirm the differences in the concentration of volatile organic compounds (VOCs) in the breathing air of schizophrenia patients compared to healthy participants. It also examined whether these VOCs remain stable or change during the early treatment course. Furthermore, it investigated the correlation between the VOCs and the existing psychopathology of schizophrenia patients.
Article
Clinical Neurology
Cristina Simonet, Philipp Mahlknecht, Kathrin Marini, Klaus Seppi, Aneet Gill, Jonathan P. Bestwick, Andrew J. Lees, Gavin Giovannoni, Anette Schrag, Alastair J. Noyce
Summary: The PREDICT-PD study utilized a risk algorithm to stratify individuals for future Parkinson's disease and found an association between risk scores and sub-threshold parkinsonism. The algorithm was able to identify individuals with motor decline over time.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Laura Perez-Carbonell, Cristina Simonet, Harneek Chohan, Aneet Gill, Guy Leschziner, Anette Schrag, Alastair J. Noyce
Summary: This study investigated the experiences and views of risk disclosure in patients with isolated rapid eye movement sleep behavior disorder (iRBD). One-third of the patients reported they were not informed about the link between iRBD and other conditions at diagnosis. Most patients wanted to receive information about the potential implications of iRBD when the diagnosis was made.
MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
Davide Martino, Vikram Karnik, Roongroj A. Bhidayasiri, Deborah A. A. Hall, Robert A. Hauser, Antonella M. Macerollo, Tamara M. Pringsheim, Daniel A. Truong, Stewart A. Factor, Matej Skorvanek, Anette Schrag, IPMDS Rating Scales Review Comm
Summary: An International Parkinson and Movement Disorder Society subcommittee aimed to rate the psychometric quality of severity and screening instruments for antipsychotic-associated movement disorders. They identified 23 instruments, of which 7 severity rating instruments and 3 screening instruments were recommended with caveats due to insufficient psychometric properties and long duration of administration. New psychometric studies and revision of existing instruments are recommended to address these caveats and improve the clarity of their nomenclature.
MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Guenther Deuschl, Angelo Antonini, Joao Costa, Katarzyna Smilowska, Daniela Berg, Jean-Christophe Corvol, Giovanni Fabbrini, Joaquim Ferreira, Tom Foltynie, Pablo Mir, Anette Schrag, Klaus Seppi, Pille Taba, Evzen Ruzicka, Marianna Selikhova, Nicholas Henschke, Gemma Villanueva, Elena Moro
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Veronica Bruno, Beatrice Achen, Francesca Morgante, Roberto Erro, Susan H. Fox, Mark J. Edwards, Anette Schrag, Maria Stamelou, Silke Appel-Cresswell, Giovanni Defazio, K. Ray Chaudhuri, Sarah Pirio Richardson, Hyder A. Jinnah, Davide Martino
Summary: This study developed and validated a new rating instrument, Pain in Dystonia Scale (PIDS), to assess pain in adult-onset idiopathic dystonia (AOID). The PIDS evaluates pain severity, functional impact, and external modulating factors. It demonstrated high-level psychometric properties in patients with cervical dystonia (CD).
MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Haotian Zou, Christopher G. Goetz, Glenn T. Stebbins, Anette Schrag, Tiago A. Mestre, Sheng Luo
MOVEMENT DISORDERS
(2023)
Article
Medicine, General & Internal
Pia M. Linder, Wenhong Lan, Nils F. Trautwein, Julia Brosch-Lenz, Sebastian von Beschwitz, Juergen Kupferschlaeger, Gerald Reischl, Gerd Groezinger, Helmut Dittmann, Christian la Fougere, Fabian P. Schmidt
Summary: Optimized imaging protocol allows high image quality and quantification accuracy for post-treatment dosimetry of Y-90 radioembolization.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jonas Vogel, Ferdinand Seith, Arne Estler, Konstantin Nikolaou, Holger Schmidt, Christian la Fougere, Thomas Kuestner
Summary: In this study, we compared the differences of HIs/TFs between simulated and measured tracer dose reductions and evaluated the changes of HIs/TFs in the liver of PET patients. The results showed that most TFs did not differ significantly between measured and simulated doses, and most TFs exhibited a linear behavior over dose reduction. This suggests that texture analysis in PET might be robust to dose modulations.
